Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Urban Rivers Corridors in the Don Catchment, UK: From Ignored, Ignoble and Industrial to Green, Seen and Celebrated

Research on urban rivers often seeks to find commonalities to advance knowledge of the effect of urbanisation on rivers, and rightly so. But it is important, also, to develop a complementary understanding of how urban rivers can be distinct, to facilitate a more nuanced view of concepts such as the ‘urban river syndrome’ and of the challenges facing those who wish to create more sustainable urban river corridors. To this end we use the Don Catchment as a case study to illustrate how historic patterns of urbanisation have been fundamental in shaping the catchment’s rivers. Following the Industrial Revolution, the catchment became an industrial centre, resulting in the ecological death of river ecosystems, and the disconnection of communities from stark urban river corridors. Widescale deindustrialisation in the 1970s and 1980s then resulted in a partial ecological recovery of the rivers, and ignited public interest. This history has imbued the catchment’s urban river corridors with a distinctive industrial character that can vary greatly between and within settlements. It has also left a legacy of particular issues, including a high degree of river habitat fragmentation and physical modification, and of negative perceptions of the rivers, which need improving to realise their potential as assets to local communities