10 research outputs found
An Open Resource for Non-human Primate Imaging.
- Author
- Ai Lei
- Amiez Céline
- Balezeau Fabien
- Baxter Mark G.
- Ben Hamed Suliann
- Blezer Erwin L.A.
- Brochier Thomas
- Centre for Biological Diversity
- Centre for Social Learning & Cognitive Evolution
- Chen Aihua
- Croxson Paula L.
- Damatac Christienne G.
- Dehaene Stanislas
- Everling Stefan
- Fair Damian A.
- Fleysher Lazar
- Freiwald Winrich
- Froudist-Walsh Sean
- Griffiths Timothy D.
- Guedj Carole
- Hadj-Bouziane Fadila
- Harel Noam
- Hiba Bassem
- Institute of Behavioural and Neural Sciences
- Jarraya Bechir
- Jung Benjamin
- Kastner Sabine
- Klink P. Christiaan
- Koo Bonhwang
- Kwok Sze Chai
- Laland Kevin Neville
- Leopold David A.
- Lindenfors Patrik
- Margulies Daniel S.
- Mars Rogier B.
- Menon Ravi S.
- Messinger Adam
- Meunier Martine
- Milham Michael P.
- Mok Kelvin
- Morrison John H.
- Nacef Jennifer
- Nagy Jamie
- Petkov Christopher I.
- Pinsk Mark
- Poirier Colline
- Procyk Emmanuel
- Rajimehr Reza
- Reader Simon M.
- Rios Michael Ortiz
- Roelfsema Pieter R.
- Rudko David A.
- Rushworth Matthew F.S.
- Russ Brian E.
- Sallet Jerome
- Schmid Michael Christoph
- School of Biology
- Schroeder Charles E.
- Schwiedrzik Caspar M.
- Scottish Oceans Institute
- Seidlitz Jakob
- Sein Julien
- Shmuel Amir
- Sullivan Elinor L.
- Thiele Alexander
- Todorov Orlin S.
- Tsao Doris
- Ungerleider Leslie
- University of St Andrews
- Wang Zheng
- Wilson Charles R.E.
- Xu Ting
- Yacoub Essa
- Ye Frank Q.
- Zarco Wilbert
- Zhou Yong-di
- Publication venue
- Neuron
- Publication date
- 01/01/2018
- Field of study
Get PDFNon-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
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- Agbeko R.
- Aggarwal S.
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- Ahmed A.
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- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
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- Albert P.
- Alegria A.
- Alexander A.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
- Allen L.
- Alshaer I.
- Altaf S.
- Amezaga M.
- Amin A.
- Amit B.
- Anand A.
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- Bujazia R.
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- Buttress D.
- Byrne J.
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- Byrne-Watts V.
- Cale E.
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- Caws C.
- Central Coordinating Office (for the RECOVERY Collaborative Group)
- Century H.
- Chadwick J.
- Chakkarapani E.
- Chakraborty A.
- Chamberlain S.
- Chambers E.
- Chambers L.
- Chan E.
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- Charles B.
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- Chatterton D.
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- Chauhan R.
- Chawla V.
- Chen F.
- Cheng F.
- Cherrie M.
- Cheung E.
- Cheyne C.
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- Chilvers A.
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- Chineka R.
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- Chiswick C.
- Chivima B.
- Chmiel C.
- Chrisopoulou A.
- Christian P.
- Christides A.
- Christmas D.
- Church E.
- Cianci N.
- Cicconi P.
- Clare E.
- Clark E.
- Clark G.
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- Clark R.
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- Clayton-Smith J.
- Cleaver C.
- Clemente de la Torre C.
- Clifford S.
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- Cocks S.
- Coe A.
- Coey D.
- Cohen D.
- Coker O.
- Cole J.
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- Collier D.
- Collini Paul
- Collins J.
- Collins V.
- Colton H.
- Condliffe R.
- Connell E.
- Connell L.
- Connelly K.
- Connolly G.
- Connor E.
- Conroy K.
- Conteh V.
- Conway R.
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- Cooke G.
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- Corbett C.
- Corbishley A.
- Cornwell J.
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- Cotterill D.
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- Darbyshire Janet
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- Data Monitoring Committee of the RECOVERY Collaborative Group
- Daunt A.
- Dave V.
- Davey M.
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- Dawson A.
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- de Silva T.
- De Soyza A.
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- Dear J.
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- Desai A.
- Deshpande S.
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- Dhani S.
- Dhasmana Devesh J.
- Dhillon R.
- Dicks P.
- Digby J.
- Dimitri P.
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- Dixon C.
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- Dobbie L.
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- Dolan D.
- Dolman M.
- Donald L.
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- Donohoe A.
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- Duggan A.
- Dummer S.
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- Dunleavy J.
- Dunn A.
- Duran B.
- Durrans L.
- Durrington H.
- Duru I.
- Dymond H.
- D’Costa J.
- D’Mello A.
- Eades C.
- Early J.
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- Edmond N.
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- Elgohary A.
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- Ellwood A.
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- Emberson Jonathan R.
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- Essa F.
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- Everden C.
- Everden S.
- Evison L.
- Ezenduka C.
- Fairbairn I.
