326 research outputs found
Bearing Loads in a Vehicular Flywheel Battery
Radial and axial rotor support bearings are critical elements in flywheel batteries for vehicle applications. This paper discusses the quantification of bearing loads required for the development of optimal bearing designs, particularly magnetic bearings. The primary contributors to bearing loads are shown to be vehicle shock, vibration, maneuvering, and gyrodynamics. Emphasis is placed on transit bus applications. Available data for each is presented, including actual measurements made on buses, and a detailed analysis of gyrodynamics.Center for Electromechanic
Band-structure trend in hole-doped cuprates and correlation with Tcmax
By calculation and analysis of the bare conduction bands in a large number of
hole-doped high-temperature superconductors, we have identified the energy of
the so-called axial-orbital as the essential, material-dependent parameter. It
is uniquely related to the range of the intra-layer hopping. It controls the Cu
4s-character, influences the perpendicular hopping, and correlates with the
observed Tc at optimal doping. We explain its dependence on chemical
composition and structure, and present a generic tight-binding model.Comment: 5 pages, Latex, 5 eps figure
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Large area black body source for ITER ECE in situ calibration
Development and testing of a hot calibration source for the ECE systems on ITER is underway. The source is intended to meet the requirements described in DDD55 Overview of Diagnostics. The requirement is for two 200 mm diameter sources. One will operate at atmospheric pressure and be well removed from the experiment. The other will operate in vacuum near the plasma. Both will operate at temperatures up to 800 °C. Here we report on the development of a prototype hot calibration source and of a realistic thermal model of the hot calibration source that will be used in simulations of the thermal properties of the source. Selection of a reliable heating method is challenging. Heating methods under consideration will be discussed.Center for Electromechanic
Genes Associated With Psychrotolerant Bacillus cereus Group Isolates
The Bacillus cereus group comprises 18 different species, including human pathogens as well as psychrotolerant strains that are an important cause of fluid milk spoilage. To enhance our understanding of the genetic markers associated with psychrotolerance (defined here as > 1 log10 increase in cfu/mL after 21 days incubation at 6°C) among dairy-associated B. cereus group isolates, we used genetic (whole genome sequencing) and phenotypic methods [growth in Skim Milk Broth (SMB) and Brain Heart Infusion (BHI) broth] to characterize 23 genetically-distinct representative isolates from a collection of 503 dairy-associated isolates. Quality threshold clustering identified three categories of psychrotolerance: (i) 14 isolates that were not psychrotolerant in BHI or SMB, (ii) 6 isolates that were psychrotolerant in BHI but not in SMB, and (iii) 2 isolates that were psychrotolerant in BHI and SMB. One isolate, which was psychrotolerant in BHI broth but was just below the cut-off of >1 log10 cfu/mL increase in SMB was not assigned to a cluster. A maximum likelihood phylogeny constructed with core genome single nucleotide polymorphisms classified all psychrotolerant isolates (i.e., psychrotolerant in BHI) into clade VI (representing B. mycoides/weihenstephanensis). Analysis of correlations between gene ortholog presence or absence patterns and psychrotolerance identified 206 orthologous gene clusters that were significantly overrepresented among psychrotolerant strains, including two clusters of cold shock proteins, which were identified in 8/9 and 7/9 psychrotolerant isolates. Gene ontology analyses revealed 36 gene ontology terms that were overrepresented in psychrotolerant isolates, including putrescine catabolic processes and putrescine transmembrane transporter activity. Lastly, Hidden Markov Model searches identified three protein family motifs, including cold shock domain proteins and fatty acid hydroxylases that were significantly associated with psychrotolerance in BHI broth. Analyses of CspA sequences revealed a positive association between psychrotolerant strains and a previously identified “psychrotolerant” CspA sequence. Overall, our data highlight genetic and phenotypic differences in psychrotolerance among B. cereus group dairy-associated isolates and show that psychrotolerance is dependent on the growth medium. We also identified a number of gene targets that could be used for specific detection or control of psychrotolerant B. cereus group isolates
MIDA boronates are hydrolysed fast and slow by two different mechanisms
MIDA boronates (N-methylimidodiacetic boronic acid esters) serve as an increasingly general platform for small-molecule construction based on building blocks, largely because of the dramatic and general rate differences with which they are hydrolysed under various basic conditions. Yet the mechanistic underpinnings of these rate differences have remained unclear, which has hindered efforts to address the current limitations of this chemistry. Here we show that there are two distinct mechanisms for this hydrolysis: one is base mediated and the other neutral. The former can proceed more than three orders of magnitude faster than the latter, and involves a rate-limiting attack by a hydroxide at a MIDA carbonyl carbon. The alternative 'neutral' hydrolysis does not require an exogenous acid or base and involves rate-limiting B-N bond cleavage by a small water cluster, (H2O)n. The two mechanisms can operate in parallel, and their relative rates are readily quantified by (18)O incorporation. Whether hydrolysis is 'fast' or 'slow' is dictated by the pH, the water activity and the mass-transfer rates between phases. These findings stand to enable, in a rational way, an even more effective and widespread utilization of MIDA boronates in synthesis
T-cell Subsets and Antifungal Host Defenses
It has been long appreciated that protective immunity against fungal pathogens is dependent on activation of cellular adaptive immune responses represented by T lymphocytes. The T-helper (Th)1/Th2 paradigm has proven to be essential for the understanding of protective adaptive host responses. Studies that have examined the significance of regulatory T cells in fungal infection, and the recent discovery of a new T-helper subset called Th17 have provided crucial information for understanding the complementary roles played by the various T-helper lymphocytes in systemic versus mucosal antifungal host defense. This review provides an overview of the role of the various T-cell subsets during fungal infections and the reciprocal regulation between the T-cell subsets contributing to the tailored host response against fungal pathogens
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