909 research outputs found
What Is Street Art?
What is street art? This paper offers a definition of street art as an art kind or art form based on its essential value: its subversiveness. It argues that street art is essentially subversive in virtue of using public space as a technical resource. By hijacking a portion of the urban landscape with its colourful forms and witty designs, street art challenges familiar ways of practising the city, while creating a ‘temporary autonomous zone’ of free expression. There, corporate control over the city’s visible surfaces is ridiculed and people reclaim their right to use the city. In this sense, street art functions as a carnivalesque tactic of social resistance, favouring the emergence of alternative ways to imagine our urban life and our uses of public space. By considering its subversiveness, one can also explain how street art (i) significantly differs from official public art; (ii) includes graffiti as its original and most radical style.12
Radically Rethinking Copyright in the Arts: A Philosophical Approach by James O. Young
A book review of James O. Young, Radically Rethinking Copyright in the Arts: A Philosophical Approach. New York: Routledge, 2021, 184 pp. ISBN 978-0-367–52183–7.757
Identification of a Common Pharmacophore for Binding to MMP2 and RGD Integrin: Towards a Multitarget Approach to Inhibit Cancer Angiogenesis and Metastasis
During tumor angiogenesis different growth factors, cytokines and other molecules interact closely with each other to facilitate tumor cell invasion and metastatic diffusion. The most intensively studied as molecular targets in anti-angiogenic therapies are vascular endothelial growth factor (VEGF) and related receptors, integrin receptors and matrix metalloproteinases (MMPs). Considering the poor efficacy of cancer angiogenesis monotherapies, we reasoned combining the inhibition of α(v)β(3) and MMP2 as a multitarget approach to deliver a synergistic blockade of tumor cell migration, invasion and metastasis. Accordingly, we identified a common pharmacophore in the binding cavity of MMP2 and α(v)β(3), demonstrating such approach with the design, synthesis and bioassays of tyrosine-derived peptidomimetics carrying the necessary functional groups to bind to key pharmacophoric elements of MMP2 and α(v)β(3) RGD integrin
Thermodynamic Assessment on the Integration of Thermo-Electric Modules in a Wood Fireplace
The growing demand for electricity produced from renewable sources and the development of new technologies for the combustion of biomass, arose a growing interest on the possible coupling of thermoelectric modules with stove-fireplaces. The current thermoelectric generators have a solid structure, do not produce noise, do not require maintenance and can be used for the recovery of waste heat or excess, at the same time they hold a very low conversion efficiency and they need an adequate cooling system. Nevertheless, they still hold a cost, which is still too high to make them attractive. Nonetheless, if the modules are applied to a heat source which otherwise would be wasted, the attractiveness of the solution certainly rises. In this study, a thermodynamic analysis of a stove-fireplace is presented, considering both combustion process and the flame – walls heat transfer of the. A design solution for a concentrator device to funnel the wasted heat from the fireplace to the thermo-electric modules is also presented
Haptic Glove and Platform with Gestural Control For Neuromorphic Tactile Sensory Feedback In Medical Telepresence †
Haptic Glove and Platform with Gestural Control For Neuromorphic Tactile Sensory Feedback In Medical Telepresence
Advancements in the study of the human sense of touch are fueling the field of haptics. This is paving the way for augmenting sensory perception during object palpation in tele-surgery and reproducing the sensed information through tactile feedback. Here, we present a novel tele-palpation apparatus that enables the user to detect nodules with various distinct stiffness buried in an ad-hoc polymeric phantom. The contact force measured by the platform was encoded using a neuromorphic model and reproduced on the index fingertip of a remote user through a haptic glove embedding a piezoelectric disk. We assessed the effectiveness of this feedback in allowing nodule identification under two experimental conditions of real-time telepresence: In Line of Sight (ILS), where the platform was placed in the visible range of a user; and the more demanding Not In Line of Sight (NILS), with the platform and the user being 50 km apart. We found that the entailed percentage of identification was higher for stiffer inclusions with respect to the softer ones (average of 74% within the duration of the task), in both telepresence conditions evaluated. These promising results call for further exploration of tactile augmentation technology for telepresence in medical interventions
