An integrated solution using bench spreadsheets to monitor Quality control indicators and performance in medicine laboratories

Laboratory Quality Control (LQC) in medical laboratories is a tool to monitor the procedures of pre analytical, intra analytical and post analytical phases. The data statistic analyze allow the quantification of the random errors using the variation coefficients (CV%) obtained by Internal Quality Control (IQC) and the systematic errors (bias%), from the results of External Quality Control (EQC). These results are combined to calculate the Total Error (TE) and Measurement of Uncertainty (MAU), that allows the knowledge of the precision and accuracy and follow the performance of laboratory by comparison with the quality specifications. The main objective is to present a tool as a bench spreadsheet developed in National Institute of Health Doctor Ricardo Jorge (INSA), aiming to help the national and portuguese speaking countries laboratories, to calculate the main indicators of the LQC: TE, Sigma level and MU using IQC and EQC results, in a simplified way.N/

Bibliotecas e WEB 2.0: as boas práticas e os desafios

Bibliotecas e WEB 2.0: as boas práticas e os desafio

Static, dynamic and creep behaviour of a full-scale GFRP-SFRSCC hybrid footbridge

A three-year research project (Pontalumis) was carried out for the development of an innovative simply supported hybrid footbridge, with 11 m of length and 2 m of width. The footbridge is composed of two pultruded I-shaped glass fibre reinforced polymer (GFRP) girders (400×200(×15) mm2) bonded and bolted to a 37.5 mm thick deck in steel fibre reinforced self-compacting concrete (SFRSCC). The present paper describes the material/structural concept of this footbridge, its design and construction process, and summarizes the response of the prototype when submitted to static short and long-term load tests, and dynamic load tests. The prototype was simple and fast to execute, presenting a reduced dead-weight of only about 3 tonf. The static and dynamic behaviour of the prototype as well as its long-term deflection fulfil standards’ requirements for footbridge structures and are in good agreement with conventional analytical and numerical design tools.AD

Pontalumis : ponte pedonal mista GFRP-betão : descrição da solução, ensaios e modelação

Este artigo descreve o desenvolvimento de um protótipo de ponte pedonal à escala real utilizando um sistema estrutural misto inovador com longarinas em perfis pultrudidos de polímero reforçado com fibra de vidro (GFRP) e tabuleiro em betão auto-compactável reforçado com fibras de aço (SFRSCC), no âmbito do projeto PONTALUMIS. O protótipo apresenta um comprimento total de 11.0 m e uma secção transversal composta por dois perfis de GFRP em I e uma laje fina (38 mm) em SFRSCC. Neste trabalho são apresentados os resultados dos ensaios (i) estáticos, (ii) de fluência e (iii) dinâmicos, bem como as simulações numérica e analítica. Os resultados obtidos revelaram uma boa resposta da estrutura, em concordância com os modelos de previsão, confirmando o elevado potencial do sistema estrutural proposto

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Phyllochron, leaf expansion and life span in adult Coffea Arabica L. plants: Impact of axis order, growth intensity period and emitted leaf position

Phyllochron is a morphogenetic characteristic defined as a time interval between the appearance of two successive leaves. In adult Arabica coffee plants (Coffea arabica L.), the greatest part of the annual vegetative growth occurs in the warm, rainy season, while the smaller part of annual growth happens during the cool, dry season. We aimed to estimate the phyllochron, leaf expansion duration and life span in adult Arabica coffee plants depending on growth intensity periods, axis order and position of emitted leaves. Four-year-old plants were codified following the VPlants methodology in dynamic multiscale-tree-graphs. The leaf growth parameters were estimated on five axis orders. To integrate the effect of temperature on leaf growth parameters, they were expressed as functions of accumulated thermal time (growing degree-days-GDD). The demands in GDD for phyllochron were roughly 30 to 40% higher during the reduced compared to the active growth period. The lowest GDD of phyllochron was observed on the 2nd order axes, and the highest on the 5th order ones. The similar requirement in GDD for leaf expansion and life span was noted in leaves on 1st and 2nd order axes, while leaves born on 3rd to 5th axis orders showed higher GDD requirements. Leaves born on 2nd order axes finished their expansion more rapidly during the reduced than during the active growth period, indicating the occurrence of acclimation to temperatures over the same tree. The leaf emission duration and life span over the axes ranks followed binomial distributions. The results suggest that the phyllochron changed within the branching hierarchy and is seasonally modified by the environment. In future studies, longer period and apex mortality rate will be considered to improve the understanding of complex orchestration in structural development of Arabica coffee plants in 3D architectural dynamics modeling3843IEEE International Conference on Functional-Structural Plant Growth Modeling, Simulation, Visualization and Applications (FSPMA)sem informaçã

Footrace

Footrace, Monroe County athletes.https://digitalcommons.brockport.edu/specolymp_images/1004/thumbnail.jp