A micro simulation model of demographic development and households' economic behavior in Italy

The relationship between the demographic structure and the saving rate of a society is the reflection of the aggregation of the behaviour of heterogeneous households, differing from one another in the type of living arrangements and in the characteristics of their members. In order to contribute to the understanding of this relationship, we construct a dynamic micro model capable of simulating the demographic development of a population, including the creation, destruction, dimension and various other important characteristics of households and their members. The demographic model is then combined with a specification of the processes generating income, social security wealth, retirement and consumption behaviour of households, and applied to a data set derived from survey data on the Italian household sector. Simulations of the model are used to study the evolution of aggregate income, saving and asset accumulation over the period 1994-2100. If fertility and mortality assumptions of recent official projections are adopted and marriage and divorce rates maintained at current levels, the dramatic ageing of the population and the marked decline in the share of population living in traditional households would lead, other things being equal, to a substantial decline in the aggregate saving rate. However, the reduction in the number of children per household and, above all, the decline in the ratio of social security wealth of households to disposable income as the effects of the recently introduced reforms begin to be felt act as offsetting factors. As a result, the aggregate saving rate increases over the initial 30 years of the simulation and moderately decreases thereafter, stabilizing slightly above the original level. Implications of changes in a number of key assumptions regarding the demographic evolution, productivity growth and individual behavioural responses are also analyzed.demographic developments, family structure, consumption, saving, social security, micro simulation model

The Stonehenge Altar Stone was probably not sourced from the Old Red Sandstone of the Anglo-Welsh Basin: time to broaden our geographic and stratigraphic horizons?

Stone 80, the recumbent Altar Stone, is the largest of the Stonehenge foreign “bluestones”, mainly igneous rocks forming the inner Stonehenge circle. The Altar Stone's anomalous lithology, a sandstone of continental origin, led to the previous suggestion of a provenance from the Old Red Sandstone (ORS) of west Wales, close to where the majority of the bluestones have been sourced (viz. the Mynydd Preseli area in west Wales) some 225 km west of Stonehenge. Building upon earlier investigations we have examined new samples from the Old Red Sandstone (ORS) within the Anglo-Welsh Basin (covering south Wales, the Welsh Borderland, the West Midlands and Somerset) using traditional optical petrography but additionally portable XRF, automated SEM-EDS and Raman Spectroscopic techniques. One of the key characteristics of the Altar Stone is its unusually high Ba content (all except one of 106 analyses have Ba &gt; 1025 ppm), reflecting high modal baryte. Of the 58 ORS samples analysed to date from the Anglo-Welsh Basin, only four show analyses where Ba exceeds 1000 ppm, similar to the lower range of the Altar Stone composition. However, because of their contrasting mineralogies, combined with data collected from new automated SEM-EDS and Raman Spectroscopic analyses these four samples must be discounted as being from the source of the Altar Stone. It now seems ever more likely that the Altar Stone was not derived from the ORS of the Anglo-Welsh Basin, and therefore it is time to broaden our horizons, both geographically and stratigraphically into northern Britain and also to consider continental sandstones of a younger age. There is no doubt that considering the Altar Stone as a ‘bluestone’ has influenced thinking regarding the long-held view to a source in Wales. We therefore propose that the Altar Stone should be ‘de-classified’ as a bluestone, breaking a link to the essentially Mynydd Preseli-derived bluestones.</p

Constraining Dark Matter Properties with Gamma-Rays from the Galactic Center with Fermi-LAT

We study the capabilities of the Fermi-LAT instrument on board of the Fermi mission to constrain particle dark matter properties, as annihilation cross section, mass and branching ratio into dominant annihilation channels, with gamma-ray observations from the galactic center. Besides the prompt gamma-ray flux, we also take into account the contribution from the electrons/positrons produced in dark matter annihilations to the gamma-ray signal via inverse Compton scattering off the interstellar photon background, which turns out to be crucial in the case of dark matter annihilations into mu+mu- and e+e- pairs. We study the signal dependence on different parameters like the region of observation, the density profile, the assumptions for the dark matter model and the uncertainties in the propagation model. We also show the effect of the inclusion of a 20% systematic uncertainty in the gamma-ray background. If Fermi-LAT is able to distinguish a possible dark matter signal from the large gamma-ray background, we show that for dark matter masses below ~200 GeV, Fermi-LAT will likely be able to determine dark matter properties with good accuracy.Comment: 38 pages, 13 figures, 4 tables; to match published versio

Vibrational analysis of coordination compounds of nickel (II): an approach to the teaching of point groups

This paper presents an IR and Raman experiment executed during the teaching of the course "Chemical Bonds" for undergraduated students of Science and Technology and Chemistry at the Federal University of ABC, in order to facilitate and encourage the teaching and learning of group theory. Some key aspects of this theory are also outlined. We believe that student learning was more significant with the introduction of this experiment, because there was an increase in the discussions level and in the performance during evaluations. This work also proposes a multidisciplinary approach to include the use of quantum chemistry tools