- Fairclough A.
- Falconer E.
- Faluyi D.
- Fancois V.
- Farmery T.
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- Farrell B.
- Farzana S.
- Fatemi A.
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- Faust Saul N.
- Fearby S.
- Felton T.
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- Fenton C.
- Ferenando G.
- Ferguson C.
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- Ferguson V.
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- Fowler Robert
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
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- Johnstone E.
- Jones A.
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- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Logue C. A.
- Lokanathan S.
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Get PDFDimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Recommended from our members
An Open Resource for Non-human Primate Imaging.
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- Ai Lei
- Amiez Céline
- Balezeau Fabien
- Baxter Mark G
- Ben Hamed Suliann
- Blezer Erwin LA
- Brochier Thomas
- Chen Aihua
- Croxson Paula L
- Damatac Christienne G
- Dehaene Stanislas
- Everling Stefan
- Fair Damian A
- Fleysher Lazar
- Freiwald Winrich
- Froudist-Walsh Sean
- Griffiths Timothy D
- Guedj Carole
- Hadj-Bouziane Fadila
- Harel Noam
- Hiba Bassem
- Jarraya Bechir
- Jung Benjamin
- Kastner Sabine
- Klink P Christiaan
- Koo Bonhwang
- Kwok Sze Chai
- Laland Kevin N
- Leopold David A
- Lindenfors Patrik
- Margulies Daniel S
- Mars Rogier B
- Menon Ravi S
- Messinger Adam
- Meunier Martine
- Milham Michael P
- Mok Kelvin
- Morrison John H
- Nacef Jennifer
- Nagy Jamie
- Petkov Christopher I
- Pinsk Mark
- Poirier Colline
- Procyk Emmanuel
- Rajimehr Reza
- Reader Simon M
- Rios Michael Ortiz
- Roelfsema Pieter R
- Rudko David A
- Rushworth Matthew FS
- Russ Brian E
- Sallet Jerome
- Schmid Michael Christoph
- Schroeder Charles E
- Schwiedrzik Caspar M
- Seidlitz Jakob
- Sein Julien
- Shmuel Amir
- Sullivan Elinor L
- Thiele Alexander
- Todorov Orlin S
- Tsao Doris
- Ungerleider Leslie
- Wang Zheng
- Wilson Charles RE
- Xu Ting
- Yacoub Essa
- Ye Frank Q
- Zarco Wilbert
- Zhou Yong-di
- Publication venue
- eScholarship, University of California
- Publication date
- 01/10/2018
- Field of study
No full textNon-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
Get PDFThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery
Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries
- Author
- ?tinas A
- Aalem HAA
- Ababneh H
- Abbas A
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- Abbas H
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- Abbassi F
- Abbasy J
- Abbood AH
- Abboud K
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- Abdelhafez MHZ
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- Publication venue
- Publication date
- 18/01/2024
- Field of study
No full textThe impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- Abad‐Gurumeta A
- Abad‐Motos A
- Abassy J
- Abate E
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- Yousof EA
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- Yüksel E
- Zafar SN
- Zakaria AD
- Zakaria Z
- Zakharenko A
- Zambon M
- Zamfir‐Chiru‐Anton M
- Zanus G
- Zegarac M
- Zelić M
- Zengin AK
- Zerbib P
- Zervas K
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- Zografos C
- Zonta S
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- Zourntou S
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- Ângelo M
- Älgå A
- Çelebi F
- Çolak E
- Öfner D
- Öhlberger L
- Özant A
- Özçay N
- Öğücü H
- Überrück L
- Ćoza I
- Ławnicka A
- Žatecký J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
Get PDFAimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P ConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study
- Author
- Abbott Tom
- Abdur‐Rahman Lukman
- Abou Chaar Mohamad K.
- Abukhalaf Sadi A.
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Adisa Adewale
- Agarwal Arnav
- Agastra Ervis
- Aguilera‐Arevalo Maria‐Lorena
- Ahmed Waheed‐Ul‐Rahman
- Aigner Felix
- Akhbari Melika
- Al Balushi Zainab
- AlAmeer Ehab
- Alameer Ehab
- Albertsmeier Markus
- Alderazi Amer
- Alsaadi Hayder
- Alser Osaid
- Alshaar Muhammad
- Alshryda Sattar
- Al‐Naggar Hamza
- Amisi Nicolas
- Argus Leah
- Arnaud Alexis P
- Ayasra Faris
- Azevedo José
- Baiocchi Glauco
- Baiocchi Glauco
- Ball Alasdair
- Bankhead‐Kendall Brittany
- Batista Sylvia
- Bele Uros
- Benson Ruth
- Bhanderi Shivam
- Bhangu Aneel
- Bhangu Aneel
- Biccard Bruce
- Blanco‐Colino Ruth
- Blanco‐Colino Ruth
- Blanco‐Colino Ruth
- Boccalatte Luis
- Bonci Eduard‐Alexandru
- Brar Amanpreet
- Brar Amanpreet
- Bravo Ana Maria Minaya
- Breen Kerry
- Buarque Igor Lima
- Bucyibaruta Georges
- Bywater Edward P
- Cal Fernando Bonilla
- Calvache Jose Andres
- Carlo V. Feo
- Carnevali Adriano
- Carpino Antonio
- Caruana Edward
- Cerovac Anis
- Chakrabortee Sohini
- Chapatwala Reema
- Charles Shane
- Chaudhry Daoud
- Chaudhry Daoud
- Chew Min Hoe
- Christensen Peter
- Costas‐Chavarri Ainhoa
- Cox Daniel
- Cristofaro Maria Giulia
- Cukier Moises
- Cunha Miguel F.
