The Effectiveness of a Proposed Enrichment Program Based on Problem-Solving and Problem Posing in Developing the Ability of Mathematical Reasoning and Sense-Making among Grade Ten High Achievers

This study aimed to reveal the effectiveness of a proposed enrichment program based on problem-solving and problem posing in developing the ability of the mathematical reasoning and sense making among students of high achievement. To achieve this goal, an enrichment training program was designed to focus on a set of mathematical ideas and skills in mathematics using problem-solving and problem- posing strategies to solve and pose non-routine mathematical problems for students of high achievement to develop their mathematical reasoning and sense making ability. The researcher designed a test to measure the mathematical reasoning and sense making. In addition, the Test of Mathematical Abilities (TOMA-3) was used to measure the students' mathematical abilities before the experiment. The sample of the study consisted of 63 grade ten high achievers randomly selected from South Batinah governorate, which was divided into control and experimental groups. For testing the study hypothesis, data was analyzed by analysis of covariance (ANCOVA) in which eta squared was obtained. The results showed that the proposed program was effective and the mathematical reasoning and sense making skills were highly achieved

The Effectiveness of a Proposed Enrichment Program Based on Problem-Solving and Problem Posing in Developing the Ability of Mathematical Reasoning and Sense-Making among Grade Ten High Achievers

This study aimed to reveal the effectiveness of a proposed enrichment program based on problem-solving and problem posing in developing the ability of the mathematical reasoning and sense making among students of high achievement. To achieve this goal, an enrichment training program was designed to focus on a set of mathematical ideas and skills in mathematics using problem-solving and problem- posing strategies to solve and pose non-routine mathematical problems for students of high achievement to develop their mathematical reasoning and sense making ability. The researcher designed a test to measure the mathematical reasoning and sense making. In addition, the Test of Mathematical Abilities (TOMA-3) was used to measure the students' mathematical abilities before the experiment. The sample of the study consisted of 63 grade ten high achievers randomly selected from South Batinah governorate, which was divided into control and experimental groups. For testing the study hypothesis, data was analyzed by analysis of covariance (ANCOVA) in which eta squared was obtained. The results showed that the proposed program was effective and the mathematical reasoning and sense making skills were highly achieved

Genetic diversity of Ardi goat based on microsatellite analysis

The aim of this study was to analyze the genetic variability of Ardi goats found in the central regions of the kingdom of Saudi Arabia using 14 microsatellite markers. Allelic richness was considerably high in this population indicating high genetic polymorphism as expected heterozygozity was 0.675. Furthermore, the population showed deviation from Hardy-Weinberg equilibrium in seven loci. Mean polymorphic information content value was found to be 0.553. Inbreeding coefficient was 0.183 suggesting moderate level of inbreeding. There was also no-significant heterozygote excess on basis of different models of infinite allele. These tests along with the mode-shift test of Ardi goat indicated no bottleneck recently. Thus, it can be recommended that the Ardi genetic variability should be maintained for its unique genetic resources, and there is a scope for further improvement in productivity through an appropriate management and breeding program. In general, results of this study can be used to establish a base of national conservation strategy of Ardi goat population in Saudi Arabia.Key words: Ardi goat, genetic diversity, microsatellite markers, inbreeding, bottleneck

Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells

Buspirone is an anxiolytic drug with robust serotonin receptor 1A (Htr1a) agonist activities. However, evidence has demonstrated that this drug also targets the dopamine D3 receptor (Drd3), where it acts as a potent antagonist. In vivo, Drd3 blockade is neuroprotective and reduces inflammation in models of Parkinson's disease. To test if buspirone also elicited anti-inflammatory activities in vitro, we generated stable Drd3-/- and Htr1a-/- BV2 microglial cell lines using CRISPR-Cas9 technology and then tested the effects of buspirone after lipopolysaccharide (LPS) challenge. We found that LPS exposure had no effect on cell viability, except in Htr1a-/- cells, where viability was reduced (p -/- cells, but not in WT or Htr1a-/- cells. Buspirone counteracted LPS-induced NO release, NOS2, IL-1β and TNF-α gene expression in WT cells, whereas it exerted limited effects in Drd3-/- or Htr1a-/- microglia. In summary, our findings indicate that buspirone attenuates microglial polarization after LPS challenge. These results also highlight some major effects of Drd3 or Htr1a genetic ablation on microglial biology, raising important questions on the complex role of neurotransmitters in regulating microglia functions

Do poor patients suffer from inaccurate diagnoses more than well-to-do patients? A randomized control trial

