101 research outputs found

    Development and evaluation of a COVID tracking system to support provision of social service in Wyandotte County, Kansas

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    BackgroundIn addition to the state-mandated case investigation and contact tracing, the Unified Government Public Health Department of Wyandotte County, Kansas implemented social support services for COVID-19 cases and contacts; however, did not have the systems in place to document the provision of these services. Our team worked with the health department to develop and implement the COVID Tracking System (CTS), an eHealth system that linked multiple involved teams. Here, we describe the development and evaluation of the CTS. The objective of this manuscript is to describe and evaluate the development and implementation process of the Covid Tracking System.MethodsDrawing from concepts of user-centered design, we took a 4-phase approach to development: understanding context, specifying needs, designing solutions, and evaluating. A mixed-methods evaluation of the development and implementation process using RE-AIM was conducted. Quantitative CTS data captured between February 1, 2021, and September 30, 2021 were exported. Descriptive statistics were calculated for categorical variables and means (SD, range) or median (IQR) for continuous variables. Qualitative discussions with key users supplemented the quantitative data.ResultsThere were 1,152 cases entered into the CTS, of whom 307 (26.6%) requested a letter be sent to their workplace to excuse them during their quarantine period, 817 (70.9%) requested and had food and cleaning supplies delivered, 21 (1.8%) requested guidance on applying for federal assistance, and 496 (43.1%) requested to be contacted by a community health worker. While a few technical glitches slowed down early implementation, these were quickly resolved and key users felt that the CTS streamlined client referral and simplified their workflow, allowing them to spend more time on patient care and follow up, rather than documentation. After study implementation ended, the Unified Government Public Health Department of Wyandotte County continued using the CTS for client tracing and follow up.DiscussionThis project provides a roadmap of how user centered design can be applied to the development and evaluation of eHealth software to support program intervention implementation, even in situations where urgent action is needed

    <i>mito</i>-QC illuminates mitophagy and mitochondrial architecture <i>in vivo</i>

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    Autophagic turnover of mitochondria, termed mitophagy, is proposed to be an essential quality-control (QC) mechanism of pathophysiological relevance in mammals. However, if and how mitophagy proceeds within specific cellular subtypes in vivo remains unclear, largely because of a lack of tractable tools and models. To address this, we have developed “mito-QC,” a transgenic mouse with a pH-sensitive fluorescent mitochondrial signal. This allows the assessment of mitophagy and mitochondrial architecture in vivo. Using confocal microscopy, we demonstrate that mito-QC is compatible with classical and contemporary techniques in histochemistry and allows unambiguous in vivo detection of mitophagy and mitochondrial morphology at single-cell resolution within multiple organ systems. Strikingly, our model uncovers highly enriched and differential zones of mitophagy in the developing heart and within specific cells of the adult kidney. mito-QC is an experimentally advantageous tool of broad relevance to cell biology researchers within both discovery-based and translational research communities

    The molecular gas in Luminous Infrared Galaxies I: CO lines, extreme physical conditions, and their drivers

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    We report results from a large molecular line survey of Luminous Infrared Galaxies (L_{IR} >= 10^{11} L_sol) in the local Universe (z<=0.1), conducted during the last decade with the James Clerk Maxwell Telescope (JCMT) and the IRAM 30-m telescope. This work presents the CO and {13}CO line data for 36 galaxies, further augmented by multi-J total CO luminosities available for other IR-bright galaxies from the literature. This yields a sample of N=70 galaxies with the star-formation (SF) powered fraction of their IR luminosities spanning L_{IR} (10^{10}-2x10^{12}) L_sol and a wide range of morphologies. Simple comparisons of their available CO Spectral Line Energy Distributions (SLEDs) with local ones, as well as radiative transfer models discern a surprisingly wide range of average ISM conditions, with most of the surprises found in the high-excitation regime. These take the form of global CO SLEDs dominated by a very warm (T_{kin}>=100 K) and dense (n>=10^4 cm^{-3}) gas phase, involving galaxy-sized (~(few)x10^9 M_sol) gas mass reservoirs under conditions that would otherwise amount only ~1% of mass per typical SF molecular cloud in the Galaxy. Some of the highest excitation CO SLEDs are found in the so-called Ultra Luminous Infrared Galaxies and seem irreducible to ensembles of ordinary SF-powered regions. Highly supersonic turbulence and high cosmic ray (CR) energy densities rather than far-UV/optical photons or SNR-induced shocks from individual SF sites can globally warm the large amounts of dense gas found in these merger-driven starbursts and easily power their extraordinary CO line excitation.....Comment: 29 pages, 12 Figures, 8 Tables, originally submitted and now accepted for publication in the Monthly Notices of the Royal Astronomical Society (only minor modifications with respect to the first version

