Instantonic Branes, Atiyah-Hirzebruch Spectral Sequence, and SL(2,Z) duality of N=4 SYM

We study the equivalence among orientifold three-planes in the context of the Atiyah-Hirzebruch Spectral Sequence. This equivalence refers to the fact that two different cohomology classes in the same cohomology group, which classify the orientifolds, are lifted to the same trivial class in K-theory. The physical interpretation of this mathematical algorithm is given by the role of D-brane instantons. By following some recent ideas, we extend the sequence to include a classification of NS-NS fluxes. We find that such equivalences, in the low energy limit of the dynamics on the worldvolume of type IIB D3-branes on top of the orientifolds, are interpreted as the SL(2,Z) duality in four dimensional N=4 SYM theories.Comment: 39+1 pages, 7 figures. Typos corrected, one reference added. One mistake in footnote 5, concerning the T-dualize version of seven-branes, is correcte

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components

G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner. However, despite the current development of experimental techniques for large-scale detection of GPCR heteromers, in order to understand their connectivity it is necessary to develop novel tools to study the global heteroreceptor networks. To provide insight into the overall topology of the GPCR heteromers and identify key players, a collective interaction network was constructed. Experimental interaction data for each of the individual human GPCR protomers was obtained manually from the STRING and SCOPUS databases. The interaction data were used to build and analyze the network using Cytoscape software. The network was treated as undirected throughout the study. It is comprised of 156 nodes, 260 edges and has a scale-free topology. Connectivity analysis reveals a significant dominance of intrafamily versus interfamily connections. Most of the receptors within the network are linked to each other by a small number of edges. DRD2, OPRM, ADRB2, AA2AR, AA1R, OPRK, OPRD and GHSR are identified as hubs. In a network representation 10 modules/clusters also appear as a highly interconnected group of nodes. Information on this GPCR network can improve our understanding of molecular integration. GPCR-HetNet has been implemented in Java and is freely available at http://www.iiia.csic.es/similar to ismel/GPCR-Nets/index.html

Eletroencephalogram and anticonceptional drugs

An electroencephalogram was made in 28 women who had been using oral anticonceptional for at least three menstrual cycles and had no neurological or psychiatric complaint. The electroencephalogram was abnormal in 7 (25%). No slowness of the sleep spindle was found in any of the cases.Após comentários sobre a literatura, os autores apresentam o material composto de 28 pacientes sem queixa neurológica ou psiquiátrica, que estavam fazendo uso de anticoncepcional oral, e nas quais foi realizado um eletrencefalograma. Este se mostrou anormal em 7 (25%). As anormalidades foram predominantemente paroxísticas e difusas. Em nenhum caso foi encontrada lentificação do fuso do sono.Escola Paulista de Medicina Departamentos de Neurologia-Neurocirurgia e de Toco-GinecologiaUNIFESP, EPM, Depto.s de Neurologia-Neurocirurgia e de Toco-GinecologiaSciEL

LES validation of lock-exchange density currents interacting with an emergent bluff obstacle

Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature B.V.We address the capability of large eddy simulation (LES) to predict the physics of density currents interacting with bluff obstacles. Most density currents of interest in engineering and geophysical applications interact with obstacles or topographic features. Validating LES solutions in these contexts is crucial to establish it as a trusted tool. We thus propose a validation effort based on simple geometries that nonetheless pose challenges common to more complex systems, including boundary layer separation and convective instabilities. We focus on lock-exchange gravity currents in the slumping phase interacting with an emergent vertical circular cylinder. Our main investment was in ensuring that the comparison of experimental data and numerical results include, at least, the velocity and the density fields , and derived quantities (e.g., second order moments). Measurements of both density and velocity fields were performed in the side and plan views for cylinder Reynolds numbers, Red, in the range 1300 to 3475. It was found that the LES accurately predicts the temporal evolution of the current front position. The computed front velocity exhibits a maximum relative error less than 8%. A good agreement between the LES and the experimental size and shape of the current head, and billows was found. The overall features upstream the cylinder, including a reflected wave, adverse pressure gradient and backflow, and downstream the cylinder, including the backflow, wake and the formation of a new head are well reproduced by LES. The agreement between the LES and the experimental time-space evolution of current spanwise- and depth-averaged density contours and the instantaneous velocity fields are not affected by Red.publishersversionpublishe

Representações sociais sobre a leitura em um espaço de interação verbal

Com base em relatos de impressões sobre uma oficina de leitura, escritos por alunos do 2º ano do Curso Técnico Integrado ao Ensino Médio em Eletrotécnica do Instituto Federal de Educação, Ciência e Tecnologia da Paraíba – Campus João Pessoa, e tendo como referência teórica os estudos de Valentin Volochinov sobre a interação verbal e as representações sociais de Serge Moscovici, o artigo analisa a influência da interação verbal na construção de representações sociais sobre a leitura, no período de atividades da oficina, a partir das relações do aluno leitor com o texto, o professor e o grupo participante, em um espaço criado para o desenvolvimento de uma leitura compartilhada. Foi observado que a análise discursiva dos relatos de impressões, dentro de um espaço de interação verbal, constitui-se um instrumento importante para melhor compreender os efeitos do ato de ler na construção de sentidos e de representações durante o processo de formação da identidade do sujeito leitor. PALAVRAS-CHAVE: Representação social. Interação verbal. Leitura compartilhada. ABSTRACT Based on the personal report about a workshop reading, made by second year students from the Technical High School in Electrotechnical of the Federal Institute of Education, Science and Technology of Paraíba – Campus João Pessoa (Brazil), and having the theoretical reference of the Valentin Voloshinov’s verbal interaction and the Serge Moscovici’s social representations, the paper analyzes the verbal interaction influence on the development of the social representations about reading in the workshop activity period, from the relation between the reading student with the text, the teacher and the participant group, in a space created for the development of a sharing reading. It was observed that the discursive analysis of the writings about the workshop reading, within a verbal interactive space, it represents an important tool to understand better the effects of the reading acts on the meaning and the social representations construction during the identity formation process of the individual reader

