Elements of attention in HIV-infected adults: Evaluation of an existing model

Because of the multifactorial nature of neuropsychological tests, attention remains poorly defined from a neuropsychological perspective, and conclusions made regarding attention across studies may be limited due to the different nature of the measures used. Thus, a more definitive schema for this neurocognitive domain is needed. We assessed the applicability of Mirsky and Duncan\u27s (2001) neuropsychological model of attention to a cohort of 104 HIV+ adults. Our analysis resulted in a five-factor structure similar to that of previous studies, which explained 74.5% of the variance. However, based on the psychometric characteristics of the measures comprising each factor, we offer an alternative interpretation of the factors. Findings also indicate that one factor, which is generally not assessed in clinical neuropsychology settings, may be more predictive of real-world behaviors (such as medication adherence) than those composed of traditional measures. Suggestions for further research in this important area are discussed

Zircon as a tracer of plumbing processes in an active magmatic system: insights from mingled magmas of the 2010 dome collapse, Montserrat, Lesser Antilles Arc, Caribbean

This project has received funding from the European Union's Hori-zon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement No. 749611 (JHS) . We also ac-knowledge funding from the Natural Environment Research Council Isotope Geoscience Facilities Steering Committee, grant IP-1746-1117 (JB) . The work has been financially supported by the Spanish grant CGL 2017-84469-P (JHS) . Funding for open access charge: Universidad de Granada/CBUA. Alexander Varychev at the University of Heidelberg, Germany, and Jeremy Rushton at the British Geological Survey, U.K., are thanked for help with analytical work. Jose Luis Macias is thanked for editorial handling. We are obliged to two anonymous reviewers for the time and effort they took to help us improve the clarity and rigour of our interpretations. 19Soufriere Hills Volcano, Montserrat, erupted from 1995 to 2010, with activity including dome growth, destructive pyroclastic density currents and Vulcanian explosions. Monitoring data, such as gas emissions, show the system is still in a state of unrest. The recent eruptions provide an opportunity to study, in real time, a complex subduction-related subvolcanic transaustal melt-mush reservoir, its magma fluxes, and the timing of crystal and melt storage prior to eruptive paroxysms. How and when mush destabilisation occurs prior to volcanic eruptions continues to be a question of intense debate. Evidence of mafic magma intrusion, a potential eruptive trigger, is preserved in enclaves with quenched and diffuse margins that are mingled with crystal-rich andesite. Here, in this first study of Soufriere Hills Volcano zircon, we report zircon ages and compositions for mafic-intermediate enclaves and host andesites from the most recent dome collapse in 2010 to place temporal constraints on magma reservoir processes. Zircon U-238-Th-230 ages disequilibrium crystallisation ages ranging between c. 2-250 ka constrain the longevity of the magmatic plumbing system. Uniform Hf isotopes, epsilon Hf 11.3 +/- 12 to 14.6 +/- 1.5, indicate invariant compositions that are typical for island arc magma sources. Zircon trace element concentrations and Ti-in-zircon crystallisation temperatures indicate crystallisation in isolated, small-volume, lenses with variable fractions of melt of heterogeneous compositions. We suggest amalgamation of assorted crystal cargoes from these lenses occurred prior to eruption during mush destabilisation triggered by mafic magma recharge. Zircon textures, on the other hand, shed light on recent centimetre-scale magma mingling immediately prior to eruption. Euhedral-subhedral zircon is preferentially preserved in or near quenched contacts of the least-evolved enclave and host andesite. By contrast, reheating of the andesite by the mafic magma recharge in the presence of zircon-undersaturated melts promoted zircon resorption. This led to the formation of subhedral-anhedral corroded zircon that is typical in the host andesite mush. Zircon thus reveals processes ranging from 100,000s of years of andesite storage to short-term partial destruction in response to transient heating and magma mixing events.European Commission 749611Natural Environment Research Council Isotope Geoscience Facilities Steering Committee IP-1746-1117Spanish Government CGL 2017-84469-PUniversidad de Granada/CBU

Immune responses in pigs vaccinated with adjuvanted and non-adjuvanted A(H1N1)pdm/09 influenza vaccines used in human immunization programmes.

Following the emergence and global spread of a novel H1N1 influenza virus in 2009, two A(H1N1)pdm/09 influenza vaccines produced from the A/California/07/09 H1N1 strain were selected and used for the national immunisation programme in the United Kingdom: an adjuvanted split virion vaccine and a non-adjuvanted whole virion vaccine. In this study, we assessed the immune responses generated in inbred large white pigs (Babraham line) following vaccination with these vaccines and after challenge with A(H1N1)pdm/09 virus three months post-vaccination. Both vaccines elicited strong antibody responses, which included high levels of influenza-specific IgG1 and haemagglutination inhibition titres to H1 virus. Immunisation with the adjuvanted split vaccine induced significantly higher interferon gamma production, increased frequency of interferon gamma-producing cells and proliferation of CD4(-)CD8(+) (cytotoxic) and CD4(+)CD8(+) (helper) T cells, after in vitro re-stimulation. Despite significant differences in the magnitude and breadth of immune responses in the two vaccinated and mock treated groups, similar quantities of viral RNA were detected from the nasal cavity in all pigs after live virus challenge. The present study provides support for the use of the pig as a valid experimental model for influenza infections in humans, including the assessment of protective efficacy of therapeutic interventions

