A Further Look at Potential Impact of Satlets on Design, Production, and Cost of Satellite Systems

For the past 50 years, the morphology for satellites has remained fundamentally unchanged despite evolutions in manufacturing, communications, and software occurring in other industries. Primary spacecraft support systems—power, attitude control, and others—are designed in the same way, whether in space telescopes, large communications satellites, interplanetary spacecraft, or Cubesats. This paradigm has been the status quo in spacecraft design and construction and has precluded any industry-wide, large-scale cost savings while maintaining performance. To change this trend and ensure performance and utility at low cost, that can scale, DARPA postulated the concept of a cellularized satellite, or “satlet,” as a satellite architectural unit. In this new morphology, each satlet would provide some fraction of the overall functions that, when aggregated via hardware and software, provide spacecraft space system with its complete required capabilities. The DARPA Phoenix program has developed this satlet morphology in Phase I and plans to validate and demonstrate it in a series of steps that exercise various applications and levels of configuration flexibility enabled by a satlet architecture. The first system experiment is planned to be conducted on orbit in 2015. This paper aims to take a deeper look at the potential impact of space systems with cellular based designs, and using historical data showcases how design, production and ultimately cost can form the foundation for next generation spacecraft opportunities. A first order analysis conducted in a previous paper indicated that U.S.-launched satellites alone could create a market demand for 2,000-8,000 satlets flown per year, while the overall annual world satellite market could create demand for 10,000-40,000 satlets. This paper explores the instantiation of a cellular morphology to design, production and development to further quantify the impact of this revolutionary space system capability

Rapid review on safeguarding to inform the Healthy Child Programme 5 to 19

This is the final version of the article. Available from PHE Publications via the DOI in this recordSummary of key points 1. The purpose of this rapid review is to update the evidence in relation to safeguarding guidance in the Healthy Child Programme for 5 to 19 year-olds. 2. It synthesises evidence about ‘what works’ in prevention and early intervention as regards child abuse and neglect, child sexual abuse and exploitation, intimate partner violence (IPV), female genital mutilation (FGM) and gang violence. 3. Focusing on the period 2006 to 2015, a total of 27 systematic reviews and 9 additional randomised controlled trials (RCTs) are included. 4. Key messages on identifying families in need of additional support, the effective implementation of interventions, and workforce skills and training are also included, as is evidence on the economic aspects of safeguarding

Attitudes and behaviour towards convenience food and food waste in the United Kingdom

Households in the UK discard much food. A reduction in such waste to mitigate environmental impact is part of UK government policy. This study investigated whether household food waste is linked to a lifestyle reliant on convenience food in younger consumers. A survey of 928 UK residents aged 18-40 years and responsible for the household food shopping (male n = 278; female n = 650) completed an online questionnaire designed to measure attitudes to convenience food and to quantify household food waste. Cluster analysis of 24 food-related lifestyle factors identified 5 consumer groups. General linear modelling techniques were used to test relationships between the purchase frequency of convenience food and household food waste. From the cluster analysis, five distinct convenience profiles emerged comprising: ‘epicures’ (n = 135), ‘traditional consumers’ (n = 255), ‘casual consumers’ (n = 246), ‘food detached consumers’ (n = 151) and ‘kitchen evaders’ (n = 141). Casual consumers and kitchen evaders were the most reliant on convenience food and notably were the most wasteful. The demographic profile of kitchen evaders matched the population groups currently targeted by UK food waste policy. Casual consumers represent a new and distinct group characterised by “buy a lot and waste a lot” behaviour. Household size, packaging format, price-awareness and marketing all appear to influence levels of food waste. However, it seems that subtle behavioural and sociocultural factors also have impact. Further research is needed to elucidate the factors that mediate the positive association between the purchase of convenience food and reported food waste in order to inform food waste policy and initiatives

