Nova Sagittarii 1943 (V1148 Sgr): A Luminous Red Nova?

Nova Sagittarii 1943 (V1148 Sgr) was an 8th-mag optical transient that was unusual in having a late-type spectrum during its outburst, in striking contrast to the normal high-excitation spectra seen in classical novae. Unfortunately, only an approximate position was given in the discovery announcement, hampering follow-up attempts to observe its remnant. We have identified the nova on two photographic plates in the Harvard archive, allowing us to determine a precise astrometric position. Apart from these two plates, obtained in 1943 and 1944, none of the photographs in the Harvard collection, from 1897 to 1950, show V1148 Sgr to limits as faint as g ~ 18.3. Modern deep images show a candidate remnant at i ~ 19.2, lying only 0".26 from the site of the nova. V1148 Sgr may have been a luminous red nova (LRN), only the sixth one known in the Milky Way. However, it lacks the near- and mid-infrared excesses, and millimeter-wave emission, seen in other LRNe, leaving its nature uncertain. We urge spectroscopy of the candidate remnant.Comment: Accepted by Astronomical Journa

Demographic and Clnical Characteristics of Military Service Members Hospitalized Following a Suicide Attempt versus Suicide Ideation

Psychiatric hospitalization for a suicide attempt (SA), rather than suicide ideation (SI) alone, is a stronger risk indicator for eventual suicide death. Yet, little is known about demographic and clinical characteristics differentiating those admitted for SA versus SI. Understanding these differences has implications for assessment and treatment. A retrospective review of electronic medical records (EMRs) was performed on service members (n = 955) admitted for SA or SI at the Walter Reed Army Medical Center between 2001–2006. Service members hospitalized for SA were younger compared to those hospitalized for SI. The proportion of women admitted for SA was significantly higher than those admitted for SI whereas their male counterparts showed the opposite pattern. Patients admitted for SA, versus SI, had significantly higher prevalence of adjustment disorder with mixed disturbance of emotion and conduct (MDEC), personality disorder not otherwise specified (PDNOS), and borderline personality disorder (BPD). Patients admitted for SI had significantly higher prevalence of adjustment disorder with depressed mood and deferred Axis II diagnosis, compared to those admitted for SA. There were no significant between-group differences in the average or median number of documented prior suicide attempts. Findings highlight the need for more standardized assessment, diagnostic decision-making, and documentation practices for all patients

The laurentian record of neoproterozoic glaciation, tectonism, and eukaryotic evolution in Death Vally, California

Neoproterozoic strata in Death Valley, California contain eukaryotic microfossils and glacial deposits that have been used to assess the severity of putative Snowball Earth events and the biological response to extreme environmental change. These successions also contain evidence for syn-sedimentary faulting that has been related to the rifting of Rodinia, and in turn the tectonic context of the onset of Snowball Earth. These interpretations hinge on local geological relationships and both regional and global stratigraphic correlations. Here we present new geological mapping, measured stratigraphic sections, carbon and strontium isotope chemostratigraphy, and micropaleontology from the Neoproterozoic glacial deposits and bounding strata in Death Valley. These new data enable us to refine regional correlations both across Death Valley and throughout Laurentia, and construct a new age model for glaciogenic strata and microfossil assemblages. Particularly, our remapping of the Kingston Peak Formation in the Saddle Peak Hills and near the type locality shows for the first time that glacial deposits of both the Marinoan and Sturtian glaciations can be distinguished in southeastern Death Valley, and that beds containing vase-shaped microfossils are slump blocks derived from the underlying strata. These slump blocks are associated with multiple overlapping unconformities that developed during syn-sedimentary faulting, which is a common feature of Cyrogenian strata along the margin of Laurentia from California to Alaska. With these data, we conclude that all of the microfossils that have been described to date in Neoproterozoic strata of Death Valley predate the glaciations and do not bear on the severity, extent or duration of Neoproterozoic Snowball Earth events