- Dajti Irida
- Daoud Hassan
- Dawson Brett E
- De Paola Gilda
- Delibegovic Samir
- Demetrashvili Zaza
- Demetriades Andreas K
- Desai Anant
- Dhufera Hailu
- Di Saverio Salomone
- Dieu Haragirimana Jean
- Domenico Lacavalla
- Drake Thomas
- Duran Irani
- Edwards John
- Efetov Sergey
- Elhadi Muhammed
- Elhadi Muhammed
- El‐Boghdadly Kariem
- El‐Hussuna Alaa
- Emile Sameh
- Evans Jonathan
- Fakhradiyev Ildar
- Faustin Ntirenganya
- Fiore Marco
- Ford Samuel
- Fotopoulou Christina
- Fowler Alexander
- Fujimoto Yuki
- Futaba Kaori
- Gallo Gaetano
- Ganly Ian
- Ghosh Dhruva
- Ghosh Dhruva
- Gialamas Eleftherios
- Giannaccare Giuseppe
- Gjata Arben
- Glasbey James C
- Glasbey James C
- Gohar Muhammad
- Gomes Gustavo Mendonça Ataíde
- Gomez‐Fernandez Hugo
- Gonzalez Diana Samantha
- Gouvas Nikolaos
- Griffiths Ewen
- Gronchi Alessandro
- Gujjuri Rohan R
- Gujjuri Rohan R
- Gulla Aiste
- Habumuremyi Sosthene
- Hadzibegovic Ana Danic
- Hailu Samuel
- Hamdun Intisar Hisham Said
- Harrison Ewen M
- Harrison Ewen M
- Hilmi Ahmed
- Horisberger Karoline
- Hossain Kamral
- Huang Abel
- Hutchinson Peter
- Hyman Gabriella Yael
- Imanishimwe Alphonsine
- Incorvia Joseph
- Ingabire Jc Allen
- Isik Arda
- Jain Ritu
- Jamal Mohammad
- James Harelimana Grace
- Jayarajah Umesh
- Jenkinson Michael
- Jiménez Pablo Mijahil Avilés
- Jin‐Young Jang
- Jlassi Haithem
- Jones Conor S
- Jonker Pascal
- Kaafarani Haytham
- Kaafarani Haytham
- Kacimi Salah Eddine Oussama
- Kamarajah Sivesh K
- Karout Lina
- Kauppila Joonas H
- Keatley James M
- Kembuan Gabriele
- Khan Tabassum
- Khosravi Mohammad
- Khosravi Mohammad Hossein
- Klat Jaroslav
- Knight Stephen Richard
- Kochetkov Viktor
- Koh Frederick
- Kolias Angelos
- Kopetskyi Slava
- Kopjar Tomislav
- Košir Jurij Aleš
- Kronberger Irmgard
- Kronberger Irmgard Elisabeth
- Kruijff Schelto
- Kudsk‐Iversen Søren
- Kuroda Naoto
- Kwan Tsun Yu
- Lawani Ismaïl
- Lawday Samuel
- Lederhuber Hans
- Lekuya Hervé Monka
- Lekuya Hervé Monka
- Leung Elaine
- Leventoğlu Sezai
- Leventoğlu Sezai
- Li Elizabeth
- Li Elizabeth
- Lincango‐Naranjo Eddy
- Litvin Andrey
- Lohsiriwat Varut
- Lou Wenhui
- Lule Herman
- Lule Herman
- Löffler Markus W.
- Maimbo Mayaba
- Major Piotr
- Mann Harvinder
- Mann Harvinder
- Marco Torchiaro
- Marson Ella J
- Marta Fazzin
- Martin Janet
- Martinez Laura
- Martínez María José
- Mashbari Hassan
- Massimiliano Bernabei
- Mayol Julio
- Mazingi Dennis
- McKay Siobhan
- Mclean Kenneth A
- Mclean Kenneth A
- Meara John G.
