Convergence rate across the Nepal Himalaya and interseismic coupling on the Main Himalayan Thrust: Implications for seismic hazard

We document geodetic strain across the Nepal Himalaya using GPS times series from 30 stations in Nepal and southern Tibet, in addition to previously published campaign GPS points and leveling data and determine the pattern of interseismic coupling on the Main Himalayan Thrust fault (MHT). The noise on the daily GPS positions is modeled as a combination of white and colored noise, in order to infer secular velocities at the stations with consistent uncertainties. We then locate the pole of rotation of the Indian plate in the ITRF 2005 reference frame at longitude = − 1.34° ± 3.31°, latitude = 51.4° ± 0.3° with an angular velocity of Ω = 0.5029 ± 0.0072°/Myr. The pattern of coupling on the MHT is computed on a fault dipping 10° to the north and whose strike roughly follows the arcuate shape of the Himalaya. The model indicates that the MHT is locked from the surface to a distance of approximately 100 km down dip, corresponding to a depth of 15 to 20 km. In map view, the transition zone between the locked portion of the MHT and the portion which is creeping at the long term slip rate seems to be at the most a few tens of kilometers wide and coincides with the belt of midcrustal microseismicity underneath the Himalaya. According to a previous study based on thermokinematic modeling of thermochronological and thermobarometric data, this transition seems to happen in a zone where the temperature reaches 350°C. The convergence between India and South Tibet proceeds at a rate of 17.8 ± 0.5 mm/yr in central and eastern Nepal and 20.5 ± 1 mm/yr in western Nepal. The moment deficit due to locking of the MHT in the interseismic period accrues at a rate of 6.6 ± 0.4 × 10^(19) Nm/yr on the MHT underneath Nepal. For comparison, the moment released by the seismicity over the past 500 years, including 14 M_W ≥ 7 earthquakes with moment magnitudes up to 8.5, amounts to only 0.9 × 10^(19) Nm/yr, indicating a large deficit of seismic slip over that period or very infrequent large slow slip events. No large slow slip event has been observed however over the 20 years covered by geodetic measurements in the Nepal Himalaya. We discuss the magnitude and return period of M > 8 earthquakes required to balance the long term slip budget on the MHT

Response of rate-and-state seismogenic faults to harmonic shear-stress perturbations

Field and laboratory observations show that seismicity has non-trivial period-dependent response to periodic stress perturbations. In Nepal, seismicity shows significant variations in response to annual monsoon-induced stress variations but not to semidiurnal tidal stresses of the same magnitude. Such period dependence cannot be explained by the Coulomb failure model and spring-slider rate-and-state model (SRM). Here, we study seismicity response to periodic stress perturbations in a 2-D continuum model of a rate-and-state fault (that is, a finite rate-and-state fault). We find that the resulting seismicity indeed exhibits nearly periodic variations. Their amplitude is maximum at a certain period, T_a, and decreases with smaller and larger periods to the SRM predictions, remaining much larger than the SRM predictions for a wide range of periods around T_a. We attribute the higher sensitivity of finite faults to their finite nucleation zones which vary in space and have a different slip-velocity evolution than that of the SRM. At periods T ≫ T_a and T ≪ T_a, the seismicity-rate variations are in phase with the stress-rate and stress variations, respectively, consistent with the SRM, although a gradual phase shift appears as T increases towards T_a. Based on the similarities with the SRM and our simulations, we propose a semi-analytical expression for T_a. Plausible sets of model parameters make T_a equal to 1 yr, potentially explaining Nepal observations and constraining the fault properties. Our finite-fault findings indicate that aσ, where a is a rate-and-state parameter and σ is the effective normal stress, can be severely underestimated based on the SRM

Daptomycin > 6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center

Background: Even if daptomycin does not have approval for the treatment of bone and joint infections (BJI), the Infectious Diseases Society of America guidelines propose this antibiotic as alternative therapy for prosthetic joint infection. The recommended dose is 6 mg/kg/d, whereas recent data support the use of higher doses in these patients.Methods: We performed a cohort study including consecutive patients that have received daptomycin >6 mg/kg/d for complex BJI between 2011 and 2013 in a French regional reference center. Factors associated with treatment failure were determined on univariate Cox analysis and Kaplan-Meier curves.Results: Forty-three patients (age, 61 ± 17 years) received a mean dose of 8 ± 0.9 mg/kg/d daptomycin, for a mean 81 ± 59 days (range, 6-303 days). Most had chronic (n = 37, 86 %) implant-associated (n = 37, 86 %) BJI caused by coagulasenegative staphylococci (n = 32, 74 %). A severe adverse event (SAE) occurred in 6 patients (14 %), including 2 cases of eosinophilic pneumonia, concomitant with daptomycin Cmin >24 mg/L. Outcome was favorable in 30 (77 %) of the 39 clinically assessable patients. Predictors for treatment failure were age, non-optimal surgery and daptomycin withdrawal for SAE.Conclusions: Prolonged high-dose daptomycin therapy was effective in patients with complex BJI. However, optimal surgery remains the cornerstone of medico-surgical strategy; and a higher incidence of eosinophilic pneumonia than expected was recorded

