The Lighthouse Song / music by Charles Dennee; words by Allen Lowe

Cover: drawing of a ship and a Lighthouse; Publisher: Arthur P. Schmidthttps://egrove.olemiss.edu/sharris_b/1035/thumbnail.jp

Hydrologic and Hydraulic Modeling of the Tunnel and Reservoir Plan System in Northeastern Illinois

The Tunnel and Reservoir Plan (TARP) was adopted by the Metropolitan Sanitary District of Greater Chicago in 1972 to address combined sewer overflow (CSO) pollution and flooding problems in 970 km2 of the Chicago metropolitan area served by combined sewers. TARP consists of about 175 km of tunnels, three reservoirs, 256 drop shafts, and over 600 connecting structures, pumping stations, and other appurtenances for the capture and storage of CSOs and for conveying the stored CSOs to water reclamation plants for treatment. The TARP system is comprised of three independent systems: the Calumet system serving the south suburbs and a portion of the south side of Chicago, the Upper Des Plaines system serving the northwest suburbs, and the Mainstream/ Des Plaines system serving the remainder of Chicago and the north, west and southwest suburbs. The Metropolitan Water Reclamation District of Greater Chicago (MWRDGC) desires to develop new, updated and enhanced computer models to allow for simulation of the TARP systems. The new models will be used to optimize operation of the system as actually constructed, to determine constraints in the system, identify physical changes that may be needed to improve performance, and allow what-if analyses to be performed for potential storm scenarios and facility revisions. The modeling includes development of a Physical Inventory system, Hydraulic Modeling of the TARP systems, and Hydrologic Modeling of the TARP service areas. The Physical Inventory provides a digital description of the physical geometry of the TARP system and the related hydraulic performance of system components. Hydrologic Modeling uses data for each dropshafts service area to determine hydrographs describing the inflows to the TARP systems. A ma jor component of the Hydrologic Modeling is to develop tools and methods that allow robust simulation of the extreme heterogeneity of highly urbanized systems and that provide guidance for data compilation needed to improve the accuracy of such simulations. Hydraulic Modeling uses the information from the Physical Inventory and the Hydrologic Modeling to simulate hydraulic response of the TARP system to different inputs. The Hydraulic Modeling tools developed are capable of simulating the range of possible flows in the system, from gravity flows over a dry bed to mixed gravity/surcharged flows to shocks and hydraulic transients

RAGE: A journey from the complications of diabetes to disorders of the nervous system – striking a fine balance between injury and repair

This is the published version. Copyright 2005 IOS Press.The Receptor for Advanced Glycation End Products (RAGE) is a multiligand member of the immunoglobulin superfamily. RAGE interacts with AGEs, the products of nonenzymatic glycation/oxidation of proteins and lipids that accumulate in diverse settings, such as diabetes, inflammation, renal failure, pro-oxidant states and natural aging. In addition, RAGE is also a receptor for amyloid-β peptide and β-sheet fibril species. Recent studies underscore the premise that RAGE interacts with pro-inflammatory molecules, including S100/calgranulins and amphoterin, the latter also known as high mobility group box 1 (HMGB1). In chronic neurodegenerative disorders as well as in nerve tissue upon acute injury, evidence points to upregulation of both RAGE and these ligand families. In this review, we will discuss the implications of transient/self-limited upregulation of RAGE and its ligands, vs sustained/chronic upregulation of this axis in neurodegeneration vs repair in both the central and peripheral nervous systems. Experimental evidence supports the premise that RAGE bears both homeostatic and injurious properties in the nervous system, thereby highlighting "yin/yang" features of this receptor and its ligand families

Knowledge politics and new converging technologies: a social epistemological perspective

The “new converging technologies” refers to the prospect of advancing the human condition by the integrated study and application of nanotechnology, biotechnology, information technology and the cognitive sciences - or “NBIC”. In recent years, it has loomed large, albeit with somewhat different emphases, in national science policy agendas throughout the world. This article considers the political and intellectual sources - both historical and contemporary - of the converging technologies agenda. Underlying it is a fluid conception of humanity that is captured by the ethically challenging notion of “enhancing evolution”

3D simulations of globules and pillars formation around HII regions: turbulence and shock curvature

We investigate the interplay between the ionization radiation from massive stars and the turbulence inside the surrounding molecular gas thanks to 3D numerical simulations. We used the 3D hydrodynamical code HERACLES to model an initial turbulent medium that is ionized and heated by an ionizing source. Three different simulations are performed with different mean Mach numbers (1, 2 and 4). A non-equilibrium model for the ionization and the associated thermal processes was used. This revealed to be crucial when turbulent ram pressure is of the same order as the ionized-gas pressure. The density structures initiated by the turbulence cause local curvatures of the dense shell formed by the ionization compression. When the curvature of the shell is sufficient, the shell collapse on itself to form a pillar while a smaller curvature leads to the formation of dense clumps that are accelerated with the shell and therefore remain in the shell during the simulation. When the turbulent ram pressure of the cold gas is sufficient to balance the ionized-gas pressure, some dense-gas bubbles have enough kinetic energy to penetrate inside the ionized medium, forming cometary globules. This suggests a direct relation in the observations between the presence of globules and the relative importance of the turbulence compared to the ionized-gas pressure. The probability density functions present a double peak structure when the turbulence is low relative to the ionized-gas pressure. This could be used in observations as an indication of the turbulence inside molecular clouds.Comment: accepted for publication in A&

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected erythrocytes. The non-uniform geographical distribution of Knops blood group CR1 alleles Sl1/2 and McCa/b may result from selective pressures exerted by differential exposure to infectious hazards. Here, four variant short recombinant versions of CR1 were produced and analyzed, focusing on complement control protein modules (CCPs) 15–25 of its ectodomain. These eleven modules encompass a region (CCPs 15–17) key to rosetting, opsonin recognition and complement regulation, as well as the Knops blood group polymorphisms in CCPs 24–25. All four CR1 15–25 variants were monomeric and had similar axial ratios. Modules 21 and 22, despite their double-length inter-modular linker, did not lie side-by-side so as to stabilize a bent-back architecture that would facilitate cooperation between key functional modules and Knops blood group antigens. Indeed, the four CR1 15–25 variants had virtually indistinguishable affinities for immobilized complement fragments C3b (KD = 0.8–1.1 µM) and C4b (KD = 5.0–5.3 µM). They were all equally good co-factors for factor I-catalysed cleavage of C3b and C4b, and they bound equally within a narrow affinity range, to immobilized C1q. No differences between the variants were observed in assays for inhibition of erythrocyte invasion by P. falciparum or for rosette disruption. Neither differences in complement-regulatory functionality, nor interactions with P. falciparum proteins tested here, appear to have driven the non-uniform geographic distribution of these alleles

Financing Direct Democracy: Revisiting the Research on Campaign Spending and Citizen Initiatives

The conventional view in the direct democracy literature is that spending against a measure is more effective than spending in favor of a measure, but the empirical results underlying this conclusion have been questioned by recent research. We argue that the conventional finding is driven by the endogenous nature of campaign spending: initiative proponents spend more when their ballot measure is likely to fail. We address this endogeneity by using an instrumental variables approach to analyze a comprehensive dataset of ballot propositions in California from 1976 to 2004. We find that both support and opposition spending on citizen initiatives have strong, statistically significant, and countervailing effects. We confirm this finding by looking at time series data from early polling on a subset of these measures. Both analyses show that spending in favor of citizen initiatives substantially increases their chances of passage, just as opposition spending decreases this likelihood

A measurement of the millimetre emission and the Sunyaev-Zel'dovich effect associated with low-frequency radio sources

We present a statistical analysis of the millimetre-wavelength properties of 1.4GHz-selected sources and a detection of the Sunyaev–Zel’dovich (SZ) effect associated with the haloes that host them. We stack data at 148, 218 and 277GHz from the Atacama Cosmology Telescope at the positions of a large sample of radio AGN selected at 1.4GHz. The thermal SZ effect associated with the haloes that host the AGN is detected at the 5σ level through its spectral signature, representing a statistical detection of the SZ effect in some of the lowest mass haloes (average M 200 ≈ 10 13 M. h −1 70 ) studied to date. The relation between the SZ effect and mass (based on weak lensing measurements of radio galaxies) is consistent with that measured by Planck for local bright galaxies. In the context of galaxy evolution models, this study confirms that galaxies with radio AGN also typically support hot gaseous haloes. Adding Herschel observations allows us to show that the SZ signal is not significantly contaminated by dust emission. Finally, we analyse the contribution of radio sources to the angular power spectrum of the cosmic microwave background

The LHC test string: first operational experience

CERN operates the first version of the LHC Test String which consists of one quadrupole and three 10-m twin aperture dipole magnets. An experimental programme aiming at the validation of the LHC systems started in February 1995. During this programme the string has been powered 100 times 35 of which at 12.4 kA or above. The experiments have yielded a number of results some of which, like quench recovery for cryogenics, have modified the design of subsystems of LHC. Others, like controlled helium leaks in the cold bore and quench propagation bewteen magnets, have given a better understanding on the evolution of the phenomena inside a string of superconducting magnets cooled at superfluid helium temperatures. Following the experimental programme, the string will be powered up and powered down in one hour cycles as a fatigue test of the structure thus simulating 20 years of operation of LHC

Expression of Distal-less, dachshund, and optomotor blind in Neanthes arenaceodentata (Annelida, Nereididae) does not support homology of appendage-forming mechanisms across the Bilateria

The similarity in the genetic regulation of arthropod and vertebrate appendage formation has been interpreted as the product of a plesiomorphic gene network that was primitively involved in bilaterian appendage development and co-opted to build appendages (in modern phyla) that are not historically related as structures. Data from lophotrochozoans are needed to clarify the pervasiveness of plesiomorphic appendage forming mechanisms. We assayed the expression of three arthropod and vertebrate limb gene orthologs, Distal-less (Dll), dachshund (dac), and optomotor blind (omb), in direct-developing juveniles of the polychaete Neanthes arenaceodentata. Parapodial Dll expression marks premorphogenetic notopodia and neuropodia, becoming restricted to the bases of notopodial cirri and to ventral portions of neuropodia. In outgrowing cephalic appendages, Dll activity is primarily restricted to proximal domains. Dll expression is also prominent in the brain. dac expression occurs in the brain, nerve cord ganglia, a pair of pharyngeal ganglia, presumed interneurons linking a pair of segmental nerves, and in newly differentiating mesoderm. Domains of omb expression include the brain, nerve cord ganglia, one pair of anterior cirri, presumed precursors of dorsal musculature, and the same pharyngeal ganglia and presumed interneurons that express dac. Contrary to their roles in outgrowing arthropod and vertebrate appendages, Dll, dac, and omb lack comparable expression in Neanthes appendages, implying independent evolution of annelid appendage development. We infer that parapodia and arthropodia are not structurally or mechanistically homologous (but their primordia might be), that Dll’s ancestral bilaterian function was in sensory and central nervous system differentiation, and that locomotory appendages possibly evolved from sensory outgrowths