Resolving Subhaloes' Lives with the Hierarchical Bound-Tracing Algorithm

We develop a new code, the Hierarchical Bound-Tracing (HBT for short) code, to find and trace dark matter subhaloes in simulations based on the merger hierarchy of dark matter haloes. Application of this code to a recent benchmark test of finding subhaloes demonstrates that HBT stands as one of the best codes to trace the evolutionary history of subhaloes. The success of the code lies in its careful treatment of the complex physical processes associated with the evolution of subhaloes and in its robust unbinding algorithm with an adaptive source subhalo management. We keep a full record of the merger hierarchy of haloes and subhaloes, and allow growth of satellite subhaloes through accretion from its "satellite-of-satellites", hence allowing mergers among satellites. Local accretion of background mass is omitted, while rebinding of stripped mass is allowed. The justification of these treatments is provided by case studies of the lives of individual subhaloes and by the success in finding the complete subhalo catalogue. We compare our result to other popular subhalo finders and show that HBT is able to well resolve subhaloes in high density environment and keep strict physical track of subhaloes' merger history. This code is fully parallelized and freely available upon request to the authors.Comment: 15 pages; accepted for publication by MNRA

A halo approach to the evaluation of the cross-correlation between the SZ sky and galaxy survey

Using a purely analytic approach to gaseous and dark matter halos, we study the cross-correlation between the Sunyaev-Zel'dovich (SZ) sky and galaxy survey under flat sky approximation, in an attempt to acquire the redshift information of the SZ map. The problem can be greatly simplified when it is noticed that the signals of the SZ-galaxy correlation arise only from hot gas and galaxies inside the same massive halos (i.e. clusters), and field galaxies make almost no contribution to the cross-correlation. Under the assumption that both the hot gas and galaxies trace the common gravitational potential of dark halos, we calculate the expected cross SZ-galaxy power spectra for the WMAP/Planck SZ maps and the SDSS galaxy sample at small scales $100<l<1000$. It turns out, however, that it is not presently feasible to measure such small angular cross power spectra because of the high noise levels at $l>400$ with the WMAP/Planck experiments. Future SZ observations with better angular resolutions and sufficiently wide sky coverages will be needed if this technique is applied for the statistical measurement of redshift distribution of the SZ sources.Comment: 6 pages, 4 figures, accepted for publication in A&

Quantifying the effect of baryon physics on weak lensing tomography

We use matter power spectra from cosmological hydrodynamic simulations to quantify the effect of baryon physics on the weak gravitational lensing shear signal. The simulations consider a number of processes, such as radiative cooling, star formation, supernovae and feedback from active galactic nuclei (AGN). Van Daalen et al. (2011) used the same simulations to show that baryon physics, in particular the strong feedback that is required to solve the overcooling problem, modifies the matter power spectrum on scales relevant for cosmological weak lensing studies. As a result, the use of power spectra from dark matter simulations can lead to significant biases in the inferred cosmological parameters. We show that the typical biases are much larger than the precision with which future missions aim to constrain the dark energy equation of state, w_0. For instance, the simulation with AGN feedback, which reproduces X-ray and optical properties of groups of galaxies, gives rise to a ~40% bias in w_0. We demonstrate that the modification of the power spectrum is dominated by groups and clusters of galaxies, the effect of which can be modelled. We consider an approach based on the popular halo model and show that simple modifications can capture the main features of baryonic feedback. Despite its simplicity, we find that our model, when calibrated on the simulations, is able to reduce the bias in w_0 to a level comparable to the size of the statistical uncertainties for a Euclid-like mission. While observations of the gas and stellar fractions as a function of halo mass can be used to calibrate the model, hydrodynamic simulations will likely still be needed to extend the observed scaling relations down to halo masses of 10 ^12 M_sun/h.Comment: 17 pages, 14 Figures, MNRAS accepted. Small changes to the published version: typos in Eq. 4 corrected, Figure 2 updated (y-ticks of the previous version were wrong). Bibliography updated with published papers when possibl

Comparison of the Metabolic Effects of Ritonavir-Boosted Darunavir or Atazanavir Versus Raltegravir, and the Impact of Ritonavir Plasma Exposure: ACTG 5257

Background. Metabolic effects following combination antiretroviral therapy (cART) vary by regimen type. Changes in metabolic effects were assessed following cART in the AIDS Clinical Trials Group (ACTG) A5257 study, and correlated with plasma ritonavir trough concentrations (C24)

Comparison of the Metabolic Effects of Ritonavir-Boosted Darunavir or Atazanavir Versus Raltegravir, and the Impact of Ritonavir Plasma Exposure: ACTG 5257

Background. Metabolic effects following combination antiretroviral therapy (cART) vary by regimen type. Changes in metabolic effects were assessed following cART in the AIDS Clinical Trials Group (ACTG) A5257 study, and correlated with plasma ritonavir trough concentrations (C24)

Week 48 resistance analyses of the once-daily, single-tablet regimen darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in adults living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is being investigated in two Phase III trials, AMBER (NCT02431247; treatment-naive adults) and EMERALD (NCT02269917; treatment-experienced, virologically suppressed adults). Week 48 AMBER and EMERALD resistance analyses are presented. Postbaseline samples for genotyping/phenotyping were analyzed from protocol-defined virologic failures (PDVFs) with viral load (VL) >= 400 copies/mL at failure/later time points. Post hoc analyses were deep sequencing in AMBER, and HIV-1 proviral DNA from baseline samples (VL = 3 thymidine analog-associated mutations (24% not fully susceptible to tenofovir) detected at screening. All achieved VL <50 copies/mL at week 48 or prior discontinuation. D/C/F/TAF has a high genetic barrier to resistance; no darunavir, primary PI, or tenofovir RAMs were observed through 48 weeks in AMBER and EMERALD. Only one postbaseline M184I/V RAM was observed in HIV-1 of an AMBER participant. In EMERALD, baseline archived RAMs to darunavir, emtricitabine, and tenofovir in participants with prior VF did not preclude virologic response

Less Bone Loss With Maraviroc- Versus Tenofovir-Containing Antiretroviral Therapy in the AIDS Clinical Trials Group A5303 Study

Background. There is a need to prevent or minimize bone loss associated with antiretroviral treatment (ART) initiation. We compared maraviroc (MVC)- to tenofovir disoproxil fumarate (TDF)–containing ART