The HI gas content of galaxies around Abell 370, a galaxy cluster at z = 0.37

We used observations from the Giant Metrewave Radio Telescope to measure the atomic hydrogen gas content of 324 galaxies around the galaxy cluster Abell 370 at a redshift of z = 0.37 (a look-back time of ~4 billion years). The HI 21-cm emission from these galaxies was measured by coadding their signals using precise optical redshifts obtained with the Anglo-Australian Telescope. The average HI mass measured for all 324 galaxies is (6.6 +- 3.5)x10^9 solar masses, while the average HI mass measured for the 105 optically blue galaxies is (19.0 +- 6.5)x10^9 solar masses. The significant quantities of gas found around Abell 370, suggest that there has been substantial evolution in the gas content of galaxy clusters since redshift z = 0.37. The total amount of HI gas found around Abell 370 is up to ~8 times more than that seen around the Coma cluster, a nearby galaxy cluster of similar size. Despite this higher gas content, Abell 370 shows the same trend as nearby clusters, that galaxies close to the cluster core have lower HI gas content than galaxies further away. The Abell 370 galaxies have HI mass to optical light ratios similar to local galaxy samples and have the same correlation between their star formation rate and HI mass as found in nearby galaxies. The average star formation rate derived from [OII] emission and from de-redshifted 1.4 GHz radio continuum for the Abell 370 galaxies also follows the correlation found in the local universe. The large amounts of HI gas found around the cluster can easily be consumed by the observed star formation rate in the galaxies over the ~4 billion years (from z = 0.37) to the present day.Comment: accepted by MNRA

Trace element fractionation between PM10 and PM2.5 in coal mine dust: Implications for occupational respiratory health

This is the final version. Available on open access from Elsevier via the DOI in this recordInvestigations into the respiratory health impacts of coal mine particulate matter (PM) face the challenge of understanding its chemical complexity. This includes highly variable concentrations of trace metals and metalloids such as Fe, Ti, Mn, Zn, Ni, V, Cr, Cu, Pb, Cd, Sb, As and Sn, which may be capable of inducing cell damage. Analysis of PM10 and PM2.5 samples size-separated from deposited coal mine dusts collected on PVC flat surfaces at a height of 1.5-2 m inside the second level in the Velenje lignite mine, Slovenia, demonstrates that some of these metallic elements (in this case Cu, Sb, Sn, Pb, Zn, As, Ni) can be concentrated in PM2.5, the most deeply inhalable and therefore potentially most bioreactive size fraction. These elements are likely to be mainly present in silicates, oxides, and perhaps antimonides and arsenides, rather than in the calcareous, carbonaceous or sulphide components which show no obvious affinity for PM2.5. Whereas in the Velenje lignites concentrations of these metallic elements are low and so do not present any obvious extra health risk to the miners, this is unlikely to be the case in mines where unusually metal-enriched coals are being excavated. We therefore recommend that levels of potentially toxic elements in PM2.5 should be assessed where metal- and metalloid-rich coals are being mined worldwide, especially given uncertainties relating to the efficiency of current dust suppression and respiratory protective equipment for such fine particle sizes.European Commission Research Fund for Coal and Stee

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates

BACKGROUND: The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a variety of intracellular sorting and trafficking functions. These proteins are highly expressed in the brain. SorLA has been shown to be down regulated in Alzheimer's disease brains, interact with ApoE, and modulate Aβ production. Sortilin has been shown to be part of proNGF mediated death signaling that results from a complex of Sortilin, p75(NTR )and proNGF. We have investigated and provide evidence for γ-secretase cleavage of this family of proteins. RESULTS: We provide evidence that these receptors are substrates for presenilin dependent γ-secretase cleavage. γ-Secretase cleavage of these sorting receptors is inhibited by γ-secretase inhibitors and does not occur in PS1/PS2 knockout cells. Like most γ-secretase substrates, we find that ectodomain shedding precedes γ-secretase cleavage. The ectodomain cleavage is inhibited by a metalloprotease inhibitor and activated by PMA suggesting that it is mediated by an α-secretase like cleavage. CONCLUSION: These data indicate that the α- and γ-secretase cleavages of the mammalian Vps10p sorting receptors occur in a fashion analogous to other known γ-secretase substrates, and could possibly regulate the biological functions of these proteins

