Age-related differences in exercise and quality of life among breast cancer survivors

Purpose: Physical activity has become a focus of cancer recovery research as it has the potential to reduce treatment-related burden and optimize health-related quality of life (HRQoL). However, the potential for physical activity to influence recovery may be age-dependent. This paper describes physical activity levels and HRQoL among younger and older women after surgery for breast cancer and explores the correlates of physical inactivity. Methods: A population-based sample of breast cancer patients diagnosed in South-East Queensland, Australia, (n=287) were assessed once every three months, from 6 to 18 months post-surgery. The Functional Assessment of Cancer Therapy-Breast questionnaire (FACTB+4) and items from the Behavioral Risk Factor Surveillance System (BRFSS) questionnaire were used to measure HRQoL and physical activity, respectively. Physical activity was assigned metabolic equivalent task (MET) values, and categorized as 3, p<0.05). Conclusions: Age influences the potential to observe HRQoL benefits related to physical activity participation. These results also provide relevant information for the design of exercise interventions for breast cancer survivors and highlights that some groups of women are at greater risk of long-term sedentary behavior

The United States, PMSCs and the state monopoly on violence: Leading the way towards norm change

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Sage.The proliferation of private military and security companies (PMSCs) in Iraq and Afghanistan has raised many questions regarding the use of armed force by private contractors. This article addresses the question of whether the increased acceptance of PMSCs indicates a transformation of the international norm regarding the state monopoly on the legitimate use of armed force. Drawing on theoretical approaches to the analysis of norm change, the article employs four measures to investigate possible changes in the strength and meaning of this norm: modifications in state behaviour, state responses to norm violation, the promulgation of varying interpretations of the norm in national and international laws and regulations, and changes in norm discourse. Based on an analysis of empirical evidence from the United States of America and its allies, the article concludes that these measures suggest that the USA is leading the way towards a transformation of the international norm of the state monopoly on violence, involving a revised meaning. Although this understanding has not yet been formally implemented in international law, it has allowed a growing number of countries to tolerate, accept or legalize the use of armed force by PMSCs in the international arena.The Alexander von Humboldt Foundation and the Peace Research Institute Frankfurt

Introduction: Ideology, propaganda, and political discourse in the Xi Jinping era

The ideology, propaganda, and political discourse of the Communist Party of China (CPC) have continued to function as key elements of the political system of the People’s Republic of China (PRC) in the post-Maoist period since 1978. In the first term of the Xi Jinping leadership (2012–2017), the CPC, for instance, elaborated on its guiding ideological concepts, devised inventive ideational framings of phenomena usually perceived as tangible (such as the BNew Normal^), engaged in complex intellectual debates on crucial topics (such as Beco-civilization^), intensified and diversified its argumentation patterns and discursive strategies, and consolidated ideational governance over some citizens’ individual values, beliefs, and loyalties. Furthermore, it is often no longer possible to differentiate between the CPC’s internal and external propaganda, as seemingly exclusively domestic ideational and discursive issues increasingly correlate with international phenomena. However, the trends in the Xi era do not present paradigmatic shifts, but rather an overall reassertion-cuminnovation of previous Maoist and post-Maoist uses of ideology, propaganda, and political discourse, primarily aiming at strengthening one-party rule

Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations

Colloidal particles placed in an energy landscape interact with each other, giving rise to complex dynamic behavior that affects the ability to process and manipulate suspensions of these particles. Propagating across scales ranging from the local behavior of 10's of particles to non-local behavior encompassing >10[superscript 6] particles, these particle interactions are pervasive and challenging to describe quantitatively, especially in the confined environments typical of microfluidic devices. To better understand the effects of particle interactions in this context, we have performed experiments and simulations involving a simple microfluidic device in which hydrodynamic and electrostatic forces are leveraged to concentrate and separate particle mixtures. These investigations reveal the mechanisms underlying the dynamic patterns formed by micron-scale particles as they impinge on a dielectrophoretic force barrier: their tendency to aggregate and recirculate under constant operating conditions, and to reorganize when the operating conditions are changed. The emergent behaviors of these ensembles of interacting particles exhibit features of dynamical frustration and cooperativity that suggest non-intuitive strategies for concentrating and sorting suspensions. Finally, we present a simple analytic model based on hydrodynamic coupling that captures important features of strongly interacting particle suspensions.National Institutes of Health (U.S.) (Grant EB005753)National Science Foundation (U.S.). Instrument Development for Biological Research (Grant DBI-0852654)Singapore-MIT Allianc

A complete classification of spherically symmetric perfect fluid similarity solutions

We classify all spherically symmetric perfect fluid solutions of Einstein's equations with equation of state p/mu=a which are self-similar in the sense that all dimensionless variables depend only upon z=r/t. For a given value of a, such solutions are described by two parameters and they can be classified in terms of their behaviour at large and small distances from the origin; this usually corresponds to large and small values of z but (due to a coordinate anomaly) it may also correspond to finite z. We base our analysis on the demonstration that all similarity solutions must be asymptotic to solutions which depend on either powers of z or powers of lnz. We show that there are only three similarity solutions which have an exact power-law dependence on z: the flat Friedmann solution, a static solution and a Kantowski-Sachs solution (although the latter is probably only physical for a1/5, there are also two families of solutions which are asymptotically (but not exactly) Minkowski: the first is asymptotically Minkowski as z tends to infinity and is described by one parameter; the second is asymptotically Minkowski at a finite value of z and is described by two parameters. A complete analysis of the dust solutions is given, since these can be written down explicitly and elucidate the link between the z>0 and z<0 solutions. Solutions with pressure are then discussed in detail; these share many of the characteristics of the dust solutions but they also exhibit new features.Comment: 63 pages. To appear in Physical Review

