584 research outputs found
Predictability of STOP-Bang Questionnaire and Epworth Sleepiness Scale in Identifying Obstructive Sleep Apnoea against Polysomnography: A Cross-sectional Study
- Author
- Publication venue
- 'JCDR Research and Publications'
- Publication date
- 01/10/2022
- Field of study
Introduction: Rising morbidty resulting from Obstructive Sleep
Apnoea (OSA) is an emerging public health concern. The
estimated prevalence of OSA in India has been investigated.
STOP-Bang and Epworth Sleepiness Scale (ESS) have proven
beneficial in identifying sleep breathing disorder. Validity of
these questionnaire has been verified against polysomnography
in many studies.
Aim: To assess the predictive ability of STOP-Bang questionnaire
and ESS in identifying OSA and comparing their efficacy with
polysomnography.
Materials and Methods: The cross-sectional study was
conducted in the Department of Respiratory Medicine,
Government Medical College, Kota, Rajasthan, India, from
January 2020 to June 2021, among 100 patients with symptoms
of OSA. The STOP-Bang questionnaires were administered
to the patients, and scoring was done, followed by overnight
attended polysomnography. The normality of data was tested
by Shapiro Wilkâs test. The values obtained were statistically
analysed and to compare the parameters between groups
and with in groups for normal data parametric test One-way
Analysis of Variance (ANOVA) followed by Tukeyâs HSD test, for
intragroup Paired t-test.
Results: Mean age of the study population was 49.46Âą6.523
years, 79 were males and 21 females. Total, 79% of the subjects
were males, and 21% of the study subjects were females. Among
the 100, 65% had OSA as per polysomnography. STOP-Bang
questionnaire had a higher sensitivity as compared to ESS in
predicting OSA (75.38% for STOP-Bang and 72.31% for ESS).
Conversely, the specificity of ESS (82.8%) was found to be
greater than STOP-Bang (45.71%). Similar results were obtained
for positive predictive value, in which ESS scored 88.6% while
STOP-Bang scored 50%. For negative predictive values, ESS
again scored higher (65%) than STOP-Bang (61.7%). Similarly,
the Likelihood Ratio for a positive result (LR+) of ESS was greater
than STOP-Bang (4.2 and 1.3 respectively). The STOP-Bang
questionnaire, however, had higher Likelihood Ratio for a negative
test (LR-) as compared to ESS (0.5 and 0.3 respectively).
Conclusion: Polysomnography is the gold standard to
diagnose OSA. For screening OSA, patients with symptoms of
sleep disordered breathing, this study found that STOP-Bang
questionnaire is better in identifying OSA as compared to ESS
Genetic variation among species, races, forms and inbred lines of lac insects belonging to the genus Kerria (Homoptera, Tachardiidae)
- Author
- Ambarish S Vidyarthi
- Archak S
- Baruffi L
- Behura SK
- Bertin S
- Castiglioni L
- Chamberlin JC
- Chamberlin JC
- Chandana Basu Mallick
- Chauhan NS
- Chauhan NS
- Chauhan NS
- Dave KN
- De Barro PJ
- Dipnarayan Saha
- Dvorak V
- Hadrys H
- Kapur AP
- Kapur AP
- Karam N
- Kethidi DR
- Kondo T
- Lopes-Da-Silva M
- Lynch M
- MagaĂąa C
- Martins WFS
- Mishra YD
- Mishra YD
- Nagaraja GM
- Nei M
- Pal G
- Prevost A
- Ramakishana W
- Ramani R
- Ramani R
- Ramani R
- Ranganathan Ramani
- Reyes A
- Rohlf FJ
- Roonwal ML
- Saitou N
- Sanjeev Kumar Ranjan
- Sarkar PC
- Sharma AK
- Sneath PHA
- Sosa-GĂłmez DR
- Varshney RK
- Varshney RK
- Varshney RK
- Weising K
- Welsh J
- Wetton JH
- Williams JGK
- Publication venue
- Sociedade Brasileira de GenĂŠtica
- Publication date
- 01/01/2011
- Field of study