VLT-UVES abundance analysis of four giants in NGC 6553

Metal-rich globular clusters trace the formation of bulges. Abundance ratios in the metal-rich globular clusters such as NGC 6553 can constrain the formation timescale of the Galactic bulge. The purpose of this study is determine the metallicity and elemental ratios in individual stars of the metal-rich bulge globular cluster NGC 6553. A detailed abundance analysis of four giants in NGC 6553 is carried out, based on optical high-resolution echelle spectra obtained with UVES at the ESO VLT-UT2 Kueyen telescope. A metallicity [Fe/H]= -0.20 dex is derived, together with $\alpha$-element enhancement of Mg and Si ([Mg/Fe]=+0.28, [Si/Fe]=+0.21), solar Ca and Ti ([Ca/Fe]=+0.05, [Ti/Fe]=-0.01), and a mild enhancement of the r-process element Eu with [Eu/Fe] = +0.10. A mean heliocentric radial velocity of -1.86 km s$^{-1}$ is measured. We compare our results with previous investigations of the cluster.Comment: 15 pages, 8 figures, A&A, in pres

Alpha element abundances and gradients in the Milky Way bulge from FLAMES-GIRAFFE spectra of 650 K giants

We obtained FLAMES-GIRAFFE spectra (R=22,500) at the ESO Very Large Telescope for 650 bulge red giant branch (RGB) stars and performed spectral synthesis to measure Mg, Ca, Ti, and Si abundances. This sample is composed of 474 giant stars observed in 3 fields along the minor axis of the Galactic bulge and at latitudes b=-4, b=-6, b=-12. Another 176 stars belong to a field containing the globular cluster NGC 6553, located at b=-3 and 5 degrees away from the other three fields along the major axis. Our results confirm, with large number statistics, the chemical similarity between the Galactic bulge and thick disk, which are both enhanced in alpha elements when compared to the thin disk. In the same context, we analyze [alpha/Fe] vs. [Fe/H] trends across different bulge regions. The most metal rich stars, showing low [alpha/Fe] ratios at b=-4 disappear at higher Galactic latitudes in agreement with the observed metallicity gradient in the bulge. Metal-poor stars ([Fe/H]<-0.2) show a remarkable homogeneity at different bulge locations. We have obtained further constrains for the formation scenario of the Galactic bulge. A metal-poor component chemically indistinguishable from the thick disk hints for a fast and early formation for both the bulge and the thick disk. Such a component shows no variation, neither in abundances nor kinematics, among different bulge regions. A metal-rich component showing low [alpha/Fe] similar to those of the thin disk disappears at larger latitudes. This allows us to trace a component formed through fast early mergers (classical bulge) and a disk/bar component formed on a more extended timescale.Comment: 13 pages, 17 figures. Accepted for publication in Astronomy and Astrophysic

A kinematic study of planetary nebulae in the dwarf irregular galaxy IC10

We present positions, kinematics, and the planetary nebula luminosity function (PNLF) for 35 planetary nebulae (PNe) in the nearest starburst galaxy IC10 extending out to 3kpc from the galaxy's centre. We take advantage of the deep imaging and spectroscopic capabilities provided by the spectrograph FOCAS on the 8.2m Subaru telescope. The PN velocities were measured through the slitless-spectroscopy technique, which allows us to explore the kinematics of IC10 with high precision. Using these velocities, we conclude that there is a kinematic connection between the HI envelope located around IC10 and the galaxy's PN population. By assuming that the PNe in the central regions and in the outskirts have similar ages, our results put strong observational constraints on the past tidal interactions in the Local Group. This is so because by dating the PN central stars, we, therefore, infer the epoch of a major episode of star formation likely linked to the first encounter of the HI extended envelope with the galaxy. Our deep [OIII] images also allow us to use the PNLF to estimate a distance modulus of 24.1+/-0.25, which is in agreement with recent results in the literature based on other techniques.Comment: 10 pages, 9 figures, 2 tables. Accepted for publication in MNRA

Hemorrhagic Meningoencephalomyelitis Due to Ectopic Localization of Aelurostrongylus abstrusus in a Cat: First Case Report

The lungworm Aelurostrongylus abstrusus is one of the main causes of respiratory diseases in cats worldwide. This report describes the unusual case of a kitten infected with A. abstrusus and presented to a veterinary clinic in Brazil with lethargy, dysphagia, non-ambulatory tetraplegia, and pelvic limbs bilateral myoclonus. The clinical picture of the kitten worsened with generalized flaccid tetraplegia and death a few days after hospitalization. At necropsy, hemorrhagic necrosis and subarachnoid hemorrhages were detected in several areas of the central nervous system. Nematode stages were found at post-mortem histological examinations in lungs, cerebellum, subarachnoid space of the brain and spinal cord. Microscopic and molecular (PCRs-coupled-sequencing protocols) examination showed the presence of A. abstrusus in histological samples. This study describes the first neurological aelurostrongylosis due to ectopic localization of adult worms in the central nervous system of a cat, causing acute hemorrhagic multifocal meningoencephalomyelitis. Further studies are necessary to elucidate whether unusual localizations and the migration of A. abstrusus are more frequent than expected