101 Eclipsing Quadruple Star Candidates Discovered in TESS Full Frame Images

We present our second catalog of quadruple star candidates, containing 101 systems discovered in TESS Full-Frame Image data. The targets were initially detected as eclipsing binary stars with the help of supervised machine learning methods applied to sectors Sectors 1 through 54. A dedicated team of citizen scientists subsequently identified through visual inspection two sets of eclipses following two different periods. All 101 systems presented here pass comprehensive photocenter motion tests confirming that both sets of eclipses originate from the target star. Some of the systems exhibit prominent eclipse time variations suggesting dynamical interactions between the two component binary stars. One target is an eclipsing quintuple candidate with a (2+1)+2 hierarchical configuration, such that the (2+1) subsystem produces eclipses on the triple orbit as well. Another has recently been confirmed as the second shortest period quadruple reported to date. This catalog provides ephemerides, eclipse depths and durations, sample statistics, and highlights potentially interesting targets for future studies.Comment: 38 pages, 21 figures, 2 tables. Table with targets available online at MNRA

The Cascadia Initiative : a sea change In seismological studies of subduction zones

Author Posting. © The Oceanography Society, 2014. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 27, no. 2 (2014): 138-150, doi:10.5670/oceanog.2014.49.Increasing public awareness that the Cascadia subduction zone in the Pacific Northwest is capable of great earthquakes (magnitude 9 and greater) motivates the Cascadia Initiative, an ambitious onshore/offshore seismic and geodetic experiment that takes advantage of an amphibious array to study questions ranging from megathrust earthquakes, to volcanic arc structure, to the formation, deformation and hydration of the Juan De Fuca and Gorda Plates. Here, we provide an overview of the Cascadia Initiative, including its primary science objectives, its experimental design and implementation, and a preview of how the resulting data are being used by a diverse and growing scientific community. The Cascadia Initiative also exemplifies how new technology and community-based experiments are opening up frontiers for marine science. The new technology—shielded ocean bottom seismometers—is allowing more routine investigation of the source zone of megathrust earthquakes, which almost exclusively lies offshore and in shallow water. The Cascadia Initiative offers opportunities and accompanying challenges to a rapidly expanding community of those who use ocean bottom seismic data.The Cascadia Initiative is supported by the National Science Foundation; the CIET is supported under grants OCE- 1139701, OCE-1238023, OCE‐1342503, OCE-1407821, and OCE-1427663 to the University of Oregon

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology

Planetary Candidates Observed by Kepler, III: Analysis of the First 16 Months of Data

New transiting planet candidates are identified in sixteen months (May 2009 - September 2010) of data from the Kepler spacecraft. Nearly five thousand periodic transit-like signals are vetted against astrophysical and instrumental false positives yielding 1,091 viable new planet candidates, bringing the total count up to over 2,300. Improved vetting metrics are employed, contributing to higher catalog reliability. Most notable is the noise-weighted robust averaging of multi-quarter photo-center offsets derived from difference image analysis which identifies likely background eclipsing binaries. Twenty-two months of photometry are used for the purpose of characterizing each of the new candidates. Ephemerides (transit epoch, T_0, and orbital period, P) are tabulated as well as the products of light curve modeling: reduced radius (Rp/R*), reduced semi-major axis (d/R*), and impact parameter (b). The largest fractional increases are seen for the smallest planet candidates (197% for candidates smaller than 2Re compared to 52% for candidates larger than 2Re) and those at longer orbital periods (123% for candidates outside of 50-day orbits versus 85% for candidates inside of 50-day orbits). The gains are larger than expected from increasing the observing window from thirteen months (Quarter 1-- Quarter 5) to sixteen months (Quarter 1 -- Quarter 6). This demonstrates the benefit of continued development of pipeline analysis software. The fraction of all host stars with multiple candidates has grown from 17% to 20%, and the paucity of short-period giant planets in multiple systems is still evident. The progression toward smaller planets at longer orbital periods with each new catalog release suggests that Earth-size planets in the Habitable Zone are forthcoming if, indeed, such planets are abundant.Comment: Submitted to ApJS. Machine-readable tables are available at http://kepler.nasa.gov, http://archive.stsci.edu/kepler/results.html, and the NASA Exoplanet Archiv

Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4) – a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity

Fibroblast growth factor-1 (FGF-1) promotes differentiation of human preadipocytes into mature adipocytes via modulation of a BMP and Activin Membrane-Bound Inhibitor (BAMBI)/Peroxisome proliferator-activated receptor (PPAR?)-dependent network. Here, we combined transcriptomic and functional investigations to identify novel downstream effectors aligned with complementary analyses of gene expression in human adipose tissue to explore relationships with insulin sensitivity. RNA-Seq and qRT-PCR analysis revealed significant down-regulation of carboxypeptidase A4 (CPA4) following FGF-1 treatment or induction of differentiation of human preadipocytes in a BAMBI/PPAR?-independent manner. siRNA-mediated knockdown of CPA4 resulted in enhanced differentiation of human preadipocytes. Furthermore, expression of CPA4 in subcutaneous adipose tissue correlated negatively with indices of local and systemic (liver and muscle) insulin sensitivity. These results identify CPA4 as a negative regulator of adipogenesis that is down-regulated by FGF-1 and a putative deleterious modulator of local and systemic insulin sensitivity. Further investigations are required to define the molecular mechanism(s) involved and potential therapeutic opportunities