The lac insects (Homoptera: Tachardiidae), belonging to the genus Kerria, are commercially exploited for the production of lac. Kerria lacca is the most commonly used species in India. RAPD markers were used for assessing genetic variation in forty-eight lines of Kerria, especially among geographic races, infrasubspecific forms, cultivated lines, inbred lines, etc., of K. lacca. In the 48 lines studied, the 26 RAPD primers generated 173 loci, showing 97.7% polymorphism. By using neighbor-joining, the dendrogram generated from the similarity matrix resolved the lines into basically two clusters and outgroups. The major cluster, comprising 32 lines, included mainly cultivated lines of the rangeeni form, geographic races and inbred lines of K. lacca. The second cluster consisted of eight lines of K. lacca, seven of the kusmi form and one of the rangeeni from the southern state of Karnataka. The remaining eight lines formed a series of outgroups, this including a group of three yellow mutant lines of K. lacca and other species of the Kerria studied, among others. Color mutants always showed distinctive banding patterns compared to their wild-type counterparts from the same population. This study also adds support to the current status of kusmi and rangeeni, as infraspecific forms of K. lacca
Measurement of CP-violation asymmetries in D0 to Ks pi+ pi-
- Author
- Aaltonen T
- Ahmed S
- Alam MS
- Albert J
- Amerio S
- Amidei D
- Anastassov A
- Annovi A
- Antos J
- Apollinari G
- Appel JA
- Arisawa T
- Artikov A
- Asaadi J
- Ashmanskas W
- Auerbach B
- Aurisano A
- Azfar F
- Azzolini V
- Badgett W
- Bae T
- Band HR
- Banerjee S
- Barbaro-Galtieri A
- Barnes VE
- Barnett BA
- Barria P
- Bartos P
- Bauce M
- Bedeschi F
- Behari S
- Bellettini G
- Bellinger J
- Benjamin D
- Beretvas A
- Bhatti A
- Bhuyan B
- Bianchi F
- Bisello D
- Bizjak I
- Bland KR
- Blumenfeld B
- Bocci A
- Bodek A
- Bomben M
- Bortoletto D
- Bosisio L
- Boudreau J
- Boveia A
- Brigliadori L
- Bromberg C
- Brucken E
- Budagov J
- Budd HS
- Bula R
- Burchat PR
- Burkett K
- Busetto G
- Bussey P
- Buzatu A
- Calamba A
- Calancha C
- Camarda S
- Campanelli M
- Campbell M
- Canelli F
- Carls B
- Carlsmith D
- Carosi R
- Carrillo S
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- Cartaro C
- Casal B
- Casarsa M
- Castro A
- Catastini P
- Cauz D
- Cavaliere V
- Cavalli-Sforza M
- Cerri A
- Cerrito L
- Chen X
- Chen YC
- Chertok M
- Chiarelli G
- Chlachidze G
- Chlebana F
- Cho K
- Chokheli D
- Chung WH
- Chung YS
- Ciocci MA
- Clark A
- Clarke C
- Compostella G
- Convery ME
- Conway J
- Corbo M
- Cordelli M
- Cossutti F
- Cox CA
- Cox DJ
- Crescioli F
- Cuevas J
- Culbertson R
- d'Ascenzo N
- d'Errico M
- D'Onofrio M
- da Costa JG
- Dagenhart D
- Dasu S
- Datta M
- de Barbaro P
- Dell'Orso M
- Della Ricca G
- Demortier L
- Deninno M
- Devoto F
- Di Canto A
- Di Ruzza B
- Dittmann JR
- Donati S
- Dong P
- Dorigo M
- Dorigo T
- Ebina K
- Eckmann R
- Edwards AJ
- Elagin A
- Eppig A
- Erbacher R
- Ernst JA
- Errede S
- Ershaidat N
- Eusebi R
- Farrington S
- Feindt M
- Fernandez JP
- Fernandez PM
- Field R
- Flanagan G
- Flood KT
- Forrest R
- Frank MJ
- Franklin M
- Freeman JC
- Funakoshi Y
- Furic I
- Gallinaro M
- Gallo F
- Gamba D
- Garcia JE
- Garfinkel AF
- Garosi P
- Gerberich H
- Gerchtein E
- Giagu S
- Giakoumopoulou V
- Giannetti P
- Gibson K
- Ginsburg CM
- Giokaris N
- Giromini P
- Giurgiu G
- Glagolev V
- Glenzinski D
- Gold M
- Goldin D
- Goldschmidt N
- Golossanov A
- Gomez G
- Gomez-Ceballos G
- Goncharov M
- Gonzalez BA
- Gonzalez O
- Gorelov I
- Goshaw AT
- Goulianos K
