Letter from Casper Whitney to [John Muir], 1907 Apr 29.

THEOUTING MAGAZINEEdited byCASPAR WHITNEY Dictated W. April 29, 1907. 35 AND 37 W. 31ST STREETNEW YORKMy dear Sir: I wonder if I can induce you to write something for The Outing Magazine . I have made one or two attempts, but unfortunately with no success. Very truly yours, [illegible]John Muir, Esq., Martimez, Contra Costa Co., Cal. Printing and Manufacturing Plant, and Subscription Offices at Deposit, N. Y. [03867

Restored Agricultural Wetlands in central Iowa: Habitat Quality and Amphibian Response

Amphibians are declining throughout the United States and worldwide due, partly, to habitat loss. Conservation practices on the landscape restore wetlands to denitrify tile drainage effluent and restore ecosystem services. Understanding how water quality, hydroperiod, predation, and disease affect amphibians in restored wetlands is central to maintaining healthy amphibian populations in the region. We examined the quality of amphibian habitat in restored wetlands relative to reference wetlands by comparing species richness, developmental stress, and adult leopard frog (Lithobates pipiens) survival probabilities to a suite of environmental metrics. Although measured habitat variables differed between restored and reference wetlands, differences appeared to have sub-lethal rather than lethal effects on resident amphibian populations. There were few differences in amphibian species richness and no difference in estimated survival probabilities between wetland types. Restored wetlands had more nitrate and alkaline pH, longer hydroperiods, and were deeper, whereas reference wetlands had more amphibian chytrid fungus zoospores in water samples and resident amphibians exhibited increased developmental stress. Restored and reference wetlands are both important components of the landscape in central Iowa and maintaining a complex of fish-free wetlands with a variety of hydroperiods will likely contribute to the persistence of amphibians in this landscape

Histone Deacetylase 3 Depletion in Osteo/Chondroprogenitor Cells Decreases Bone Density and Increases Marrow Fat

Histone deacetylase (Hdac)3 is a nuclear enzyme that contributes to epigenetic programming and is required for embryonic development. To determine the role of Hdac3 in bone formation, we crossed mice harboring loxP sites around exon 7 of Hdac3 with mice expressing Cre recombinase under the control of the osterix promoter. The resulting Hdac3 conditional knockout (CKO) mice were runted and had severe deficits in intramembranous and endochondral bone formation. Calvarial bones were significantly thinner and trabecular bone volume in the distal femur was decreased 75% in the Hdac3 CKO mice due to a substantial reduction in trabecular number. Hdac3-CKO mice had fewer osteoblasts and more bone marrow adipocytes as a proportion of tissue area than their wildtype or heterozygous littermates. Bone formation rates were depressed in both the cortical and trabecular regions of Hdac3 CKO femurs. Microarray analyses revealed that numerous developmental signaling pathways were affected by Hdac3-deficiency. Thus, Hdac3 depletion in osterix-expressing progenitor cells interferes with bone formation and promotes bone marrow adipocyte differentiation. These results demonstrate that Hdac3 inhibition is detrimental to skeletal health

Treatment of anorexia nervosa:A multimethod investigation translating experimental neuroscience into clinical practice

