103 research outputs found
Finding consistent disease subnetworks across microarray datasets
- Author
- A Bhattacharjee
- A Subramanian
- AY Sivachenko
- B Gerull
- D Dong
- D Krishna
- D Singh
- D Soh
- D Soh
- Difeng Dong
- Donny Soh
- E Yeoh
- H Lähdesmäki
- J Lapointe
- J Wang
- JJ Goeman
- JN Haslett
- L Ein-Dor
- L Juliana
- Limsoon Wong
- M Itoh-Satoh
- M Liu
- M Pescatori
- M Zhang
- MA Booden
- ME Garber
- ME Ross
- ML Green
- N Friedman
- N Kotecha
- N Salomonis
- P Baker
- P Balagopal
- P Hackman
- P Khatri
- P Pavlidis
- R Kristelly
- S Garvey
- S Katzav
- S Michiels
- SA Armstrong
- TH Cormen
- TR Golub
- VG Tusher
- Yike Guo
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>While contemporary methods of microarray analysis are excellent tools for studying individual microarray datasets, they have a tendency to produce different results from different datasets of the same disease. We aim to solve this reproducibility problem by introducing a technique (SNet). SNet provides both quantitative and descriptive analysis of microarray datasets by identifying specific connected portions of pathways that are significant. We term such portions within pathways as “subnetworks”.</p> <p>Results</p> <p>We tested SNet on independent datasets of several diseases, including childhood ALL, DMD and lung cancer. For each of these diseases, we obtained two independent microarray datasets produced by distinct labs on distinct platforms. In each case, our technique consistently produced almost the same list of significant nontrivial subnetworks from two independent sets of microarray data. The gene-level agreement of these significant subnetworks was between 51.18% to 93.01%. In contrast, when the same pairs of microarray datasets were analysed using GSEA, t-test and SAM, this percentage fell between 2.38% to 28.90% for GSEA, 49.60% tp 73.01% for t-test, and 49.96% to 81.25% for SAM. Furthermore, the genes selected using these existing methods did not form subnetworks of substantial size. Thus it is more probable that the subnetworks selected by our technique can provide the researcher with more descriptive information on the portions of the pathway actually affected by the disease.</p> <p>Conclusions</p> <p>These results clearly demonstrate that our technique generates significant subnetworks and genes that are more consistent and reproducible across datasets compared to the other popular methods available (GSEA, t-test and SAM). The large size of subnetworks which we generate indicates that they are generally more biologically significant (less likely to be spurious). In addition, we have chosen two sample subnetworks and validated them with references from biological literature. This shows that our algorithm is capable of generating descriptive biologically conclusions.</p
Phylogenomic analysis of the Chlamydomonas genome unmasks proteins potentially involved in photosynthetic function and regulation
- Author
- A Amunts
- A Camargo
- A Fu
- A Makino
- A Melis
- A Vardi
- A Wilson
- AE Gau
- AL Givan
- AR Grossman
- AR Grossman
- Arthur R. Grossman
- AY Mulkidjanian
- AZ Worden
- B Moll
- B Naumann
- B Palenik
- B Zybailov
- BL Gutman
- Blaise Hamel
- C Bowler
- C de Vitry
- C Raynaud
- C-S Im
- D Drapier
- D González-Ballester
- D González-Ballester
- D Higgs
- D Rumeau
- David Dewez
- DL Herrin
- DM Kehoe
- DS Gorman
- E Asamizu
- E Asamizu
- E Fernandez
- E Fernández
- E Fernández
- EH Harris
- EH Harris
- EJ Stauber
- EV Armbrust
- Francis-André Wollman
- G Barbier
- G DalCorso
- G Finazzi
- G Forti
- G Peers
- G Ren
- G Rocap
- GW Schmidt
- HK Ledford
- HK Ledford
- Huiying Li
- J Lavorel
- J Minagawa
- J Moseley
- J Rohr
- J Shrager
- J Zhu
- JC Long
- JD Rochaix
- JD Rochaix
- Jean Alric
- JR Bordowitz
- K Asada
- K Duan
- K Niyogi
- K Redding
- K Schult
- KP Lee
- Krishna K. Niyogi
- L Lezhneva
- LA Rymarquis
- LC Keller
- M Goldschmidt-Clermont
- M Jain
- M Kusaba
- M Matsuzaki
- M Nakao
- M Posewitz
- M Schmid
- M Schmidt
- M Tejada-Jimenez
- Mark Heinnickel
- MJ Whitaker
- ML Ghirardi
- N Rolland
- NPA Huner
- O Misumi
- P Bennoun
- P May
- P May
- P Stepien
- PJ Krysan
- R Kuras
- R Sager
- RA Eversole
- Rachel Dent
- RG Walters
- RM Dent
- RP Levine
- RP Levine
- RP Levine
- S Baginsky
- S Bailey
- S Eberhard
- S Lu
- S Ozawa
- Sabeeha S. Merchant
- SL Zimmer
- SS Merchant
- SS Merchant
- Steven J. Karpowicz
- T Kleffmann
- T Kohinata
- T Pfannschmidt
- T Zhao
- TJ Bollenbach
- U Heber
- U Klein
- U Maheswari
- V Sato
- V Wagner
- V Wagner
- V Wagner
- W Zerges
- X Gokhale
- X Li
- Xenie Johnson
- Y Choquet
- Y Sato
- Z Li
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2010
- Field of study