Clinical value of tone burst vestibular evoked myogenic potentials at threshold in acute and stable Ménière's disease

Introduction: The objectives of this preliminary, prospective, cohort study were to ascertain the characteristics of vestibular evoked myogenic potentials at threshold levels in two groups of Ménière's disease patients – acute and stable – and to identify whether vestibular evoked myogenic potentials can provide any specific, objective information to distinguish acute from stable Ménière's disease. Subjects and methods: The study was based at a tertiary neuro-otology centre. Twenty adult patients who fulfilled the American Academy of Otolaryngology–Head and Neck Surgery1 criteria for Ménière's disease were divided into two groups: 11 patients with acute Ménière's disease and nine patients with stable Ménière's disease. Eighteen healthy adult volunteers served as controls. All subjects underwent vestibular evoked myogenic potential testing with ipsilateral, short tone burst stimuli at 500 Hz, as well as pure tone audiometry. The patients also underwent caloric testing. Results: Vestibular evoked myogenic potentials were present in all controls, and were present in 65 per cent of patients but absent in 35 per cent. The mean absolute threshold (Tvestibular evoked myogenic potential) ± standard deviation in normal controls was 116 ± 7.7 dBSPL; this did not differ statistically from that in patients, nor did it differ between acute and stable Ménière's disease. The p13/n23 latencies at the threshold levels in the normal, acute and stable groups (mean ± standard deviation) were respectively: 15 ± 2.2 ms/23.0 ± 2.5 ms; 15.7 ± 0.9 ms/23.7 ± 0.9 ms; and 15.3 ± 2.0 ms/24.2 ± 1.9 ms. The mean interaural amplitude difference ratio (IAD) ± standard deviation was significantly higher in the stable group compared with the acute group (0.54 ± 0.33 vs −0.15 ± 0.22; p = 0.007) and with the controls (0.54 ± 0.33 vs 0.1 ± 0.22; p = 0.05). Conclusions: The parameter that best differentiated acute from stable Ménière's disease at threshold was the interaural amplitude difference ratio. Therefore, this parameter may be used to monitor the clinical course of Ménière's disease

The HI content of star-forming galaxies at z = 0.24

We use observations from the Giant Metrewave Radio Telescope (GMRT) to measure the atomic hydrogen gas content of star-forming galaxies at z = 0.24 (i.e. a look-backtime of ~3 Gyr). The sample of galaxies studied were selected from Halpha-emitting field galaxies detected in a narrow-band imaging survey with the Subaru Telescope. The Anglo-Australian Telescope was used to obtain precise optical redshifts for these galaxies. We then coadded the HI 21 cm emission signal for all the galaxies within the GMRT spectral line data cube. From the coadded signal of 121 galaxies, we measure an average atomic hydrogen gas mass of (2.26 +- 0.90)*10^9 solar masses. We translate this HI signal into a cosmic density of neutral gas at z = 0.24 of Omega_gas = (0.91 +- 0.42)*10^-3. This is the current highest redshift at which Omega_gas has been constrained from 21 cm emission and our value is consistent with that estimated from damped Lyman-alpha systems around this redshift. We also find that the correlations between the Halpha luminosity and the radio continuum luminosity and between the star formation rate and the HI gas content in star-forming galaxies at z = 0.24 are consistent with the correlations found at z = 0. These two results suggest that the star formation mechanisms in field galaxies ~3 Gyr ago were not substantially different from the present, even though the star formation rate is 3 times higher.Comment: 11 pages, contains 9 figures and 1 table. Accepted for publishing in MNRAS 2007 January 22. Received 2007 January 22; in original form 2006 November 3