Beyond the flammantia moenia mundi: the Transgressive Notion of the Sublime in Lucretius’ De rerum natura

pp. 64-78 of the Journal of the LUCAS Graduate Conference, Issue 4 (2016). The complete issue can be found at: http://hdl.handle.net/1887/38532Wetensch. publicati

Happiness and Superlative Value in the Eudemian Ethics

In my dissertation Happiness and Superlative Value in the Eudemian Ethics, I analyze dimensions of the Eudemian Ethics (EE) that, as I see it, make the EE a distinctive contribution to ethics. The EE discusses a superlative excellence called kalokagathia, the virtue of being-beautiful-and-good, which does not figure in the Nicomachean Ethics (NE). The agent who possesses kalokagathia is the best agent of Aristotle’s EE. Scholars tend to hold that the practically wise person, the phronimos, or the theoretically wise person, the sophos, are the best agents of the NE. If my reading of the EE is right, then the EE and the NE conceive differently of the best agent. This is salient in both treatises’ construals of the unity of the virtues. In the NE, the unity of the virtues includes the character virtues and phronêsis. In the EE, it additionally includes the virtues of theoretical thinking, or so I argue. The EE starts with what I call the Superlative Thesis (ST): happiness is what is best, most beautiful, and most pleasant of all. I take this beginning to be programmatic. Aristotle aims to show how these three kinds of value combine in the best human life, rather than coming apart. The Pleasure Thesis (PT) is the most contested aspect of ST: happiness is the most pleasant thing of all. On my reading, Aristotle fully embraces PT. In laying out his proposal for the best human life, the Aristotle of the EE develops a distinctive kind of naturalism, which I call Natural Goods Naturalism. I reconstruct this position in two steps: by interpreting the EE’s function argument; and by exploring the notion of natural goods, which is central to the EE, but does not figure in the NE. In sum, my dissertation argues that the EE contains a distinctive and under-appreciated option within ancient ethics, and that it contains ideas that are relevant to today’s virtue ethics and ethical naturalism

Elimination In Vivo of Developing T Cells by Natural Killer Cells

Natural killer cells gauge the absence of self class I MHC on susceptible target cells by means of inhibitory receptors such as members of the Ly49 family. To initiate killing by natural killer cells, a lack of inhibitory signals must be accompanied by the presence of activating ligands on the target cell. Although natural killer cell–mediated rejection of class I MHC–deficient bone marrow (BM) grafts is a matter of record, little is known about the targeting in vivo of specific cellular subsets by natural killer cells. We show here that development of class I MHC–negative thymocytes is delayed as a result of natural killer cell toxicity after grafting of a class I MHC–positive host with class I MHC–negative BM. Double positive thymocytes that persist in the presence of natural killer cells display an unusual T cell receptor–deficient phenotype, yet nevertheless give rise to single positive thymocytes and yield mature class I MHC–deficient lymphocytes that accumulate in the class I MHC–positive host. The resulting class I MHC–deficient CD8 T cells are functional and upon activation remain susceptible to natural killer cell toxicity in vivo. Reconstitution of class I MHC–deficient BM precursors with H2-Kb by retroviral transduction fully restores normal thymic development

Specialized odorant receptors in social insects that detect cuticular hydrocarbon cues and candidate pheromones.

Eusocial insects use cuticular hydrocarbons as components of pheromones that mediate social behaviours, such as caste and nestmate recognition, and regulation of reproduction. In ants such as Harpegnathos saltator, the queen produces a pheromone which suppresses the development of workers' ovaries and if she is removed, workers can transition to a reproductive state known as gamergate. Here we functionally characterize a subfamily of odorant receptors (Ors) with a nine-exon gene structure that have undergone a massive expansion in ants and other eusocial insects. We deorphanize 22 representative members and find they can detect cuticular hydrocarbons from different ant castes, with one (HsOr263) that responds strongly to gamergate extract and a candidate queen pheromone component. After systematic testing with a diverse panel of hydrocarbons, we find that most Harpegnathos saltator Ors are narrowly tuned, suggesting that several receptors must contribute to detection and discrimination of different cuticular hydrocarbons important in mediating eusocial behaviour.Cuticular hydrocarbons (CHC) mediate the interactions between individuals in eusocial insects, but the sensory receptors for CHCs are unclear. Here the authors show that in ants such as H. saltator, the 9-exon subfamily of odorant receptors (HsOrs) responds to CHCs, and ectopic expression of HsOrs in Drosophila neurons imparts responsiveness to CHCs

L’appropriation collective d’un dispositif pédagogique à l’école primaire. La construction d’un compromis provisoire entre des principes de justice différents : le cas du « plan de travail »