Attitudes toward Methadone among Out-of-Treatment Minority Injection Drug Users: Implications for Health Disparities

Injection drug use (IDU) continues to be a significant public health issue in the U.S. and internationally, and there is evidence to suggest that the burden of injection drug use and associated morbidity and mortality falls disproportionately on minority communities. IDU is responsible for a significant portion of new and existing HIV/AIDS cases in many parts of the world. In the U.S., the prevalence of HIV and hepatitis C virus is higher among populations of African-American and Latino injection drug users (IDUs) than among white IDUs. Methadone maintenance therapy (MMT) has been demonstrated to effectively reduce opiate use, HIV risk behaviors and transmission, general mortality and criminal behavior, but opiate-dependent minorities are less likely to access MMT than whites. A better understanding of the obstacles minority IDUs face accessing treatment is needed to engage racial and ethnic disparities in IDU as well as drug-related morbidity and mortality. In this study, we explore knowledge, attitudes and beliefs about methadone among 53 out-of-treatment Latino and African-American IDUs in Providence, RI. Our findings suggest that negative perceptions of methadone persist among racial and ethnic minority IDUs in Providence, including beliefs that methadone is detrimental to health and that people should attempt to discontinue methadone treatment. Additional potential obstacles to entering methadone therapy include cost and the difficulty of regularly attending a methadone clinic as well as the belief that an individual on MMT is not abstinent from drugs. Substance use researchers and treatment professionals should engage minority communities, particularly Latino communities, in order to better understand the treatment needs of a diverse population, develop culturally appropriate MMT programs, and raise awareness of the benefits of MMT

5-hydroxy-L-tryptophan Suppressed Food Intake in Rats Despite an Increase in the Arcuate NPY Expression

This study was conducted to define the underlying mechanism of hypophagia induced by increased central serotonergic action. Rats received 3 daily injections of 5-hydroxy-L-tryptophan (5-HTP), a serotonin precursor, at a dose of 100 mg/kg/10 ml saline at 1 h before lights off. A significant suppression in food intake was observed shortly after the 5-HTP injection and persisted during 3 daily 5-HTP injections. Neuropeptide Y (NPY) expression in the arcuate nucleus increased after 3 days of 5-HTP treatment, as high as in the pair-fed group. Immunoreactivity of phosphorylated extracellular signal-regulated protein kinase (pERK1/2) in the hypothalamic paraventricular nucleus (PVN) was increased markedly by 3 days of 5-HTP treatment, but not by 3 days of pair-fed. mRNA expression levels of serotonin reuptake transporter (5-HTT) was increased in the dorsal raphe nucleus of the 5-HTP treated rats, but not in the pair-fed group. Results suggest that increased pERK1/2 in the PVN of 5-HTP injected rats may be a part of serotonergic anorectic signaling, perhaps blunting the orectic action of NPY; i.e., 5-HTP injected rats showed hypophagia despite of increased NPY expression in the arcuate nucleus

Aesthetic and spiritual values of ecosystems: recognising the ontological and axiological plurality of cultural ecosystem 'services'.

This paper explores spiritual and aesthetic cultural values associated with ecosystems. We argue that these values are not best captured by instrumental or consequentialist thinking, and they are grounded in conceptions of nature that differ from the ecosystem services conceptual framework. To support our case, we engage with theories of the aesthetic and the spiritual, sample the discourse of ‘wilderness’, and provide empirical evidence from the recent UK National Ecosystem Assessment Follow-on Phase. We observe that accounts of spiritual and aesthetic value in Western culture are diverse and expressed through different media. We recognise that humans do benefit from their aesthetic and spiritual experiences of nature. However, aesthetic and spiritual understandings of the value of nature lead people to develop moral responsibilities towards nature and these are more significant than aesthetic and spiritual benefits from nature. We conclude that aesthetic and spiritual values challenge economic conceptions of ecosystems and of value (including existence value), and that an analysis of cultural productions and a plural-values approach are needed to evidence them appropriately for decision-making

The Similarity Hypothesis in General Relativity

Self-similar models are important in general relativity and other fundamental theories. In this paper we shall discuss the ``similarity hypothesis'', which asserts that under a variety of physical circumstances solutions of these theories will naturally evolve to a self-similar form. We will find there is good evidence for this in the context of both spatially homogenous and inhomogeneous cosmological models, although in some cases the self-similar model is only an intermediate attractor. There are also a wide variety of situations, including critical pheneomena, in which spherically symmetric models tend towards self-similarity. However, this does not happen in all cases and it is it is important to understand the prerequisites for the conjecture.Comment: to be submitted to Gen. Rel. Gra