Chlamydomonas reinhardtii, a unicellular green alga, has been exploited as a reference organism for identifying proteins and activities associated with the photosynthetic apparatus and the functioning of chloroplasts. Recently, the full genome sequence of Chlamydomonas was generated and a set of gene models, representing all genes on the genome, was developed. Using these gene models, and gene models developed for the genomes of other organisms, a phylogenomic, comparative analysis was performed to identify proteins encoded on the Chlamydomonas genome which were likely involved in chloroplast functions (or specifically associated with the green algal lineage); this set of proteins has been designated the GreenCut. Further analyses of those GreenCut proteins with uncharacterized functions and the generation of mutant strains aberrant for these proteins are beginning to unmask new layers of functionality/regulation that are integrated into the workings of the photosynthetic apparatus
Consensus guidelines for the use and interpretation of angiogenesis assays
- Author
- A Adini
- A Anisimov
- A Aspelund
- A Bikfalvi
- A Bouchet
- A Caporali
- A Fantin
- A Folch
- A Fraccaroli
- A Grutzkau
- A Haeger
- A Hayer
- A Helisch
- A Hruscha
- A Johns
- A Khademhosseini
- A Laude
- A Moldobaeva
- A Ny
- A Otani
- A Passaniti
- A Poltorak
- A Reade
- A Rossi
- A Sadanandam
- A Sakaue-Sawano
- A Scarpa
- A Scott
- A Stahl
- A Stahl
- A Stahl
- A Vargas
- A Vargas
- A Warth
- A Weiss
- A Weiss
- A Weiss
- A Zumsteg
- AA Hellingman
- AA Keskinov
- AA Nazarov
- AC Aplin
- AC Aplin
- AC Newman
- AC Tufan
- Adrian L. Harris
- AE Birsner
- AF Alghanem
- AF Orozco
- Agnes Noel
- AH Rizvi
- AJ Bastiaansen
- AJ Bastiaansen
- AJ Donato
- Alfred C. Aplin
- AM Cimpean
- AM Cimpean
- AM Ochsenbein
- Amber N. Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- Anca M. Cimpean
- Andreas Bikfalvi
- Andrew C. Dudley
- Andrey Anisimov
- Anna Dimberg
- Anna M. Randi
- Anna-Karin Olsson
- AO Dokun
- AO Dokun
- AO Smith
- AQ Reuwer
- Arjan W. Griffioen
- AS Harney
- AV Gore
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AY Nossent
- B Blouw
- B Garmy-Susini
- B Huang
- B St Croix
- B Uzzan
- Bahar Yetkin-Arik
- Barbara C. Böck
- Bart Ghesquière
- Bertan Cakir
- BH Annex
- BJ Vakoc
- BL Roman
- BM Hogan
- BM Kenyon
- BM Weinstein
- BM Weinstein
- BP Dranka
- Brant M. Weinstein
- Brenda R. Kwak
- C Abe
- C Bais
- C Betz
- C D’Souza-Schorey
- C Gentile
- C Korn
- C Monaco
- C Navarro-Requena
- C Poelma
- C Sarkar
- C Secondini
- C Stockmann
- C Viallard
- CA Bichsel
- CA Fernandez
- CA Staton
- CB Kimmel
- CB Moens
- CD Sarsons
- CF Buchanan
- Christopher C. W. Hughes
- CM Clavel
- CM Clavel
- CM Svensson
- CP Dagg
- CT Farrar
- CT Guy
- Curzio Ruegg
- CV Crosby
- CW Chiu
- D Boulate
- D Butler
- D Chalothorn
- D Fukumura
- D Fukumura
- D Fukumura
- D Gau
- D Hanahan
- D Hanahan
- D Hanahan
- D Huh
- D Kardamakis
- D Ribatti
- D Ribatti
- D Ribatti
- D Ribatti
- D Ribatti
- D Stibal
- D Thomas
- D Verdegem
- DA Berk
- DA Ingram
- DA MacDonald
- Dai Fukumura
- Daniel Castranova
- David O. Bates
- DC Duffy
- DC West
- DG DeNardo
- DH Ausprunk
- DH Ausprunk
- DH Nguyen
- DM Roth
- DO Croci
- DO Traktuev
- Domenico Ribatti
- DP Kodack
- DR Enis
- DR Senger
- DS Dohle
- DS Friedman
- DT Nguyen
- DTT Phan
- DY Stainier
- E Akbari
- E Allen
- E Berthier
- E Boscolo
- E Brown
- E Debefve
- E Morgan
- E Passalidou
- E Paunescu
- E Raymond
- E Rooijen van
- E Stabile
- E Wienholds
- E Zudaire
- EA Kleibeuker
- EA Kuczynski
- EA Pierce
- EB Brown
- ED Perryn
- EI Deryugina
- EI Deryugina
- EJ Huijbers
- EJ Yeo
- EK Sackmann
- Elisabeth Kuczynski
- Elizabeth Allen
- EY Lin
- EY Lin
- EY Lin
- EY Lin
- F Bussolino
- F Denizot
- F Hillen
- F Kuonen
- F Pezzella
- F Pezzella
- F Piffaretti
- F Pisati
- F Soulet
- F Soulet
- F Winkler
- F Yuan
- F Yuan
- Federico Bussolino
- FO Kok
- G Alexandrakis
- G Benton
- G Bergers
- G Bergers
- G Bergers
- G Bergers
- G Cheng
- G Christofori
- G Costa
- G Degenfeld von
- G Gruionu
- G Helmlinger
- G Hendrikx
- G Lorusso
- G Martano
- G Seano
- G Serini
- G Solinas
- G Tang
- GA Truskey
- Gabriel A. Rabinovich
- Gabriele Bergers
- GE Davis
- George Coukos
- George E. Davis
- GH Algire
- GJ Patti
- GK Varshney
- GK Varshney
- GM Birdsey
- GM Whitesides
- GR Martin
- GT Motz
- H Gerhardt
- H Huang
- H Lee
- H Naito
- H Ozaki
- H Xin
- Hellmut G. Augustin
- HF Clark
- HG Augustin-Voss
- HK Kleinman
- HM Jung
- HM Jung
- HM Shapiro
- Hong Xin
- HS Jeong
- HS Jeong
- Hynda K. Kleinmann
- I Ahmet
- I Keklikoglou
- I Kholova
- I Martinez-Corral
- I Masaki
- I Mattsby-Baltzer
- I Moreno-Jimenez
- IF Tannock
- IK Zervantonakis
- IK Zervantonakis
- IL Weissman
- IM Aspalter
- Ingeborg Klaassen
- International Chicken Genome Sequencing C
- IP Torres Filho
- IW Tattersal
- J Borges
- J Chen
- J Folkman
- J Folkman
- J Folkman
- J Folkman
- J Hoarau-Vechot
- J Kalucka
- J Laurent
- J Laurent
- J LeCouter
- J Loegl
- J Muppidi
- J Nissanov
- J Nurro
- J Patel
- J Sandison
- J Torres-Vazquez
- J Waltenberger
- J Wilting
- J Zhang
- J Zhou
- JA Nagy
- JA Villefranc
- JA Villefranc
- JA Yu
- Jan Kitajewski
- JB Wyckoff
- JC Wigle
- JC Yao
- JE Lahteenvuo
- Jeffrey W. Pollard
- JH Gao
- JH Harmey
- JI Lundin
- Jimmy Stalin
- JJ Belch
- JJ Sheu
- JK Patel
- JL Lucitti
- JM Buescher
- JM Herbert
- JM Melero-Martin
- JM Melero-Martin
- JM Melero-Martin
- Joanna Kalucka
