\u3ci\u3eEl Milagro\u3c/i\u3e: The Miracle of Service Learning on the Border

In 2000, DoZa Ana Branch Community College (DABCC) received a grant from the American Association of Community Colleges Broadening Horizons through Service Learning program to develop service learning in southern New Mexico. Poised on the United States- Mexico border, DABCC serves a population that includes 40% colonia residents. Colonias are communities within 150 miles of the border that lack basic infrastructure such as paved roads, water and sewage treatment facilities, and adequate housing. DABCC has developed community partnerships with colonia residents and with agencies that provide services within the colonias. In their presentation, a DABCC team will describe service learning projects in technical, vocational, and developmental courses that place students at the core of learning and service in their own community. They will provide a list of courses that have a service learning component, a brochure describing El Milagro Service Learning Initiative, photos from service learning activities, and a brief video of colonia life

The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing revised 93% of karyotypes and demonstrated complexity that was cryptic to karyotyping in 21% of BCAs, highlighting the limitations of conventional cytogenetic approaches. At least 33.9% of BCAs resulted in gene disruption that likely contributed to the developmental phenotype, 5.2% were associated with pathogenic genomic imbalances, and 7.3% disrupted topologically associated domains (TADs) encompassing known syndromic loci. Remarkably, BCA breakpoints in eight subjects altered a single TAD encompassing MEF2C, a known driver of 5q14.3 microdeletion syndrome, resulting in decreased MEF2C expression. We propose that sequence-level resolution dramatically improves prediction of clinical outcomes for balanced rearrangements and provides insight into new pathogenic mechanisms, such as altered regulation due to changes in chromosome topology

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder