Concert recording 2021-11-09

[Track 1]. Studio entire recital. Come all, come all ye youngsters / Henry Purcell -- Vergin tutto amor / Francesco Durante -- Du bist die Ruh / Franz Schubert -- Paride ed Elena. Spiagge amate / Christoph Gluck -- Dichterliebe. Ich grolle nicht / Robert Schumann -- L’ultima canzone / Francesco Tosti -- A chloris / Reynaldo Hahn -- Nichts / Richard Strauss -- Let beauty awake / Ralph Vaughan Williams -- Beau soir / Claude Debussy -- Die nachtigall / Alban Berg -- Four Dickinson songs. Will there really be a morning? / Lori Laitman -- Pierrot / Debussy -- Die Entführung aus dem Serail. Durch Zärtlichkeit und Schmeicheln / Wolfgang Amadeus Mozart -- Dos canciones. Mexicanas estrellita / Manuel Ponce -- Granada / Agustin Lara -- Mandoline / Debussy -- Five art songs. Sympathy / Florence Price -- Winterreise. Die Wetterfahne ; Gerfrorne Tränen / Schubert -- Louise. Depuis le jour / Gustave Charpentier -- No ordinary woman. Bones, be good! / Gwyneth Walker

Modelagem Cross-Layer de Perdas de Pacotes Sobre Perdas de PSNR em rede IEEE 802.11ac / Cross-Layer Modeling of Packet Losses Over PSNR in IEEE 802.11ac Network

Neste artigo é apresentado o comportamento da perda de qualidade de vídeo com resolução espacial de 3840x2160 pixel codificados em H.264/AVC e transmitidos pela rede sem fio no padrão IEEE 802.11ac. Para o estudo são realizadas transmissões em ambiente real, onde métricas de QoS (Quality of Service) e QoE (Quality of Experience) são extraídas para proposição da modelagem. Técnicas de regressão linear são utilizadas nos dados medidos, onde a partir da porcentagem de perda de pacote é estimado a perda de PSNR (Peak Signal-to-Noise). O valor de RMSE (Root Mean Square Error) e o Desvio Padrão do Erro (DPE) são calculados para avaliar o desempenho da proposta, e foram encontrados valores inferiores a 2,5 dB para ambas as métricas de desempenho. Validando a proposta

COVID-19-Related Thrombotic and Bleeding Events in Adults With Congenital Heart Disease.

BACKGROUND Altered coagulation is a striking feature of COVID-19. Adult patients with congenital heart disease (ACHD) are prone to thromboembolic (TE) and bleeding complications. OBJECTIVES The purpose of this study was to investigate the prevalence and risk factors for COVID-19 TE/bleeding complications in ACHD patients. METHODS COVID-19-positive ACHD patients were included between May 2020 and November 2021. TE events included ischemic cerebrovascular accident, systemic and pulmonary embolism, deep venous thrombosis, myocardial infarction, and intracardiac thrombosis. Major bleeding included cases with hemoglobin drop >2 g/dl, involvement of critical sites, or fatal bleeding. Severe infection was defined as need for intensive care unit, endotracheal intubation, renal replacement therapy, extracorporeal membrane oxygenation, or death. Patients with TE/bleeding were compared to those without events. Factors associated with TE/bleeding were determined using logistic regression. RESULTS Of 1,988 patients (age 32 [IQR: 25-42] years, 47% male, 59 ACHD centers), 30 (1.5%) had significant TE/bleeding: 12 TE events, 12 major bleeds, and 6 with both TE and bleeding. Patients with TE/bleeding had higher in-hospital mortality compared to the remainder cohort (33% vs 1.7%; P < 0.0001) and were in more advanced physiological stage (P = 0.032) and NYHA functional class (P = 0.01), had lower baseline oxygen saturation (P = 0.0001), and more frequently had a history of atrial arrhythmia (P < 0.0001), previous hospitalization for heart failure (P < 0.0007), and were more likely hospitalized for COVID-19 (P < 0.0001). By multivariable logistic regression, prior anticoagulation (OR: 4.92; 95% CI: 2-11.76; P = 0.0003), cardiac injury (OR: 5.34; 95% CI: 1.98-14.76; P = 0.0009), and severe COVID-19 (OR: 17.39; 95% CI: 6.67-45.32; P < 0.0001) were independently associated with increased risk of TE/bleeding complications. CONCLUSIONS ACHD patients with TE/bleeding during COVID-19 infection have a higher in-hospital mortality from the illness. Risk of coagulation disorders is related to severe COVID-19, cardiac injury during infection, and use of anticoagulants

Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019

INTRODUCTION: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. METHODS: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. RESULTS: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41–4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27–2.71]) than men (0.56 million [0.14–1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-to-male ratio 1.19 [1.10–1.26]). Due to population aging, there was a large increase in all-age mortality rates from dementia between 1990 and 2019 (100.1% [89.1–117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. DISCUSSION: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Debate Between St. Irenaeus of Lyon and the Gnostic Valentinus

