Langue anglaise

Rick Willett, lecteur de langue anglaise Anglais écrit et oral pour les sciences sociales Compte rendu non communiqu

The micro-damage process zone during transverse cortical bone fracture: No ears at crack growth initiation

Apply high-resolution benchtop micro-computed tomography (micro-CT) to gain greater understanding and knowledge of the formation of the micro-damage process zone formed during traverse fracture of cortical bone. Bovine cortical bone was cut into single edge notch (bending) fracture testing specimens with the crack on the transverse plane and oriented to grow in the circumferential direction. We used a multi-specimen technique and deformed the specimens to various individual secant modulus loss levels (P-values) up to and including maximum load (Pmax). Next, the specimens were infiltrated with a BaSO4 precipitation stain and scanned at 3.57-μm isotropic voxel size using a benchtop high resolution-micro-CT. Measurements of the micro-damage process zone volume, width and height were made. These were compared with the simple Irwin's process zone model and with finite element models. Electron and confocal microscopy confirmed the formation of BaSO4 precipitate in micro-cracks and other porosity, and an interesting novel mechanism similar to tunneling. Measurable micro-damage was detected at low P values and the volume of the process zone increased according to a second order polynomial trend. Both width and height grew linearly up to Pmax, at which point the process zone cross-section (perpendicular to the plane of the crack) was almost circular on average with a radius of approximately 550µm (approximately one quarter of the unbroken ligament thickness) and corresponding to the shape expected for a biological composite under plane stress conditions. This study reports details of the micro-damage fracture process zone previously unreported for cortical bone. High-resolution micro-CT enables 3D visualization and measurement of the process zone and confirmation that the crack front edge and process zone are affected by microstructure. It is clear that the process zone for the specimens studied grows to be meaningfully large, confirming the need for the J-integral approach and it does not achieve steady state at Pmax in most specimens. With further development, this approach may become valuable towards better understanding the role of the process zone in cortical bone fracture and the effects of relevant modifications towards changes in fracture toughness in a cost effective way.Canadian Institutes of Health Researc

Hormonal response to lipid and carbohydrate meals during the acute postprandial period

<p>Abstract</p> <p>Background</p> <p>Optimizing the hormonal environment during the postprandial period in favor of increased anabolism is of interest to many active individuals. Data are conflicting regarding the acute hormonal response to high fat and high carbohydrate feedings. Moreover, to our knowledge, no studies have compared the acute hormonal response to ingestion of lipid and carbohydrate meals of different size.</p> <p>Methods</p> <p>We compared the hormonal response to lipid and carbohydrate meals of different caloric content during the acute postprandial period. Nine healthy men (22 ± 2 years) consumed in a random order, cross-over design one of four meals/beverages during the morning hours in a rested and fasted state: dextrose at 75 g (300 kcals), dextrose at 150 g (600 kcals), lipid at 33 g (300 kcals), lipid at 66 g (600 kcals). Blood samples were collected Pre meal, and at 0.5 hr, 1 hr, 2 hr, and 3 hr post meal. Samples were assayed for testosterone, cortisol, and insulin using ELISA techniques. Area under the curve (AUC) was calculated for each variable, and a 4 × 5 ANOVA was used to further analyze data.</p> <p>Results</p> <p>A meal × time effect (p = 0.0003) was noted for insulin, with values highest for the dextrose meals at the 0.5 hr and 1 hr times, and relatively unaffected by the lipid meals. No interaction (p = 0.98) or meal (p = 0.39) effect was noted for testosterone, nor was an interaction (p = 0.99) or meal (p = 0.65) effect noted for cortisol. However, a time effect was noted for both testosterone (p = 0.04) and cortisol (p < 0.0001), with values decreasing during the postprandial period. An AUC effect was noted for insulin (p = 0.001), with values higher for the dextrose meals compared to the lipid meals (p < 0.05). No AUC effect was noted for testosterone (p = 0.85) or cortisol (p = 0.84).</p> <p>Conclusions</p> <p>These data indicate that 1) little difference is noted in serum testosterone or cortisol during the acute postprandial period when healthy men consume lipid and dextrose meals of different size; 2) Both testosterone and cortisol experience a drop during the acute postprandial period, which is similar to what is expected based on the normal diurnal variation--feeding with lipid or dextrose meals does not appear to alter this pattern; 3) dextrose meals of either 75 g or 150 g result in a significant increase in serum insulin, in particular at 0.5 hr and 1 hr post-ingestion; 4) lipid meals have little impact on serum insulin.</p