The effects of a hot gaseous halo on disc thickening in galaxy minor mergers

We employ hydrodynamical simulations to study the effects of dissipational gas physics on the vertical heating and thickening of disc galaxies during minor mergers. For the first time we present a suite of simulations that includes a diffuse, rotating, cooling, hot gaseous halo, as predicted by cosmological hydrodynamical simulations as well as models of galaxy formation. We study the effect of this new gaseous component on the vertical structure of a Milky Way-like stellar disc during 1:10 and 1:5 mergers. For 1:10 mergers we find no increased final thin disc scale height compared to the isolated simulation, leading to the conclusion that thin discs can be present even after a 1:10 merger if a reasonable amount of hot gas is present. The reason for this is the accretion of new cold gas, leading to the formation of a massive new thin stellar disc that dominates the surface brightness profile. In a previous study, in which we included only cold gas in the disk, we showed that the presence of cold gas decreased the thickening by a minor merger relative to the no-gas case. Here, we show that the evolution of the scale height in the presences of a cooling hot halo is dominated by the formation of the new stellar disc. In this scenario, the thick disc is the old stellar disc that has been thickened in a minor merger at z>1, while the thin disc is the new stellar disc that reforms after this merger. In addition, we study the evolution of the scale height during a 1:5 merger and find that a thin disc can be present even after this merger, provided enough hot gas is available. The final scale height in our simulations depends on the mass of the hot gaseous halo, the efficiency of the winds and the merger mass ratio. We find post-merger values in the range 0.5<z0<1.0 kpc in good agreement with observational constraints by local galaxies.Comment: 14 pages, 10 figures, 2 tables, submitted to MNRA

Nonequilibrium clumped isotope signals in microbial methane

Methane is a key component in the global carbon cycle with a wide range of anthropogenic and natural sources. Although isotopic compositions of methane have traditionally aided source identification, the abundance of its multiply-substituted “clumped” isotopologues, e.g., 13CH3D, has recently emerged as a proxy for determining methane-formation temperatures; however, the impact of biological processes on methane’s clumped isotopologue signature is poorly constrained. We show that methanogenesis proceeding at relatively high rates in cattle, surface environments, and laboratory cultures exerts kinetic control on 13CH3D abundances and results in anomalously elevated formation temperature estimates. We demonstrate quantitatively that H2 availability accounts for this effect. Clumped methane thermometry can therefore provide constraints on the generation of methane in diverse settings, including continental serpentinization sites and ancient, deep groundwaters.National Science Foundation (U.S.) (EAR-1250394)National Science Foundation (U.S.) (EAR-1322805)Deep Carbon Observatory (Program)Natural Sciences and Engineering Research Council of CanadaDeutsche Forschungsgemeinschaft (Gottfried Wilhelm Leibniz Program)United States. Dept. of Defense (National Defense Science and Engineering Graduate Fellowship)Neil & Anna Rasmussen FoundationGrayce B. Kerr Fund, Inc. (Fellowship)MIT Energy Initiative (Shell-MITEI Graduate Fellowship)Shell International Exploration and Production B.V. (N. Braunsdorf and D. Smit of Shell PTI/EG grant

Cosmological simulations of the high-redshift radio universe

Using self-consistent cosmological simulations of disc galaxy formation, we analyse the 1.4 GHz radio flux from high-redshift progenitors of present-day normal spirals within the context of present-day and planned next-generation observational facilities. We demonstrate that while current radio facilities such as the Very Large Array (VLA) are unlikely to trace these progenitors beyond redshifts z<0.2, future facilities such as the Square Kilometer Array (SKA) will readily probe their characteristics to redshifts z<2, and are likely to provide detections beyond z~3. We also demonstrate that the progenitors of present-day cD galaxies can emit in excess of 10 uJy of flux at redshifts z>1, and may be a non-negligible contributor to the micro-Jansky source counts derived from current deep VLA cm-wave surveys.Comment: 7 pages, 5 figures, accepted for publication in MNRAS. High resolution version is available at http://astronomy.swin.edu.au/staff/dkawata/research/papers.htm

Can Gas prevent the Destruction of Thin Stellar Discs by Minor Mergers?