- Johannes Waltenberger
- Jonathan W. Song
- Joyce Bischoff
- JP Cooke
- JP Nolan
- JP Sleeman
- JQ Yu
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Beijnum van
- JR Neely
- JS Miller
- JS Schechner
- JS Silvestre
- Juan M. Melero-Martin
- Judy R. van Beijnum
- Jussi Nurro
- JW Baish
- JW Baish
- JW Song
- JW Song
- JW Song
- JY Perentes
- K Bock De
- K Hida
- K Inagaki
- K Jung
- K Kawakami
- K Lu
- K Norrby
- K Yaniv
- K Zhi
- K-T Kang
- Kari Alitalo
- KE Bogt van der
- KH Wong
- KJ Gotink
- KM Argraves
- KM Chrobak
- KM Connor
- KM Downs
- KM Downs
- KM Downs
- KM Kwan
- KM Malinda
- KM Malinda
- KM Marien
- KM Shaw
- Koen Marien
- Kristian Pietras
- KS Samkoe
- KS Samkoe
- KT Kang
- KT Kang
- L Dumartin
- L Eklund
- L Gambardella
- L Guedez
- L Guen Le
- L Huang
- L Jakobsson
- L Morbidelli
- L Nebuloni
- L Norgren
- L Schaad
- LA Herzenberg
- Lance L. Munn
- LB Rivera
- LB Rivera
- LC Hamming
- LE Jao
- LE Smith
- LE Smith
- LI Shlush
- LK Chang
- LL Bischel
- LM Ebert
- LM Ellis
- Lois E. H. Smith
- M Ackermann
- M Arditi
- M Arras
- M Baker
- M Bani
- M Bulkowska
- M Chen
- M Chiba
- M Dellian
- M Fujita
- M Garcia-Caballero
- M Gotberg
- M Hagedorn
- M Hellstrom
- M Inoue
- M Jeltsch
- M Jost
- M Kamei
- M Kucinska
- M Leunig
- M Masiero
- M Merjaneh
- M Mura
- M Nguyen
- M Paez-Ribes
- M Palma De
- M Palma De
- M Palma De
- M Papoutsi
- M Potente
- M Potente
- M Prewett
- M Prokopi
- M Schmittnaegel
- M Schmittnaegel
- M Singh
- M Skobe
- M Snuderl
- M Stroh
- M Sugimoto
- M Upreti
- M Venero Galanternik
- M Westerfield
- M Winderlich
- M Won
- M Yuan
- M Ziche
- M. Luisa Iruela-Arispe
- MA Gimbrone Jr
- MA Lijkwan
- Marcus Fruttiger
- Marius Raica
- Mark J. Post
- Maureen Van de Velde
- MB Gorbet
- MB Powner
- MC Kibbey
- MC Mullins
- MC Oostrom van
- ME Hartnett
- ME Pennesi
- ME Pitulescu
- ME Staab
- Melita Irving
- Mervin C. Yoder
- MG Krzystolik
- MI Bogorad
- Michele De Palma
- MJ Hamm
- MJ Siemerink
- MN Nakatsu
- MN Nakatsu
- MP Craig
- MR Mancuso
- MR Ritter
- MS Rogers
- MW Laschke
- N Bhattacharjee
- N Chang
- N Gao
- N Guex
- N Koike
- N Lange
- N Linde
- N Prasain
- N Rigamonti
- N Weidner
- Nan W. Hultgren
- Napoleone Ferrara
- ND Kirkpatrick
- ND Lawson
- ND Lawson
- ND Lawson
- ND Wangsa-Wirawan
- NE Timmins
- Neil P. Dufton
- NN Rahbari
- NW Choi
- O Casanovas
- O Chen
- O Chen
- Ondine Cleaver
- P Allen
- P Allen
- P Au
- P Au
- P Au
- P Carmeliet
- P Carmeliet
- P Fergelot
- P Jain
- P Lovelace
- P Mistriotis
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Nowak-Sliwinska
- P Parsons-Wingerter
- P Pedrosa
- P Rous
- P Spuul
- P Thirusangu
- P Vennemann
- P Vitorino
- P Zorzi
- PA Galie
- PA Williams
- Patrycja Nowak-Sliwinska
- Paul H. A. Quax
- PB Vermeulen
- Peter B. Vermeulen
- Peter C. Brooks
- Peter Carmeliet
- PH Burri
- Pieter Koolwijk
- PJ Dam van
- PJ Polverini
- PK Shireman
- PO Magalhaes
- PR Blackburn
- PT Jong de
- Q Chang
- QC Yu
- R Arora
- R Arora
- R Auerbach
- R Auerbach
- R Brauer
- R Cavill
- R Forough
- R Hlushchuk
- R Hlushchuk
- R Hlushchuk
- R Kalluri
- R Mazzieri
- R Medzhitov
- R Montesano
- R Nicosia
- R Noy
- R Salcedo
- R Samuel
- R Sealock
- R Swadi
- R Toro del
- R Xu
- R Zhang
- R. Hugh F. Bender
- Raghu Kalluri
- Rakesh K. Jain
- RE Conway
- RE Unger
- Reinier O. Schlingemann
- RF Nicosia
- RF Nicosia
- RF Nicosia
- RF Nicosia
- RH Berndsen
- RH Berndsen
- RJ Blatt
- RJ DeBerardinis
- RJ Medina
- RJ Melder
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RK Jain
- RN Kaplan
- RO Schlingemann
- Robert Auerbach
- Robert J. Griffin
- Robert S. Kerbel
- Roberto F. Nicosia
- Roberto Pili
- RP Dings
- RR Ramjiawan
- RS Camplejohn
- Ruud P. M. Dings
- RZ Lin
- RZ Lin
- RZ Lin
- RZ Lin
- RZ Lin
- S Akira
- S Blacher
- S Boyden
- S Cattin
- S Comsa
- S Dymarkowski
- S Fang
- S Ferber
- S Frentzas
- S Ghaffari
- S Ghaffari
- S Goel
- S Greenberger
- S Greenberger
- S Haricharan
- S Hirakawa
- S Isogai
- S Isogai
- S Isogai
- S Javerzat
- S Kim
- S Kim
- S Lalonde
- S Lotfi
- S Mocellin
- S Nakao
- S Parangi
- S Rezzola
- S Rezzola
- S Sawamiphak
- S Schoors
- S Schulte-Merker
- S Schwartz
- S Seaman
- S Stillfried von
- S Tual-Chalot
- S Xiao
- S Yla-Herttuala
- SA Stacker
- SA Stacker
- Sarah-Maria Fendt
- SE Epstein
- Seppo Yla-Herttuala
- SH Lim
- SH Poor
- SJ Ryan
- SJ Wakelin
- SK Hobbs
- SL Bowers
- SM Ehsan
- SM Eswarappa
- SM Krishna
- SM Welten
- SM Wilson
- SO Park
- SP Crampton
- SP Williams
- SP Williams
- SR Chary
- SS Edwards
- Stefan Schulte-Merker
- Steven A. Stacker
- SV Prykhozhij
- T Asahara
- T Couffinhal
- T Donnem
- T Donnem
- T Gohongi
- T Kochi
- T Kuusk
- T Lagerweij
- T Murakami
- T Reiberger
- T Schreier
- T Wisenbaugh
- Tatiana V. Petrova
- TD Palmer
- TI Valdes
- TI Valdes
- TJ Gambino
- TO Auer
- TP Padera
- TP Padera
- TS Westvik
- TT Rissanen
- TT Rissanen
- TV Petrova
- TV Petrova
- U Sauer
- V Djonov
- V Hamburger
- V Huntosova
- V Joukov
- V Lambert
- V Muthukkaruppan
- V Perugini
- V Tchaikovski
- V Tchaikovski
- V Torres-Estay
- V Vickerman
- V Weel van
- V Weel van
- V Weel van