    Report on the Challenges of Air Transportation Experienced by People with Disabilities

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    Boarding an airplane is difficult for persons with mobility impairments and increases the risk of injury to both passengers and employees. Airplane seats are uncomfortable and lack the necessary support for many individuals with disabilities. Additionally, airplane restrooms can be inaccessible to wheelchair users. Potential solutions for these issues include the use of detachable plane seats or personal wheelchairs on board and an airplane redesign to provide additional restroom space. The number of service and emotional support animals being brought on airplanes have also increased substantially over the past few years. Passengers that travel with their service animals must contend with having to follow different rules for different airlines carriers and not having sufficient space for animals to be safe and comfortable

    The Relation Between the Surface Brightness and the Diameter for Galactic Supernova Remnants

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    In this work, we have constructed a relation between the surface brightness (Σ\Sigma) and diameter (D) of Galactic C- and S-type supernova remnants (SNRs). In order to calibrate the Σ\Sigma-D dependence, we have carefully examined some intrinsic (e.g. explosion energy) and extrinsic (e.g. density of the ambient medium) properties of the remnants and, taking into account also the distance values given in the literature, we have adopted distances for some of the SNRs which have relatively more reliable distance values. These calibrator SNRs are all C- and S-type SNRs, i.e. F-type SNRs (and S-type SNR Cas A which has an exceptionally high surface brightness) are excluded. The Sigma-D relation has 2 slopes with a turning point at D=36.5 pc: Σ\Sigma(at 1 GHz)=8.46.3+19.5^{+19.5}_{-6.3}×1012\times10^{-12} D5.990.33+0.38^{{-5.99}^{+0.38}_{-0.33}} Wm2^{-2}Hz1^{-1}ster1^{-1} (for Σ\Sigma3.7×1021\le3.7\times10^{-21} Wm2^{-2}Hz1^{-1}ster1^{-1} and D\ge36.5 pc) and Σ\Sigma(at 1 GHz)=2.71.4+2.1^{+2.1}_{-1.4}×\times 1017^{-17} D2.470.16+0.20^{{-2.47}^{+0.20}_{-0.16}} Wm2^{-2}Hz1^{-1}ster1^{-1} (for Σ\Sigma>3.7×1021>3.7\times10^{-21} Wm2^{-2}Hz1^{-1}ster1^{-1} and D<<36.5 pc). We discussed the theoretical basis for the Σ\Sigma-D dependence and particularly the reasons for the change in slope of the relation were stated. Added to this, we have shown the dependence between the radio luminosity and the diameter which seems to have a slope close to zero up to about D=36.5 pc. We have also adopted distance and diameter values for all of the observed Galactic SNRs by examining all the available distance values presented in the literature together with the distances found from our Σ\Sigma-D relation.Comment: 45 pages, 2 figures, accepted for publication in Astronomical and Astrophysical Transaction

    Identifying the need for good practices in Health Technology Assessment : summary of the ISPOR HTA Council Working Group Report on Good Practices in HTA

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    The systematic use of evidence to inform healthcare decisions, particularly health technology assessment (HTA), has gained increased recognition. HTA has become a standard policy tool for informing decision makers who must manage the entry and use of pharmaceuticals, medical devices, and other technologies (including complex interventions) within health systems, for example, through reimbursement and pricing. Despite increasing attention to HTA activities, there has been no attempt to comprehensively synthesize good practices or emerging good practices to support populationbased decision-making in recent years. After the identification of some good practices through the release of the ISPOR Guidelines Index in 2013, the ISPOR HTA Council identified a need to more thoroughly review existing guidance. The purpose of this effort was to create a basis for capacity building, education, and improved consistency in approaches to HTA-informed decision-making. Our findings suggest that although many good practices have been developed in areas of assessment and some other key aspects of defining HTA processes, there are also many areas where good practices are lacking. This includes good practices in defining the organizational aspects of HTA, the use of deliberative processes, and measuring the impact of HTA. The extent to which these good practices are used and applied by HTA bodies is beyond the scope of this report, but may be of interest to future researchers
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