172 research outputs found
Bioreactor With Electrically Deformable Curved Membranes for Mechanical Stimulation of Cell Cultures
Physiologically relevant in vitro models of stretchable biological tissues, such as muscle, lung, cardiac and gastro-intestinal tissues, should mimic the mechanical cues which cells are exposed to in their dynamic microenvironment in vivo. In particular, in order to mimic the mechanical stimulation of tissues in a physiologically relevant manner, cell stretching is often desirable on surfaces with dynamically controllable curvature. Here, we present a device that can deform cell culture membranes without the current need for external pneumatic/fluidic or electrical motors, which typically make the systems bulky and difficult to operate. We describe a modular device that uses elastomeric membranes, which can intrinsically be deformed by electrical means, producing a dynamically tuneable curvature. This approach leads to compact, self-contained, lightweight and versatile bioreactors, not requiring any additional mechanical equipment. This was obtained via a special type of dielectric elastomer actuator. The structure, operation and performance of early prototypes are described, showing preliminary evidence on their ability to induce changes on the spatial arrangement of the cytoskeleton of fibroblasts dynamically stretched for 8 h
The RMS Survey: 13CO observations of candidate massive YSOs in the southern hemisphere
Abridged: The Red MSX Source (RMS) survey is an ongoing multi-wavelength
observational programme designed to return a large, well-selected sample of
massive young stellar objects (MYSOs). Here we present 13CO observations made
towards 854 MYSOs candidates located in the 3rd and 4th quadrants. We detected
13CO emission towards a total of 751 of the 854 RMS sources observed (~88%). In
total 2185 emission components are detected above 3 level. Multiple
emission profiles are observed towards the majority of these sources - 455
sources (~60%) - with an average of ~4 molecular clouds along the line of
sight. These multiple emission features make it difficult to assign a kinematic
velocity to many of our sample. We have used archival CS (J=2-1) and maser
velocities to resolved the component multiplicity towards 82 sources and have
derived a criterion which is used to identify the most likely component for a
further 202 multiple component sources. Combined with the single component
detections we have obtained unambiguous kinematic velocities towards 580
sources (~80% of the detections). The 171 sources for which we have not been
able to determine the kinematic velocity will require additional line data.
Using the rotation curve of Brand and Blitz (1993) and their radial velocities
we calculate kinematic distances for all components detected.Comment: Summitted to A&A, the resolution of figure 1 has been reduced,
samples of Table 3 and Figure 11 are now included but the full version will
only be available in the online version of the journa
Financial phantasmagoria: corporate image-work in times of crisis
Our purpose in this article is to relate the real movements in the economy during 2008 to the ?image-work? of financial institutions. Over the period January?December 2008 we collected 241 separate advertisements from 61 financial institutions published in the Financial Times. Reading across the ensemble of advertisements for themes and evocative images provides an impression of the financial imaginaries created by these organizations as the global financial crisis unfolded. In using the term ?phantasmagoria? we move beyond its colloquial sense of a set of strange images designed to dazzle towards the more technical connotation used by Ranci�re (2004) who suggested that words and images can offer a trace of an overall determining set-up if they are torn from their obviousness so they become phantasmagoric figures. The key phantasmagoric figure we identify here is that of the financial institution as timeless, immortal and unchanging; a coherent and autonomous entity amongst other actors. This notion of uniqueness belies the commonality of thinking which precipitated the global financial crisis as well as the limited capacity for control of financial institutions in relation to market events. It also functions as a powerful naturalizing force, making it hard to question certain aspects of the recent period of ?capitalism in crisis?
The RMS Survey: 6 cm continuum VLA observations towards candidate massive YSOs in the northern hemisphere
(Abridged) Context: The Red MSX Source (RMS) survey is an ongoing
multi-wavelength observational programme designed to return a large,
well-selected sample of massive young stellar objects (MYSOs). We have
identified 2000 MYSO candidates located throughout the Galaxy by
comparing the colours of MSX and 2MASS point sources to those of known MYSOs.