BACKGROUND: Poor patients have greater morbidity and die up to 10 years earlier than patients who have higher socio-economic status. These findings are often attributed to differences in life-style between groups. The present study aimed at investigating the extent to which physicians contribute to the effect by providing relative poorer care, resulting in relative neglect in terms of time spent with a poor patient and more inaccurate diagnoses. METHODS: A randomised experiment with 45 internal medicine residents. Doctors diagnosed 12 written clinical vignettes that were exactly the same except for the description of the patients' socio-economic status. Each participant diagnosed four of the vignettes in a poor-patient version, fou

Migrating Thermal Tides in the Martian Atmosphere During Aphelion Season Observed by EMM/EMIRS

Funding Information: Funding for development of the EMM mission was provided by the United Arab Emirates (UAE) government, and to co‐authors outside of the UAE by the Mohammed bin Rashid Space Centre (MBRSC). RMBY acknowledges funding from UAE University grants G00003322 and G00003407.Peer reviewe

Utility of interferon-γ ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa

BACKGROUND: Interferon-gamma (IFN-gamma) ELISPOT assays incorporating Mycobacterium tuberculosis-specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However, their utility in patients with advanced HIV is unknown. We studied determinants of ELISPOT responses among patients with advanced HIV infection (but without active TB) living in a South African community with very high TB notification rates. METHODS: IFN-gamma responses to ESAT-6 and CFP-10 in overnight ELISPOT assays and in 7-day whole blood assays (WBA) were compared in HIV-infected patients (HIV+, n = 40) and healthy HIV-negative controls (HIV-, n = 30) without active TB. Tuberculin skin tests (TSTs) were also done. RESULTS: ELISPOTs, WBAs and TSTs were each positive in >70% of HIV- controls, reflecting very high community exposure to M. tuberculosis. Among HIV+ patients, quantitative WBA responses and TSTs (but not the proportion of positive ELISPOT responses) were significantly impaired in those with CD4 cell counts <100 cells/mul compared to those with higher counts. In contrast, ELISPOT responses (but not WBA or TST) were strongly related to history of TB treatment; a much lower proportion of HIV+ patients who had recently completed treatment for TB (n = 19) had positive responses compared to those who had not been treated (11% versus 62%, respectively; P < 0.001). Multivariate analysis confirmed that ELISPOT responses had a strong inverse association with a history of recent TB treatment (adjusted OR = 0.06, 95%CI = 0.10-0.40, P < 0.01) and that they were independent of CD4 cell count and viral load. Among HIV+ individuals who had not received TB treatment both the magnitude and proportion of positive ELISPOT responses (but not TST or WBA) were similar to those of HIV-negative controls. CONCLUSION: The proportion of positive ELISPOT responses in patients with advanced HIV infection was independent of CD4 cell count but had a strong inverse association with history of TB treatment. This concurs with the previously documented low TB risk among patients in this cohort with a history of recent treatment for TB. These data suggest ELISPOT assays may be useful for patient assessment and as an immuno-epidemiological research tool among patients with advanced HIV and warrant larger scale prospective evaluation

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology

Introductory programming: a systematic literature review

As computing becomes a mainstream discipline embedded in the school curriculum and acts as an enabler for an increasing range of academic disciplines in higher education, the literature on introductory programming is growing. Although there have been several reviews that focus on specific aspects of introductory programming, there has been no broad overview of the literature exploring recent trends across the breadth of introductory programming. This paper is the report of an ITiCSE working group that conducted a systematic review in order to gain an overview of the introductory programming literature. Partitioning the literature into papers addressing the student, teaching, the curriculum, and assessment, we explore trends, highlight advances in knowledge over the past 15 years, and indicate possible directions for future research

Ammonia-Nitrogen Recovery from Synthetic Solution using Agricultural Waste Fibers

In this study, modification of Empty Fruit Bunch (EFB) fibers as a means to recover ammonianitrogen from a synthetic solution was investigated. Methods: The EFB fiber was modified using sodium hydroxide.Adsorption-desorption studies of ammonia nitrogen into the modified EFB fiber were investigated Findings: Theincrease in adsorption capacity was found to be proportional with the increase of pH up to 7, temperature and ammoniaconcentration. The maximum adsorption capacity is 0.53-10.89 mg/g. The attachment of ammonia nitrogen involves ionexchange-chemisorption. The maximum desorption capacity of 0.0999 mg/g. Applications: This study can be used as abaseline for designing a low cost adsorbent system for ammonia nitrogen recovery drainage and industrial wastewater aswell as EFBs-palm oil mill effluent composting