We study the effect of dissipational gas physics on the vertical heating and thickening of disc galaxies during minor mergers. We produce a suite of minor merger simulations for Milky Way-like galaxies. This suite consists of collisionless simulations as well as hydrodynamical runs including a gaseous component in the galactic disc. We find that in dissipationless simulations minor mergers cause the scale height of the disc to increase by up to a factor of ~2. When the presence of gas in the disc is taken into account this thickening is reduced by 25% (50%) for an initial disc gas fraction of 20% (40%), leading to a final scale height z0 between 0.6 and 0.7 kpc, regardless of the initial scale height. We argue that the presence of gas reduces disc heating via two mechanisms: absorption of kinetic impact energy by the gas and/or formation of a new thin stellar disc that can cause heated stars to recontract towards the disc plane. We show that in our simulations most of the gas is consumed during the merger and thus the regrowth of a new thin disc has a negligible impact on the z0 of the post merger galaxy. Final disc scale heights found in our simulations are in good agreement with studies of the vertical structure of spiral galaxies where the majority of the systems are found to have scale heights of 0.4 kpc < z0 < 0.8 kpc. We also found no tension between recent measurements of the scale height of the Milky Way thin disc and results coming from our hydrodynamical simulations. We conclude that the existence of a thin disc in the Milky Way and in external galaxies is not in obvious conflict with the predictions of the CDM model.Comment: 12 pages, 13 figures, two additional simulations, discussion enlarged, two figures added, updated references, accepted for publication in MNRA

A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study.

Funder: Victorian Cancer AgencyFunder: NIHR Manchester Biomedical Research CentreFunder: Cancer Research UKFunder: Cancer Council TasmaniaFunder: Instituto de Salud Carlos IIIFunder: Cancer AustraliaFunder: NIHR Oxford Biomedical Research CentreFunder: Fundación Científica de la Asociación Española Contra el CáncerFunder: Cancer Council South AustraliaFunder: Swedish Cancer SocietyFunder: NIHR Cambridge Biomedical Research CentreFunder: Institut Català de la SalutFunder: Cancer Council VictoriaFunder: Prostate Cancer Foundation of AustraliaFunder: National Institutes of HealthBACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospectively assessing prostate-specific antigen (PSA) screening in men with germline mismatch repair pathogenic variants. Here, we report the usefulness of PSA screening, prostate cancer incidence, and tumour characteristics after the first screening round in men with and without these germline pathogenic variants. METHODS: The IMPACT study is an international, prospective study. Men aged 40-69 years without a previous prostate cancer diagnosis and with a known germline pathogenic variant in the MLH1, MSH2, or MSH6 gene, and age-matched male controls who tested negative for a familial pathogenic variant in these genes were recruited from 34 genetic and urology clinics in eight countries, and underwent a baseline PSA screening. Men who had a PSA level higher than 3·0 ng/mL were offered a transrectal, ultrasound-guided, prostate biopsy and a histopathological analysis was done. All participants are undergoing a minimum of 5 years' annual screening. The primary endpoint was to determine the incidence, stage, and pathology of screening-detected prostate cancer in carriers of pathogenic variants compared with non-carrier controls. We used Fisher's exact test to compare the number of cases, cancer incidence, and positive predictive values of the PSA cutoff and biopsy between carriers and non-carriers and the differences between disease types (ie, cancer vs no cancer, clinically significant cancer vs no cancer). We assessed screening outcomes and tumour characteristics by pathogenic variant status. Here we present results from the first round of PSA screening in the IMPACT study. This study is registered with ClinicalTrials.gov, NCT00261456, and is now closed to accrual. FINDINGS: Between Sept 28, 2012, and March 1, 2020, 828 men were recruited (644 carriers of mismatch repair pathogenic variants [204 carriers of MLH1, 305 carriers of MSH2, and 135 carriers of MSH6] and 184 non-carrier controls [65 non-carriers of MLH1, 76 non-carriers of MSH2, and 43 non-carriers of MSH6]), and in order to boost the sample size for the non-carrier control groups, we randomly selected 134 non-carriers from the BRCA1 and BRCA2 cohort of the IMPACT study, who were included in all three non-carrier cohorts. Men were predominantly of European ancestry (899 [93%] of 953 with available data), with a mean age of 52·8 years (SD 8·3). Within the first screening round, 56 (6%) men had a PSA concentration of more than 3·0 ng/mL and 35 (4%) biopsies were done. The overall incidence of prostate cancer was 1·9% (18 of 962; 95% CI 1·1-2·9). The incidence among MSH2 carriers was 4·3% (13 of 305; 95% CI 2·3-7·2), MSH2 non-carrier controls was 0·5% (one of 210; 0·0-2·6), MSH6 carriers was 3·0% (four of 135; 0·8-7·4), and none were detected among the MLH1 carriers, MLH1 non-carrier controls, and MSH6 non-carrier controls. Prostate cancer incidence, using a PSA threshold of higher than 3·0 ng/mL, was higher in MSH2 carriers than in MSH2 non-carrier controls (4·3% vs 0·5%; p=0·011) and MSH6 carriers than MSH6 non-carrier controls (3·0% vs 0%; p=0·034). The overall positive predictive value of biopsy using a PSA threshold of 3·0 ng/mL was 51·4% (95% CI 34·0-68·6), and the overall positive predictive value of a PSA threshold of 3·0 ng/mL was 32·1% (20·3-46·0). INTERPRETATION: After the first screening round, carriers of MSH2 and MSH6 pathogenic variants had a higher incidence of prostate cancer compared with age-matched non-carrier controls. These findings support the use of targeted PSA screening in these men to identify those with clinically significant prostate cancer. Further annual screening rounds will need to confirm these findings. FUNDING: Cancer Research UK, The Ronald and Rita McAulay Foundation, the National Institute for Health Research support to Biomedical Research Centres (The Institute of Cancer Research and Royal Marsden NHS Foundation Trust; Oxford; Manchester and the Cambridge Clinical Research Centre), Mr and Mrs Jack Baker, the Cancer Council of Tasmania, Cancer Australia, Prostate Cancer Foundation of Australia, Cancer Council of Victoria, Cancer Council of South Australia, the Victorian Cancer Agency, Cancer Australia, Prostate Cancer Foundation of Australia, Asociación Española Contra el Cáncer (AECC), the Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional (FEDER), the Institut Català de la Salut, Autonomous Government of Catalonia, Fundação para a Ciência e a Tecnologia, National Institutes of Health National Cancer Institute, Swedish Cancer Society, General Hospital in Malmö Foundation for Combating Cancer

