Targeting the Premium Market: Organic Crops for Iowa

According to the USDA Economic Research Service, statistics on organic production in the U.S. lag far behind those complied for conventional agriculture. In the last USDA census in 1995, there were 4,050 organic farmers reporting 1.5 million acres of production (Greene 1999). The Organic Farming Research Foundation estimates that there were 10,000 U.S. organic farmers in 1998. In Iowa, 120,000 acres of organic production were reported to the Iowa Department of Agriculture and Land Stewardship (IDALS 1999). This figure reflects only acreage reported by those farmers who returned their survey; thus, more acres are believed to go unreported. This increase in organic acreage represents a doubling from the previous year, and a four-fold increase since 1993. The organic industry has been experiencing a 20% annual growth rate, with U.S. sales listed at $4.5 billion in 1998 (OT A 1998). The organic industry is a consumer-driven market based on consumers\u27 belief that organic products are safer for human consumption and beneficial to the environment (Bourne 1999). Many consumers affirm the superior health benefits and taste of organic products (Sylvander 1993), although scientific studies are limited, except in the area of pesticide content (C.U. 1999). Researchers found 52% more of the conventional produce on U.S. supermarket shelves contained pesticide residues compared with the organic produce

Windbreaks in Sustainable Agricultural Systems

Sustainable agriculture is a system of whole-farm resource use balanced with whole-farm productivity. The overall level of productivity achieved is dependent upon the ability to coordinate and manage simultaneously the soil, water, plant, and animal resources within climatic and economic limits. Both the kind and amount of plants and animals supported by the system are important and play significant roles, both individually and collectively in maintaining a healthy farm environment. In the future, integrated systems will help reduce human impact on resources while providing sufficient supplies of high quality food and fiber. Windbreaks provide protection for people, animals, buildings, crops, and natural resources. They reduce soil erosion by wind and contribute to the control of runoff from agricultural lands. Individually, trees and shrubs can provide food and shelter for wildlife or be harvested for timber and fuelwood. Specialized tree crops, such as fruits or nuts can be harvested from windbreaks providing additional economic returns

TGF-β Suppresses β-Catenin-Dependent Tolerogenic Activation Program in Dendritic Cells

The mechanisms that underlie the critical dendritic cell (DC) function in maintainance of peripheral immune tolerance are incompletely understood, although the β-catenin signaling pathway is critical for this role. The molecular details by which β-catenin signaling is regulated in DCs are unknown. Mechanical disruption of murine bone marrow-derived DC (BMDC) clusters activates DCs while maintaining their tolerogenic potential and this activation is associated with β-catenin signaling, providing a useful model with which to explore tolerance-associated β-catenin signaling in DCs. In this report, we demonstrate novel molecular features of the signaling events that control DC activation in response to mechanical stimulation. Non-canonical β-catenin signaling is an essential component of this tolerogenic activation and is modulated by adhesion molecules, including integrins. This unique β-catenin-dependent signaling pathway is constitutively active at low levels, suggesting that mechanical stimulation is not necessarily required for induction of this unique activation program. We additionally find that the immunomodulatory cytokine TGF-β antagonizes β-catenin in DCs, thereby selectively suppressing signaling associated with tolerogenic DC activation while having no impact on LPS-induced, β-catenin-independent immunogenic activation. These findings provide new molecular insight into the regulation of a critical signaling pathway for DC function in peripheral immune tolerance

Letter - Direct characterization of a nonlinear photonic circuit's wave function with laser light