- Valentin Djonov
- Victor W. M. van Hinsbergh
- VL Bridgeman
- VL Thijssen
- VN Pham
- VP Chauhan
- VP Chauhan
- VS Shirure
- VS Shirure
- VV Masson
- VV Tuchin
- W Driever
- W Huang
- W Jakob
- W Jin
- W Kim
- W Koh
- W Lu
- W Lu
- W Pan
- W Song
- W Yi
- WS Kamoun
- WS Lee
- WW Kilarski
- WW Kilarski
- WW Kilarski
- WY Choi
- WY Hwang
- WY Hwang
- X Chen
- X Gu
- X Li
- X Meng
- X Wang
- X Wang
- X Wang
- XM Lopez
- XM Wijk van
- Y Adar
- Y Gazit
- Y Gazit
- Y Gong
- Y He
- Y Izumi
- Y Lei
- Y Li
- Y Lin
- Y Sato
- Y Tsuzuki
- Y Yang
- Y Yang
- Y Zhang
- Y Zhang
- Y Zheng
- Y Zheng
- Y Zhu
- Yan Gong
- YC Chen
- YH Hsu
- YK Young
- YR Cha
- Z Raval
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
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- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
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- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
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- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
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- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
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- Abdelhady S
- Abdelhamed R
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- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
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- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
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- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
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- Eyssartier E
- Ezzat E
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- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
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- Farhangmehr N
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- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
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- Fermani C
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- Fernandes C
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- Filatau A
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- Francone E
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- Frey D
- Frisk B
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- Fujii F
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- Gaarder T
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- Gadhvi V
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- Halicioglu I
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- Mironescu A
- Mironescu AS
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- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
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- Mittal A
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- Moe TT
- Mogan YP
- Moghazy ME
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- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
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- Mohammed AR
- Mohammed H
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- Mohammed MMH
- Mohammed S
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- Montrimaite M
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- Mosalum O
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- Mostafa M
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- Mshelbwala P
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- Nanthakumaran S
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- Negida A
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- Njokanma I
- Nnajiuba H
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- Samaraweera DI
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- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Competitive cobalt for zinc substitution in mammalian methionine sulfoxide reductase B1 overexpressed in E. coli: structural and functional insight
- Author
- A Curdel
- A Rodrigue
- Alexander Dikiy
- AY Mulkidjanian
- B Xu
- B Xu
- BC Lee
- BL Vallee
- C Andreini
- D Koch
- DC Speckhard
- DM Veine
- DR Holland
- DS Auld
- Elena Shumilina
- F Aachmann
- FM Ranaivoson
- G Minetti
- GV Kryukov
- H Irving
- H Weissbach
- Henrik Waldal Holen
- HY Kim
- HY Kim
- I Bertini
- I Bertini
- I Bertini
- I Moura
- J Moskovitz
- L Banci
- L Banci
- LB Dugad
- LS Sal
- M Stefanidou
- M Vasak
- O Seneque
- Olena Dobrovolska
- RA Kumar
- Rebecca Del Conte
- RH Holm
- RJP Williams
- S Balayssac
- S Boschi-Muller
- SP Salowe
- SR Lee
- SS Krishna
- T Wassenaar
- TC Stadtman
- TW Lane
- VN Gladyshev
- W Maret
- W Maret
- WT Lowther
- Y Shi
- Y Zhang
- YK Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Wine and music (II): can you taste the music? Modulating the experience of wine through music and sound
- Author
- A Klapetek
- A Krishna
- A North
- A-S Crisinel
- A-S Crisinel
- AA Labroo
- AC North
- AC North
- AC North
- AC North
- AY Lee
- B Mesz
- B Mesz
- BC Smith
- BC Smith
- C Ferber
- C Fielden
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- C Spence
- CS Areni
- D Chen
- D Laing
