168 research outputs found
Effect of surgical treatment on the cellular immune response of gastric cancer patients
Patients with gastric cancer have a variety of immunological abnormalities. In the present study the lymphocytes and their subsets were determined in the peripheral blood of patients with gastric cancer (N = 41) both before and after surgical treatment. The percent of helper/inducer CD4 T cells (43.6 ± 8.9) was not different after tumor resection (43.6 ± 8.2). The percent of the cytotoxic CD8+ T cell population decreased significantly, whether patients were treated surgically (27.2 ± 5.8%, N = 20) or not (27.3 ± 7.3%, N = 20) compared to individuals with inflammatory disease (30.9 ± 7.5%) or to healthy individuals (33.2 ± 7.6%). The CD4/CD8 ratio consequently increased in the group of cancer patients. The peripheral blood lymphocytes of gastric cancer patients showed reduced responsiveness to mitogens. The defective blastogenic response of the lymphocytes was not associated with the production of transforming growth factor beta (TGF-Ă) since the patients with cancer had reduced production of TGF-Ă1 (269 ± 239 pg/ml, N = 20) in comparison to the normal individuals (884 ± 175 pg/ml, N = 20). These results indicate that the immune response of gastric cancer patients was not significantly modified by surgical treatment when evaluated four weeks after surgery and that the immunosuppression observed was not due to an increase in TGF-Ă1 production by peripheral leukocytes.33934
A prediction algorithm for drug response in patients with mesial temporal lobe epilepsy based on clinical and genetic information
FAPESP - FUNDAĂĂO DE AMPARO Ă PESQUISA DO ESTADO DE SĂO PAULOMesial temporal lobe epilepsy is the most common form of adult epilepsy in surgical series. Currently, the only characteristic used to predict poor response to clinical treatment in this syndrome is the presence of hippocampal sclerosis. Single nucleotide121FAPESP - FUNDAĂĂO DE AMPARO Ă PESQUISA DO ESTADO DE SĂO PAULOFAPESP - FUNDAĂĂO DE AMPARO Ă PESQUISA DO ESTADO DE SĂO PAULO2013/07559-
Patterns Of Seizure Control In Patients With Mesial Temporal Lobe Epilepsy With And Without Hippocampus Sclerosis [padrÔes De Controle De Crises Em Pacientes Com Epilepsia De Lobo Temporal Com Ou Sem Esclerose Hipocampal]
Objective: Patients with mesial temporal lobe epilepsy (MTLE) may present unstable pattern of seizures. We aimed to evaluate the occurrence of relapse-remitting seizures in MTLE with (MTLE-HS) and without (MTLE-NL) hippocampal sclerosis. Method: We evaluated 172 patients with MTLE-HS (122) or MTLE-NL (50). Relapse-remitting pattern was defined as periods longer than two years of seizure-freedom intercalated with seizure recurrence. âInfrequent seizuresâ was considered as up to three seizures per year and âfrequent seizuresâ as any period of seizures higher than that. Results: Thirty-seven (30%) MTLE-HS and 18 (36%) MTLE-NL patients had relapse-remitting pattern (X2, p = 0.470). This was more common in those with infrequent seizures (X2, p < 0.001). Twelve MTLE-HS and one MTLE-NL patients had prolonged seizure remission between the first and second decade of life (X2, p = 0.06). Conclusion: Similar proportion of MTLE-HS or MTLE-NL patients present relapse-remitting seizures and this occurs more often in those with infrequent seizures.7327982Kwan, P., Brodie, M.J., Early identification of refractory epilepsy (2010) N Engl Jmed, 342 (5), pp. 314-319. , http://dx.doi.org/10.1056/NEJM200002033420503Goodridge, D.M., Shorvon, S.D., Epileptic seizures in a population of 6000. II: Treatment and prognosis (1983) Br Med J, 287 (6393), pp. 645-647. , http://dx.doi.org/10.1136/bmj.287.6393.645Brodie, M.J., Barry, S., Bamagous, G.A., Norrie, J.D., Kwan, P., Patterns of treatment response in newly diagnosed epilepsy (2012) Neurology, 78 (20), pp. 1548-1554. , http://dx.doi.org/10.1212/WNL.0b013e3182563b19Semah, F., Picot, M.C., Adam, C., Broglin, D., Arzimanoglou, A., Bazin, B., Is the underlying cause of epilepsy a major prognostic factor for recurrence? (1998) Neurology, 51 (5), pp. 1256-1262. , http://dx.doi.org/10.1212/WNL.51.5.1256Hauser, W.A., Annegers, J.F., Kurland, L.T., Prevalence of epilepsy in Rochester, Minnesota: 1940-1980 (1991) Epilepsia, 32 (4), pp. 