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TAO Conceptual Design Report: A Precision Measurement of the Reactor Antineutrino Spectrum with Sub-percent Energy Resolution
The Taishan Antineutrino Observatory (TAO, also known as JUNO-TAO) is a
satellite experiment of the Jiangmen Underground Neutrino Observatory (JUNO). A
ton-level liquid scintillator detector will be placed at about 30 m from a core
of the Taishan Nuclear Power Plant. The reactor antineutrino spectrum will be
measured with sub-percent energy resolution, to provide a reference spectrum
for future reactor neutrino experiments, and to provide a benchmark measurement
to test nuclear databases. A spherical acrylic vessel containing 2.8 ton
gadolinium-doped liquid scintillator will be viewed by 10 m^2 Silicon
Photomultipliers (SiPMs) of >50% photon detection efficiency with almost full
coverage. The photoelectron yield is about 4500 per MeV, an order higher than
any existing large-scale liquid scintillator detectors. The detector operates
at -50 degree C to lower the dark noise of SiPMs to an acceptable level. The
detector will measure about 2000 reactor antineutrinos per day, and is designed
to be well shielded from cosmogenic backgrounds and ambient radioactivities to
have about 10% background-to-signal ratio. The experiment is expected to start
operation in 2022
Elliptic flow of charged particles in Pb-Pb collisions at 2.76 TeV
We report the first measurement of charged particle elliptic flow in Pb-Pb
collisions at 2.76 TeV with the ALICE detector at the CERN Large Hadron
Collider. The measurement is performed in the central pseudorapidity region
(||<0.8) and transverse momentum range 0.2< < 5.0 GeV/. The
elliptic flow signal v, measured using the 4-particle correlation method,
averaged over transverse momentum and pseudorapidity is 0.087 0.002
(stat) 0.004 (syst) in the 40-50% centrality class. The differential
elliptic flow v reaches a maximum of 0.2 near = 3
GeV/. Compared to RHIC Au-Au collisions at 200 GeV, the elliptic flow
increases by about 30%. Some hydrodynamic model predictions which include
viscous corrections are in agreement with the observed increase.Comment: 10 pages, 4 captioned figures, published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/389
A polarimetrically oriented X-ray stare at the accreting pulsar EXO 2030+375
Accreting X-ray pulsars (XRPs) are presumably ideal targets for polarization
measurements, as their high magnetic field strength is expected to polarize the
emission up to a polarization degree of ~80%. However, such expectations are
being challenged by recent observations of XRPs with the Imaging X-ray
Polarimeter Explorer (IXPE). Here we report on the results of yet another XRP,
EXO 2030+375, observed with IXPE and contemporarily monitored with Insight-HXMT
and SRG/ART-XC. In line with recent results obtained with IXPE for similar
sources, analysis of the EXO 2030+375 data returns a low polarization degree of
0%-3% in the phase-averaged study and variation in the range 2%-7% in the
phase-resolved study. Using the rotating vector model we constrain the geometry
of the system and obtain a value for the magnetic obliquity of ~.
Considering also the estimated pulsar inclination of ~, this
indicates that the magnetic axis swings close to the observer line of sight.
Our joint polarimetric, spectral and timing analysis hint to a complex
accreting geometry where magnetic multipoles with asymmetric topology and
gravitational light bending significantly affect the observed source behavior.Comment: A&A accepted. Proofs versio
First X-ray polarization measurement confirms the low black-hole spin in LMC X-3
X-ray polarization is a powerful tool to investigate the geometry of
accreting material around black holes, allowing independent measurements of the
black hole spin and orientation of the innermost parts of the accretion disk.
We perform the X-ray spectro-polarimetric analysis of an X-ray binary system in
the Large Magellanic Cloud, LMC X-3, that hosts a stellar-mass black hole,
known to be persistently accreting since its discovery. We report the first
detection of the X-ray polarization in LMC X-3 with the Imaging X-ray
Polarimetry Explorer, and find the average polarization degree of 3.2% +- 0.6%
and a constant polarization angle -42 deg +- 6 deg over the 2-8 keV range.
Using accompanying spectroscopic observations by NICER, NuSTAR, and the Neil
Gehrels Swift observatories, we confirm previous measurements of the black hole
spin via the X-ray continuum method, a ~ 0.2. From polarization analysis only,
we found consistent results with low black-hole spin, with an upper limit of a
< 0.7 at a 90% confidence level. A slight increase of the polarization degree
with energy, similar to other black-hole X-ray binaries in the soft state, is
suggested from the data but with a low statistical significance.Comment: 14 pages, 8 figures, submitted to Ap
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