202 research outputs found
Isotopic ratios of H, C, N, O, and S in comets C/2012 F6 (Lemmon) and C/2014 Q2 (Lovejoy)
The apparition of bright comets C/2012 F6 (Lemmon) and C/2014 Q2 (Lovejoy) in
March-April 2013 and January 2015, combined with the improved observational
capabilities of submillimeter facilities, offered an opportunity to carry out
sensitive compositional and isotopic studies of the volatiles in their coma. We
observed comet Lovejoy with the IRAM 30m telescope between 13 and 26 January
2015, and with the Odin submillimeter space observatory on 29 January - 3
February 2015. We detected 22 molecules and several isotopologues. The
HO and HO production rates measured with Odin follow a
periodic pattern with a period of 0.94 days and an amplitude of ~25%. The
inferred isotope ratios in comet Lovejoy are O/O = 499 24
and D/H = 1.4 0.4 in water, S/S = 24.7
3.5 in CS, all compatible with terrestrial values. The ratio
C/C = 109 14 in HCN is marginally higher than terrestrial
and N/N = 145 12 in HCN is half the Earth ratio. Several
upper limits for D/H or 12C/13C in other molecules are reported. From our
observation of HDO in comet C/2014 Q2 (Lovejoy), we report the first D/H ratio
in an Oort Cloud comet that is not larger than the terrestrial value. On the
other hand, the observation of the same HDO line in the other Oort-cloud comet,
C/2012 F6 (Lemmon), suggests a D/H value four times higher. Given the previous
measurements of D/H in cometary water, this illustrates that a diversity in the
D/H ratio and in the chemical composition, is present even within the same
dynamical group of comets, suggesting that current dynamical groups contain
comets formed at very different places or times in the early solar system.Comment: Accepted for publication in Astronomy and Astrophysic
Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of ÎČ-Cell Function in Therapeutic Trials in Type 1 Diabetes
OBJECTIVEâÎČ-Cell function in type 1 diabetes clinical trials is commonly measured by C-peptide response to a secretagogue in either a mixed-meal tolerance test (MMTT) or a glucagon stimulation test (GST). The Type 1 Diabetes TrialNet Research Group and the European C-peptide Trial (ECPT) Study Group conducted parallel randomized studies to compare the sensitivity, reproducibility, and tolerability of these procedures
Early Fermi Gamma-ray Space Telescope Observations of the Quasar 3C 454.3
This is the first report of Fermi Gamma-ray Space Telescope observations of
the quasar 3C 454.3, which has been undergoing pronounced long-term outbursts
since 2000. The data from the Large Area Telescope (LAT), covering 2008 July 7
- October 6, indicate strong, highly variable gamma-ray emission with an
average flux of ~3 x 10^{-6} photons cm^{-2} s^{-1}, for energies above 100
MeV. The gamma-ray flux is variable, with strong, distinct,
symmetrically-shaped flares for which the flux increases by a factor of several
on a time scale of about three days. This variability indicates a compact
emission region, and the requirement that the source is optically thin to
pair-production implies relativistic beaming with Doppler factor delta > 8,
consistent with the values inferred from VLBI observations of superluminal
expansion (delta ~ 25). The observed gamma-ray spectrum is not consistent with
a simple power-law, but instead steepens strongly above ~2 GeV, and is well
described by a broken power-law with photon indices of ~2.3 and ~3.5 below and
above the break, respectively. This is the first direct observation of a break
in the spectrum of a high luminosity blazar above 100 MeV, and it is likely
direct evidence for an intrinsic break in the energy distribution of the
radiating particles. Alternatively, the spectral softening above 2 GeV could be
due to gamma-ray absorption via photon-photon pair production on the soft X-ray
photon field of the host AGN, but such an interpretation would require the
dissipation region to be located very close (less than 100 gravitational radii)
to the black hole, which would be inconsistent with the X-ray spectrum of the
source.Comment: Accepted by the Astrophysical Journal; corresponding authors: Greg
Madejski ([email protected]) and Benoit Lott ([email protected]
Fermi/LAT discovery of gamma-ray emission from a relativistic jet in the narrow-line quasar PMN J0948+0022
We report the discovery by the Large Area Telescope (LAT) onboard the Fermi
Gamma-ray Space Telescope of high-energy gamma-ray emission from the peculiar
