1,636 research outputs found
Trifarotene: a current review and perspectives in dermatology
Retinoids have numerous applications in inflammatory, dyskeratotic, and oncohematology diseases. Retinoids have now reached the fourth generation, progressively reducing toxicity whilst increasing their efficacy. Trifarotene is a new fourth-generation retinoid with a selective action on RAR-Îł. In this review, we reported the trialsâboth concluded and in progressâincluding the use of trifarotene in dermatological diseases. Studies were identified by searching electronic databases (MEDLINE, EMBASE, PubMed, Cochrane, Trials.gov) from 2012 to today and reference lists of respective articles. Only articles published in English language were included. Randomized trials evaluating trifarotene tolerability, safety, and efficacy in congenital ichthyosis and acne have demonstrated great results and mild side effects, leading to the approval by the FDA of trifarotene for the treatment of lamellar ichthyosis in 2014, and of acne vulgaris in October 2019. No high-quality randomized clinical trials have evaluated the treatment of primary cutaneous lymphomas with trifarotene. Finally, we are hypothesizing future perspectives in the treatment of non-melanoma skin cancers, fungal infections, photoaging, and hand-foot skin reactions with trifarotene
Microstructural and morphological properties of homoepitaxial (001)ZnTe layers investigated by x-ray diffuse scattering
The microstructural and morphological properties of homoepitaxial (001)ZnTe
layers are investigated by x-ray diffuse scattering. High resolution reciprocal
space maps recorded close to the ZnTe (004) Bragg peak show different diffuse
scattering features. One kind of cross-shaped diffuse scattering streaks along
directions can be attributed to stacking faults within the epilayers.
Another kind of cross-shaped streaks inclined at an angle of about 80deg with
respect to the in-plane direction arises from the morphology of the
epilayers. (abridged version
Comparison of Different Methods of Automated Landform Classification at the Drainage Basin Scale: Examples from the Southern Italy
In this work, we tested the reliability of two different methods of
automated landform classification (ACL) in three geological domains of the
southern Italian chain with contrasting morphological features. ACL maps
deriving from the TPI-based (topographic position index) algorithm are strictly
dependent to the search input parameters and they are not able to fully capture
landforms of different size. Geomorphons-based classification has shown a
higher potential and can represent a powerful method of ACL, although it
should be improved with the introduction of additional DEM-based parameters
for the extraction of landform classe
Prospects for the measurement of muon-neutrino disappearance at the FNAL-Booster
Neutrino physics is nowadays receiving more and more attention as a possible
source of information for the long-standing problem of new physics beyond the
Standard Model. The recent measurement of the mixing angle in the
standard mixing oscillation scenario encourages us to pursue the still missing
results on leptonic CP violation and absolute neutrino masses. However,
puzzling measurements exist that deserve an exhaustive evaluation. The NESSiE
Collaboration has been setup to undertake conclusive experiments to clarify the
muon-neutrino disappearance measurements at small , which will be able to
put severe constraints to models with more than the three-standard neutrinos,
or even to robustly measure the presence of a new kind of neutrino oscillation
for the first time. To this aim the use of the current FNAL-Booster neutrino
beam for a Short-Baseline experiment has been carefully evaluated. This
proposal refers to the use of magnetic spectrometers at two different sites,
Near and Far. Their positions have been extensively studied, together with the
possible performances of two OPERA-like spectrometers. The proposal is
constrained by availability of existing hardware and a time-schedule compatible
with the CERN project for a new more performant neutrino beam, which will
nicely extend the physics results achievable at the Booster. The possible FNAL
experiment will allow to clarify the current disappearance tension
with appearance and disappearance at the eV mass scale. Instead, a new
CERN neutrino beam would allow a further span in the parameter space together
with a refined control of systematics and, more relevant, the measurement of
the antineutrino sector, by upgrading the spectrometer with detectors currently
under R&D study.Comment: 76 pages, 52 figure
The risk stratification of adverse neonatal outcomes in women with gestational diabetes (STRONG) study