- D Oberfeld
- D Schildknecht
- DG Laing
- DG Laing
- DW Wesson
- DW Wesson
- E Peynaud
- EP Köster
- F Reinoso Carvalho
- FB Baraldi
- H Berlioz
- H-S Seo
- J Driver
- J Henrich
- JM Williams
- JP Bachorik
- JPS Yeoh
- K Belkin
- K Bronner
- K Holt-Hansen
- K Holt-Hansen
- K Marshall
- KM Knöferle
- KM Knöferle
- KS Yan
- L Bartoshuk
- L Cheskin
- LD Stafford
- LD Stafford
- LW Frandsen
- M Macht
- M Sachse-Weinert
- MG Rigg
- N Lavie
- N Lavie
- NK Dess
- O Deroy
- O Pollatos
- P Brown
- P Walker
- P White
- P Winkielman
- PN Juslin
- Q(J) Wang
- R Chiou
- R Deliza
- R Ee van
- R Walker
- R Watt
- RJ Stevenson
- T Yamasaki
- TP Heath
- VJ Konečni
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 24/12/2015
- Field of study
A growing body of scientific evidence now shows that what people taste when evaluating a wine, and how much they enjoy the experience, can be influenced by the music that happens to be playing at the same time. It has long been known that what we hear can influence the hedonic aspects of tasting. However, what the latest research now shows is that by playing the “right” music one can also impact specific sensory-discriminative aspects of tasting as well. Music has been shown to influence the perceived acidity, sweetness, fruitiness, astringency, and length of wine. We argue against an account of such results in terms of synaesthesia, or “oenesthesia,” as some have chosen to call it. Instead, we suggest that attention, directed via the crossmodal correspondences that exist between sound and taste (in the popular meaning of the term, i.e., flavor), can modify (perhaps enhance, or certainly highlight when attended, or suppress when unattended) certain elements in the complex tasting experience that is drinking wine. We also highlight the likely role played by any change in the mood or emotional state of the person listening to the music on taste/aroma perception as well. Finally, we highlight how the crossmodal masking of sweetness perception may come into effect if the music happens to be too loud (a form of crossmodal sensory masking). Taken together, the evidence reviewed here supports the claim that, strange though it may seem, what we hear (specifically in terms of music) really can change our perception of the taste of wine, not to mention how much we enjoy the experience. Several plausible mechanisms that may underlie such crossmodal effects are outlined
Efficacy in Action: Mobilising Community Participation for Inclusive Urban Development
- Author
- A Appadurai
- A Appadurai
- A Appadurai
- A Bandura
- A Bandura
- A Cornwall
- A Hammar
- A Krishna
- A Sen
- A Toit Du
- AK Tibaijuka
- AY Kamete
- C D’Cruz
- C D’Cruz
- C McFarlane
- C Tilly
- D Hulme
- D Hulme
- D MacKinnon
- D Mitlin
- D Mitlin
- D Mitlin
- D Mitlin
- D North
- D Potts
- D Potts
- D Satterthwaite
- D Satterthwaite
- E Banana
- E Ostrom
- E Ostrom
- E Pieterse
- F Cleaver
- F Miraftab
- G Rauniyar
- H Nyamweru
- I Ali
- J Alexander
- J Bolnick
- J Gaventa
- J Gupta
- L Sachikonye
- M Aliber
- M Millstein
- M Olsen
- M Prowse
- M Woolcock
- P Evans
- P Freire
- R Thorp
- RD Benford
- RJ Sampson
- RJ Sampson
- S Bracking
- S Hickey
- S Hickey
- S Moyo
- S Parnell
- S Patel
- S Patel
- S Robins
- S Robins
- United Nations
- Wayne Shand
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014
- Author
- A Cárdenas
- A Duseja
- A Duseja
- A Jindal
- A Katoonizadeh
- A Khanam
- A Kribben
- A Kumar
- A Rastogi
- A Rastogi
- A Rastogi
- A. Kadir Dokmeci
- AC Chan
- AK Jha
- Albert C. Chan
- Amna Subhan Butt
- Anoop Saraya
- Archana Rastogi
- AY Kim
- Brajesh Chander Sharma
- C Chatzicostas
- C Granja
- C Ripoll
- C Trey
- Chandan Kumar Kedarisetty
- Chhagan Bihari
- Chitranshu Vashishtha
- D Thabut
- Deepak Amarapurkar
- Diana Alcantara Payawal
- Didier Samuel
- DL Shawcross
- Dong Joon Kim
- E Akriviadis
- E Levesque
- E Sagnelli
- EL Graaf de
- FC Kruger
- G Atienza Merino
- G Kalambokis
- Gamal Shiha
- Guan Huei Lee
- H Garg
- Hasmik Ghazinyan
- HE Wasmuth
- Hitendra Garg
- IR Wanless
- J Altamirano
- J Cordoba
- J Ros
- JC Olson
- JH Hoofnagle
- JL Vincent
- JP Donovan
- JP Hwang
- JS Bajaj
- JW Yu
- KA Wlodzimirow
- Kapil Sharma
- KH Lin
- KSh Chok
- L Amitrano
- L Libbrecht
- L Xu
- LA Adams
- Laurentius A. Lesmana
- LJ Sun
- LL Kjaergard
- LM Guo
- LP Bechmann
- M Cazzaniga
- M Gabrielli
- M Guevara
- M Huang
- M Kumar
- M Martín-Llahí
- M Mikulska
- M Ninivaggi
- Mamun Mahtab
- Man-Fung Yuen
- Manoj Kumar Sharma
- MH Zheng
- MJ Poveda
- MM Levy
- Mohamed Rela
- MV Catalina
- MY Kim
- N Bhala
- Osamu Yokosuka
- P Angulo
- P Ferenci
- P Gines
- P Saxena
- Piyawat Komolmit
- PS Kamath
- Q Ling
- QF Sun
- Qin Ning
- R Bahirwani
- R Banares
- R Jalan
- R Jalan
- R Jalan
- R Jalan
- R Kar
- R Loomba
- R Luddington
- R Moreau
- R Moreau
- R Pei
- Rakhi Maiwall
- Richard Moreau
- RK Magalhaes
- RP Myers
- RP Myers
- RS Hotchkiss
- RT Stravitz
- S Holt
- S Kusumoto
- S Kusumoto
- S Sen
- Saeed Hamid
- Salimur Rahman
- Samir Shah
- SG Lim
- SG Sheth
- SH Caldwell
- Shiv Kumar Sarin
- SK Acharya
