2,026 research outputs found
Incompressible strips in dissipative Hall bars as origin of quantized Hall plateaus
We study the current and charge distribution in a two dimensional electron
system, under the conditions of the integer quantized Hall effect, on the basis
of a quasi-local transport model, that includes non-linear screening effects on
the conductivity via the self-consistently calculated density profile. The
existence of ``incompressible strips'' with integer Landau level filling factor
is investigated within a Hartree-type approximation, and non-local effects on
the conductivity along those strips are simulated by a suitable averaging
procedure. This allows us to calculate the Hall and the longitudinal resistance
as continuous functions of the magnetic field B, with plateaus of finite widths
and the well-known, exactly quantized values. We emphasize the close relation
between these plateaus and the existence of incompressible strips, and we show
that for B values within these plateaus the potential variation across the Hall
bar is very different from that for B values between adjacent plateaus, in
agreement with recent experiments.Comment: 13 pages, 11 figures, All color onlin
Efficient Encodings of First-Order Horn Formulas in Equational Logic
We present several translations from first-order Horn formulas to equational logic. The goal of these translations is to allow equational theorem provers to efficiently reason about non-equational problems. Using these translations we were able to solve 37 problems of rating 1.0 (i.e. which had not previously been automatically solved) from the TPTP
AC-KBO Revisited
Equational theories that contain axioms expressing associativity and
commutativity (AC) of certain operators are ubiquitous. Theorem proving methods
in such theories rely on well-founded orders that are compatible with the AC
axioms. In this paper we consider various definitions of AC-compatible
Knuth-Bendix orders. The orders of Steinbach and of Korovin and Voronkov are
revisited. The former is enhanced to a more powerful version, and we modify the
latter to amend its lack of monotonicity on non-ground terms. We further
present new complexity results. An extension reflecting the recent proposal of
subterm coefficients in standard Knuth-Bendix orders is also given. The various
orders are compared on problems in termination and completion.Comment: 31 pages, To appear in Theory and Practice of Logic Programming
(TPLP) special issue for the 12th International Symposium on Functional and
Logic Programming (FLOPS 2014
Effect of supplementation with an 80:20 cis9,trans11 conjugated linoleic acid blend on the human platelet proteome.
Automatic Generation of Invariants for Circular Derivations in {SUP(LA)} 1
The hierarchic combination of linear arithmetic and firstorder logic with free function symbols, FOL(LA), results in a strictly more expressive logic than its two parts. The SUP(LA) calculus can be turned into a decision procedure for interesting fragments of FOL(LA). For example, reachability problems for timed automata can be decided by SUP(LA) using an appropriate translation into FOL(LA). In this paper, we extend the SUP(LA) calculus with an additional inference rule, automatically generating inductive invariants from partial SUP(LA) derivations. The rule enables decidability of more expressive fragments, including reachability for timed automata with unbounded integer variables. We have implemented the rule in the SPASS(LA) theorem prover with promising results, showing that it can considerably speed up proof search and enable termination of saturation for practically relevant problems
BIG enhances Arg/N-degron pathway-mediated protein degradation to regulate Arabidopsis hypoxia responses and suberin deposition
BIG/DARK OVEREXPRESSION OF CAB1/TRANSPORT INHIBITOR RESPONSE3 is a 0.5-MDa protein associated with multiple functions in Arabidopsis (Arabidopsis thaliana) signalling and development. However, the biochemical functions of BIG are unknown. We investigated a role for BIG in the Arg/N-degron pathways, in which substrate protein fate is influenced by the N-terminal (Nt) residue. We crossed a big loss-of-function allele to two N-degron pathway E3 ligase mutants, proteolysis6 (prt6) and prt1, and examined the stability of protein substrates. Stability of model substrates was enhanced in prt6-1 big-2 and prt1-1 big-2 relative to the respective single mutants and the abundance of the PRT6 physiological substrates, HYPOXIA-RESPONSIVE ERF2 (HRE2) and VERNALIZATION2 (VRN2) was similarly increased in prt6 big double mutants. Hypoxia marker expression was enhanced in prt6 big double mutants; this constitutive response required arginyltransferase activity and RAP-type ERFVII transcription factors. Transcriptomic analysis of roots not only demonstrated increased expression of multiple hypoxia-responsive genes in the double mutant relative to prt6, but also revealed other roles for PRT6 and BIG, including regulation of suberin deposition through both ERFVII-dependent and independent mechanisms, respectively. Our results show that BIG acts together with PRT6 to regulate the hypoxia response and broader processes in Arabidopsis
Compressed representation of a partially defined integer function over multiple arguments
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Enzymatic Blockade of the Ubiquitin-Proteasome Pathway
Ubiquitin-dependent processes control much of cellular physiology. We show that expression of a highly active, Epstein-Barr virus-derived deubiquitylating enzyme (EBV-DUB) blocks proteasomal degradation of cytosolic and ER-derived proteins by preemptive removal of ubiquitin from proteasome substrates, a treatment less toxic than the use of proteasome inhibitors. Recognition of misfolded proteins in the ER lumen, their dislocation to the cytosol, and degradation are usually tightly coupled but can be uncoupled by the EBV-DUB: a misfolded glycoprotein that originates in the ER accumulates in association with cytosolic chaperones as a deglycosylated intermediate. Our data underscore the necessity of a DUB activity for completion of the dislocation reaction and provide a new means of inhibition of proteasomal proteolysis with reduced cytotoxicity.National Institutes of Health (U.S.)EMBO (long term Fellowship 2008-379)Boehringer Ingelheim Fond
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