Background Anorexia nervosa (AN) is a severe psychiatric condition and evidence on how to best treat it is limited. Objectives This programme consists of seven integrated work packages (WPs) and aims to develop and test disseminable and cost-effective treatments to optimise management for people with AN across all stages of illness. Methods WP1a used surveys, focus groups and a pre–post trial to develop and evaluate a training programme for school staff on eating disorders (EDs). WP1b used a randomised controlled trial (RCT) [International Standard Randomised Controlled Trial Number (ISRCTN) 42594993] to evaluate a prevention programme for EDs in schools. WP2a evaluated an inpatient treatment for AN using case reports, interviews and a quasi-experimental trial. WP2b used a RCT (ISRCTN67720902) to evaluate two outpatient psychological therapies for AN. WP3 used a RCT (ISRCTN06149665) to evaluate an intervention for carers of inpatients with AN. WP4 used actimetry, self-report and endocrine assessment to examine physical activity (PA) in AN. WP5 conducted a RCT (ISRCTN18274621) of an e-mail-guided relapse prevention programme for inpatients with AN. WP6 analysed cohort data to examine the effects of maternal EDs on fertility and their children’s diet and growth. WP7a examined clinical case notes to explore how access to specialist ED services affects care pathways and user experiences. Finally, WP7b used data from this programme and the British Cohort Study (1970) to identify the costs of services used by people with AN and to estimate annual costs of AN for England. Results WP1a: a brief training programme improved knowledge, attitudes and confidence of school staff in managing EDs in school. WP1b: a teacher-delivered intervention was feasible and improved risk factors for EDs in adolescent girls. WP2a: both psychological therapies improved outcomes in outpatients with AN similarly, but patients preferred one of the treatments. WP2b: the inpatient treatment (Cognitive Remediation and Emotional Skills Training) was acceptable with perceived benefits by patients, but showed no benefits compared with treatment as usual (TAU). WP3: compared with TAU, the carer intervention improved a range of patient and carer outcomes, including carer burden and patient ED symptomatology. WP4: drive to exercise is tied to ED pathology and a desire to improve mood in AN patients. PA was not increased in these patients. WP5: compared with TAU, the e-mail-guided relapse prevention programme resulted in higher body mass index and lower distress in patients at 12 months after discharge. WP6: women with an ED had impaired fertility and their children had altered dietary and growth patterns compared with the children of women without an ED. WP7a: direct access to specialist ED services was associated with higher referral rates, lower admission rates, greater consistency of care and user satisfaction. WP7b: the annual costs of AN in England are estimated at between £45M and £230M for 2011. Conclusions This programme has produced evidence to inform future intervention development and has developed interventions that can be disseminated to improve outcomes for individuals with AN. Directions for future research include RCTs with longer-term outcomes and sufficient power to examine mediators and moderators of change. Trial registration Current Controlled Trials ISRCTN42594993, ISRCTN67720902, ISRCTN06149665 and ISRCTN18274621

Letter from Casper Whitney to [John Muir], 1907 Apr 29.

THEOUTING MAGAZINEEdited byCASPAR WHITNEY Dictated W. April 29, 1907. 35 AND 37 W. 31ST STREETNEW YORKMy dear Sir: I wonder if I can induce you to write something for The Outing Magazine . I have made one or two attempts, but unfortunately with no success. Very truly yours, [illegible]John Muir, Esq., Martimez, Contra Costa Co., Cal. Printing and Manufacturing Plant, and Subscription Offices at Deposit, N. Y. [03867

Letter from Casper Whitney to John Muir, 1906 Jan 25.

THEOUTING MAGAZINEEdited byCASPAR WHITNEYDictated - P239 FIFTH AVENUE, NEW YORKJanuary 25, 1906.My dear Sir:I am sending you the February number of THE OUTING MAGAZINE which happens to be a Pacific Coast number. I send you also a January number which better shows you the average magazine. I have wanted very much to have some papers from you in our magazine and I am writing to get in touch with you and ask if you would do something for us and whether you have any subjects in mind you feel you would like to write upon.Sincerely yours,[illegible]John Muir, Esq.,Martinez, Contra Costa Co., Cal.Printing and Manufacturing Plant, and Subscription Offices at Deposit, N. Y.0368

Letter from Casper Whitney to John Muir, 1906 Jan 25.

THEOUTING MAGAZINEEdited byCASPAR WHITNEYDictated - P239 FIFTH AVENUE, NEW YORKJanuary 25, 1906.My dear Sir:I am sending you the February number of THE OUTING MAGAZINE which happens to be a Pacific Coast number. I send you also a January number which better shows you the average magazine. I have wanted very much to have some papers from you in our magazine and I am writing to get in touch with you and ask if you would do something for us and whether you have any subjects in mind you feel you would like to write upon.Sincerely yours,[illegible]John Muir, Esq.,Martinez, Contra Costa Co., Cal.Printing and Manufacturing Plant, and Subscription Offices at Deposit, N. Y.03687https://scholarlycommons.pacific.edu/jmcl/29863/thumbnail.jp

Letter from Casper Whitney to [John Muir], 1907 Apr 29.

THEOUTING MAGAZINEEdited byCASPAR WHITNEY Dictated W. April 29, 1907. 35 AND 37 W. 31ST STREETNEW YORKMy dear Sir: I wonder if I can induce you to write something for The Outing Magazine . I have made one or two attempts, but unfortunately with no success. Very truly yours, [illegible]John Muir, Esq., Martimez, Contra Costa Co., Cal. Printing and Manufacturing Plant, and Subscription Offices at Deposit, N. Y. [03867]https://scholarlycommons.pacific.edu/jmcl/29550/thumbnail.jp