42,391 research outputs found
Behaviour-based Knowledge Systems: An Epigenetic Path from Behaviour to Knowledge
In this paper we expose the theoretical background underlying our current research.
This consists in the development of behaviour-based knowledge systems, for closing
the gaps between behaviour-based and knowledge-based systems, and also
between the understandings of the phenomena they model. We expose the
requirements and stages for developing behaviour-based knowledge systems and
discuss their limits. We believe that these are necessary conditions for the
development of higher order cognitive capacities, in artificial and natural cognitive
systems
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Cocaine Addiction as a Homeostatic Reinforcement Learning Disorder
Drug addiction implicates both reward learning and homeostatic regulation mechanisms of the brain. This has stimulated 2 partially successful theoretical perspectives on addiction. Many important aspects of addiction, however, remain to be explained within a single, unified framework that integrates the 2 mechanisms. Building upon a recently developed homeostatic reinforcement learning theory, the authors focus on a key transition stage of addiction that is well modeled in animals, escalation of drug use, and propose a computational theory of cocaine addiction where cocaine reinforces behavior due to its rapid homeostatic corrective effect, whereas its chronic use induces slow and long-lasting changes in homeostatic setpoint. Simulations show that our new theory accounts for key behavioral and neurobiological features of addiction, most notably, escalation of cocaine use, drug-primed craving and relapse, individual differences underlying dose-response curves, and dopamine D2-receptor downregulation in addicts. The theory also generates unique predictions about cocaine self-administration behavior in rats that are confirmed by new experimental results. Viewing addiction as a homeostatic reinforcement learning disorder coherently explains many behavioral and neurobiological aspects of the transition to cocaine addiction, and suggests a new perspective toward understanding addiction
Deleterious effect of suboptimal diet on rest-activity cycle in Anastrepha ludens manifests itself with age.
Activity patterns and sleep-wake cycles are among the physiological processes that change most prominently as animals age, and are often good indicators of healthspan. In this study, we used the video-based high-resolution behavioral monitoring system (BMS) to monitor the daily activity cycle of tephritid fruit flies Anastrepha ludens over their lifetime. Surprisingly, there was no dramatic change in activity profile with respect to age if flies were consistently fed with a nutritionally balanced diet. However, if flies were fed with sugar-only diet, their activity profile decreased in amplitude at old age, suggesting that suboptimal diet affected activity patterns, and its detrimental effect may not manifest itself until the animal ages. Moreover, by simulating different modes of behavior monitoring with a range of resolution and comparing the resulting conclusions, we confirmed the superior performance of video-based monitoring using high-resolution BMS in accurately representing activity patterns in an insect model
Preclinical Assessment of HIV Vaccines and Microbicides by Repeated Low-Dose Virus Challenges
BACKGROUND: Trials in macaque models play an essential role in the evaluation of biomedical interventions that aim to prevent HIV infection, such as vaccines, microbicides, and systemic chemoprophylaxis. These trials are usually conducted with very high virus challenge doses that result in infection with certainty. However, these high challenge doses do not realistically reflect the low probability of HIV transmission in humans, and thus may rule out preventive interventions that could protect against “real life” exposures. The belief that experiments involving realistically low challenge doses require large numbers of animals has so far prevented the development of alternatives to using high challenge doses. METHODS AND FINDINGS: Using statistical power analysis, we investigate how many animals would be needed to conduct preclinical trials using low virus challenge doses. We show that experimental designs in which animals are repeatedly challenged with low doses do not require unfeasibly large numbers of animals to assess vaccine or microbicide success. CONCLUSION: Preclinical trials using repeated low-dose challenges represent a promising alternative approach to identify potential preventive interventions
Auditory communication in domestic dogs: vocal signalling in the extended social environment of a companion animal
Domestic dogs produce a range of vocalisations, including barks, growls, and whimpers, which are shared with other canid species. The source–filter model of vocal production can be used as a theoretical and applied framework to explain how and why the acoustic properties of some vocalisations are constrained by physical characteristics of the caller, whereas others are more dynamic, influenced by transient states such as arousal or motivation. This chapter thus reviews how and why particular call types are produced to transmit specific types of information, and how such information may be perceived by receivers. As domestication is thought to have caused a divergence in the vocal behaviour of dogs as compared to the ancestral wolf, evidence of both dog–human and human–dog communication is considered. Overall, it is clear that domestic dogs have the potential to acoustically broadcast a range of information, which is available to conspecific and human receivers. Moreover, dogs are highly attentive to human speech and are able to extract speaker identity, emotional state, and even some types of semantic information
Effects of social disruption in elephants persist decades after culling.
