Neutrino Masses, Mixing and Oscillations

Basics of neutrino oscillations is discussed. Importance of time-energy uncertainty relation is stressed. Neutrino oscillations in the leading approximation and evidence for neutrino oscillations are briefly summarized.Comment: A report at the International School of Nuclear Physics ``Neutrino in Cosmology, in Astro, Particle and Nuclear Physics'' Erice, Italy, Sept. 16-24, 200

Relation between the instrumental activities of daily living and physical fitness tests in elderly women.

A cross-sectional study was conducted to quantitatively evaluate the relationship between the instrumental activities of daily living (IADL) and various physical fitness tests in elderly women living at home. The study focused on the total population of those women aged 65 years and over living in Y Town, Hyogo Prefecture, Japan, who visited a nursing home for day services. A total of 128 subjects were divided into two groups: dependent in IADL group (n = 49) and independent in IADL group (n = 79). The magnitude of the relation was evaluated by the odds ratio (OR). The following tests showed a significant decrease in IADL: knee-raising test [age-adjusted OR = 4.23, 95% confidence interval (CI) 1.81-9.87], height (age-adjusted OR = 4.09, 95% CI 1.75-9.56), grip strength (age-adjusted OR = 3.68, 95% CI 1.57-8.60), sit-and-reach test (age-adjusted OR = 2.76, 95% CI 1.20-6.34), and standing on one leg with closed eyes (age-adjusted OR = 2.56, 95% CI 1.09-5.97). Multivariate analysis using Hayashi's quantification method I indicated that knee-raising was the test most highly correlated with decreased IADL. These results suggest that measurement of knee-raising ability, muscle strength of the lower extremities and flexibility of hip joint could be the most useful factors to assess the level of instrumental self-support ability.</p

A Beta Beam complex based on the machine upgrades for the LHC

The Beta Beam CERN design is based on the present LHC injection complex and its physics reach is mainly limited by the maximum rigidity of the SPS. In fact, some of the scenarios for the machine upgrades of the LHC, particularly the construction of a fast cycling 1 TeV injector (``Super-SPS''), are very synergic with the construction of a higher $\gamma$ Beta Beam. At the energies that can be reached by this machine, we demonstrate that dense calorimeters can already be used for the detection of $\nu$ at the far location. Even at moderate masses (40 kton) as the ones imposed by the use of existing underground halls at Gran Sasso, the CP reach is very large for any value of $\theta_{13}$ that would provide evidence of $\nu_e$ appearance at T2K or NO$\nu$A ($\theta_{13}\geq 3^\circ$). Exploitation of matter effects at the CERN to Gran Sasso distance provides sensitivity to the neutrino mass hierarchy in significant areas of the $\theta_{13}-\delta$ plane

Properties of Fermion Mixings in Intersecting D-brane Models

We consider the Yukawa couplings for quarks and leptons in the context of Pati-Salam model using intersecting D-brane models where the Yukawa coupling matrices are rank one in a simple choice of family replication. The CKM mixings can be explained by perturbing the rank 1 matrix using higher order terms involving new Higgs fields available in the model. We show that the near bi-large neutrino mixing angles can be naturally explained, choosing the light neutrino mass matrix to be type II seesaw dominant. The predicted value of U_{e3} is in the range \simeq 0.05-0.15. In the quark sector, V_{cb} is naturally close to the strange/bottom quark mass ratio and we obtain an approximate relation V_{ub} V_{cb} \simeq (m_s/m_b)^2 V_{us}. The geometrical interpretations of the neutrino mixings are also discussed.Comment: 17 pages, 3 figure

Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand–receptor relationships

AbstractMedaka (Oryzias latipes) is a small freshwater teleost that provides an excellent developmental genetic model complementary to zebrafish. Our recent mutagenesis screening using medaka identified headfish (hdf) which is characterized by the absence of trunk and tail structures with nearly normal head including the midbrain–hindbrain boundary (MHB). Positional-candidate cloning revealed that the hdf mutation causes a functionally null form of Fgfr1. The fgfr1hdf is thus the first fgf receptor mutant in fish. Although FGF signaling has been implicated in mesoderm induction, mesoderm is induced normally in the fgfr1hdf mutant, but subsequently, mutant embryos fail to maintain the mesoderm, leading to defects in mesoderm derivatives, especially in trunk and tail. Furthermore, we found that morpholino knockdown of medaka fgf8 resulted in a phenotype identical to the fgfr1hdf mutant, suggesting that like its mouse counterpart, Fgf8 is a major ligand for Fgfr1 in medaka early embryogenesis. Intriguingly, Fgf8 and Fgfr1 in zebrafish are also suggested to form a major ligand–receptor pair, but their function is much diverged, as the zebrafish fgfr1 morphant and zebrafish fgf8 mutant acerebellar (ace) only fail to develop the MHB, but develop nearly unaffected trunk and tail. These results provide evidence that teleost fish have evolved divergent functions of Fgf8–Fgfr1 while maintaining the ligand–receptor relationships. Comparative analysis using different fish is thus invaluable for shedding light on evolutionary diversification of gene function

Status of global fits to neutrino oscillations

We review the present status of global analyses of neutrino oscillations, taking into account the most recent neutrino data including the latest KamLAND and K2K updates presented at Neutrino2004, as well as state-of-the-art solar and atmospheric neutrino flux calculations. We give the two-neutrino solar + KamLAND results, as well as two-neutrino atmospheric + K2K oscillation regions, discussing in each case the robustness of the oscillation interpretation against departures from the Standard Solar Model and the possible existence of non-standard neutrino physics. Furthermore, we give the best fit values and allowed ranges of the three-flavour oscillation parameters from the current worlds' global neutrino data sample and discuss in detail the status of the small parameters \alpha \equiv \Dms/\Dma as well as $\sin^2\theta_{13}$, which characterize the strength of CP violating effects in neutrino oscillations. We also update the degree of rejection of four-neutrino interpretations of the LSND anomaly in view of the most recent developments.Comment: v6: In the last Appendix we provide updated neutrino oscillation results which take into account the relevant oscillation data released by the MINOS and KamLAND collaboration

Deletion of CDKAL1 Affects Mitochondrial ATP Generation and First-Phase Insulin Exocytosis

A variant of the CDKAL1 gene was reported to be associated with type 2 diabetes and reduced insulin release in humans; however, the role of CDKAL1 in β cells is largely unknown. Therefore, to determine the role of CDKAL1 in insulin release from β cells, we studied insulin release profiles in CDKAL1 gene knockout (CDKAL1 KO) mice.Total internal reflection fluorescence imaging of CDKAL1 KO β cells showed that the number of fusion events during first-phase insulin release was reduced. However, there was no significant difference in the number of fusion events during second-phase release or high K(+)-induced release between WT and KO cells. CDKAL1 deletion resulted in a delayed and slow increase in cytosolic free Ca(2+) concentration during high glucose stimulation. Patch-clamp experiments revealed that the responsiveness of ATP-sensitive K(+) (K(ATP)) channels to glucose was blunted in KO cells. In addition, glucose-induced ATP generation was impaired. Although CDKAL1 is homologous to cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1, there was no difference in the kinase activity of CDK5 between WT and CDKAL1 KO islets.We provide the first report describing the function of CDKAL1 in β cells. Our results indicate that CDKAL1 controls first-phase insulin exocytosis in β cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2+) channels through pathways other than CDK5-mediated regulation

地域全体での病院前脳卒中分類スケールの使用が急性期脳卒中患者の管理へ与える影響

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora