Plan for spent fuel waste form testing for NNWSI [Nevada Nuclear Waste Storage Investigations]

The purpose of spent fuel waste form testing is to determine the rate of release of radionuclides from failed disposal containers holding spent fuel, under conditions appropriate to the Nevada Nuclear Waste Storage Investigations (NNWSI) Project tuff repository. The information gathered in the activities discussed in this document will be used: to assess the performance of the waste package and engineered barrier system (EBS) with respect to the containment and release rate requirements of the Nuclear Regulatory Commission, as the basis for the spent fuel waste form source term in repository-scale performance assessment modeling to calculate the cumulative releases to the accessible environment over 10,000 years to determine compliance with the Environmental Protection Agency, and as the basis for the spent fuel waste form source term in repository-scale performance assessment modeling to calculate cumulative releases over 100,000 years as required by the site evaluation process specified in the DOE siting guidelines. 34 refs

HNPCC (Lynch Syndrome): Differential Diagnosis, Molecular Genetics and Management - a Review

HNPCC (Lynch syndrome) is the most common form of hereditary colorectal cancer (CRC), wherein it accounts for between 2-7 percent of the total CRC burden. When considering the large number of extracolonic cancers integral to the syndrome, namely carcinoma of the endometrium, ovary, stomach, hepatobiliary system, pancreas, small bowel, brain tumors, and upper uroepithelial tract, these estimates of its frequency are likely to be conservative. The diagnosis is based upon its natural history in concert with a comprehensive cancer family history inclusive of all anatomic sites. In order for surveillance and management to be effective and, indeed, lifesaving, among these high-risk patients, the linchpin to cancer control would be the physician, who must be knowledgeable about hereditary cancer syndromes, their molecular and medical genetics, genetic counseling, and, most importantly, the natural history of the disorders, so that the entirety of this knowledge can be melded to highly-targeted management

Data cultures of mobile dating and hook-up apps : emerging issues for critical social science research

The ethical and social implications of data mining, algorithmic curation and automation in the context of social media have been of heightened concern for a range of researchers with interests in digital media in recent years, with particular concerns about privacy arising in the context of mobile and locative media. Despite their wide adoption and economic importance, mobile dating apps have received little scholarly attention from this perspective – but they are intense sites of data generation, algorithmic processing, and cross-platform data-sharing; bound up with competing cultures of pro- duction, exploitation and use. In this paper, we describe the ways various forms of data are incorporated into, and emerge from, hook-up apps’ business logics, socio-technical arrangements, and cultures of use to produce multiple and intersecting data cultures. We propose a multi-layered research agenda for critical and empirical inquiry into this field, and suggest appropriate conceptual and methodological frameworks for exploring the social and political challenges of data cultures

Planetary nebulae in M33: probes of AGB nucleosynthesis and ISM abundances

We have obtained deep optical spectrophotometry of 16 planetary nebulae in M33, mostly located in the central two kpc of the galaxy, with the Subaru and Keck telescopes. We have derived electron temperatures and chemical abundances from the detection of the [OIII]4363 line for the whole sample. We have found one object with an extreme nitrogen abundance, 12+log(N/H)=9.20, accompanied by a large helium content. After combining our data with those available in the literature for PNe and HII regions, we have examined the behavior of nitrogen, neon, oxygen and argon in relation to each other, and as a function of galactocentric distance. We confirm the good correlation between Ne/H and O/H for PNe in M33. Ar/H is also found to correlate with O/H. This strengthens the idea that at the metallicity of the bright PNe analyzed in M33, which is similar to that found in the LMC, these elements have not been significantly modified during the dredge-up processes that take place during the AGB phase of their progenitor stars. We find no significant oxygen abundance offset between PNe and HII regions at any given galactocentric distance, despite the fact that these objects represent different age groups in the evolution of the galaxy. Combining the results from PNe and HII regions, we obtain a representative slope of the ISM alpha-element (O, Ar, Ne) abundance gradient in M33 of -0.025 +/- 0.006 dex/kpc. Both PNe and HII regions display a large abundance dispersion at any given distance from the galactic center. We find that the N/O ratio in PNe is enhanced, relative to the HII regions, by approximately 0.8 dex.Comment: 21 pages, 20 figures. Accepted for publication in MNRA

Neon and Argon optical emission lines in ionized gaseous nebulae: Implications and applications

In this work we present a study of the strong optical collisional emission lines of Ne and Ar in an heterogeneous sample of ionized gaseous nebulae for which it is possible to derive directly the electron temperature and hence the chemical abundances of neon and argon. We calculate using a grid of photoionization models new ionization correction factors for these two elements and we study the behaviour of Ne/O and Ar/O abundance ratios with metallicity. We find a constant value for Ne/O, while there seems to be some evidence for the existence of negative radial gradients of Ar/O over the disks of some nearby spirals. We study the relation between the intensities of the emission lines of [NeIII] at 3869 \AA and [OIII] at 4959 \AA and 5007 \AA. This relation can be used in empirical calibrations and diagnostic ratios extending their applicability to bluer wavelengths and therefore to samples of objects at higher redshifts. Finally, we propose a new diagnostic using [OII], [NeIII] and Hdelta emission lines to derive metallicities for galaxies at high z.Comment: 12 pages, 12 figures, accepted for publication in Monthly Notices of the Royal Astronomical Societ

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium.

BACKGROUND: The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term probabilities for a cardiovascular disease event associated with non-HDL cholesterol and modelled its risk reduction by lipid-lowering treatment. METHODS: In this risk-evaluation and risk-modelling study, we used Multinational Cardiovascular Risk Consortium data from 19 countries across Europe, Australia, and North America. Individuals without prevalent cardiovascular disease at baseline and with robust available data on cardiovascular disease outcomes were included. The primary composite endpoint of atherosclerotic cardiovascular disease was defined as the occurrence of the coronary heart disease event or ischaemic stroke. Sex-specific multivariable analyses were computed using non-HDL cholesterol categories according to the European guideline thresholds, adjusted for age, sex, cohort, and classical modifiable cardiovascular risk factors. In a derivation and validation design, we created a tool to estimate the probabilities of a cardiovascular disease event by the age of 75 years, dependent on age, sex, and risk factors, and the associated modelled risk reduction, assuming a 50% reduction of non-HDL cholesterol. FINDINGS: Of the 524 444 individuals in the 44 cohorts in the Consortium database, we identified 398 846 individuals belonging to 38 cohorts (184 055 [48·7%] women; median age 51·0 years [IQR 40·7-59·7]). 199 415 individuals were included in the derivation cohort (91 786 [48·4%] women) and 199 431 (92 269 [49·1%] women) in the validation cohort. During a maximum follow-up of 43·6 years (median 13·5 years, IQR 7·0-20·1), 54 542 cardiovascular endpoints occurred. Incidence curve analyses showed progressively higher 30-year cardiovascular disease event-rates for increasing non-HDL cholesterol categories (from 7·7% for non-HDL cholesterol <2·6 mmol/L to 33·7% for ≥5·7 mmol/L in women and from 12·8% to 43·6% in men; p<0·0001). Multivariable adjusted Cox models with non-HDL cholesterol lower than 2·6 mmol/L as reference showed an increase in the association between non-HDL cholesterol concentration and cardiovascular disease for both sexes (from hazard ratio 1·1, 95% CI 1·0-1·3 for non-HDL cholesterol 2·6 to <3·7 mmol/L to 1·9, 1·6-2·2 for ≥5·7 mmol/L in women and from 1·1, 1·0-1·3 to 2·3, 2·0-2·5 in men). The derived tool allowed the estimation of cardiovascular disease event probabilities specific for non-HDL cholesterol with high comparability between the derivation and validation cohorts as reflected by smooth calibration curves analyses and a root mean square error lower than 1% for the estimated probabilities of cardiovascular disease. A 50% reduction of non-HDL cholesterol concentrations was associated with reduced risk of a cardiovascular disease event by the age of 75 years, and this risk reduction was greater the earlier cholesterol concentrations were reduced. INTERPRETATION: Non-HDL cholesterol concentrations in blood are strongly associated with long-term risk of atherosclerotic cardiovascular disease. We provide a simple tool for individual long-term risk assessment and the potential benefit of early lipid-lowering intervention. These data could be useful for physician-patient communication about primary prevention strategies. FUNDING: EU Framework Programme, UK Medical Research Council, and German Centre for Cardiovascular Research

Ultrafast domain dilation induced by optical pumping in ferromagnetic CoFe/Ni multilayers

Ultrafast optical pumping of systems with spatially nonuniform magnetic textures is known to cause far-from-equilibrium spin transport effects, such as the broadening of domain-walls. Here, we study the dynamics of labyrinth domain networks in ferromagnetic CoFe/Ni multilayers subject to a femtosecond optical pump and find an ultrafast domain dilation by 6% within 1.6 ps. This surprising result is based on the unambiguous determination of a harmonically-related shift of ultrafast magnetic X-ray diffraction for the first- and third-order rings. Domain dilation is plausible from conservation of momentum arguments, whereby inelastic scattering from a hot, quasi-ballistic, radial current transfers momentum to the magnetic domains. Our results suggest a potentially rich variety of unexpected physical phenomena associated with far-from-equilibrium inelastic electron-magnon scattering processes in the presence of spin textures