- Medina Antonio Ramos‐De
- Mengesha Mengistu G
- Mengesha Mengistu Gebreyohanes
- Mersich Tamás
- Metallidis Symeon
- Michele Rubbini
- Mihanovic Jakov
- Milan Peiman Brouki
- Mills Emily
- Modolo Maria Marta
- Modolo Maria Marta
- Modolo Maria Marta
- Mohan Helen
- Mohsen Mustafa Abo
- Moug Susan
- Mozafari Masoud
- Munyaneza Emmanuel
- Nashidengo Pueya Rashid
- Nayen Alejandra
- Ncogoza Isaie
- Ndong Abdourahmane
- Negoi Ionut
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Ngu James
- Ng‐Kamstra Joshua
- Nicolò Fabbri
- Noltes Milou
- Norman Lisa
- Norman Lisa
- Novembre Daniela
- Novysedlák René
- Ntirenganya Faustin
- Nunez Jade
- Nwegbu Chukwuemeka
- Ofori Bernard
- Ojeda Ximena Paola Vasquez
- Olivos Maricarmen
- Omar Omar M
- Osinaike Babatunde
- Ots Riinu
- Outani Oumaima
- Outani Oumaima
- Outani Oumaima
- Padmore Greg
- Panyko Arpád
- Pata Francesco
- Patel Akshay
- Pejkova Sofija
- Pellino Gianluca
- Perez Rivera Carlos J
- Perinotti Roberto
- Picciochi Maria
- Picciochi Maria
- Pius Riinu
- Pockney Peter
- Pockney Peter
- Qureshi Ahmad Uzair
- Qureshi Ahmad Uzair
- Radenkovic Dejan
- Ramshorst Gabrielle
- Rasoaherinomenjanahary Fanjandrainy
- Recinos Gustavo
- Ren Dong‐Lin
- Rice Henry E.
- Roberts Keith
- Roslani April Camilla
- Roslani April Camilla
- Rutegård Martin
- Sacdalan Marie Dione
- Samadov Elgun
- Samison Luc Hervé
- Sammarco Giuseppe
- Sandoval Danilo Alfonso Arévalo
- Santos Irène
- Santos Irène
- Satoi Sohei
- Satoi Sohei
- Savino Occhionorelli
- Sayyed Raza
- Schache Andrew
- Scorcia Vincenzo
- Seyi‐Olajide Justina
- Shah Rakesh
- Shaw Catherine
- Shaw Catherine
- Shaw Richard
- Shrestha Ashish Lal
- Simoes Joana FF
- Simoes Joana FF
- Simoes Joana FF
- Slavchev Mihail
- Smart Neil
- Steinkamp Pieter
- Stephens Matthew
- Stewart Grant D.
- Sund Malin
- Sánchez Iran Irani Durán
- Tabiri Stephen
- Taylor Elliott H
- Teasdale Ella
- Thereska Dariel
- Townend Philip
- Trout Isobel M
- Tsoulfas Georgios
- Varghese Chris
- Varghese Chris
- Vaughan‐Shaw Peter
- Venn Mary L
- Vidya Raghavan
- Wettstein Dániel
- Wickramasinghe Dakshitha
- Williams Emmanuel
- Williams Omolara
- Wright Deborah
- Wright Naomi
- Wuraola Funmilola
- Wuraola Funmilola
- Xu William
- Yip Sebastian Shu
- Yu Angeli Christy
- Zarour Ahmad
- Zimmelman Natalie
- Zmora Oded
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
No full textPeri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1% (3.3-4.8), 3.9% (2.6-5.1) and 3.6% (2.0-5.2), respectively). Surgery performed >= 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5% (0.9-2.1%)). After a >= 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0%), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms >= 7 weeks from diagnosis may benefit from further delay
Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
- Author
- Ababneh Hazim
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abbo Olivier
- Abbott Tom
- Abd Elwahab Sami
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala'a
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abukhalaf Sadi A.
- Abuleil Amro
- Achalandabaso Boira Mar
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguiar Junior Samuel
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Alberdi San Roman Igor
- Albertsmeier Markus
- Alcaraz Fuentes Marta
- Alderazi Amer
- Aldressi Wafa
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhefdhi Amal
- Alkadeeki Ghadah
- Alkaseek Akram
- Alkhatib Ahmad
- Almabayev Ydyrys
- Almeida-Reis Rui
- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
- Alonso Mendoza Veronica
- Alqudah Majdi Ali
- Alrayes Bourhan
- Alsaadi Hayder
- Alser Osaid
- Alshaar Muhammad
- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
- Althumairi Azah
- Althumairi Azah
- Alyami Mohammad
- Alzahrani Abdulrahman
- Alzaidi Turki M.
- Alzerwi Nasser
- Amisi Nicolas
- Amnaina Mohamed
- Andre Benoit
- Andres Calvache Jose
- Angeles Martina Aida
- Anwer Mariyah
- Anyanwu Lofty-John
- Aqeelah Ahmed
- Aqil Sabra
- Arevalo Sandoval Danilo Alfonso
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
- Asif Muhammad
- Assefa Melatework
- Ataide Gomes Gustavo Mendonca
- Atnafu Bahru
- Aviles Jimenez Pablo Mijahil
- Awad Selmy
- Ayasra Faris
- Ayoub Abdu
- Ayub Bushra
- Azevedo Jose
- Azevedo Jose
- Azevedo Pedro
- Aziz Aliya
- Azzam Ahmed Y.
- Bacalbasa Nicolae
- Badareesh L.