- Grinstein S
- Griso SP
- Grosso-Pilcher C
- Group RC
- Hahn SR
- Halkiadakis E
- Hamaguchi A
- Hamano K
- Han JY
- Happacher F
- Hara K
- Hare D
- Hare M
- Harr RF
- Harrison PF
- Hatakeyama K
- Hays C
- Heck M
- Heinrich J
- Herndon M
- Hewamanage S
- Hocker A
- Hollar JJ
- Hopkins W
- Horn D
- Hou S
- Hughes RE
- Hurwitz M
- Husemann U
- Hussain N
- Hussein M
- Huston J
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- Introzzi G
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- Ivanov A
- Izen JM
- Jain V
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- Jang D
- Jayatilaka B
- Jeon EJ
- Jindariani S
- Jones M
- Joo KK
- Jun SY
- Junk TR
- Kamon T
- Karchin PE
- Kasmi A
- Kato Y
- Ketchum W
- Keung J
- Khotilovich V
- Kilminster B
- Kim DH
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- Kim JE
- Kim MJ
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- Kim SH
- Kim YJ
- Kim YK
- Kimura N
- Kirby M
- Klimenko S
- Knoepfel K
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- Konigsberg J
- Kotwal AV
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- Kreps M
- Krishnamurthy M
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- Krop D
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- Krutelyov V
- Kuhr T
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- Kutter PE
- Kwang S
- Laasanen AT
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- Lander RL
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- Limosani A
- Lin CJ
- Lindgren M
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- Shepard PF
- Shimojima M
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- Shreyber-Tecker I
- Simonenko A
- Sinervo P
- Sliwa K
- Smith JR
- Snider FD
- Snyder A
- Sobie RJ
- Soha A
- Song H
- Sorin V
- Spanier SM
- Squillacioti P
- St Denis R
- Stancari M
- Stelzer B
- Stelzer-Chilton O
- Stentz D
- Strologas J
- Strycker GL
- Su D
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- Suslov I
- Suzuki K
- Swain SK
- Takemasa K
- Takeuchi Y
- Tang J
- Tecchio M
- Teng PK
- Thom J
- Thome J
- Thompson GA
- Thompson JM
- Thomson E
- Toback D
- Tokar S
- Tollefson K
- Tomura T
- Tonelli D
- Torre S
- Torretta D
- Totaro P
- Trovato M
- Ukegawa F
- Uozumi S
- Va'vra J
- Varganov A
- Vazquez F
- Velev G
- Vellidis C
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- Vila I
- Vilar R
- Vitale L
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- Volpi G
- Wagner AP
- Wagner P
- Wagner RL
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- Wallny R
- Wang SM
- Wappler FR
- Warburton A
- Waters D
- Weaver M
- Wester WC
- Whiteson D
- Wick F
- Wicklund AB
- Wicklund E
- Wilbur S
- Wilden L
- Williams HH
- Wilson JS
- Wilson P
- Winer BL
- Wisniewski WJ
- Wittgen M
- Wittich P
- Wolbers S
- Wolfe H
- Wright DH
- Wright T
- Wu SL
- Wu X
- Wu Z
- Yamamoto K
- Yamato D
- Yang T
- Yang UK
- Yang YC
- Yao WM
- Yarritu AK
- Ye S
- Yeh GP
- Yi K
- Yi K
- Yoh J
- Yorita K
- Yoshida T
- Young CC
- Yu GB
- Yu I
- Yu SS
- Yun JC
- Zain SB
- Zanetti A
- Zeng Y
- Zhou C
- Ziegler V
- Zucchelli S
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
We report a measurement of time-integrated CP-violation asymmetries in the
resonant substructure of the three-body decay D0 to Ks pi+ pi- using CDF II
data corresponding to 6.0 invfb of integrated luminosity from Tevatron ppbar
collisions at sqrt(s) = 1.96 TeV. The charm mesons used in this analysis come
from D*+(2010) to D0 pi+ and D*-(2010) to D0bar pi-, where the production
flavor of the charm meson is determined by the charge of the accompanying pion.
