Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation

The current status of electric dipole moments of diamagnetic atoms which involves the synergy between atomic experiments and three different theoretical areas -- particle, nuclear and atomic is reviewed. Various models of particle physics that predict CP violation, which is necessary for the existence of such electric dipole moments, are presented. These include the standard model of particle physics and various extensions of it. Effective hadron level combined charge conjugation (C) and parity (P) symmetry violating interactions are derived taking into consideration different ways in which a nucleon interacts with other nucleons as well as with electrons. Nuclear structure calculations of the CP-odd nuclear Schiff moment are discussed using the shell model and other theoretical approaches. Results of the calculations of atomic electric dipole moments due to the interaction of the nuclear Schiff moment with the electrons and the P and time-reversal (T) symmetry violating tensor-pseudotensor electron-nucleus are elucidated using different relativistic many-body theories. The principles of the measurement of the electric dipole moments of diamagnetic atoms are outlined. Upper limits for the nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained combining the results of atomic experiments and relativistic many-body theories. The coefficients for the different sources of CP violation have been estimated at the elementary particle level for all the diamagnetic atoms of current experimental interest and their implications for physics beyond the standard model is discussed. Possible improvements of the current results of the measurements as well as quantum chromodynamics, nuclear and atomic calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for EPJ

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

A BAFF/APRIL axis regulates obesogenic diet-driven weight gain.

The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitously uncovered a role for B cell activating factor (BAFF). Here we show that overexpression of BAFF in multiple mouse models associates with protection from weight gain, approximating a log-linear dose response relation to BAFF concentrations. Gene expression analysis of BAFF-stimulated subcutaneous white adipocytes unveils upregulation of lipid metabolism pathways, with BAFF inducing white adipose tissue (WAT) lipolysis. Brown adipose tissue (BAT) from BAFF-overexpressing mice exhibits increased Ucp1 expression and BAFF promotes brown adipocyte respiration and in vivo energy expenditure. A proliferation-inducing ligand (APRIL), a BAFF homolog, similarly modulates WAT and BAT lipid handling. Genetic deletion of both BAFF and APRIL augments diet-induced obesity. Lastly, BAFF/APRIL effects are conserved in human adipocytes and higher BAFF/APRIL levels correlate with greater BMI decrease after bariatric surgery. Together, the BAFF/APRIL axis is a multifaceted immune regulator of weight gain and adipose tissue function

Recent developments for optimal end-points in rheumatoid arthritis clinical studies

Clinical studies in patients with rheumatoid arthritis (RA) provide valuable information on the course and outcome of the disease whereas clinical trials provide information on optimal treatment for patients. This paper discusses measurement concepts and most frequently used measures in RA. To optimise the information that can be obtained from clinical studies, uniform measures are essential, Therefore, the international rheumatology community has made an effort to propose uniform end-points for clinical studies in RA, Measurement in RA is traditionally divided into the measurement of 'the process' and measurement of 'outcome'. Current measures in use include: (i) disease activity measures - global assessments, symptoms (e.g. morning stiffness), health status! physical function, physical signs (e.g. joint counts) and laboratory assessments; and (ii) measures of damage - radiography of affected joints and physical function. Several Outcome Measures in Rheumatology (OMERACT) conferences have resulted in a core set of end-points to be used in RA clinical trials, which are supported by the World Health Organization and International League of Associations for Rheumatology (WHO/ILAR). In addition, the OMERACT conferences focused on minimum important differences for patients and in trials, resulting in recommendations for improvement criteria. Improvement criteria were further developed and validated by both the American College of Rheumatology (ACR) and European League Against Rheumatology (EULAR). The ACR criteria use the WHO/ILAR core set of end-points to define minimum improvement in each of the measures. The EULAR criteria define improvement using the Disease Activity Score

Apophis Planetary Defense Campaign

We describe results of a planetary defense exercise conducted during the close approach to Earth by the near-Earth asteroid (99942) Apophis during 2020 December–2021 March. The planetary defense community has been conducting observational campaigns since 2017 to test the operational readiness of the global planetary defense capabilities. These community-led global exercises were carried out with the support of NASA’s Planetary Defense Coordination Office and the International Asteroid Warning Network. The Apophis campaign is the third in our series of planetary defense exercises. The goal of this campaign was to recover, track, and characterize Apophis as a potential impactor to exercise the planetary defense system including observations, hypothetical risk assessment and risk prediction, and hazard communication. Based on the campaign results, we present lessons learned about our ability to observe and model a potential impactor. Data products derived from astrometric observations were available for inclusion in our risk assessment model almost immediately, allowing real-time updates to the impact probability calculation and possible impact locations. An early NEOWISE diameter measurement provided a significant improvement in the uncertainty on the range of hypothetical impact outcomes. The availability of different characterization methods such as photometry, spectroscopy, and radar provided robustness to our ability to assess the potential impact risk. © 2022. The Author(s). Published by the American Astronomical Society.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

The SRG/eROSITA All-Sky Survey: Dark Energy Survey Year 3 Weak Gravitational Lensing by eRASS1 selected Galaxy Clusters

International audienceNumber counts of galaxy clusters across redshift are a powerful cosmological probe, if a precise and accurate reconstruction of the underlying mass distribution is performed -- a challenge called mass calibration. With the advent of wide and deep photometric surveys, weak gravitational lensing by clusters has become the method of choice to perform this measurement. We measure and validate the weak gravitational lensing (WL) signature in the shape of galaxies observed in the first 3 years of the DES Y3 caused by galaxy clusters selected in the first all-sky survey performed by SRG/eROSITA. These data are then used to determine the scaling between X-ray photon count rate of the clusters and their halo mass and redshift. We empirically determine the degree of cluster member contamination in our background source sample. The individual cluster shear profiles are then analysed with a Bayesian population model that self-consistently accounts for the lens sample selection and contamination, and includes marginalization over a host of instrumental and astrophysical systematics. To quantify the accuracy of the mass extraction of that model, we perform mass measurements on mock cluster catalogs with realistic synthetic shear profiles. This allows us to establish that hydro-dynamical modelling uncertainties at low lens redshifts ($z<0.6$) are the dominant systematic limitation. At high lens redshift the uncertainties of the sources' photometric redshift calibration dominate. With regard to the X-ray count rate to halo mass relation, we constrain all its parameters. This work sets the stage for a joint analysis with the number counts of eRASS1 clusters to constrain a host of cosmological parameters. We demonstrate that WL mass calibration of galaxy clusters can be performed successfully with source galaxies whose calibration was performed primarily for cosmic shear experiments