- Badenes Rafael
- Badiani Sarit
- Baia Catarina
- Bains Lovenish
- Baiocchi Glauco
- Bajaj Ankur
- Balanta-Melo Julian
- Baliarsing Lipika
- Ball Alasdair
- Ballouhey Quentin
- Bankhead-Kendall Brittany
- Barillas Sabrina
- Barker John
- Barrena Lopez Cristina
- Barros Aldo Vieira
- Basu Somprakas
- Batista Sylvia
- Behzadi Abdollah
- Bekele Kebebe
- Bele Uros
- Bele Uros
- Bella Romera Susana
- Ben Amer Anass
- Ben Jouira Rayet al Islam
- Benson Ruth
- Bergeat Damien
- Bertrand Marta
- Bescos Coro
- Betalleluz Pallardel Jenner
- Bezabih Yoseph Solomon
- Bhanderi Shivam
- Bhangu Aneel
- Bhat Dhananjaya
- Bhatti Abu Bakar Hafeez
- Bhende Vishal
- Biccard Bruce
- Blanco-Colino Ruth
- Boccalatte Luis
- Boisson Matthieu
- Bolatbekova Raikhan
- Bolger Jarlath
- Bolivar Saenz Dinimo
- Bonci Eduard-Alexandru
- Borda-Luque Giuliano
- Borges Filipe Castro
- Bork Ulrich
- Borowski David W.
- Bouche Pierre-Alban
- Boucher Sophie
- Bouhuwaish Ahmad
- Branquinho Rita
- Brar Amanpreet
- Breen Kerry
- Bright Tim
- Brown Wendy
- Brunaud Laurent
- Brunner Stefan M.
- Buarque Igor
- Buarque Igor Lima
- Bucyibaruta Georges
- Bukhari Syed Imran
- Burgan Dania
- Butyrskii Aleksandr
- Bwala Kefas
- Bywater Edward P.
- Cabanero Sanchez Alberto
- Caiado Andre
- Caicedo Lina
- Caja Vivancos Patricia
- Cal Fernando Bonilla
- Calderon Arancibia Jose Alfredo
- Calvo Espino Pablo
- Canals Sin Ma Pilar
- Canno Velasco Jorge
- Cappeliez Serge
- Cardenas Puiggros Laura
- Cardoso Paulo
- Carlos Bernal-Sprekelsen Juan
- Carpio Colmenares Yahaira Tatiana
- Carrasco Prats Milagros
- Carrera Jacqueline
- Carreras-Castaner Anna
- Caruana Edward
- Castell Gomez Jose Tomas
- Catala Bauset Juan Carlos
- Cerovac Anis
- Chadi Sami
- Chakrabortee Sohini
- Chapatwala Reema
- Charbonneau Helene
- Charles Shane
- Chaudhary Muhammad Hamid
- Chaudhry Daoud
- Chaudhry Navneet Kumar
- Chebaro Alexandre
- Chew Min Hoe
- Choong Peter
- Chowdappa Raghunandan Gorantlu
- Chowdhury Sharfuddin
- Christensen Peter
- Chuan Alwin
- Chwat Carina
- Clancy Cillian
- Colas-Ruiz Enrique
- Connelly Tara
- Connor Clare O.
- Corella Fernando
- Corripio-Sanchez Ramon
- Costa Luciana Cidade
- Costas-Chavarri Ainhoa
- Costea Radu
- Cox Daniel
- Creavin Ben
- Crego Vita Diana
- Cretolle Celia
- Cristina Rahy-Martin Aida
- Croghan Stefanie M.
- Cukier Moises
- Cullinane Carolyn
- Cunha Miguel F.
- D'Aulerio Giuliana
- Dajti Irida
- Daoud Hassan
- Davis Niall
- Dawson Amanda Caroline
- Dawson Brett E.
- De Andres-Asenjo Beatriz
- de Dieu Haragirimana Jean
- De Simone Belinda
- Degefa Eyueal
- Delgado Fernandez Juan
- Delibegovic Samir
- Delisau-Puig Olga
- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K.
- Derilo Habtamu
- des Deserts Marc Danguy
- Desai Anant
- Deus Ana Claudia
- Dharap Satish
- Dhondt Bert
- Dhufera Hailu
- Di Martino Marcello
- Di Saverio Salomone
- Diaz Martinez Eneida
- Diaz-Feijoo Berta
- Diego Garcia Lucia
- Diez Alonso Manuel
- Dimofte Mihail-Gabriel
- Dione Sacdalan Marie
- do Amaral Campos Heloisa Galvao
- Doerner Johannes
- Domenech Julio
- Donlon Noel
- Drake Thomas
- Drasovean Radu
- Duarte Amalia Barrios
- Dube Surya Kumar
- Duchalais Emilie
- Dudi-Venkata Nagendra
- Duprat Neto Joao Pedreira
- Duran Sanchez Iran Irani
- Duran Irani
- Duro Agustin
- Dwaga Sumayya Essayah
- Dziakova Jana
- Earley Helen
- Eberbach Helge
- Edwards John
- Efetov Sergey
- Efetov Sergey
- Egoroff Natasha
- Ekenze Sebastian
- Ekiti Ido
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- El-Hussuna Alaa
- Elhadi Muhammed
- Elhadi Muhammed
- Elhajdawe Fras
- Elliott Brodie
- Ellojli Ibrahim
- Emile Sameh
- Enjuto Diego
- Escudero Mario I.
