66 research outputs found
Task Failure Prediction in Cloud Data Centers Using Deep Learning
A large-scale cloud data center must reduce the likelihood of failure while simultaneously providing high service dependability and availability. However, modern large-scale cloud data centers continue to experience high failure rates due to software and hardware flaws that frequently cause task and job failures. Such failures may have a significant negative impact on the dependability of cloud services and necessitate significant resource restoration. Task or work failures must be accurately predicted prior to their occurrence in order to reduce unexpected waste. Evaluation of previous system message logs and recognition of the relationship between the data and failures are two methods that have been published that use machine learning and deep learning to predict task or job failures. We present a cloud task and job failure prediction strategy based on multi-layer Bidirectional Long Short Term Memory (Bi-LSTM) to improve the accuracy of machine learning and deep learning-based failure prediction systems. The Bi-LSTM prediction algorithm determines the success of jobs and projects. With 93% and 87% accuracy for task failures, respectively, our method outperforms current cutting-edge prediction algorithms in trace-driven experiments
All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis
Background
Although alcohol use disorders (AUD) are known to increase the relative risk of all-cause and some cause-specific mortalities, the absolute mortality rates of the AUD population are unknown. Such knowledge would benefit planners of the provision of services for this population, including in prioritising the identification and/or treatment of diseases likely to cause their death.
Methods
We conducted a systematic review of studies in English, reporting the cause-specific mortality rates among people treated for AUD. Number of deaths by cause, and total person-years of follow-up were extracted. All-cause and cause-specific mortality rates per 1000 person-years were meta-analysed assuming random effects.
Results
31 studies were included. Participants were mainly middle-aged males. The quality of studies was generally good. 6,768 all-cause deaths in 276,990.7 person-years of follow-up (36,375 patients) were recorded and the pooled all-cause mortality rate was 27.67/1000 person years (py) (95% confidence interval (CI) 23.9, 32.04). The commonest cause of death in the AUD population was cardiovascular disease (CVD) (6.9/1000py (95%CI 5.61, 8.49)), followed by gastrointestinal deaths (5.63/1000py (95%CI 4.1, 7.74)), unnatural deaths (4.95/1000py (95%CI 4.01, 6.09)), neoplasms, respiratory diseases and substance use disorders.
Conclusions
Patients with AUD have increased rates of all-cause and cause-specific mortality compared to the general population. Like the general population, they are most likely to die of CVD. In contrast to the general population, gastrointestinal and unnatural deaths are the next most common causes of death. We believe these facts should be considered when planning healthcare services for patients with AUD
Modulation of Plant Defense System in Response to Microbial Interactions
© Copyright © 2020 Nishad, Ahmed, Rahman and Kareem. At different stages throughout their life cycle, plants often encounter several pathogenic microbes that challenge plant growth and development. The sophisticated innate plant immune system prevents the growth of harmful microbes via two interconnected defense strategies based on pathogen perception. These strategies involve microbe-associated molecular pattern-triggered immunity and microbial effector-triggered immunity. Both these immune responses induce several defense mechanisms for restricting pathogen attack to protect against pathogens and terminate their growth. Plants often develop immune memory after an exposure to pathogens, leading to systemic acquired resistance. Unlike that with harmful microbes, plants make friendly interactions with beneficial microbes for boosting their plant immune system. A spike in recent publications has further improved our understanding of the immune responses in plants as triggered by interactions with microbes. The present study reviews our current understanding of how plant–microbe interactions can activate the sophisticated plant immune system at the molecular level. We further discuss how plant-microbe interaction boost the immune system of plants by demonstrating the examples of Mycorrhizal and Rhizobial association and how these plant-microbe interactions can be exploited to engineer disease resistance and crop improvement.This study was supported by GSRA (Grant GSRA2-1-0608-14021) from the Qatar National Research Fund (a member of Qatar foundation)
A modified multi-level inverter system for grid-tied DES applications
Energy harvesting from renewable energy sources is trending in the world due to inventions in modern technology. This paper proposes a grid-tied single-phase modified W-type 81-level inverter. Inverter design equations to calculate various parameters, such as the number of voltage levels and the number of DC power sources, along with the feedback controller equations, are developed to integrate the proposed topology with an electric power grid. The modeling of the control system for the proposed topology is carried out in the synchronously rotating reference frame for single-phase systems. The PWM generation part of the proposed inverter system makes use of the binary search nearest level algorithm to efficiently track the grid voltage signal. The proposed system integrates the inverter with the grid without the need for an output filter. The efficiency analysis shows that the proposed system delivers active and reactive power to the grid with an efficiency of around 90% and a THD of 1.04%. The voltage and current waveforms for the dynamic active and reactive power flow reveal that the proposed system exhibits a good transient and steady-state response. The overall system is simulated in MATLAB/Simulink and the results are verified using a hardware implementation of the prototype circuit.Web of Science1424art. no. 1654
Exploring UK Knife crime and its associated factors: A content analysis of online newspapers
Knife crime has become a common phrase used by the media, but it is not always clear what it refers to or what
they mean when they use the term. Knife crime can cover many offences, making it challenging to define and
estimate its prevalence. This review aimed to evaluate potential knife crimes in the UK from 2011 to 2021 and
analyse the causes and risk factors associated with the crimes. Six UK online news portals were purposefully
chosen to be included in the study, and knife crime news was searched retrospectively. The term "knife crime"
was used to search. The news portals were the: Metro, the Sun, the Guardian, Daily Mail, Daily Mirror and the
Evening Standard. In the assigned news portals, 692 reports were found between January 2011 and December
2021. The study revealed that the 11-20 years of age group individuals are more vulnerable as victims, and
males are more reported as victims when compared to females. About 61.8% of knife crimes are reported from
South England. Knife crime risk is higher in early adulthood and among males. Street violence, fights/gang
attacks, family issues and robbery are the leading causes of knife crime and have all been identified as risk
factors that must be addressed with caution
A novel method for life estimation of power transformers using fuzzy logic systems: An intelligent predictive maintenance approach
Power transformers are a fundamental component of the modern power distribution network. The fault-free operation of step-up and step-down transformers is of prime importance to the continuous supply of electrical energy to the consumers. To ensure such efficient operation, power distribution companies carry out routine maintenance of distribution transformers through preplanned schedules. The efficacy of such maintenance depends on a proper understanding of the transformer and its components and efficient prediction of faults in these components. There are several components whose condition can be studied to predict transformer failures and therefore the overall health of a transformer. These include transformer windings, insulations, transformer oil, core insulations, and ferromagnetic cores. This work develops a new, simplified fuzzy logic-based method to predict the health of a transformer by taking into account the state of several individual components. Case studies are used to demonstrate the efficacy of the developed method
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.
Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231.
Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001).
Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey
Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020
Global Retinoblastoma Presentation and Analysis by National Income Level.
Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs
- …