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (i.e., nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. Currently, the driver for this progression is not fully understood; in particular, it is not known how NAFLD and its early progression affects the distribution of lipids in the liver, producing lipotoxicity and inflammation. In this study, we used dietary and genetic mouse models of NAFL and NASH and translated the results to humans by correlating the spatial distribution of lipids in liver tissue with disease progression using advanced mass spectrometry imaging technology. We identified several lipids with distinct zonal distributions in control and NAFL samples and observed partial to complete loss of lipid zonation in NASH. In addition, we found increased hepatic expression of genes associated with remodeling the phospholipid membrane, release of arachidonic acid (AA) from the membrane, and production of eicosanoid species that promote inflammation and cell injury. The results of our immunohistochemistry analyses suggest that the zonal location of remodeling enzyme LPCAT2 plays a role in the change in spatial distribution for AA-containing lipids. This results in a cycle of AA-enrichment in pericentral hepatocytes, membrane release of AA, and generation of proinflammatory eicosanoids and may account for increased oxidative damage in pericentral regions in NASH. Conclusion: NAFLD is associated not only with lipid enrichment, but also with zonal changes of specific lipids and their associated metabolic pathways. This may play a role in the heterogeneous development of NAFLD. (Hepatology 2017;65:1165-1180)

Anomalous Microwave Emission from the HII region RCW175

We present evidence for anomalous microwave emission in the RCW175 \hii region. Motivated by 33 GHz 13\arcmin resolution data from the Very Small Array (VSA), we observed RCW175 at 31 GHz with the Cosmic Background Imager (CBI) at a resolution of 4\arcmin. The region consists of two distinct components, G29.0-0.6 and G29.1-0.7, which are detected at high signal-to-noise ratio. The integrated flux density is $5.97\pm0.30$ Jy at 31 GHz, in good agreement with the VSA. The 31 GHz flux density is $3.28\pm0.38$ Jy ($8.6\sigma$) above the expected value from optically thin free-free emission based on lower frequency radio data and thermal dust constrained by IRAS and WMAP data. Conventional emission mechanisms such as optically thick emission from ultracompact \hii regions cannot easily account for this excess. We interpret the excess as evidence for electric dipole emission from small spinning dust grains, which does provide an adequate fit to the data.Comment: 5 pages, 2 figures, submmited to ApJ Letter

Statistical analysis plan for the Dex-CSDH trial: a randomised, double-blind, placebo-controlled trial of a 2-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematoma

Abstract Background The incidence of chronic subdural haematoma (CSDH) is increasing. Although surgery remains the mainstay of management for symptomatic patients, uncertainty remains regarding the role of steroids. Hence, the Dex-CSDH trial was launched in the UK in 2015 aiming to determine whether, compared to placebo, dexamethasone can improve the 6-month functional outcome of patients with symptomatic CSDH by reducing the rate of surgical intervention and recurrence rate. Methods and design Dex-CSDH is a multi-centre, pragmatic, parallel group, double-blind, randomised trial assessing the clinical utility of a 2-week course of dexamethasone following a CSDH. Seven hundred fifty patients were randomised to either dexamethasone or placebo. The primary outcome is the modified Rankin Scale at 6 months which is dichotomised to favourable (a score of 0–3) versus unfavourable (a score of 4–6). Conclusions This paper and the accompanying additional material describe the statistical analysis plan for the trial. Trial registration ISRCTN, ISRCTN80782810. Registered on 7 November 2014. http://www.isrctn.com/ISRCTN80782810. EudraCT, 2014-004948-35. Registered on 20 March 2015. </jats:sec

A parametric physical model for the intracluster medium and its use in joint SZ/X-ray analyses of galaxy clusters

We present a parameterized model of the intra-cluster medium that is suitable for jointly analysing pointed observations of the Sunyaev-Zel'dovich (SZ) effect and X-ray emission in galaxy clusters. The model is based on assumptions of hydrostatic equilibrium, the Navarro, Frenk and White (NFW) model for the dark matter, and a softened power law profile for the gas entropy. We test this entropy-based model against high and low signal-to-noise mock observations of a relaxed and recently-merged cluster from N-body/hydrodynamic simulations, using Bayesian hyper-parameters to optimise the relative statistical weighting of the mock SZ and X-ray data. We find that it accurately reproduces both the global values of the cluster temperature, total mass and gas mass fraction (fgas), as well as the radial dependencies of these quantities outside of the core (r > kpc). For reference we also provide a comparison with results from the single isothermal beta model. We confirm previous results that the single isothermal beta model can result in significant biases in derived cluster properties.Comment: Published in MNRAS. 20 pages. 9 figure