- Eskander Antoine
- Espin-Basany Eloy
- Espinosa-Bravo Martin
- Estaire Gomez Mercedes
- Evans Jonathan
- Evelyn R Nissi
- Ezanno Anne-Cecile
- Fahadullah Muhammad
- Fahmy Mohamed
- Fakhradiyev Ildar
- Falcon Pacheco Glenda Marina
- Farfus Anthony
- Farik Shebani
- Farooq Umer
- Faustin Ntirenganya
- Fernandez Coimbra Felipe Jose
- Fernandez Martin Maria Teresa
- Fernandez Martinez Daniel
- Fernandez-Lopez Antonio-Jose
- Figueroa-Casanova Rafael
- Filipce Venko
- Filipescu Daniela
- Fiore Marco
- Fisseha Tigist
- Flamey Nicolas
- Fleming Christina
- Flexman Alana
- Fluegen Georg
- Flumignan Ronald
- Ford Samuel
- Forero-Torres Alexander
- Fotopoulou Christina
- Fowler Alexander
- Fredon Fabien
- Freiria Eiras Miguel Angel
- Fuentes Tyare
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- Garcia Laura Saura
- Garcia Soria Vanesa
- Garcia-Adamez Jorge
- Garcia-Montoya Oscar-Julian
- Gaujoux Sebastien
- Gavalda Pellice M. Teresa
- Gebreyohanes Mengistu
- Gempt Jens
- Ghazwani Salman
- Ghodke Rahul
- Ghosh Dhruva
- Ghosh Indranil
- Ghozy Sherief
- Ghunaim Mohammed
- Gialamas Eleftherios
- Gil-Sala Daniel
- Ginghina Octav
- Girard Edouard
- Girard Noemie
- Gjata Arben
- Glasbey James C.
- Glasbey James C.
- Glowka Tim R.
- Gohar Muhammad
- Gomez Fernandez Laura
- Gomez Perez Beatriz
- Gomez-Fernandez Hugo
- Gomez-Rosado Juan-Carlos
- Gonzalez-Suarez Susana
- Gourlay Ralph
- Gousias Konstantinos
- Gouvas Nikolaos
- Grama Florin
- Griffiths Ewen
- Gronchi Alessandro
- Groot Gary
- Gross Jefferson
- Gujjuri Rohan R.
- Gulla Aiste
- Gupta Anand
- Gupta Rahul
- Gut Anna Eleonora
- Gutierrez Perdomo Valentina
- Gutierrez Ruiz Alitza
- Ha Jeong
- Habumuremyi Sosthene
- Hadzibegovic Ana Danic
- Haidar Hanan
- Haider Fayza
- Hailu Samuel
- Hailu Samuel
- Hakami Ibrahim
- Hamad Faten Reyad Bani
- Hamdun Intisar Hisham Said
- Hameed B. M. Zeeshan
- Haran Cheyaanthan
- Harper Luke
- Harrison Ewen M.
- Hashimoto Daisuke
- Hassan Ramy A.
- Hecker Andreas
- Heredia Fernando
- Heriot Alexander
- Hervieux Erik
- Herzberg Jonas
- Hilmi Ahmed
- Hirschburger Markus
- Hodgson Russell
- Hoehn Philipp
- Hollington Paul
- Horch Raymund E.
- Horisberger Karoline
- Hossain Kamral
- Huang Abel
- Husain Shatha
- Hutchinson Peter
- Hyman Gabriella Yael
- Ikele Hilary
- Imanishimwe Alphonsine
- Incorvia Joseph
- Ingabire Jc Allen
- Ionescu Sebastian
- Isik Arda
- Iskander Othman
- Jain Kavitha
- Jain Ritu
- Jamal Mohammad
- James Harelimana Grace
- Javadpour Mohsen
- Javed Saad
- Jaworska Natalia
- Jayarajah Umesh
- Jeandel Clement
- Jenkinson Michael
- Jimaale Elmi Ahmed Mohamed
- Jimenez Toscano Marta
- Jimenez Raul
- Jimenez Virginia
- Jin-Young Jang
- Jira Moa
- Jlassi Haithem
- Jones Conor S.
- Jonker Pascal
- Jorda Sole Misericordia
- Jose Gonzalez-Gimeno Maria
- Jose Martinez Maria
- Jouffret Lionel
- Julia Bergkvist David
- Kaafarani Haytham
- Kabir Syed Mohammad Umar
- Kache Stephen
- Kacimi Salah Eddine Oussama
- Kaidarova Dilyara
- Kaiser Julia Christina
- Kaman Lileswar
- Kamarajah Sivesh K.
- Kamphues Carsten
- Kandevani Naser Yousefzadeh
- Kannaiyan Lavanya
- Kannan Ravi
- Karout Lina
- Karthigeyan Madhivanan
- Kassir Radwan
- Kauppila Joonas H.
- Kavalaka Alfie
- Keatley James M.
- Kembuan Gabriele
- Keppler Alexander M.
- Keppler Lena
- Kerawala Asad Ali
- Khalifa Houda
- Khamees Almu'atasim
- Khan Tabassum
- Khokhar Muhammad Imran
- Khosravi Mohammad Hossein
- Kieser David
- King Jasmin
- Kirov Mikhail
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- Knight Stephen Richard
- Kochetkov Viktor
- Koenigsrainer Alfred
- Koh Cherry
- Koh Frederick
- Kolias Angelos
- Komen Niels
- Konate Ibrahima
- Konrads Christian
- Kopetskyi Slava
- Kopjar Tomislav
- Kosir Jurij Ales
- Kowalski Luiz Paulo
- Kpangon Cyrille
- Kronberger E.