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

A multi-center prospective study of plant-based nutritional support in adult community-based patients at risk of disease-related malnutrition

IntroductionThere is an emerging need for plant-based, vegan options for patients requiring nutritional support.MethodsTwenty-four adults at risk of malnutrition (age: 59 years (SD 18); Sex: 18 female, 6 male; BMI: 19.0 kg/m2 (SD 3.3); multiple diagnoses) requiring plant-based nutritional support participated in a multi-center, prospective study of a (vegan suitable) multi-nutrient, ready-to-drink, oral nutritional supplement (ONS) [1.5 kcal/mL; 300 kcal, 12 g protein/200 mL bottle, mean prescription 275 mL/day (SD 115)] alongside dietary advice for 28 days. Compliance, anthropometry, malnutrition risk, dietary intake, appetite, acceptability, gastrointestinal (GI) tolerance, nutritional goal(s), and safety were assessed.ResultsPatients required a plant-based ONS due to personal preference/variety (33%), religious/cultural reasons (28%), veganism/reduce animal-derived consumption (17%), environmental/sustainability reasons (17%), and health reasons (5%). Compliance was 94% (SD 16). High risk of malnutrition (‘MUST’ score ≥ 2) reduced from 20 to 16 patients (p = 0.046). Body weight (+0.6 kg (SD 1.2), p = 0.02), BMI (+0.2 kg/m2 (SD 0.5), p = 0.03), total mean energy (+387 kcal/day (SD 416), p &lt; 0.0001) and protein intake (+14 g/day (SD 39), p = 0.03), and the number of micronutrients meeting the UK reference nutrient intake (RNI) (7 vs. 14, p = 0.008) significantly increased. Appetite (Simplified Nutritional Appetite Questionnaire (SNAQ) score; p = 0.13) was maintained. Most GI symptoms were stable throughout the study (p &gt; 0.06) with no serious adverse events related.DiscussionThis study highlights that plant-based nutrition support using a vegan-suitable plant-based ONS is highly complied with, improving the nutritional outcomes of patients at risk of malnutrition