429-445. , http://dx.doi.org/10.1111/j.1528-1157.1991.tb04675.xFrench, J.A., Williamson, P.D., Thadani, V.M., Darcey, T.M., Mattson, R.H., Spencer, S.S., Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination (1993) Ann Neurol, 34 (6), pp. 774-780. , http://dx.doi.org/10.1002/ana.410340604Berg, A.T., The natural history of mesial temporal lobe epilepsy (2008) Curr Opin Neurol, 21 (2), pp. 173-178. , http://dx.doi.org/10.1097/WCO.0b013e3282f36ccdSillanpÀÀ, M., Schmidt, D., Natural history of treated childhood-onset epilepsy: Prospective, long-term population based study (2006) Brain, 129, pp. 617-624. , http://dx.doi.org/10.1093/brain/awh726Coan, A.C., Kubota, B.Y., Bergo, F., Campos, B.M., Cendes, F., 3T MRI quantification of hippocampal volume and signal in mesial temporal lobe epilepsy improves detection of hippocampal sclerosis (2014) AJNR am J Neuroradiol, 35 (1), pp. 77-83. , http://dx.doi.org/10.3174/ajnr.A3640Wieser, H.G., ILAE Commission on Neurosurgery of Epilepsy. Mesial temporal lobe epilepsy with hippocampal sclerosis (2004) Epilepsia, 45 (6), pp. 695-714. , http://dx.doi.org/10.1111/j.0013-9580.2004.09004.xKwan, P., Arzimanoglou, A., Berg, A.T., Brodie, M.J., Allen Hauser, W., Mathern, G., Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies (2010) Epilepsia, 51 (6), pp. 1069-1077. , http://dx.doi.org/10.1111/j.1528-1167.2009.02397.xVan Paesschen, W., Connelly, A., King, M.D., Jackson, G.D., Duncan, J.S., The spectrum of hippocampal sclerosis: A quantitative magnetic resonance imaging study (1997) Ann Neurol, 41 (1), pp. 41-51. , http://dx.doi.org/10.1002/ana.410410109Cohen-Gadol, A.A., Bradley, C.C., Williamson, A., Kim, J.H., Westerveld, M., Duckrow, R.B., Normal magnetic resonance imaging and medial temporal lobe epilepsy: The clinical syndrome of paradoxical temporal lobe epilepsy (2005) J Neurosur, 102 (5), pp. 902-909. , http://dx.doi.org/10.3171/jns.2005.102.5.0902Pittau, F., Bisulli, F., Mai, R., Fares, J.E., Vignatelli, L., Labate, A., Prognostic factors in patients with mesial temporal lobe epilepsy (2009) Epilepsia, 50, pp. 41-44. , http://dx.doi.org/10.1111/j.1528-1167.2008.01969.xKobayashi, E., Lopes-Cendes, I., Guerreiro, C.A., Sousa, S.C., Guerreiro, M.M., Cendes, F., Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy (2001) Neurology, 56 (2), pp. 166-172. , http://dx.doi.org/10.1212/WNL.56.2.166Labate, A., Gambardella, A., Ermann, E., Aguglia, U., Cendes, F., Berkovic, S.F., Benign mesial temporal lobe epilepsy (2011) Nat Rev Neurol, 7 (4), pp. 237-240. , http://dx.doi.org/10.1038/nrneurol.2010.21
Search for Higgs bosons decaying to tautau pairs in ppbar collisions at sqrt(s) = 1.96 TeV
We present a search for the production of neutral Higgs bosons decaying into
tautau pairs in ppbar collisions at a center-of-mass energy of 1.96 TeV. The
data, corresponding to an integrated luminosity of 5.4 fb-1, were collected by
the D0 experiment at the Fermilab Tevatron Collider. We set upper limits at the
95% C.L. on the product of production cross section and branching ratio for a
scalar resonance decaying into tautau pairs, and we then interpret these limits
as limits on the production of Higgs bosons in the minimal supersymmetric
standard model (MSSM) and as constraints in the MSSM parameter space.Comment: 7 pages, 5 figures, submitted to PL
Measurement of the photon-jet production differential cross section in collisions at \sqrt{s}=1.96~\TeV
We present measurements of the differential cross section dsigma/dpT_gamma
for the inclusive production of a photon in association with a b-quark jet for
photons with rapidities |y_gamma|< 1.0 and 30<pT_gamma <300 GeV, as well as for
photons with 1.5<|y_gamma|< 2.5 and 30< pT_gamma <200 GeV, where pT_gamma is
the photon transverse momentum. The b-quark jets are required to have pT>15 GeV
and rapidity |y_jet| < 1.5. The results are based on data corresponding to an
integrated luminosity of 8.7 fb^-1, recorded with the D0 detector at the
Fermilab Tevatron Collider at sqrt(s)=1.96 TeV. The measured cross
sections are compared with next-to-leading order perturbative QCD calculations
using different sets of parton distribution functions as well as to predictions
based on the kT-factorization QCD approach, and those from the Sherpa and
Pythia Monte Carlo event generators.Comment: 10 pages, 9 figures, submitted to Phys. Lett.