- Kronberger Irmgard Elisabeth
- Kroon Hidde M.
- Kruijff Schelto
- Kruijff Schelto
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- Kulimbet Mukhtar
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- Kumar Ashwani
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- Leung Elaine
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- Li Elizabeth
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- Lindert Judith
- Linz Valerie Catherine
- Litvin Andrey
- Litvin Andrey
- Llaquet Bayo Heura
- Loaloa Mohamed Reda
- Loeffler Markus
- Loeffler Markus W.
- Lohsiriwat Varut
- Losada Manuel
- Lott Natalie
- Lou Wenhui
- Lowey Megan
- Lucia Portilla Ana
- Lugo Duarte Carolina
- Lule Herman
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- Mabood Waleed
- Macchiavello Roberto
- MacKenzie Shawn
- Madabhavi Irappa
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- Maimbo Mayaba
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- Majid Haroon Javaid
- Major Piotr
- Makdissi Fabiana
- Makkai-Popa Silviu Tiberiu
- Maldonado-Marcos Eloy
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- Malik Muhammad Usman
- Manceau Gilles
- Mann Harvinder
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- Marcal Andre
- Maria Trujillo Lina
- Marquez Lucila
- Marson Ella J.
- Marta Modolo Maria
- Martin Lucchini Sergio
- Martin Sole Oriol
- Martin Janet
- Martin-Laez Ruben
- Martinez Alonso Jesus Aaron
- Martinez Laura
- Marulanda Toro Carlos Andres
- Mas Melendez Robinson
- Mashbari Hassan
- Massoud John George
- Matai Anil
- Mateo-Sierra Olga
- Mayol Julio
- Mazingi Dennis
- McDonnell Brendan
- McGuinness Matthew James
- McIntosh Nick
- McKay Siobhan
- Mclean Kenneth A.
- McNestry Catherine
- Meara John G.
- Meelad Ayman
- Mege Diane
- Megersa Abebe
- Mehraj Asif
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- Mendoza Arango Maria Clara
- Mengesha Mengistu G.
- Mersich Tamas
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- Mihanovic Jakov
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- Minaya Bravo Ana Maria
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- Nakagawa Suely
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- Nashidengo Pueya Rashid
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- Nitschke Christine
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- Novysedlak Rene
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- O'Brien Stephen
- Ofori Bernard
- Ojeda Thies Cristina
- Okereke Chukwuma
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- Olaogun Julius
- Olaywah Noor
- Oliveira Joao
- Oliver Guillen Jose Ramon
- Olivos Maricarmen
- Olori Samson
- Omari Rand Y.
- Oosterlinck Wouter
- Ortega Vazquez Irene
- Ortiz Silva Camilo
- Osinaike Babatunde
- Otiniano Alvarado Carlos Eduardo
- Ots Riinu
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- Outani Oumaima
- Pablo Alzate Juan
- Pacilli Maurizio
- Padmore Greg
- Palazon Bellver Pedro
- Pantoja Pachajoa Diana Alejandra
- Panyko Arpad
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Paucar Urbina Arazzelly Del Pilar
- Pawar Pranay
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- Pedraza Salazar Ivana Ines
- Peiper Christian
- Pejkova Sofija
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- Perez-Bertolez Sonia
- Perez-Chrzanowska Hanna
- Perinotti Roberto
- Pfister Karin
- Phadnis Ashish
- Picciochi Maria
- Pigeolet Manon
- Plarre Philipp
- Pockney Peter
- Pockney Peter
- Police Andrea
- Porteiro Marino Lucia
- Porumb Vlad
- Prada Jorge
- Pramesh C. S.
- Prat-Ortells Jordi
- Prieto Mikel
- Putnis Soni
- Pykhteev Vadim
- Qasem Abdulrahman
- Qassem Faisal
- Qassem Mohamed
- Quante Markus
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- Qureshi Ahmad Uzair
- Ra'ed Hazim
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- Raevskaya Marianna
- Rahbari Nuh
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- Rajan Shiv
- Rajanbabu Anupama
- Ramallo-Solis Irene
- Rammohan Ashwin
- Ramos-De la Medina Antonio
- Ramos-Luengo Adolfo
- Ranganath N.
- Rasoaherinomenjanahary Fanjandrainy
- Rassweiler-Seyfried Marie-Claire
- Raut Monish
- Recinos Gustavo
- Regalo Guillermo
- Reim Daniel
- Reinhard Tobias
- Ren Dong-Lin
- Rennie Sarah
- Rennie Sarah
- Rey Valcarcel Cristina
- Riba Martinez Mireia
- Rice Henry E.