quasar PMN J0948+0022 (z=0.5846). The optical spectrum of this object exhibits
rather narrow Hbeta (FWHM(Hbeta) ~ 1500 km s^-1), weak forbidden lines and is
therefore classified as a narrow-line type I quasar. This class of objects is
thought to have relatively small black hole mass and to accrete at high
Eddington ratio. The radio loudness and variability of the compact radio core
indicates the presence of a relativistic jet. Quasi simultaneous
radio-optical-X-ray and gamma-ray observations are presented. Both radio and
gamma-ray emission (observed over 5-months) are strongly variable. The
simultaneous optical and X-ray data from Swift show a blue continuum attributed
to the accretion disk and a hard X-ray spectrum attributed to the jet. The
resulting broad band spectral energy distribution (SED) and, in particular, the
gamma-ray spectrum measured by Fermi are similar to those of more powerful
FSRQ. A comparison of the radio and gamma-ray characteristics of PMN J0948+0022
with the other blazars detected by LAT shows that this source has a relatively
low radio and gamma-ray power, with respect to other FSRQ. The physical
parameters obtained from modelling the SED also fall at the low power end of
the FSRQ parameter region discussed in Celotti & Ghisellini (2008). We suggest
that the similarity of the SED of PMN J0948+0022 to that of more massive and
more powerful quasars can be understood in a scenario in which the SED
properties depend on the Eddington ratio rather than on the absolute power.Comment: 10 pages, 5 figures, accepted for publication on ApJ Main Journal.
Corresponding author: L. Foschin
Fermi Large Area Telescope Bright Gamma-ray Source List
Following its launch in June 2008, the Fermi Gamma-ray Space Telescope
(Fermi) began a sky survey in August. The Large Area Telescope (LAT) on Fermi
in 3 months produced a deeper and better-resolved map of the gamma-ray sky than
any previous space mission. We present here initial results for energies above
100 MeV for the 205 most significant (statistical significance greater than
~10-sigma) gamma-ray sources in these data. These are the best-characterized
and best-localized point-like (i.e., spatially unresolved) gamma-ray sources in
the early-mission data.Comment: Accepted by ApJS. Many helpful comments by referee incorporated 57
pages, 12 figure
Free-living use of artificial pancreas for children with type 1 diabetes: systematic review
BACKGRAUND: A closed-loop glucose control system or artificial pancreas consists of three components a Continuous Glucose Monitor (CGM), infusion pumps to deliver hormone(s) and a sophisticated dosing algorithm to control hormone delivery. In the past years, numerous studies with closed-loop system devices were conducted with gradual shift to out-of-hospital environment and with lengthening study duration.
AIMS: To compare efficacy and safety of closed-loop insulin pump use in children with type 1 diabetes mellitus in compare with conventional insulin treatment (continuous subcutaneous insulin infusion (CSII) with our without CGM) based on randomized control trials data (RCT).
METHODS: In the systematic review we have include 28 randomized controlled trials results indexed in PubMed, Medline databases published till 15 June 2017. The efficacy on metabolic control in this study evaluated by the proportion of time within target range (preferably 70 to 180 mg/dl if reported) and mean (median) glucose based on sensor measurements, and the safety evaluated by time in hypoglycemia (below 70 mg/dl if reported).
RESULTS: Increased time in range in the night period was observed in all RCT. Only 3 RCT showed decrease of the time in range within 24 h evaluation period. In one RCT the significant positive differences have been shown in the time in range for dual hormone closed-loop glucose control system in compare with insulin-only artificial pancreas. Mean glycaemia and glucose variability changes were not in the same manner in different RCT, both in the night only and in 24 h estimation period. Night hypoglycemia duration decreased in most RCT with closed-loop control in compare with CSII, and increased only in 2 RCT. When all-day estimation period the time in hypoglycemia changed not in the same manner in different RCT. Valuable methodology differences of the glycaemic control estimation within observed RCT brought significant complications in the data analysis and made impossible the results quantitative estimation to prepare a metaanalysis.