The Atacama Cosmology Telescope: Two-Season ACTPol Lensing Power Spectrum

We report a measurement of the power spectrum of cosmic microwave background (CMB) lensing from two seasons of Atacama Cosmology Telescope Polarimeter (ACTPol) CMB data. The CMB lensing power spectrum is extracted from both temperature and polarization data using quadratic estimators. We obtain results that are consistent with the expectation from the best-fit Planck LCDM model over a range of multipoles L=80-2100, with an amplitude of lensing A_lens = 1.06 +/- 0.15 (stat.) +/- 0.06 (sys.) relative to Planck. Our measurement of the CMB lensing power spectrum gives sigma_8 Omega_m^0.25 = 0.643 +/- 0.054; including baryon acoustic oscillation scale data, we constrain the amplitude of density fluctuations to be sigma_8 = 0.831 +/- 0.053. We also update constraints on the neutrino mass sum. We verify our lensing measurement with a number of null tests and systematic checks, finding no evidence of significant systematic errors. This measurement relies on a small fraction of the ACTPol data already taken; more precise lensing results can therefore be expected from the full ACTPol dataset.Comment: 17 pages, 11 figures, to be submitted to Physical Review

Neutrino Physics at the Turn of the Millenium

Recent solar & atmospheric nu-data strongly indicate need for physics beyond the Standard Model. I review the ways of reconciling them in terms of 3-nu oscillations. Though not implied by data, bi-maximal nu-mixing models emerge as a possibility. SUSY with broken R-parity provides an attractive way to incorporate it, opening the possibility of testing nu-anomalies at high- energy colliders such as the LHC or at the upcoming long-baseline or nu- factory experiments. Reconciling, in addition, the LSND hint requires a fourth, light sterile neutrino, nus. The simplest are the most symmetric scenarios, in which 2 of the 4 neutrinos are maximally-mixed and lie at the LSND scale, while the others are at the solar scale. The lightness of nus, the nearly maximal atmospheric mixing, and the solar/atmospheric splittings all follow naturally from the assumed lepton-number symmetry and its breaking. These basic schemes can be distinguished at neutral-current-sensitive solar & atmospheric neutrino experiments such as SNO. However underground experiments have not yet proven neutrino masses, as there are many alternatives. For example flavour changing interactions can play an important role in the explanation of solar and contained atmospheric data and could be tested e.g through \mu \to e + \gamma, \mu-e conversion in nuclei, unaccompanied by neutrino-less double beta decay. Conversely, a short-lived numu might play a role in the explanation of the atmospheric data. Finally, in the presence of a nus, a long-lived heavy nutau could delay the time at which the matter and radiation contributions to the energy density of the Universe become equal, reducing density fluctuations on smaller scales, thus saving the standard CDM scenario, while the light nue, numu and nus would explain the solar & atmospheric data.Comment: Invited talk at 2nd International Conference on Non-Accelerator New Physics (NANP-99), Dubna, June 28 - July 3, 199

Update on neutrino mixing in the early Universe

From the current cosmological observations of CMB and nuclear abundances we show, with an analytic procedure, that the total effective number of extra neutrino species $\Delta N_{\nu}^{\rm tot}< 0.3$. We also describe the possible signatures of non standard effects that could be revealed in future CMB observations. This cosmological information is then applied to neutrino mixing models. Taking into account the recent results from the SNO and SuperKamiokande experiments, disfavouring pure active to sterile neutrino oscillations, we show that all 4 neutrino mixing models, both of 2+2 and 3+1 type, lead to a full thermalization of the sterile neutrino flavor. Moreover such a sterile neutrino production excludes the possibility of an electron neutrino asymmetry generation and we conclude that $\Delta N_{\nu}^{\rm tot}\simeq 1$, in disagreement with the cosmological bound. This result is valid under the assumption that the initial neutrino asymmetries are small. We suggest the existence of a second sterile neutrino flavor, with mixing properties such to generate a large electron neutrino asymmetry, as a possible way out.Comment: 29 pages, 3 figures; to appear on Phys.Rev.D; added discussion (at page 19) and references; typos correcte