Research Data Management Policy & Implementation Strategy

This Research Data Management Plan is designed to enable a comprehensive and co-created approach to Research Data Management with UK/DAC partners and researchers which will align and enhance Tomorrow’s Cities (TC) mission and impact. Data management goals Tomorrow’s Cities has three principal goals for research data management: • to support each city in developing its own open data infrastructure, following the roadmap in “Open Data Infrastructure for City Resilience” (UNISDR 2018); • to create a data hub outside the Hub, both to support continuity and disaster recovery and to provide a common research environment for the Hub; • to facilitate data sharing and research pooling across the consortium, but particularly “south-south partnerships”. Data use in Tomorrow’s Cities The Hub will create, collect and collate data of multiple types from multiple sources centred in the four global cities, for a number of research purposes: • detailed local mapping of hazards and vulnerability, incorporating local knowledge; • real-time monitoring of hazards, their impacts and people's responses; initialisation of predictions and models (both manual and computer-based); verification and improvement of predictions and model (to build trust in their accuracy); • characterisation of multi-hazard events; • assessing and improving risk management systems (hazard, impact, response); • reassessment and reuse of the research

Statins as antifungal agents

This poster paper describes the objectives, approach and use casesof the EC FP7 Integrated Project PERICLES. The project beganon 1st February 2013 and runs for four years. The aim is toresearch and prototype solutions for digital preservation incontinually evolving environments including changes in context,semantics and practices. The project addresses use cases focusingon digital art, media and science.Proceedings source: http://purl.pt/24107/1/iPres2013_PDF/iPres2013-Proceedings.pd

Koinonia

The Epistemological Development of College Students, Marcia B. Baxter Magolda President\u27s Corner, The Editor\u27s Disk CoCCA: Marketing Your Student Leadership Experience & Hot Ideas Making Your Own RA Manual Great Lakes Regional Conferencehttps://pillars.taylor.edu/acsd_koinonia/1040/thumbnail.jp

Tracking Community Intelligence with Trac

We report on experiences at the Software Sustainability Institute (SSI) in customizing and using the Trac system to provide a single platform for recording, managing and tracking a wide range of community interactions. We note the essential requirement of a lightweight, easy-to-use system for recording ‘community metadata’ and discuss the pros and cons of using Trac in this way for day-to-day operations within SSI, and more generally as a means to record and track interactions with a wide and potentially very large community

Analysis of jak2 catalytic function by peptide microarrays: The role of the JH2 domain and V617F mutation

Janus kinase 2 (JAK2) initiates signaling from several cytokine receptors and is required for biological responses such as erythropoiesis. JAK2 activity is controlled by regulatory proteins such as Suppressor of Cytokine Signaling (SOCS) proteins and protein tyrosine phosphatases. JAK2 activity is also intrinsically controlled by regulatory domains, where the pseudokinase (JAK homology 2, JH2) domain has been shown to play an essential role. The physiological role of the JH2 domain in the regulation of JAK2 activity was highlighted by the discovery of the acquired missense point mutation V617F in myeloproliferative neoplasms (MPN). Hence, determining the precise role of this domain is critical for understanding disease pathogenesis and design of new treatment modalities. Here, we have evaluated the effect of inter-domain interactions in kinase activity and substrate specificity. By using for the first time purified recombinant JAK2 proteins and a novel peptide micro-array platform, we have determined initial phosphorylation rates and peptide substrate preference for the recombinant kinase domain (JH1) of JAK2, and two constructs comprising both the kinase and pseudokinase domains (JH1-JH2) of JAK2. The data demonstrate that (i) JH2 drastically decreases the activity of the JAK2 JH1 domain, (ii) JH2 increased the Kmfor ATP (iii) JH2 modulates the peptide preference of JAK2 (iv) the V617F mutation partially releases this inhibitory mechanism but does not significantly affect substrate preference or Kmfor ATP. These results provide the biochemical basis for understanding the interaction between the kinase and the pseudokinase domain of JAK2 and identify a novel regulatory role for the JAK2 pseudokinase domain. Additionally, this method can be used to identify new regulatory mechanisms for protein kinases that provide a better platform for designing specific strategies for therapeutic approaches

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

A Federated Architecture for a National Data Library

The UK National Data Library: Technical White Paper Challenge, initiated by Wellcome and the Economic and Social Research Council (ESRC), sought visionary approaches to enhancing access to UK public sector datasets. Evaluated by an expert panel, this paper was recognised as a distinguished and successful response to the call, offering innovative insights for creating a National Data Library that benefits both the research community and the public good.The call for a National Data Library (NDL) is timely. Granting authorised researchers controlled access to sensitive public data at scale will be key to enabling more efficient services and research within the UK. In 2021, the DARE UK programme was set up by UKRI with a mission to put the UK at the forefront of sensitive data research and innovation by assembling the tools, technologies, and standards needed to streamline secure data linkage and use. Since then, the programme has conducted public and professional consultations, landscape reviews, and programmes of research, development, and proofs-of-concept to assemble most of the key elements needed for a federated approach to the NDL. Our focus is access to sensitive data for approved research purposes, and this white paper describes a comprehensive and self-consistent way to achieve this. In defining the overall architecture, we have assimilated not only the pioneering results from the DARE UK programme to date but also current thinking and practice from large-scale scientific infrastructures, data spaces, and digital public infrastructures both domestically and internationally. The associated HDR UK white paper provides a health data perspective

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Scottish Medical Imaging Service:Technical and Governance controls

Objectives The Scottish Medical Imaging (SMI) service provides linkable, population based, “research-ready” real-world medical images for researchers to develop or validate AI algorithms within the Scottish National Safe Haven. The PICTURES research programme is developing novel methods to enhance the SMI service offering through research in cybersecurity and software/data/infrastructure engineering. Approach Additional technical and governance controls were required to enable safe access to medical images. The researcher is isolated from the rest of the trusted research environment (TRE) using a Project Private Zone (PPZ). This enables researchers to build and install their own software stack, and protects the TRE from malicious code. Guidelines are under development for researchers on the safe development of algorithms and the expected relationship between the size of the model and the training dataset. There is associated work on the statistical disclosure control of models to enable safe release of trained models from the TRE. Results A policy enabling the use of “Non-standard software” based on prior research, domain knowledge and experience gained from two contrasting research studies was developed.  Additional clauses have been added to the legal control – the eDRIS User Agreement – signed by each researcher and their Head of Department.  Penalties for attempting to import or use malware, remove data within models or any attempt to deceive or circumvent such controls are severe, and apply to both the individual and their institution. The process of building and deploying a PPZ has been developed allowing researchers to install their own software. No attempt has yet been made to add additional ethical controls; however, a future service development could be validating the performance of researchers’ algorithms on our training dataset. Conclusion The availability to conduct research using images poses new challenges and risks for those commissioning and operating TREs. The Private Project Zone and our associated governance controls are a huge step towards supporting the needs of researchers in the 21st century

Texas Parks & Wildlife

Magazine discussing natural resources, parks, hunting and fishing, and other information related to the outdoors in Texas