Aims: To identify the populations of UCHII regions and PNe within the sample
and examine their Galactic distribution. Method: We have conducted high
resolution radio continuum observations at 6 cm towards 659 MYSO candidates in
the northern hemisphere (10\degr< l < 250\degr) using the VLA. In addition to
these targeted observations we present archival data towards a further 315 RMS
sources extracted from a previous VLA survey of the inner Galaxy. Results: We
find radio emission towards 272 (27% of the observed sample). Using
results from other parts of our multi-wavelength survey we separate these
RMS-radio associations into two distinct types of objects, classifying 51 as
PNe and a further 208 as either compact or UC HII regions. Using this well
selected sample of HII regions we estimate their Galactic scale height to be
0.6\degr. Conclusions: Using radio continuum and archival data we have
identified 79 PNe and 391 HII regions within the northern RMS catalogue. We
estimate the total fraction of contamination by PNe in the RMS sample is of
order 10%. The sample of HII regions is probably the best representation to
date of the Galactic population of HII regions as a whole.Comment: Accepted for publication in Astronomy and Astrophysics. 15 pages, 9
figures and 5 tables. Full versions of Tables 3, 4 and 5 and Figs. 2, 4 and 7
will only be available via CDS or the RMS website at
http:/www.ast.leeds.ac.uk/cgi-bin/RMS/RMS_VLA_IMAGES.cg
New Perspectives on Glacial Geomorphology in Earth's Deep Time Record
International audienceThe deep time (pre-Quaternary) glacial record is an important means to understand the growth, development, and recession of the global cryosphere on very long timescales (10 6-10 8 Myr). Sedimentological description and interpretation of outcrops has traditionally played an important role. Whilst such data remain vital, new insights are now possible thanks to freely accessible aerial and satellite imagery, the widespread availability and affordability of Uncrewed Aerial Vehicles, and accessibility to 3D rendering software. In this paper, we showcase examples of glaciated landscapes from the Cryogenian, Ediacaran, Late Ordovician and Late Carboniferous where this approach is revolutionizing our understanding of deep time glaciation. Although some problems cannot be overcome (erosion or dissolution of the evidence), robust interpretations in terms of the evolving subglacial environment can be made. Citing examples from Australia (Cryogenian), China (Ediacaran), North and South Africa (Late Ordovician, Late Carboniferous), and Namibia (Late Carboniferous), we illustrate how the power of glacial geomorphology can be harnessed to interpret Earth's ancient glacial record
Thermomechanical Characterization of Carbon Black Reinforced Rubbers During Rapid Adiabatic Straining
The thermo-mechanical properties of carbon black reinforced natural and styrene butadiene rubbers are investigated under rapid adiabatic conditions. Eleven carbon black grades with varying surface area and structure properties at 40 parts per hundred (phr) loading are studied and the unreinforced equivalents are included for reference. The results show a strong correlation of the modulus, mechanical hysteresis, temperature rise and calculated crystallinity of the rubbers measured in tensile extension with strain amplification factors. This highlights the influence of matrix overstraining on microstructural deformations of the rubber upon extension. The strain amplification factors are calculated via the Guth-Gold equation directly from carbon black type and loading, allowing a correlation of the fundamental morphological properties of carbon black with thermal and mechanical properties of rubbers upon extension. Analysis of the thermal measurements of the rubber compounds upon extension and retraction and contrasting between crystallizing and non-crystallizing rubbers reveals that a substantial irreversible heat generation is present upon extension of the rubber compounds. These irreversible effects most likely originate from microstructural damage mechanisms which have been proposed to account for the Mullins Effect in particle reinforced rubbers
The RMS Survey: Distribution and properties of a sample of massive young stars
The Red MSX Source (RMS) survey has identified a large sample of massive
young stellar objects (MYSOs) and ultra compact (UC) HII regions from a sample
of ~2000 MSX and 2MASS colour selected sources. Using a recent catalogue of
molecular clouds derived from the Boston University-Five College Radio
Astronomy Observatory Galactic Ring Survey (GRS), and by applying a Galactic
scaleheight cut off of 120 pc, we solve the distance ambiguity for RMS sources
located within 18\degr 54\degr. These two steps yield kinematic
distances to 291 sources out of a possible 326 located within the GRS longitude
range. Combining distances and integrated fluxes derived from spectral energy
distributions, we estimate luminosities to these sources and find that > 90%
are indicative of the presence of a massive star. We find the completeness
limit of our sample is ~10^4 Lsun, which corresponds to a zero age main
sequence (ZAMS) star with a mass of ~12 Msun. Selecting only these sources, we
construct a complete sample of 196 sources. Comparing the properties of the
sample of young massive stars with the general population, we find the
RMS-clouds are generally larger, more massive, and more turbulent. We examine
the distribution of this sub-sample with respect to the location of the spiral
arms and the Galactic bar and find them to be spatially correlated. We identify
three significant peaks in the source surface density at Galactocentric radii
of approximately 4, 6 and 8 kpc, which correspond to the proposed positions of
the Scutum, Sagittarius and Perseus spiral arms, respectively. Fitting a scale
height to the data we obtain an average value of ~29+-0.5 pc, which agrees well
with other reported values in the literature, however, we note a dependence of
the scale height on galactocentric radius with it increases from 30 pc to 45 pc
between 2.5 and 8.5 kpc.Comment: Accepted for publication by MNRAS. Paper consists of 15 pages
including 12 figures and four tables. Full versions of Tables 2 and 3 will
only be available online. The resolution of Figure 9 has been reduced - a
full resolution version of the paper can be download from here:
http://www.ast.leeds.ac.uk/cgi-bin/RMS/RMS_PUBLICATIONS.cg
The RMS Survey: Resolving kinematic distance ambiguities towards a sample of compact HII regions using HI absorption
We present high-resolution HI data obtained using the Australia Telescope
Compact Array to resolve the near/far distance ambiguities towards a sample of
compact HII regions from the Red MSX Source (RMS) survey. The high resolution
data are complemented with lower resolution archival HI data extracted from the
Southern and VLA Galactic Plane surveys. We resolve the distance ambiguity for
nearly all of the 105 sources where the continuum was strong enough to allow
analysis of the HI absorption line structure. This represents another step in
the determination of distances to the total RMS sample, which with over 1,000
massive young stellar objects and compact HII regions, is the largest and most
complete sample of its kind. The full sample will allow the distribution of
massive star formation in the Galaxy to be examined.Comment: Accepted by MNRAS. This paper consists of 15 pages and contains 10
figures and 5 table
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