Beliefs Predicting Peace, Beliefs Predicting War: Jewish Americans and the Israeli-Palestinian Conflict

Jewish Americans' opinions on the Israeli-Palestinian conflict influence both the Israeli and the U.S. governments. Consequently, the Jewish American diaspora can act to promote or inhibit the peace process between Israelis and Palestinians. Several different sociopsychological beliefs have been postulated to lead individuals to support the perpetuation of conflict. Among these beliefs are a sense of collective victimhood, dehumanization and delegitimization of the other side, a zero-sum view on the conflict, and a monolithic narrative about the conflict. In this exploratory study we examined the role of these beliefs in predicting Jewish Americans' rejection or support of compromise solutions to the Israeli-Palestinian conflict. A survey study of 176 Jewish Americans shows that a monolithic view on the conflict, dehumanizing and delegitimizing of the other side, and a zero-sum view on the conflict played an important role in predicting opposition to compromise solutions for the Palestinian-Israeli conflict. Beliefs about collective victimhood did not predict support for compromise solutions. Findings are discussed in terms of the centrality of narrative misrecognition in preventing agreement to concessions toward the other side. © 2013 The Society for the Psychological Study of Social Issues

1297. Examining the Successes and Challenges of Implementing HIV Testing Clinical Decision Support in the Emergency Department

Abstract Background In 2016, MetroHealth System (MHS) launched the FOCUS (Frontlines of Communities in the United States) project to routinize HIV testing in the emergency department (ED). Before 2016, clinical decision support (CDS) for HIV testing was not in place, nor was there a policy to support the importance of opt-out, nontargeted screening. The purpose of this study was to outline the progress of HIV testing after the integration of CDS, as well as describe the implementation challenges, and how certain events impacted HIV testing. Methods HIV testing data from MHS EDs were collected from October 1, 2015 to March 31, 2019 and graphed into a run chart. The dataset was mapped with the following events: project start date, ED testing begins (without CDS), CDS implementation, the staffing of the ED Testing Coordinator (EDTC), and optimization of CDS (Figure 1). To determine whether observed variation in the dataset is due to random or special cause variation, these run chart rules were applied: Run, Shift (Figure 2), and Trend. Results There were 42 data points and 4 runs. With 42 points, the lower limit of runs was 16 and the upper limit of runs was 28. This signals that one or more special cause variations were present. A total of three distinct shifts were observed indicating special cause variation. The run chart did not include any downward or upward trends. Testing increased as much as 3971% (7 tests in October 2015 vs. 285 tests in March 2018). Conclusion HIV testing increased from 7 tests to 86 tests (Shift 1). This coincided with establishment of an ED testing policy in April 2016. Testing increased to 266 tests in October 2016 (Shift 2). This directly related to implementation of CDS in the ED. December 2017 displayed the lowest testing with 117 tests. This was due to lack of policy awareness, and to the rarely-visited location of the HIV screening tool during the triage process. Staff was re-educated and the HIV screening tool was moved to a more visible location. This resulted in 227 tests in February 2018, and was followed by the highest testing month with 285 tests (Shift 3). Continued challenges prohibit sustained upward trends in ED testing. A control chart may be the appropriate next step to identify new control limits Disclosures All authors: No reported disclosures. </jats:sec

Oncotarget

Impaired expression of connexins, the gap junction subunits that facilitate direct cell-cell communication, have been implicated in prostate cancer growth. To elucidate the crucial role of connexins in prostate cancer progression, we performed a systematic quantitative RT-PCR screening of connexin expression in four representative prostate cancer cell lines across the spectrum of malignancy. Transcripts of several connexin subunits were detected in all four cell lines, and connexin 43 (Cx43) showed marked elevation at both RNA and protein levels in cells with increased metastatic potential. Analysis of gap-junction-mediated intercellular communication revealed homocellular coupling in PC-3 cells, which had the highest C x 43 expression, with minimal coupling in LNCaP cells where C x 43 expression was very low. Treatment with the gap junction inhibitor carbenoxolone or connexin mimetic peptide ACT-1 did not impair cell growth, suggesting that growth is independent of functional gap junctions. PC-3 cells with C x 43 expression reduced by shRNA showed decreased migration in monolayer wound healing assay, as well as decreased transwell invasion capacities when compared to control cells expressing non-targeting shRNA. These results, together with the correlation between C x 43 expression levels and the metastatic capacity of the cell lines, suggest a role of C x 43 in prostate cancer invasion and metastasis.Published versio