We apply a Dalitz-amplitude analysis for the description of the dynamic decay
structure and use two complementary approaches, namely a full Dalitz-plot fit
employing the isobar model for the contributing resonances and a
model-independent bin-by-bin comparison of the D0 and D0bar Dalitz plots. We
find no CP-violation effects and measure an asymmetry of ACP = (-0.05 +- 0.57
(stat) +- 0.54 (syst))% for the overall integrated CP-violation asymmetry,
consistent with the standard model prediction.Comment: 15 page
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
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- Attikis A
- Auffray E
- Autermann C
- Auzinger G
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- Avetisyan A
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- Barnett BA
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- Bauerdick LAT
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- Bazterra VE
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- Beaudette F
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- Casal B
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- Cheung HWK
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- Clerbaux B
- Cline D
- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
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- Yilmaz Y
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- Zanetti M
- Zang J
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Acosta MV
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- Christiansen T
- Chuang SH
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- Clerbaux B
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- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
- Colino N
- Collard C
- Colling D
- Conetti S
- Contardo D
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- Conway J
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- Cooper SI
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- Cornelis T
- Correa Martins Junior M
- Cortezon EP
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- Coughlan JA
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- Cuevas J
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- Cumalat JP
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- Czellar S
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- Da Costa EM
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- Yilmaz Y
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- Yun JC
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- Zalewski P
- Zanetti M
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Acosta MV
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- Cumalat JP
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- Cutajar M
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- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
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- Yumiceva F
- Yun JC
- Zabel J
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- Zakaria M
- Zalewski P
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- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- Vitulo P
- Vizan Garcia JM
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- Xiao H
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- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
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- Yu I
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
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- Zeinali M
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- Zheng Y
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- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Compressed representation of a partially defined integer function over multiple arguments
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Acosta D
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- Zhang L
- Zheng Y
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Measurement of jet fragmentation into charged particles in pp and PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alexander J
- Aliev T
- Alimena J
- Almeida N
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Appelt E
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- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Jet fragmentation in pp and PbPb collisions at a centre-of-mass energy of
2.76 TeV per nucleon pair was studied using data collected with the CMS
detector at the LHC. Fragmentation functions are constructed using
charged-particle tracks with transverse momenta pt > 4 GeV for dijet events
with a leading jet of pt > 100 GeV. The fragmentation functions in PbPb events
are compared to those in pp data as a function of collision centrality, as well
as dijet-pt imbalance. Special emphasis is placed on the most central PbPb
events including dijets with unbalanced momentum, indicative of energy loss of
the hard scattered parent partons. The fragmentation patterns for both the
leading and subleading jets in PbPb collisions agree with those seen in pp data
at 2.76 TeV. The results provide evidence that, despite the large parton energy
loss observed in PbPb collisions, the partition of the remaining momentum
within the jet cone into high-pt particles is not strongly modified in
comparison to that observed for jets in vacuum.Comment: Submitted to the Journal of High Energy Physic
A Novel Cold-Regulated Cold Shock Domain Containing Protein from Scallop Chlamys farreri with Nucleic Acid-Binding Activity
- Author
- A Polesskaya
- A Salvetti
- AF Fusaro
- AM Giuliodori
- AP Wolffe
- AV Pisarev
- B Xia
- CG Burd
- Chuanyan Yang
- CPAM Kloks
- CY Yang
- D Karlson
- D Karlson
- EG Moss
- Fengmei Li
- GR Franco
- HA Thieringer
- HA Thieringer
- Huan Zhang
- J Goldstein
- J Sommerville
- Jingjing Wang
- JS Kim
- JY Yu
- K Kohno
- K Matsumoto
- K Matsumoto
- K Nakaminami
- K Nakaminami
- K Sasaki
- K Stuart
- K Yamanaka
- KJ Kwak
- Lingling Wang
- Linsheng Song
- LL Wang
- M Gupta-Malhotra
- M Houde
- M Pelletier
- M Ranjan
- MH Kim
- MHW Weber
- ML Hayman
- MP Nekrasov
- MT Murray
- N Wang
- P Bouvet
- PA Skehel
- PK Smith
- PL Graumann
- Qiufen Jiang
- S Danno
- S Phadtare
- S Phadtare
- S Phadtare
- SR Viswanathan
- Vinu S. Siva
- Vladimir N. Uversky
- W Gu
- WH Bae
- Xiaowei Shi
- Y Zhang
- Z Keresztessy
- Publication venue
- Public Library of Science
- Publication date
- 16/02/2012
- Field of study
Background: The cold shock domain (CSD) containing proteins (CSDPs) are one group of the evolutionarily conserved nucleic acid-binding proteins widely distributed in bacteria, plants, animals, and involved in various cellular processes, including adaptation to low temperature, cellular growth, nutrient stress and stationary phase. Methodology: The cDNA of a novel CSDP was cloned from Zhikong scallop Chlamys farreri (designated as CfCSP) by expressed sequence tag (EST) analysis and rapid amplification of cDNA ends (RACE) approach. The full length cDNA of CfCSP was of 1735 bp containing a 927 bp open reading frame which encoded an N-terminal CSD with conserved nucleic acids binding motif and a C-terminal domain with four Arg-Gly-Gly (RGG) repeats. The CSD of CfCSP shared high homology with the CSDs from other CSDPs in vertebrate, invertebrate and bacteria. The mRNA transcripts of CfCSP were mainly detected in the tissue of adductor and also marginally detectable in gill, hepatopancreas, hemocytes, kidney, mantle and gonad of healthy scallop. The relative expression level of CfCSP was up-regulated significantly in adductor and hemocytes at 1 h and 24 h respectively after low temperature treatment (P,0.05). The recombinant CfCSP protein (rCfCSP) could bind ssDNA and in vitro transcribed mRNA, but it could not bind dsDNA. BX04, a cold sensitive Escherichia coli CSP quadruple-deletion mutant, was used to examine the cold adaptation ability of CfCSP. After incubation at 17uC for 120 h, the strain of BX04 containing the vector pINIII showed growth defect and failed to form colonies, while strain containing pINIII-CSPA or pINIII
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