Aims: To assess the risk of adverse neonatal outcomes in women with gestational diabetes (GDM) by identifying subgroups of women at higher risk to recognize the characteristics most associated with an excess of risk. Methods: Observational, retrospective, multicenter study involving consecutive women with GDM. To identify distinct and homogeneous subgroups of women at a higher risk, the RECursive Partitioning and AMalgamation (RECPAM) method was used. Overall, 2736 pregnancies complicated by GDM were analyzed. The main outcome measure was the occurrence of adverse neonatal outcomes in pregnancies complicated by GDM. Results: Among study participants (median age 36.8 years, pre-gestational BMI 24.8Â kg/m2), six miscarriages, one neonatal death, but no maternal death was recorded. The occurrence of the cumulative adverse outcome (OR 2.48, 95% CI 1.59â3.87), large for gestational age (OR 3.99, 95% CI 2.40â6.63), fetal malformation (OR 2.66, 95% CI 1.00â7.18), and respiratory distress (OR 4.33, 95% CI 1.33â14.12) was associated with previous macrosomia. Large for gestational age was also associated with obesity (OR 1.46, 95% CI 1.00â2.15). Small for gestational age was associated with first trimester glucose levels (OR 1.96, 95% CI 1.04â3.69). Neonatal hypoglycemia was associated with overweight (OR 1.52, 95% CI 1.02â2.27) and obesity (OR 1.62, 95% CI 1.04â2.51). The RECPAM analysis identified high-risk subgroups mainly characterized by high pre-pregnancy BMI (OR 1.68, 95% CI 1.21â2.33 for obese; OR 1.38 95% CI 1.03â1.87 for overweight). Conclusions: A deep investigation on the factors associated with adverse neonatal outcomes requires a risk stratification. In particular, great attention must be paid to the prevention and treatment of obesity
The ATLAS trigger muon "vertical slice"
The muon trigger system is a fundamental component of the ATLAS detector at the LHC collider. In this paper we describe the ATLAS multi-level trigger selecting events with muons: the Muon Trigger Slic
High intensity neutrino oscillation facilities in Europe
The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the FrĂ©jus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of ÎŒ+ and ÎŒâ beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He6 and Ne18, also stored in a ring. The far detector is also the MEMPHYS detector in the FrĂ©jus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive
Implementation and performance of the ATLAS Trigger Muon "Vertical Slice"
The ATLAS (A Toroidal LHC ApparatuS) trigger system is designed to keep high effiency for interesting events while achieving a rejection of low transverse momentum (p_T) physics of about 10^7, thus reaching the ~200Hz data storage capability of the Data Aquisition system. A three levels structure has been implemented for this purpose, as described in this work for the case of the muon trigger system. After describing the implementation, some performance results are presented in terms of final trigger rates, resolutions, efficiencies, background rejection and algorithm latency
Virgo calibration and reconstruction of the gravitational wave strain during VSR1
Virgo is a kilometer-length interferometer for gravitational waves detection
located near Pisa. Its first science run, VSR1, occured from May to October
2007. The aims of the calibration are to measure the detector sensitivity and
to reconstruct the time series of the gravitational wave strain h(t). The
absolute length calibration is based on an original non-linear reconstruction
of the differential arm length variations in free swinging Michelson
configurations. It uses the laser wavelength as length standard. This method is
used to calibrate the frequency dependent response of the Virgo mirror
actuators and derive the detector in-loop response and sensitivity within ~5%.
The principle of the strain reconstruction is highlighted and the h(t)
systematic errors are estimated. A photon calibrator is used to check the sign
of h(t). The reconstructed h(t) during VSR1 is valid from 10 Hz up to 10 kHz
with systematic errors estimated to 6% in amplitude. The phase error is
estimated to be 70 mrad below 1.9 kHz and 6 micro-seconds above.Comment: 8 pages, 8 figures, proceedings of Amaldi 8 conference, to be
published in Journal of Physics Conference Series (JPCS). Second release:
correct typo
Calibration and sensitivity of the Virgo detector during its second science run
The Virgo detector is a kilometer-length interferometer for gravitational
wave detection located near Pisa (Italy). During its second science run (VSR2)
in 2009, six months of data were accumulated with a sensitivity close to its
design. In this paper, the methods used to determine the parameters for
sensitivity estimation and gravitational wave reconstruction are described. The
main quantities to be calibrated are the frequency response of the mirror
actuation and the sensing of the output power. Focus is also put on their
absolute timing. The monitoring of the calibration data as well as the
parameter estimation with independent techniques are discussed to provide an
estimation of the calibration uncertainties. Finally, the estimation of the
Virgo sensitivity in the frequency-domain is described and typical
sensitivities measured during VSR2 are shown.Comment: 30 pages, 23 figures, 1 table. Published in Classical and Quantum
Gravity (CQG), Corrigendum include
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