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Bactericidal Activity of the Human Skin Fatty Acid cis-6-Hexadecanoic Acid on Staphylococcus aureus

Human skin fatty acids are a potent aspect of our innate defenses, giving surface protection against potentially invasive organisms. They provide an important parameter in determining the ecology of the skin microflora, and alterations can lead to increased colonization by pathogens such as Staphylococcus aureus. Harnessing skin fatty acids may also give a new avenue of exploration in the generation of control measures against drug-resistant organisms. Despite their importance, the mechanism(s) whereby skin fatty acids kill bacteria has remained largely elusive. Here, we describe an analysis of the bactericidal effects of the major human skin fatty acid cis-6-hexadecenoic acid (C6H) on the human commensal and pathogen S. aureus. Several C6H concentration-dependent mechanisms were found. At high concentrations, C6H swiftly kills cells associated with a general loss of membrane integrity. However, C6H still kills at lower concentrations, acting through disruption of the proton motive force, an increase in membrane fluidity, and its effects on electron transfer. The design of analogues with altered bactericidal effects has begun to determine the structural constraints on activity and paves the way for the rational design of new antistaphylococcal agents

Detection fusion under dependence

Most results about quantized detection rely strongly on an assumption of independence among random variables. With this assumption removed, little is known. Thus, in this paper, Bayes optimal binary quantization for the detection of a shift in mean in a pair of dependent Gaussian random variables is studied. For certain problem parametrizations (meaning: the signals and correlation coefficient) optimal quantization is achievable via a single threshold applied to each observation-The same as under independence. In other cases one observation is best ignored, or is quantised with two thresholds; neither behavior is seen under independence. Further, and again in distinction from the case of independence, it is seen that in certain situations an XOR fusion rule is optimal, and in these cases the implied decision rule is bizarre. © 2000 Int. Soc. Inf. Fusion

The good, bad, and ugly: Distributed detection of a known signal in dependent gaussian noise

Most results about quantized detection rely strongly on an assumption of independence among random variables. With this assumption removed, little is known. Thus, in this paper, Bayes-optimal binary quantization for the detection of a shift in mean in a pair of dependent Gaussian random variables is studied. This is arguably the simplest meaningful problem one could consider. If results and rules are to be found, they ought to make themselves plain in this problem. For certain problem parametrizations (meaning the signals and correlation coefficient), optimal quantization is achievable via a single threshold applied to each observation-the same as under independence. In other cases, one observation is best ignored or is quantized with two thresholds; neither behavior is seen under independence. Further, and again in distinction from the case of independence, it is seen that in certain situations, an XOR fusion rule is optimal, and in these cases, the implied decision rule is bizarre. The analysis is extended to the multivariate Gaussian problem. © 2000 IEEE

Partnering with an Area Hospital to Provide Senior Consumer Health Information

Objective: The purpose of this project is to provide better consumer health information and services to a patient population of a hospital-based nursing home. Methods: A hospital partnered with an academic medical library and obtained National Network of Libraries of Medicine funding. Wii devices with television monitors were purchased to improve physical activity in the nursing home. All nurses were trained to use MedlinePlus, and computers were made available for their use to search MedlinePlus in the nursing home. MedlinePlus materials were added to the consumer health library in the hospital, and DVD players were purchased to use for watching consumer health videos. Results: The capacity of the nursing home and hospital to deliver consumer health information to patients and their families has been improved. Conclusions: A small project like this is a great way to introduce a health care system to the services and products of the National Library of Medicine and empower the staff to better provide consumer health information