BACKGROUND
Multi-level fission-fusion societies, characteristic of a number of large brained mammal species including some primates, cetaceans and elephants, are among the most complex and cognitively demanding animal social systems. Many free-ranging populations of these highly social mammals already face severe human disturbance, which is set to accelerate with projected anthropogenic environmental change. Despite this, our understanding of how such disruption affects core aspects of social functioning is still very limited.
RESULTS
We now use novel playback experiments to assess decision-making abilities integral to operating successfully within complex societies, and provide the first systematic evidence that fundamental social skills may be significantly impaired by anthropogenic disruption. African elephants (Loxodonta africana) that had experienced separation from family members and translocation during culling operations decades previously performed poorly on systematic tests of their social knowledge, failing to distinguish between callers on the basis of social familiarity. Moreover, elephants from the disrupted population showed no evidence of discriminating between callers when age-related cues simulated individuals on an increasing scale of social dominance, in sharp contrast to the undisturbed population where this core social ability was well developed.
CONCLUSIONS
Key decision-making abilities that are fundamental to living in complex societies could be significantly altered in the long-term through exposure to severely disruptive events (e.g. culling and translocation). There is an assumption that wildlife responds to increasing pressure from human societies only in terms of demography, however our study demonstrates that the effects may be considerably more pervasive. These findings highlight the potential long-term negative consequences of acute social disruption in cognitively advanced species that live in close-knit kin-based societies, and alter our perspective on the health and functioning of populations that have been subjected to anthropogenic disturbance
Limitations in Predicting the Space Radiation Health Risk for Exploration Astronauts
Despite years of research, understanding of the space radiation environment
and the risk it poses to long-duration astronauts remains limited. There is a
disparity between research results and observed empirical effects seen in human
astronaut crews, likely due to the numerous factors that limit terrestrial
simulation of the complex space environment and extrapolation of human clinical
consequences from varied animal models. Given the intended future of human
spaceflight, with efforts now to rapidly expand capabilities for human missions
to the moon and Mars, there is a pressing need to improve upon the
understanding of the space radiation risk, predict likely clinical outcomes of
interplanetary radiation exposure, and develop appropriate and effective
mitigation strategies for future missions. To achieve this goal, the space
radiation and aerospace community must recognize the historical limitations of
radiation research and how such limitations could be addressed in future
research endeavors. We have sought to highlight the numerous factors that limit
understanding of the risk of space radiation for human crews and to identify
ways in which these limitations could be addressed for improved understanding
and appropriate risk posture regarding future human spaceflight.Comment: Accepted for publication by Nature Microgravity (2018
Evolution of optimal L\'evy-flight strategies in human mental searches
Recent analysis of empirical data [F. Radicchi, A. Baronchelli & L.A.N.
Amaral. PloS ONE 7, e029910 (2012)] showed that humans adopt L\'evy flight
strategies when exploring the bid space in on-line auctions. A game theoretical
model proved that the observed L\'evy exponents are nearly optimal, being close
to the exponent value that guarantees the maximal economical return to players.
Here, we rationalize these findings by adopting an evolutionary perspective. We
show that a simple evolutionary process is able to account for the empirical
measurements with the only assumption that the reproductive fitness of a player
is proportional to her search ability. Contrarily to previous modeling, our
approach describes the emergence of the observed exponent without resorting to
any strong assumptions on the initial searching strategies. Our results
generalize earlier research, and open novel questions in cognitive, behavioral
and evolutionary sciences.Comment: 8 pages, 4 figure
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