Integrated photonics is a leading platform for quantum technologies including nonclassical state generation1, 2, 3, 4, demonstration of quantum computational complexity5 and secure quantum communications6. As photonic circuits grow in complexity, full quantum tomography becomes impractical, and therefore an efficient method for their characterization7, 8 is essential. Here we propose and demonstrate a fast, reliable method for reconstructing the two-photon state produced by an arbitrary quadratically nonlinear optical circuit. By establishing a rigorous correspondence between the generated quantum state and classical sum-frequency generation measurements from laser light, we overcome the limitations of previous approaches for lossy multi-mode devices9, 10. We applied this protocol to a multi-channel nonlinear waveguide network and measured a 99.28±0.31% fidelity between classical and quantum characterization. This technique enables fast and precise evaluation of nonlinear quantum photonic networks, a crucial step towards complex, large-scale, device production.This work was supported by the Australian Research Council (ARC) under the Grants DP140100808 and DP160100619, the Centre of Excellence for Ultrahigh bandwidth Devices for Optical Systems (CUDOS), Centre of Excellence for Quantum Computation and Communication Technology (CE170100012), and the Griffith University Research Infrastructure Program. BH and PF are supported by the Australian Government Research Training Program Scholarship. ANP acknowledges partial support from the Russian Ministry of Education and Science project 3.1365.2017/4.6

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD

Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR <60ml/min/1.73m2 at follow-up) and with ESRD in four case-control studies in subjects of European ancestry (3,775 cases, 4,577 controls). SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR) were associated with incident CKD; p-values ranged from p = 4.1e-9 in UMOD to p = 0.03 in GCKR. After adjusting for baseline eGFR, six of these loci remained significantly associated with incident CKD (UMOD, PRKAG2, ANXA9, DAB2, DACH1, and STC1). SNPs in UMOD (OR = 0.92, p = 0.04) and GCKR (OR = 0.93, p = 0.03) were nominally associated with ESRD. In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis

Mining the human phenome using allelic scores that index biological intermediates

J. Kaprio ja M-L. Lokki työryhmien jäseniä.It is common practice in genome-wide association studies (GWAS) to focus on the relationship between disease risk and genetic variants one marker at a time. When relevant genes are identified it is often possible to implicate biological intermediates and pathways likely to be involved in disease aetiology. However, single genetic variants typically explain small amounts of disease risk. Our idea is to construct allelic scores that explain greater proportions of the variance in biological intermediates, and subsequently use these scores to data mine GWAS. To investigate the approach's properties, we indexed three biological intermediates where the results of large GWAS meta-analyses were available: body mass index, C-reactive protein and low density lipoprotein levels. We generated allelic scores in the Avon Longitudinal Study of Parents and Children, and in publicly available data from the first Wellcome Trust Case Control Consortium. We compared the explanatory ability of allelic scores in terms of their capacity to proxy for the intermediate of interest, and the extent to which they associated with disease. We found that allelic scores derived from known variants and allelic scores derived from hundreds of thousands of genetic markers explained significant portions of the variance in biological intermediates of interest, and many of these scores showed expected correlations with disease. Genome-wide allelic scores however tended to lack specificity suggesting that they should be used with caution and perhaps only to proxy biological intermediates for which there are no known individual variants. Power calculations confirm the feasibility of extending our strategy to the analysis of tens of thousands of molecular phenotypes in large genome-wide meta-analyses. We conclude that our method represents a simple way in which potentially tens of thousands of molecular phenotypes could be screened for causal relationships with disease without having to expensively measure these variables in individual disease collections.Peer reviewe

EC91-1767 Windbreaks For Rural Living

In many parts of the United States, the constant force of the wind exaggerates daily weather conditions and can make living in these areas seem unbearable. A well-designed windbreak around the home, ranch, or farmstead slows the wind and improves the overall environment. Farm and ranch windbreaks conserve energy, provide snow control, improve working and recreational environments, enhance wildlife populations, provide visual screening and dust control, and increase the production of various wood and food products. Ranch and farmstead windbreaks provide the greatest benefits in areas with high winds, large amounts of snow, extreme temperature fluctuations, or minimal natural forest cover. Traditionally, the most extensive use of ranch and farmstead windbreaks in the United States is in the Western, North Central, and Great Plains regions. However, windbreak use for privacy screens, dust control, and noise reduction as well as wind protection are important throughout the country