Contractile properties of the pigeon supracoracoideus during different modes of flight

The supracoracoideus (SUPRA) is the primary upstroke muscle for avian flight and is the antagonist to the downstroke muscle, the pectoralis (PECT). We studied in vivo contractile properties and mechanical power output of both muscles during take-off, level and landing flight. We measured muscle length change and activation using sonomicrometry and electromyography, and muscle force development using strain recordings on the humerus. Our results support a hypothesis that the primary role of the SUPRA is to supinate the humerus. Antagonistic forces exerted by the SUPRA and PECT overlap during portions of the wingbeat cycle, thereby offering a potential mechanism for enhancing control of the wing. Among flight modes, muscle strain was approximately the same in the SUPRA (33–40%) and the PECT (35–42%), whereas peak muscle stress was higher in the SUPRA $(85–126 N m^{–2})$ than in the PECT $(50–58 N m^{–2})$. The SUPRA mainly shortened relative to resting length and the PECT mainly lengthened. We estimated that elastic energy storage in the tendon of the SUPRA contributed between 28 and 60% of the net work of the SUPRA and 6–10% of the total net mechanical work of both muscles. Mechanical power output in the SUPRA was congruent with the estimated inertial power required for upstroke, but power output from the PECT was only 42–46% of the estimated aerodynamic power requirements for flight. There was a significant effect of flight mode upon aspects of the contractile behavior of both muscles including strain, strain rate, peak stress, work and power.Organismic and Evolutionary BiologyOther Research Uni

Квазиклассическое описание излучения электрона в графене

Supplementary Item 12: Tracer isotope data

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to long working hours and of the effect of exposure to long working hours on depression

Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years from depression attributable to exposure to long working hours, to inform the development of the WHO/ILO joint methodology. Objectives: We aim to systematically review studies on occupational exposure to long working hours (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of long working hours on depression (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework, conducting both systematic reviews in tandem and in a harmonized way. Data sources: Separately for Systematic Reviews 1 and 2, we will search electronic academic databases for potentially relevant records from published and unpublished studies, including Medline, EMBASE, Web of Science, CISDOC and PsycINFO. We will also search electronic grey literature databases, Internet search engines and organizational websites; hand search reference list of previous systematic reviews and included study records; and consult additional experts. Study eligibility and criteria: We will include working-age (≥15 years) participants in the formal and informal economy in any WHO and/or ILO Member State, but exclude child workers (&lt;15 years) and unpaid domestic workers. For Systematic Review 1, we will include quantitative prevalence studies of relevant levels of occupational exposure to long working hours (i.e. 35–40, 41–48, 49–54 and ≥55 h/week) stratified by country, sex, age and industrial sector or occupation, in the years 2005–2018. For Systematic Review 2, we will include randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies with an estimate of the relative effect of relevant level(s) of long working hours on the incidence of or mortality due to depression, compared with the theoretical minimum risk exposure level (i.e. 35–40 h/week). Study appraisal and synthesis methods: At least two review authors will independently screen titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, followed by extraction of data from qualifying studies. At least two review authors will assess risk of bias and the quality of evidence, using the most suited tools currently available. For Systematic Review 2, if feasible, we will combine relative risks using meta-analysis. We will report results using the guidelines for accurate and transparent health estimates reporting (GATHER) for Systematic Review 1 and the preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) for Systematic Review 2. PROSPERO registration number: CRD42018085729The publication was prepared with financial support from the World Health Organization cooperative agreement with the Centres for Disease Control and Prevention National Institute for Occupational Safety and Health of the United States of America on implementing Resolution WHA 60.26 “Workers' Health: Global Plan of Action” (Grant 1 E11 OH0010676-02)

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19

The biological determinants of the wide spectrum of COVID-19 clinical manifestations are not fully understood. Here, over 1400 plasma proteins and 2600 single-cell immune features comprising cell phenotype, basal signaling activity, and signaling responses to inflammatory ligands were assessed in peripheral blood from patients with mild, moderate, and severe COVID-19, at the time of diagnosis. Using an integrated computational approach to analyze the combined plasma and single-cell proteomic data, we identified and independently validated a multivariate model classifying COVID-19 severity (multi-class AUCtraining = 0.799, p-value = 4.2e-6; multi-class AUCvalidation = 0.773, p-value = 7.7e-6). Features of this high-dimensional model recapitulated recent COVID-19 related observations of immune perturbations, and revealed novel biological signatures of severity, including the mobilization of elements of the renin-angiotensin system and primary hemostasis, as well as dysregulation of JAK/STAT, MAPK/mTOR, and NF-κB immune signaling networks. These results provide a set of early determinants of COVID-19 severity that may point to therapeutic targets for the prevention of COVID-19 progression

Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice

Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has been reported to lower Aβ plaque deposition and improve cognitive function in AD transgenic mice