Dans le cadre d’une recherche-accompagnement menée au sein d’une école primaire, nous interrogerons les processus d’appropriation collective d’un dispositif pédagogique particulier conçu par l’équipe enseignante : le plan de travail. Les objectifs visés par les enseignants, à partir de ce dispositif, sont de favoriser l’individualisation des apprentissages scolaires des élèves, de prendre en compte leurs rythmes individuels puis de favoriser leur autonomie dans le travail. À partir de données issues des réunions collectives menées dans le cadre de la recherche-accompagnement, nous analyserons les justifications que les enseignants mobilisent pour construire des accords à propos du dispositif mis en œuvre. La sociologie de la justification (Boltanski & Thévenot, 1991) sera convoquée pour mettre en évidence les compromis qui caractérisent le dispositif, à partir notamment des systèmes de valeurs et des différents « mondes » à partir desquels se référent les enseignants pour coordonner leurs actions au sein du dispositif.As part of a research conducted in support of a primary school, we will question the collective ownership process of a particular educational device designed by the teaching team: the work plan. The objectives of teachers from this device, are to promote the individualisation of academic learning of students, taking into account their individual rhythms and promote their autonomy in work. Using data from group meetings conducted within research and support, we will analyze the reasons that teachers mobilize to build agreements for the device used. The sociology of justification (Boltanski and Thevenot, 1991) will be convened to highlight the tradeoffs that characterize the device from particular value systems and different "worlds" from which refer teachers to coordinate their actions within the devic

HIstome—a relational knowledgebase of human histone proteins and histone modifying enzymes

Histones are abundant nuclear proteins that are essential for the packaging of eukaryotic DNA into chromosomes. Different histone variants, in combination with their modification ‘code’, control regulation of gene expression in diverse cellular processes. Several enzymes that catalyze the addition and removal of multiple histone modifications have been discovered in the past decade, enabling investigations of their role(s) in normal cellular processes and diverse pathological conditions. This sudden influx of data, however, has resulted in need of an updated knowledgebase that compiles, organizes and presents curated scientific information to the user in an easily accessible format. Here, we present HIstome, a browsable, manually curated, relational database that provides information about human histone proteins, their sites of modifications, variants and modifying enzymes. HIstome is a knowledgebase of 55 human histone proteins, 106 distinct sites of their post-translational modifications (PTMs) and 152 histone-modifying enzymes. Entries have been grouped into 5 types of histones, 8 types of post-translational modifications and 14 types of enzymes that catalyze addition and removal of these modifications. The resource will be useful for epigeneticists, pharmacologists and clinicians. HIstome: The Histone Infobase is available online at http://www.iiserpune.ac.in/∼coee/histome/ and http://www.actrec.gov.in/histome/

Epigenetic regulation of adaptive responses of forest tree species to the environment

Epigenetic variation is likely to contribute to the phenotypic plasticity and adaptative capacity of plant species, and may be especially important for long-lived organisms with complex life cycles, including forest trees. Diverse environmental stresses and hybridization/polyploidization events can create reversible heritable epigenetic marks that can be transmitted to subsequent generations as a form of molecular “memory”. Epigenetic changes might also contribute to the ability of plants to colonize or persist in variable environments. In this review, we provide an overview of recent data on epigenetic mechanisms involved in developmental processes and responses to environmental cues in plant, with a focus on forest tree species. We consider the possible role of forest tree epigenetics as a new source of adaptive traits in plant breeding, biotechnology, and ecosystem conservation under rapid climate chang

The Molecular Clockwork of the Fire Ant Solenopsis invicta

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication

Vitellogenin Underwent Subfunctionalization to Acquire Caste and Behavioral Specific Expression in the Harvester Ant Pogonomyrmex barbatus

PMCID: PMC3744404This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication

RNA Binding to CBP Stimulates Histone Acetylation and Transcription

CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-regulatory elements that control patterns of gene expression in multicellular organisms. Active enhancers produce bi-directional enhancer RNAs (eRNAs) and display CBP/p300-dependent histone acetylation. Here, we demonstrate that CBP binds directly to RNAs in vivo and in vitro. RNAs bound to CBP in vivo include a large number of eRNAs. Using steady-state histone acetyltransferase (HAT) assays, we show that an RNA binding region in the HAT domain of CBP—a regulatory motif unique to CBP/p300—allows RNA to stimulate CBP’s HAT activity. At enhancers where CBP interacts with eRNAs, stimulation manifests in RNA-dependent changes in the histone acetylation mediated by CBP, such as H3K27ac, and by corresponding changes in gene expression. By interacting directly with CBP, eRNAs contribute to the unique chromatin structure at active enhancers, which, in turn, is required for regulation of target genes