Search for Flavoured Multiquarks in a Simple Bag Model

We use a bag model to study flavoured mesonic $(Qq\bar q\bar q)$ and baryonic $({\overline Q}qqqq)$ states, where one heavy quark $Q$ is associated with light quarks or antiquarks, and search for possible stable multiquarks. No bound state is found. However some states lie not too high above their dissociation threshold, suggesting the possibility of resonances, or perhaps bound states in improved models.Comment: REVTEX, VERSION 3.

Controlling fluid-induced seismicity during a 6.1-km-deep geothermal stimulation in Finland

We show that near–real-time seismic monitoring of fluid injection allowed control of induced earthquakes during the stimulation of a 6.1-km-deep geothermal well near Helsinki, Finland. A total of 18,160 m3 of fresh water was pumped into crystalline rocks over 49 days in June to July 2018. Seismic monitoring was performed with a 24-station borehole seismometer network. Using near–real-time information on induced-earthquake rates, locations, magnitudes, and evolution of seismic and hydraulic energy, pumping was either stopped or varied—in the latter case, between well-head pressures of 60 and 90 MPa and flow rates of 400 and 800 liters/min. This procedure avoided the nucleation of a project-stopping magnitude MW 2.0 induced earthquake, a limit set by local authorities. Our results suggest a possible physics-based approach to controlling stimulation-induced seismicity in geothermal projects.Peer reviewe

Weakly-Bound Three-Body Systems with No Bound Subsystems

We investigate the domain of coupling constants which achieve binding for a 3-body system, while none of the 2-body subsystems is bound. We derive some general properties of the shape of the domain, and rigorous upper bounds on its size, using a Hall--Post decomposition of the Hamiltonian. Numerical illustrations are provided in the case of a Yukawa potential, using a simple variational method.Comment: gzipped ps with 11 figures included. To appear in Phys. Rev.

Mass Spectrometry-based Absolute Quantification of 20S Proteasome Status for Controlled Ex-vivo Expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells

International audienceIn Brief 20S proteasomes are very heterogeneous protein complexes involved in many cellular processes. In the present study, we combined an MRM-based assay with the production and purification of entire SILAC labelled pro-teasome to monitor absolute quantities of the different 20S proteasome subtypes in various human cells and tissues. This method applied to adipocyte-derived stem cells (ADSCs) amplified under various conditions highlights an increased expression of immunoproteasome when this type of cell is primed with IFN␥ or amplified in a 20% O 2 environment. Graphical Abstract Highlights • Design of an MRM assay to determine the absolute quantity and stoichiometry of ubiquitous and tissue-specific human 20S proteasome subtypes. • Use of purified isotopically labelled 20S proteasome as internal standard for accurate quantification. • Variation in the expression of immunoproteasome in adipocyte-derived stem cells (ADSCs) grown under different O 2 levels might be causal for change in cells differentiation capacity. • The status of 20S proteasome during ADSCs expansion might constitute an additional relevant quality control parameter to contribute to predict, among other quality markers, their therapeutic capacity

The effect of varying practitioner communication on patients' health status and treatment outcomes

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects of interventions in which healthcare practitioner communication in face-to-face consultations with patients is experimentally varied in comparison to usual care or contrasted active control interventions, on patient health and treatment outcomes. A secondary aim is to investigate if the intervention effect is modified by intervention type, type of illness, length of follow-up, type of outcome and the way the subjects are exposed to communication in studies (real versus simulated)

Invasive pulmonary aspergillosis in patients with decompensated cirrhosis: case series

BACKGROUND: Opportunistic invasive fungal infections are increasingly frequent in intensive care patients. Their clinical spectrum goes beyond the patients with malignancies, and for example invasive pulmonary aspergillosis has recently been described in critically ill patients without such condition. Liver failure has been suspected to be a risk factor for aspergillosis. CASE PRESENTATION: We describe three cases of adult respiratory distress syndrome with sepsis, shock and multiple organ failure in patients with severe liver failure among whom two had positive Aspergillus antigenemia and one had a positive Aspergillus serology. In all cases bronchoalveolar lavage fluid was positive for Aspergillus fumigatus. Outcome was fatal in all cases despite treatment with voriconazole and agressive symptomatic treatment. CONCLUSION: Invasive aspergillosis should be among rapidly raised hypothesis in cirrhotic patients developing acute respiratory symptoms and alveolar opacities