Experience in Predicting Fault-Prone Software Modules Using Complexity Metrics

Complexity metrics have been intensively studied in predicting fault-prone software modules. However, little work is done in studying how to effectively use the complexity metrics and the prediction models under realistic conditions. In this paper, we present a study showing how to utilize the prediction models generated from existing projects to improve the fault detection on other projects. The binary logistic regression method is used in studying publicly available data of five commercial products. Our study shows (1) models generated using more datasets can improve the prediction accuracy but not the recall rate; (2) lowering the cut-off value can improve the recall rate, but the number of false positives will be increased, which will result in higher maintenance effort. We further suggest that in order to improve model prediction efficiency, the selection of source datasets and the determination of cut-off values should be based on specific properties of a project. So far, there are no general rules that have been found and reported to follow

Computational Models for Transplant Biomarker Discovery.

Translational medicine offers a rich promise for improved diagnostics and drug discovery for biomedical research in the field of transplantation, where continued unmet diagnostic and therapeutic needs persist. Current advent of genomics and proteomics profiling called "omics" provides new resources to develop novel biomarkers for clinical routine. Establishing such a marker system heavily depends on appropriate applications of computational algorithms and software, which are basically based on mathematical theories and models. Understanding these theories would help to apply appropriate algorithms to ensure biomarker systems successful. Here, we review the key advances in theories and mathematical models relevant to transplant biomarker developments. Advantages and limitations inherent inside these models are discussed. The principles of key -computational approaches for selecting efficiently the best subset of biomarkers from high--dimensional omics data are highlighted. Prediction models are also introduced, and the integration of multi-microarray data is also discussed. Appreciating these key advances would help to accelerate the development of clinically reliable biomarker systems

1992 NASA/ASEE Summer Faculty Fellowship Program

For the 28th consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The program was conducted by the University of Alabama and MSFC during the period June 1, 1992 through August 7, 1992. Operated under the auspices of the American Society for Engineering Education, the MSFC program, was well as those at other centers, was sponsored by the Office of Educational Affairs, NASA Headquarters, Washington, DC. The basic objectives of the programs, which are the 29th year of operation nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate and exchange ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA centers

Workshop on computer applications in water management: proceedings of the 1995 workshop

Compiled and edited by L. Ahuja, J. Leppert, K. Rojas, E. Seely.Also published as: Great Plains Agricultural Council publication, no. 154.Includes bibliographical references.Presented at the Workshop on computer applications in water management: proceedings of the 1995 workshop held on May 23-25, 1995 at Colorado State University in Fort Collins, Colorado

In Silico Resources to Assist in the Development and Evaluation of Physiologically-Based Kinetic Models

Since their inception in pharmaceutical applications, physiologically-based kinetic (PBK) models are increasingly being used across a range of sectors, such as safety assessment of cosmetics, food additives, consumer goods, pesticides and other chemicals. Such models can be used to construct organ-level concentration-time profiles of xenobiotics. These models are essential in determining the overall internal exposure to a chemical and hence its ability to elicit a biological response. There are a multitude of in silico resources available to assist in the construction and evaluation of PBK models. An overview of these resources is presented herein, encompassing all attributes required for PBK modelling. These include predictive tools and databases for physico-chemical properties and absorption, distribution, metabolism and elimination (ADME) related properties. Data sources for existing PBK models, bespoke PBK software and generic software that can assist in model development are also identified. On-going efforts to harmonise approaches to PBK model construction, evaluation and reporting that would help increase the uptake and acceptance of these models are also discussed