CONCLUSIONS: Much work has been done to develop effective and safe artificial pancreas, but not all RCTs confirmed advantages of closed-loop glucose control in compare with CSII in children and adolescents in real life. More research with prospective randomized control design required to prove benefits of closed-loop glucose control. Further RCTs should have an uniform methodology for glycemic control assessment and long duration that will allow to use cumulative measures in a closed-loop efficacy estimation (HbA1c)
Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes: experience of the PedPump Study in 17 countries
AIMS/HYPOTHESIS: To assess the use of paediatric continuous subcutaneous infusion (CSII) under real-life conditions by analysing data recorded for up to 90 days and relating them to outcome. METHODS: Pump programming data from patients aged 0-18 years treated with CSII in 30 centres from 16 European countries and Israel were recorded during routine clinical visits. HbA(1c) was measured centrally. RESULTS: A total of 1,041 patients (age: 11.8 +/- 4.2 years; diabetes duration: 6.0 +/- 3.6 years; average CSII duration: 2.0 +/- 1.3 years; HbA(1c): 8.0 +/- 1.3% [means +/- SD]) participated. Glycaemic control was better in preschool (n = 142; 7.5 +/- 0.9%) and pre-adolescent (6-11 years, n = 321; 7.7 +/- 1.0%) children than in adolescent patients (12-18 years, n = 578; 8.3 +/- 1.4%). There was a significant negative correlation between HbA(1c) and daily bolus number, but not between HbA(1c) and total daily insulin dose. The use of 7.5%. The incidence of severe hypoglycaemia and ketoacidosis was 6.63 and 6.26 events per 100 patient-years, respectively. CONCLUSIONS/INTERPRETATION: This large paediatric survey of CSII shows that glycaemic targets can be frequently achieved, particularly in young children, and the incidence of acute complications is low. Adequate substitution of basal and prandial insulin is associated with a better HbA(1c)
Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA)
Physical exercise is an important component in the management of type 1 diabetes across the lifespan. Yet, acute exercise increases the risk of dysglycaemia, and the direction of glycaemic excursions depends, to some extent, on the intensity and duration of the type of exercise. Understandably, fear of hypoglycaemia is one of the strongest barriers to incorporating exercise into daily life. Risk of hypoglycaemia during and after exercise can be lowered when insulinâdose adjustments are made and/or additional carbohydrates are consumed. Glycaemic management during exercise has been made easier with continuous glucose monitoring (CGM) and intermittently scanned continuous glucose monitoring (isCGM) systems; however, because of the complexity of CGM and isCGM systems, both individuals with type 1 diabetes and their healthcare professionals may struggle with the interpretation of given information to maximise the technological potential for effective use around exercise (ie, before, during and after). This position statement highlights the recent advancements in CGM and isCGM technology, with a focus on the evidence base for their efficacy to sense glucose around exercise and adaptations in the use of these emerging tools, and updates the guidance for exercise in adults, children and adolescents with type 1 diabetes
Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
We describe here a minimally invasive glucose biosensor based on a microneedle array electrode fabricated from an epoxy-based negative photoresist (SU8 50) and designed for continuous measurement in the dermal compartment with minimal pain. These minimally invasive, continuous monitoring sensor devices (MICoMS) were produced by casting the structures in SU8 50, crosslinking and then metallising them with platinum or silver to obtain the working and reference electrodes, respectively. The metallised microneedle array electrodes were subsequently functionalised by entrapping glucose oxidase in electropolymerised polyphenol (PP) film. Sensor performance in vitro showed that glucose concentrations down to 0.5 mM could be measured with a response times (T90) of 15 s. The effect of sterilisation by Co60 irradiation was evaluated. In preparation for further clinical studies, these sensors were tested in vivo in a healthy volunteer for a period of 3â6 h. The sensor currents were compared against point measurements obtained with a commercial capillary blood glucometer. The epoxy MICoMS devices showed currents values that could be correlated with these
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