Numerous people in the contemporary world are finding the message of Gnosticism relevant in their lives, but do we have a clear understanding of the Gnostics? The word Gnosticism is a modern development derived from the Greek word meaning knowledge, gnosis. Gnosis itself refers to a specialized form of knowledge, meaning personal awareness of oneself, another person, or in the case of the Gnostics, the divine. Previous to the discovery of the Nag Hammadi codices in December 1945, bishops, thinkers and historians of the early church who were opponents of so called “Gnostic” teachings bequeathed to us much of what we understood regarding the Gnostics. On the one hand, some of these ancient heresiologists or opponents believed that the Gnostic movement lacked morality and that it was corrupting Christianity with nonsense that did not have a place within the theology. Such heresiologists include figures like Irenaeus, Tertullian and Clement. Neo-Gnostics (those who have appropriated Gnosticism in the contemporary world, specifically in New Age circles), on the other hand, have a different impression of the ancient Gnostics. They refer to the heresiologists as “organizers” and believe them to have been invested in the sole interest of acquiring power within the Church. To them, the Gnostics were a liberal sect of Christianity that embraced equality among all as well as sexuality. Works such as the Da Vinci Code further perpetuate this image in the media. Through a historical overview, textual analysis, and finally in the construction of a debate between Irenaeus and Valentinus, this inquiry seeks to provide a better image of Gnosticism by relieving Gnosticism of some of the heresiological and Neo-Gnostic misconceptions that have characterized the movement. Firstly, I will a present a historical overview of Irenaeus, Valentinus and the Gnostics; secondly I will present a section of Irenaeus of Lyon’s Against Heresies regarding the Valentinian myth juxtaposed to the Gnostic text, Gospel of Truth written by Valentinus. Communicating Irenaeus’ account of the Valentinian myth in conjunction with a text from the actual creator of the myth will allow readers to become acquainted with the complex Gnostic worldview. I will present as consistent an account of the materials as allowed given the fragmentary nature of some of the sources. I will then engage in textual analysis, highlighting themes within the myth that provide insight into its function and challenges both heresiological and neo-Gnostic interpretations of Gnosticism regarding their social behaviors and theology. Lastly, I will reconstruct a debate between Valentinus and Irenaeus. I use the debate in order to explain differences between Irenaeus and Valentinus that further enhance the understanding of Gnosticism. The relationship between Gnosticism and Orthodox Christianity is essential in becoming acquainted with the main doctrines of Gnosticism. I employ debate because it best reflects the time period before the outlaw of Gnosticism when active discussion on theological matters was not uncommon

Implementation of a Multi-Site Digitally-Enhanced School Clinician Training and ADHD/ODD Intervention Program in Mexico: Randomized Controlled Trial of CLS-R-FUERTE

Abstract: Childhood conditions of inattention and disruptive behavior, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Oppositional Defiant Disorder (ODD), are prevalent but undertreated worldwide. One promising solution is harnessing digital technology to enhance school clinician training and ADHD/ODD intervention programs. We conducted a school-clustered randomized controlled trial of CLS-R-FUERTE: a program featuring training/consultation for school clinicians to deliver a six-week intervention comprised of weekly parent and student skills groups, as well as support teachers’ classroom management in the form of a Daily Report Card, all facilitated by electronic program manuals/materials and videoconferencing. A total of N = 163 (n = 6–8 students/school [ages 6–12] and their parents, teachers, and school clinicians) participated across eight public schools in Sinaloa, Mexico. We randomly assigned four schools to receive CLS-R-FUERTE immediately and four schools to receive school services as usual. We compared groups post-treatment on parent- and teacher-rated ADHD/ODD and impairment. We observed the program implementation in vivo, tracking trainer and school clinician program fidelity, as well as participant attendance and adherence, to evaluate feasibility. We also collected participant ratings of satisfaction and usability on the System Usability Scale to evaluate acceptability. Our CLS-R-FUERTE trial demonstrated high rates of program feasibility and acceptability comparable to prior in-person program trial findings. Students receiving CLS-R-FUERTE showed greater improvement in parent- and teacher-rated ADHD, as well as parent-rated ODD and impairment, compared to students receiving school services as usual. Results support the utility of global digital mental health programs training school clinicians to implement ADHD/ODD interventions, which have the potential to increase evidence-based treatment access and uptake across worldwide contexts

Kinbank : A global database of kinship terminology

Publisher Copyright: Copyright: © 2023 Passmore et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.For a single species, human kinship organization is both remarkably diverse and strikingly organized. Kinship terminology is the structured vocabulary used to classify, refer to, and address relatives and family. Diversity in kinship terminology has been analyzed by anthropologists for over 150 years, although recurrent patterning across cultures remains incompletely explained. Despite the wealth of kinship data in the anthropological record, comparative studies of kinship terminology are hindered by data accessibility. Here we present Kinbank, a new database of 210,903 kinterms from a global sample of 1,229 spoken languages. Using open-access and transparent data provenance, Kinbank offers an extensible resource for kinship terminology, enabling researchers to explore the rich diversity of human family organization and to test longstanding hypotheses about the origins and drivers of recurrent patterns. We illustrate our contribution with two examples. We demonstrate strong gender bias in the phonological structure of parent terms across 1,022 languages, and we show that there is no evidence for a coevolutionary relationship between cross-cousin marriage and bifurcate-merging terminology in Bantu languages. Analysing kinship data is notoriously challenging; Kinbank aims to eliminate data accessibility issues from that challenge and provide a platform to build an interdisciplinary understanding of kinship.Peer reviewe