- SK Sarin
- Soek Siam Tan
- SR Mitzner
- ST Martin
- Suman Lata
- T Bruns
- T Lisman
- T Xing
- TI Hassanein
- V Arvaniti
- V Das
- V Garg
- V Stadlbauer
- Viniyendra Pamecha
- Vivek Saraswat
- VJ Desmet
- W Laleman
- W Laleman
- WJ Kox
- WK Seto
- X Xu
- XZ Duan
- Y Radha Krishna
- Y Tsutsumi
- Y Yan
- YC Chen
- Yogesh Kumar Chawla
- Zaigham Abbas
- Zeeshan Ahmed Wani
- ZH Wan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
- Author
- Ç
- Ö
- Ž
- Ž
- Ž
- &apos
- Aahlin Ek
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader Sm
- Abdel-Wahab Nye
- Abdelaal A
- Abdelaty M
- Abdelazeam Ar
- Abdelazim G
- Abdelaziz Ma
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf Am
- Abdelrouf Dm
- Abdelshafy M
- Abdelshakour M
- Abdrabou Ak
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem Em
- Abdullah Ma
- Abdullah N
- Abdullah Nan
- Abdullah Nan
- Abdullahi L
- Abdurrazzaaq A
- Abebe Ns
- Abebe Ns
- Abem Oe
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud Mr
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga Ms
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed Maf
- Abu-Toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adı
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel Be
- Adel I
- Adella Fj
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa Ao
- Ademuyiwa Ao
- Ademuyiwa Ao
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa Ao
- Adisa Ao
- Adnan Ab
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi Am
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguilar Wlm
- Aguilar Wlm
- Aguilar-Jimenez J
- Aguilera M
- Aguilera Ml
- Aguilera Ml
- Aguilera O
- Aguilera-Arevalo Ml
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed Ea
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed Lam
- Ahmed S
- Ahmed S
- Ahmed Sm
- Ahounou Eys
- Aigrain Y
- Ajah J
- Ajai O
- Ajao A
- Ajao Ae
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag Aa
- Al-Azraqi Iaa
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi Jj
- Al-Faqawi M
- Al-Farram H
- Al-Hameedi Hii
- Al-Hasani Rkmj
- Al-Khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-Saqqa S
- Al-Saqqa Sw
- Al-Shammari A
- Al-Slaibi I
- Al-Taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi Ma
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi Msa
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali Cdm
- Ali E
- Ali Fm
- Ali H
- Ali S
- Ali Sawew
- Ali Ss
- Ali Tha
- Ali W
- Alihonou T
- Alimi Q
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen Jly
- Allen-Ingabire Jc
- Allott R
- Almallah A
- Almanon Cl
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby Mh
- Alnawam E
- Alnuqaydan Sa
- Alnusairat A
- Alomar In
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf Mu
- Alsaggaf Mu
- Alser Oh
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry Am
- Altwijri A
- Alvarez Iiz
- Alvi Ar
- Alwafai Mg
- Aly Ak
- Aly Mym
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzahrani M
- Alzahrani Mna
- Alzayat T
- Aman Nf
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer Ma
- Amin Haa
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar Ms
- Amoah M
- Amoako J
- Amoako Pt
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika Ffa
- Andreotti D
- Andress C
- Andriola V
- Ang Yl
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar Aw
- Anwar N
- Anwer W
- Anyanwu Lj
- Anyanwu Lj
- Aonzo P
- Appeadu-Mensah W
- Appiah Ek
- Aql S
- Aquilino F
- Arachchi Pp
- Arachchige Lajj
- Arafa O
- Arafa S
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Arango Mcm
- Araujo Jslr
- Arcudi C
- Ardley R
- Arenas A
- Arman S
- Arman S
- Armellini A
- Arnaud A
- Arnaud Ap
- Arnaud Ap
- Arnaud Ap
- Arshad Mm
- Arslan E
- Arsyad Hm
- Arthur T
- Arulampalam T
- Aruldas N
- Asaat Ul Razi S
- Asal M
- Asar Yh
- Asare-Bediako K
- Asele Fa
- Ashour A
- Ashour A
- Ashour K
- Ashraf Sf
- Ashtari M
- Ashton A
- Asi F
- Asilah Smd
- Assal A
- Assouto Pa
- Asturias S
- Asumah H
- Ata A
- Ata Aaa
- Ata Ay
- Atiyeh A
- Atkins Et
- Atkinson K
- Atobatele K
- Attallah Na
- Attard M
- Attia A
- Attia Am
- Augestad Km
- Aung Kp
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad Sa
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo Oo
- Aydin Mc
- Ayyar S
- Aziz Dna
- Aziz Mra
- Aziz Na
- Azizeldine Mg
- Azmitia Jra
- Azodo Ia
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki Ma
- Badicel M
- Badr A
- Badr Mfm
- Badwi Nm
- Badwi Nm
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki Be
- Bakr A
- Bakry Hm
- Baky Fahmy MA
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila Rmh
- Balkan Aza
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis Vj
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal Gs
- Baraka H
- Barakat Sae
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas Gn
- Barnacle J
- Barneo L
- Barrantes Ams
- Barreda Lma
- Barrientos Lam
- Barrios E
- Barrios E
- Barrios E
- Barry J
- Basilicò
- Basir Erm
- Bassem M
- Bassit Ka
- Basso Sm
- Basson S
- Basto Caa
- Batt J
- Bautista Acm
- Bautista Acm
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada Ag
