Proof of concept – Enterprise Crowdfunding

In this short paper it will be discussed how crowdfunding concepts can be successfully used to support internal financing projects towards Enterprise Crowdfunding. A central platform to be developed will guarantee transparency in order to ease and facilitate synergy-effects between company divisions and departments. Besides transparency crowdfunding – especially through its federalistic financing concepts – can contribute to the evaluation of new planned projects. Furthermore, fair according to the input involved is not more problematic. The probability to not get funding for those projects which deserve support it is significantly reduced

Model of mobility demands for future short distance public transport systems

Short distance public transport faces huge challenges, although it is very important within a sustainable transport system to reduce traffic emissions. Revenues and subsidization are decreasing and especially in rural regions the offer is constantly diminishing. New approaches for public transport systems are strongly needed to avoid traffic infarcts in urban and rural areas to grant a basic offer of mobility services for everyone. In the proposed work a demand centered approach of dynamic public transport planning is introduced which relies on regional traffic data. The approach is based on a demand model which is represented as a dynamic undirected attributed graph. The demands are logged through traffic sensors and sustainability focused traveler information systems

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

© 2024 The Authors. Journal of Extracellular Vesicles, published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.Peer reviewe

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

ARM-cortex-basiertes Plugin-System für MIDI-Synthesizer

Um einen Klangerzeuger oder Audioe ekt auf einem Microprozessor wie dem ARM-cortex-m3 zu implementieren wird Detailwissen über die Hardware benötigt. Diese Arbeit soll es ermöglichen Klangerzeuger und Audioe ekte zu implementieren, ohne ein Vorwissen von der Hardware zu haben. Dazu wurden einfache Schnittstellen dafür entwickelt, die es ermöglichen einen Klangerzeuger und mehrere Audioe ekte gleichzeitig auf einem ARM-cortex-Mikrocontroller laufen zu lassen. In dieser Arbeit werden die Hard- und Software die als Grundlage dienen, sowie das Framework und die Schnittstellen die entwickelt wurden, vorgestelltImpementing a synthesizer or audio-e ect on a microprocessor such as the ARM-cortex-m3 requires detailed knowledge about the hardware. This thesis enables the implementation of sythesizers and audio-e ects without having prior knowledge of the hardware. Therefore simple interfaces have been developed, making it possible to run a synthesizer and several audio-e ects simlutaniously on an ARM-cortex-microporcessor. In this thesis the hardware and software that serve as a basis, as well as the framework and the interfaces that were developed will be presented

Influence of change in sales networks on a firm’s sales strategy

This research revolves around two major theoretical topics: international network and international sales. The study aims to combine both distinct research areas in order to understand how changes in the sales network influence the sales strategy of the firm. The focus is hereby on born global companies respectively international new ventures. For this reason a framework is introduced that explains the inherent dynamics between sales network and sales strategy with a cycle model. Hereby it is argued that sales network characteristics have influence on specific dimensions of the sales strategy. The sales strategy itself apparently affects the firm’s performance which in turn is argued to influence the sales network. This framework is further on tested with the help of propositions. The empirical basis is provided by a qualitative single case study that is conducted with observations and interviews. The empirical data shows the influence between sales network characteristics and sales strategy components. Whereas no significant empirical proof can be granted to the introduced framework there is evidence that it should be tested with a bigger sample of firms in order to check its validity. Therefore this study contributes to theory in providing a framework for researching dynamics in sales network and sales strategy context. As is this research combines international network and sales literature it is adding to a more holistic understanding of international business. It is also contributing to managerial knowledge in a way that it adds to an understanding of how the sales environment of a firm influences the sales strategy and what impact is expected on the performance of the company

Pathological overproduction: the bad side of adenosine.

Adenosine is an endogenous ubiquitous purine nucleoside, which is increased by hypoxia, ischaemia and tissue damage and mediates a number of physiopathological effects by interacting with four GPCRs, identified as A1 , A2A , A2B and A3 . Physiological and acutely increased adenosine is mostly associated with beneficial effects that include vasodilatation and a decrease in inflammation. In contrast, chronic overproduction of adenosine occurs in important pathological states, where long-lasting increases in the nucleoside levels are responsible for the bad side of adenosine associated with chronic inflammation, fibrosis and organ damage. In this review, we describe and critically discuss the pathological overproduction of adenosine and analyse when, where and how adenosine exerts its detrimental effects throughout the body