- Rida Ahmed Hossam Eldin Fouad
- Rio Javier
- Rios Chiuyari Jose
- Ripolles-Melchor Javier
- Rissmann Anke
- Rivera Lau Lorena Fuentes
- Rivera Carlos J-Perez
- Roberts Keith
- Rodas Alejandra
- Rodriguez Infante Antonio
- Rodriguez Juliana
- Rodriguez-Abreu Julia
- Rodriguez-Tesouro Ana
- Rojas Portilla Fabian
- Rokohl Alexander Christopher
- Roldon Golet Marta
- Roman Garcia de Leon Laura
- Ronellenfitsch Ulrich
- Rosa Ortiz Maria
- Roslani April Camilla
- Roth Andreas
- Rubio-Palau Josep
- Ruiz Velasquez Enrique Jose
- Ruiz-Marin Miguel
- Russell Crispin
- Rutegard Martin
- Ryan Eanna
- Saad Mahmoud M.
- Sacras Maria Luis
- Safieddine Najib
- Saier Tim
- Sale Danjuma
- Saleh Ismail Ali
- Salem Marwa
- Saliev Timur
- Sallam Asser
- Samadov Elgun
- Samaka Rehab
- Samantha Gonzalez Diana
- Samison Luc Herve
- Sampaio-Alves Mafalda
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- Sanchez Lopez Anna
- Sanchez Mozo Ana
- Sanchez-Cabus Santiago
- Sancho-Muriel Jorge
- Santos Irene
- Santos-Costa Paulo
- Sanz-Gonzalez Rosa
- Sarjanoja Elise
- Sarwar Muhammad Zeeshan
- Satoi Sohei
- Sayyed Raza
- Scalabre Aurelien
- Schache Andrew
- Schlager Daniel
- Schmedding Andrea
- Schnitzbauer Andreas
- Schoneveld Martijn
- Seeliger Barbara
- Seguin-Givelet Agathe
- Sekar Arunkumar
- Serralheiro Pedro
- Serrano Gonzalez Javier
- Seyi-Olajide Justina
- Shah Rakesh
- Shanthanna Harsha
- Sharma Abhishek
- Sharma Rahul Deo
- Sharma Shilpa
- Shaw Catherine
- Shaw Richard
- Shehata Sameh
- Shehta Ahmed
- Sherif Ahmed Elshawadfy
- Shrestha Ashish Lal
- Shu Yip Sebastian
- Shu Sebastian
- Shumbash Kibruyisfaw
- Sieira-Gil Ramon
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- Publication date
- 01/01/2021
- Field of study
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Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study an international prospective cohort study
- Author
- Ababneh Hazim
- Abad-Motos Ane
- Abbas Ferial Mohamed Ali
- Abbo Olivier
- Abbott Tom
- Abbott Tom
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdoun Meriem
- Abdur-Rahman Lukman
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala A.
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abuawad Carla
- Abukhalaf Sadi A.
- Abuleil Amro
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agarwal Ketan
- Agastra Ervis
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguilera-Arevalo Maria-Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmadi Navid
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Aiken Taylor
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Islam Ben Jouira Rayet
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Al-Naggar Hamza
- Al-Raimi Ibrahim
- Al-Sabbagh Yusra
- Al-Shehari Mohammed
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- AlAmeer Ehab
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Albared Sara Maa
- Albertsmeier Markus
- Albertsmeier Markus
- Alderazi Amer
- Aldlyami Ehab
- Aldressi Wafa
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- Alharthi Mohammed
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- Alkhatib Ahmad
- Allemand Carola
- Almabayev Ydyrys
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- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
- Alnachoukati Omar
- Alnahr Hareth
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
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- Alrayes Bourhan
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- Villanueva Julio
- Vimalakanthan Thanusan
- Vita Diana Crego
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- Vives Josep Maria Muñoz
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- Vázquez Irene Ortega
- Wafi Omar
- Wagner Arthur
- Waissbluth Sofia
- Waqar Shahzad Hussain
- Watson David
- Watson Eleanor
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- Weeraddana Prabuth Dulanjan
- Wells Cameron
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- Wettstein Dániel
- Wickramasinghe Dakshitha
- Wickramasinghe Dakshitha
- Wiegering Armin
- Wijeysundera Duminda
- Williams Emmanuel
- Williams Omolara
- Williams Omolara
- Wilson Michael
- Wolf Sebastian
- Wolfer Susanne
- Wong Enoch
- Wright Deborah
- Wright Deborah
- Wright Naomi
- Wuraola Funmilola
- Wuraola Funmilola
- Xaviour Okedi Francis
- Xu William
- Yadev I.
- Yagoub Ghozlan
- Yaqoob Eesha
- Yaqoob Hassan Nawaz
- Yasin Seid Mohammed
- Yazbek Guilherme
- Yebes Alvaro
- Yeung Justin
- Yip Sebastian Shu
- Youssef Mina
- Zabaleta Jon
- Zahid Imdad Ahmad
- Zanoni Gerardo
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarnescu Narcis Octavian
- Zarour Ahmad
- Zarour Ahmad
- Zarour Ahmad
- Zarratea Celeste Soledad
- Zegarra Sergio
- Zequi Stenio C.
- Zezular Damaris Idara Anabel
- Zhou Xuanyu
- Zhussupov Baurzhan
- Zijaj Lorena
- Zimmelman Natalie
- Zmora Oded
- Zmora Oded
- Zohra Belabbes Fatima
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
No full textWe aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