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet Ah
- Bekhet Nm
- Beleñ
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai Rm
- Benons N
- Bentounsi Z
- Benyaiche C
- Bermú
- Bernardo Cg
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezzina M
- Bhangu A
- Bhangu A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj Is
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal Kf
- Bhopal Kf
- Bianco F
- Bigaran A
- Billy M
- Birindelli A
- Birring A
- Bisset C
- Bjö
- Bjö
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksø
- Blower E
- Bluelle R
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- Chidambaram S
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- Clegg-Lamptey Jn
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- De La Medina AR
- de Leó
- De Leon MZP
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- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
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- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
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- Diab A
- Diaconescu B
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- Diaz-Jover P
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- Djivoh F
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- El Salam YA
- El Sayed GS
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- El-Sagheer N
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- Elbe P
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- Eldafrawy M
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- Elena G
- Elfarargy A
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- Elfiky M
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- Elkorashy Am
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- Eng C
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- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
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- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
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- Fitzgerald Je
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- Koh S
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- Kojo Att
- Kojo Att
- Kojo Att
- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong Sn
- Kong V
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- Konstantina K
- Kontos M
- Kordorwu Hek
- Korkolis D
- Kosai Nr
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- Kose E
- Koskenvuo L
- Kostov E
- Kotb Ahe
- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
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- Kretzmann H
- Krishna K
- Kruspi S
- Kufeji D
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- Kumwenda D
- Kushwaha S
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- Kusi K
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- Kwakyeafriyie P
- Kwatiwani C
- Kwizera S
- Kwok Sh
- Kyereh M
- Kyriazanos I
- Kyrou G
- Kyziridis D
- Ló
- L&apos
- La Brocca A
- la Medina AR
- la Medina AR
- la Medina AR
- Labib P
- Ladukas A
- Lafferty K
- Lagunavicius K
- Lai Ac
- Lakhani Sm
- Lakshmi Hn
- Lam Fy
- Lam Jcy
- Lam Wh
- Lamanna Gl
- Lanau Miv
- Lando J
- Landolfo G
- Landolfo G
- Lap G
- Lapitan Mc
- Lapitan Mc
- Larsen Jw
- Lasek A
- Lasheen A
- Lasheen Kt
- Latif A
- Laufer Lav
- Laugzemys E
- Laugzemys E
- Laurie K
- Lauzikas G
- Law Jh
- Lawal A
- Lawal Ao
- Lawal T
- Lawal Ta
- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Leal A
- Leal M
- Lecompte Jf
- Lee C
- Lee Ex
- Lee F
- Lee K
- Lee Kc
- Lee Ky
- Lee Tsb
- Lemaire Sb
- Leone N
- Leong Fqh
- Leppä
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- Leroux J
- Leung Kw
- Leung Mf
- Leusink A
- Lewis J
- Li Ws
- Licari L
- Lieske B
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- Liew I
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- Lilford R
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- Lim G
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- Lim J
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- Lim Sj
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- Lim Sy
- Limache S
- Limaye N
- Limoges B
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- Lipnickas V
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- Livesey A
- Livingston M
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- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
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- Loizides S
- Lokman Maa
- Longstaff L
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- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
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- Luck J
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- Luglio G
- Lund J
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- Lundgren Po
- Luque Gb
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- Lytras D
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- Má
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- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
