Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Nations within a nation: variations in epidemiological transition across the states of India, 1990–2016 in the Global Burden of Disease Study

18% of the world's population lives in India, and many states of India have populations similar to those of large countries. Action to effectively improve population health in India requires availability of reliable and comprehensive state-level estimates of disease burden and risk factors over time. Such comprehensive estimates have not been available so far for all major diseases and risk factors. Thus, we aimed to estimate the disease burden and risk factors in every state of India as part of the Global Burden of Disease (GBD) Study 2016

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Geriatric Disability and Associated Risk Factors: A Community Based Study in a Rural Area of West Bengal, India

Background: Similar to developed countries, aging is increasedin India. Because of the epidemiology and demographictransition phase, chronic diseases and disabilitiesalong with health costs are increasing day by day. As socialfactors and chronic diseases are the major reasons for geriatricdisability, the present study was done with the following objectives:to assess and compare the socio-demographic characteristicsamong the disabled and non-disabled geriatric population,and to find out the association between sociodemographicand chronic diseases with functional disabilityamong the study population.Methods: A cross-sectional study was done in a rural communityof West Bengal, India. House to house visit, clinicalexamination, observation, and interview were done with a predesigned,pre-tested proforma. Epi Info and SPSS softwarewere used for statistical analysis.Results: A total of 458 people had chronic conditions and theprevalence of disability was 17.47%. Among the sociodemographicvariables, age, female sex, marital status, literacystatus, and family composition and among the chronic diseases,tuberculosis, chronic obstructive pulmonary diseases, ischemicheart disease, osteoarthritis, neuropathy, acid peptic disorder,prostatic hypertrophy, and osteoporosis were found as risk factorsof disability in binary logistic regression analysis. 71.2% ofthe disabilities were explained by these risk factors.Conclusion: The data highlighted the different risk factorsassociated with disability. No single measure rather multidimensionalapproach should be the model for the preventionof disability

Multiplicity dependence of light (anti-)nuclei production in p–Pb collisions at sNN=5.02 TeV

The measurement of the deuteron and anti-deuteron production in the rapidity range −1 < y < 0 as a function of transverse momentum and event multiplicity in p–Pb collisions at √sNN = 5.02 TeV is presented. (Anti-)deuterons are identified via their specific energy loss dE/dx and via their time-of- flight. Their production in p–Pb collisions is compared to pp and Pb–Pb collisions and is discussed within the context of thermal and coalescence models. The ratio of integrated yields of deuterons to protons (d/p) shows a significant increase as a function of the charged-particle multiplicity of the event starting from values similar to those observed in pp collisions at low multiplicities and approaching those observed in Pb–Pb collisions at high multiplicities. The mean transverse particle momenta are extracted from the deuteron spectra and the values are similar to those obtained for p and particles. Thus, deuteron spectra do not follow mass ordering. This behaviour is in contrast to the trend observed for non-composite particles in p–Pb collisions. In addition, the production of the rare 3He and 3He nuclei has been studied. The spectrum corresponding to all non-single diffractive p-Pb collisions is obtained in the rapidity window −1 < y < 0 and the pT-integrated yield dN/dy is extracted. It is found that the yields of protons, deuterons, and 3He, normalised by the spin degeneracy factor, follow an exponential decrease with mass number

Constraints on jet quenching in p-Pb collisions at sNN\mathbf{\sqrt{s_{NN}}} = 5.02 TeV measured by the event-activity dependence of semi-inclusive hadron-jet distributions

The ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high-transverse momentum trigger hadron in p–Pb collisions at sNN=5.02 TeV. Jets are reconstructed from charged-particle tracks using the anti- kT algorithm with resolution parameter R=0.2 and 0.4. A data-driven statistical approach is used to correct the uncorrelated background jet yield. Recoil jet distributions are reported for jet transverse momentum 15<pT,jetch<50GeV/c and are compared in various intervals of p–Pb event activity, based on charged-particle multiplicity and zero-degree neutral energy in the forward (Pb-going) direction. The semi-inclusive observable is self-normalized and such comparisons do not require the interpretation of p–Pb event activity in terms of collision geometry, in contrast to inclusive jet observables. These measurements provide new constraints on the magnitude of jet quenching in small systems at the LHC. In p–Pb collisions with high event activity, the average medium-induced out-of-cone energy transport for jets with R=0.4 and 15<pT,jetch<50GeV/c is measured to be less than 0.4 GeV/c at 90% confidence, which is over an order of magnitude smaller than a similar measurement for central Pb–Pb collisions at sNN=2.76TeV . Comparison is made to theoretical calculations of jet quenching in small systems, and to inclusive jet measurements in p–Pb collisions selected by event activity at the LHC and in d–Au collisions at RHIC

Relative particle yield fluctuations in Pb-Pb \text{ Pb-Pb } collisions at sNN=2.76 TeV\sqrt{s_\mathrm{{NN}}} =2.76\hbox { TeV}

First results on $\hbox {K}/\pi$ , $\hbox {p}/\pi$ and K/p fluctuations are obtained with the ALICE detector at the CERN LHC as a function of centrality in $\text{ Pb-Pb }$ collisions at $\sqrt{s_\mathrm{{NN}}} =2.76\hbox { TeV}$ . The observable $\nu _{\mathrm{dyn}}$ , which is defined in terms of the moments of particle multiplicity distributions, is used to quantify the magnitude of dynamical fluctuations of relative particle yields and also provides insight into the correlation between particle pairs. This study is based on a novel experimental technique, called the Identity Method, which allows one to measure the moments of multiplicity distributions in case of incomplete particle identification. The results for $\hbox {p}/\pi$ show a change of sign in $\nu _{\mathrm{dyn}}$ from positive to negative towards more peripheral collisions. For central collisions, the results follow the smooth trend of the data at lower energies and $\nu _{\mathrm{dyn}}$ exhibits a change in sign for $\hbox {p}/\pi$ and K/p

Relative particle yield fluctuations in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}} = 2.76 TeV

First results on K/$\pi$, p/$\pi$ and K/p fluctuations are obtained with the ALICE detector at the CERN LHC as a function of centrality in Pb-Pb collisions at $\sqrt{s_{\rm NN}}=2.76$ TeV. The observable $\nu_{\rm dyn}$, which is defined in terms of the moments of particle multiplicity distributions, is used to quantify the magnitude of dynamical fluctuations of relative particle yields and also provides insight into the correlation between particle pairs. This study is based on a novel experimental technique, called the Identity Method, which allows one to measure the moments of multiplicity distributions in case of incomplete particle identification. The results for p/$\pi$ show a change of sign in $\nu_{\rm dyn}$ from positive to negative towards more peripheral collisions. For central collisions, the results follow the smooth trend of the data at lower energies and $\nu_{\rm dyn}$ exhibits a change in sign for p/$\pi$ and K/p.First results on $\hbox {K}/\pi$ , $\hbox {p}/\pi$ and K/p fluctuations are obtained with the ALICE detector at the CERN LHC as a function of centrality in $\text{ Pb--Pb }$ collisions at $\sqrt{s_\mathrm{{NN}}} =2.76\hbox { TeV}$ . The observable $\nu _{\mathrm{dyn}}$ , which is defined in terms of the moments of particle multiplicity distributions, is used to quantify the magnitude of dynamical fluctuations of relative particle yields and also provides insight into the correlation between particle pairs. This study is based on a novel experimental technique, called the Identity Method, which allows one to measure the moments of multiplicity distributions in case of incomplete particle identification. The results for $\hbox {p}/\pi$ show a change of sign in $\nu _{\mathrm{dyn}}$ from positive to negative towards more peripheral collisions. For central collisions, the results follow the smooth trend of the data at lower energies and $\nu _{\mathrm{dyn}}$ exhibits a change in sign for $\hbox {p}/\pi$ and K/p