4,633 research outputs found

    Quaternary research in New Zealand since 2000: an overview

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    With the AQUA milestone of 30 years it seems an appropriate time to review the progress and achievements of Quaternary research in New Zealand. This article highlights some of the major achievements since the formal review of New Zealand’s Quaternary record by Newnham et al. (1999). The focus here is on paleoclimate and geochronology and is by no means a comprehensive review. We encourage members to write future articles for Quaternary Australasia (QA) about their exciting projects to keep the wider Australasian community informed. One of the main differences between Australian and New Zealand Quaternary science is the wide use of tephrochronology to correlate and date deposits and events across the landscape, helping to link terrestrial and marine records, especially in the North Island. There have been significant advances using glass-based fission-track dating, corrected for annealing, and the use of the electron microprobe and laser ablation inductively-coupled plasma mass spectrometry for obtaining major- and trace-element analyses, respectively, to chemically fingerprint individual glass shards in tephras to aid their correlation (Shane, 2000; Lowe, 2011). Also the identification and analysis of cryptotephras (concentrations of glass shards not visible as a layer) have greatly expanded the geographic range of many tephras, allowing the application of tephrochronology as a stratigraphic and dating tool across much wider areas than previously possible (Gehrels et al., 2008)

    Metamaterial/graphene active terahertz modulators

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    Within the last years there has been a tremendous thrust into research and technology in the THz spectral region (broadly defined as 0.1-10 THz) mainly driven by the unique potential where this radiation finds applications in, such as imaging, spectroscopy and communication. In all these fields a fast, integrated and versatile platform for modulating light is required. Metamaterial/graphene devices fulfill all these requirements as their subwavelength nature lends itself naturally to strong light-matter interaction, and therefore highly efficient and miniaturized devices. Graphene's unique properties, e.g. the large carrier concentration modulation, provide a large degree of compatibility with several architectures which can be exploited in a range of modulation or detection schemes. Finally, metamaterial/graphene devices realize a fast, versatile platform, which can be easily scaled to other frequencies, and adapted into amplitude, frequency, polarization and phase modulators, as well as integrated detectors, for the next generation of wireless-communication

    Envelope Determinants of Equine Lentiviral Vaccine Protection

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    Lentiviral envelope (Env) antigenic variation and associated immune evasion present major obstacles to vaccine development. The concept that Env is a critical determinant for vaccine efficacy is well accepted, however defined correlates of protection associated with Env variation have yet to be determined. We reported an attenuated equine infectious anemia virus (EIAV) vaccine study that directly examined the effect of lentiviral Env sequence variation on vaccine efficacy. The study identified a significant, inverse, linear correlation between vaccine efficacy and increasing divergence of the challenge virus Env gp90 protein compared to the vaccine virus gp90. The report demonstrated approximately 100% protection of immunized ponies from disease after challenge by virus with a homologous gp90 (EV0), and roughly 40% protection against challenge by virus (EV13) with a gp90 13% divergent from the vaccine strain. In the current study we examine whether the protection observed when challenging with the EV0 strain could be conferred to animals via chimeric challenge viruses between the EV0 and EV13 strains, allowing for mapping of protection to specific Env sequences. Viruses containing the EV13 proviral backbone and selected domains of the EV0 gp90 were constructed and in vitro and in vivo infectivity examined. Vaccine efficacy studies indicated that homology between the vaccine strain gp90 and the N-terminus of the challenge strain gp90 was capable of inducing immunity that resulted in significantly lower levels of post-challenge virus and significantly delayed the onset of disease. However, a homologous N-terminal region alone inserted in the EV13 backbone could not impart the 100% protection observed with the EV0 strain. Data presented here denote the complicated and potentially contradictory relationship between in vitro virulence and in vivo pathogenicity. The study highlights the importance of structural conformation for immunogens and emphasizes the need for antibody binding, not neutralizing, assays that correlate with vaccine protection. © 2013 Craigo et al

    The Long-Term Consequences of the Global 1918 Influenza Pandemic: A Systematic Analysis of 117 IPUMS International Census Data Sets

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    Several country-level studies, including a prominent one for the United States, have identified long-term effects of in-utero exposure to the 1918 influenza pandemic (also known as the Spanish Flu) on economic outcomes in adulthood. In-utero conditions are theoretically linked to adult health and socioeconomic status through the fetal origins or Barker hypothesis. Historical exposure to the Spanish Flu provides a natural experiment to test this hypothesis. Although the Spanish Flu was a global phenomenon, with around 500 million people infected worldwide, there exists no comprehensive global study on its long-term economic effects. We attempt to close this gap by systematically analyzing 117 Census data sets provided by IPUMS International. We do not find consistent global long-term effects of influenza exposure on education, employment and disability outcomes. A series of robustness checks does not alter this conclusion. Our findings indicate that the existing evidence on long-term economic effects of the Spanish Flu is likely a consequence of publication bias

    Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS

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    The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured

    Measurement of the production of a W boson in association with a charm quark in pp collisions at √s = 7 TeV with the ATLAS detector

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    The production of a W boson in association with a single charm quark is studied using 4.6 fb−1 of pp collision data at s√ = 7 TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96+0.26−0.30 at Q 2 = 1.9 GeV2, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally, the cross-section ratio σ(W + +c¯¯)/σ(W − + c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s−s¯¯¯ quark asymmetry
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