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- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
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- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
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- Mahmoud B
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- Mahmoud Mi
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- Mansuri A
- Mao P
- Mapasse D
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- Marey A
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- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
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- Matos-Puig R
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- Mendoza I
- Menegussi J
- Mensah E
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- Mentula P
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- Mihaljevic Al
- Mihanovic J
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- Mikuckyte D
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- Milligan W
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- Minguez G
- Minocha A
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- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
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- Mittal A
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- Mizzi C
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- Moaty M
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- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
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- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
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- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora Jjv
- Morais Pab
- Morales C
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- Moreira G
- Moreno Sc
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- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
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- Munera A
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- Munipalle Pc
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- Murphy J
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- Musa Aek
- Musleh A
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- Musyoka Ck
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- Mutlu D
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- Muzio E
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- Næ
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- Nada F
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- Nagy Gs
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- Nanthakumaran S
- Napolitano L
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- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
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- Nashaat A
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- Ndajiwo A
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- Ndegwa W
- Ndlovu Sr
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- Ne&apos
- Negida A
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- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
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- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng S
- Ng Yk
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- Nikoloudis N
- Nikoloudis N
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
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- North As
- Notarnicola M
- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
- Nsengiyumva C
- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
- O&apos
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- Obute Rd
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- Odeyemi B
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- Odutola O
- Ogunsua O
- Ogunyemi A
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- Olaolorun A
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- Olori S
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- Ortiz N
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- Ozben V
- Ozkan Bb
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- Padmore G
- Pagano G
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- Parseliunas A
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- Preckailaite E
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- Redota Map
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- Sallinen V
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- Salma M
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- Samaniego Cs
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- Schivo D
- Schmid R
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- Septiem Jg
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- Shahbaz Ar
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- Sokratous A
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- Soldevila-Verdeguer C
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
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