Limits on anomalous trilinear gauge boson couplings from WW, WZ and Wgamma production in pp-bar collisions at sqrt{s}=1.96 TeV
We present final searches of the anomalous gammaWW and ZWW trilinear gauge
boson couplings from WW and WZ production using lepton plus dijet final states
and a combination with results from Wgamma, WW, and WZ production with leptonic
final states. The analyzed data correspond to up to 8.6/fb of integrated
luminosity collected by the D0 detector in pp-bar collisions at sqrt{s}=1.96
TeV. We set the most stringent limits at a hadron collider to date assuming two
different relations between the anomalous coupling parameters
Delta\kappa_\gamma, lambda, and Delta g_1^Z for a cutoff energy scale Lambda=2
TeV. The combined 68% C.L. limits are -0.057<Delta\kappa_\gamma<0.154,
-0.015<lambda<0.028, and -0.008<Delta g_1^Z<0.054 for the LEP parameterization,
and -0.007<Delta\kappa<0.081 and -0.017<lambda<0.028 for the equal couplings
parameterization. We also present the most stringent limits of the W boson
magnetic dipole and electric quadrupole moments.Comment: 10 pages, 5 figures, submitted to PL
Measurement of three-jet differential cross sections d sigma-3jet / d M-3jet in p anti-p collisions at sqrt(s)=1.96 TeV
We present the first measurement of the inclusive three-jet differential
cross section as a function of the invariant mass of the three jets with the
largest transverse momenta in an event in p anti-p collisions at sqrt(s) = 1.96
TeV. The measurement is made in different rapidity regions and for different
jet transverse momentum requirements and is based on a data set corresponding
to an integrated luminosity of 0.7 fb^{-1} collected with the D0 detector at
the Fermilab Tevatron Collider. The results are used to test the three-jet
matrix elements in perturbative QCD calculations at next-to-leading order in
the strong coupling constant. The data allow discrimination between
parametrizations of the parton distribution functions of the proton.Comment: 10 pages, 4 figures, 2 tables, submitted to Phys. Lett. B, corrected
chi2 values for NNPD
Search for pair production of the scalar top quark in muon+tau final states
We present a search for the pair production of scalar top quarks
(), the lightest supersymmetric partners of the top quarks, in
collisions at a center-of-mass energy of 1.96 TeV, using data
corresponding to an integrated luminosity of {7.3 } collected with the
\dzero experiment at the Fermilab Tevatron Collider. Each scalar top quark is
assumed to decay into a quark, a charged lepton, and a scalar neutrino
(). We investigate final states arising from and
. With no significant excess of events observed above the
background expected from the standard model, we set exclusion limits on this
production process in the (,) plane.Comment: Submitted to Phys. Lett.
Measurements of inclusive W+jets production rates as a function of jet transverse momentum in ppbar collisions at sqrt{s}=1.96 TeV
This Letter describes measurements of inclusive W (--> e nu) + n jet cross
sections (n = 1-4), presented as total inclusive cross sections and
differentially in the nth jet transverse momentum. The measurements are made
using data corresponding to an integrated luminosity of 4.2 fb-1 collected by
the D0 detector at the Fermilab Tevatron Collider, and achieve considerably
smaller uncertainties on W +jets production cross sections than previous
measurements. The measurements are compared to next-to-leading order
perturbative QCD (pQCD) calculations in the n =1-3 jet multiplicity bins and to
leading order pQCD calculations in the 4-jet bin. The measurements are
generally in agreement with pQCD predictions, although certain regions of phase
space are identified where the calculations could be improved
- âŠ