La defensa europea después del Brexit

Este documento de trabajo se ha beneficiado de los comentarios realizados por los asistentes al Coloquio: La Europa de la Defensa y la Seguridad tras el Brexit; realizado el 8 de noviembre. Este Documento de Trabajo ha sido publicado por El Observatorio de Política Exterior OPEX de la Fundación Alternativas. Es un centro de investigación y propuesta español, de espíritu marcadamente europeísta, que pretende impulsar la proyección exterior de España, en todas sus dimensiones: política, de seguridad, económica y cultural

Immunohistochemical analysis of ß3 integrin (CD61): expression in pig tissues and human tumors

CD61 is a membrane glycoprotein that associates with CD41 (aIIb) to form the heterodimeric complex gpIIb/IIIa (CD41/CD61), predominantly expressed in platelets and megakariocytes. CD61 or ß3 integrin also associates with av (CD51) to form the vitronectin receptor, which is expressed in many tissues. We have used a monoclonal antibody against the porcine gpIIIa or CD61 (JM2E5) to study the distribution of this molecule in different normal pig tissues. As in humans, CD61 was broadly expressed in all tissues examined. In the kidney, strong expression of CD61 was observed in epithelial cells from renal tubules. In the testis, CD61 expression was detected in the Leydig cells. However, in liver, CD61 was weak or not detected. Many integrins are particularly involved in tumogenicity and in tumor progression mediating cellcell interaction. Immunofluorescence experiments using cultured human tumor HeLa cells showed nuclear and cytoplasmic staining of mAb JM2E5. Immunohistochemical analysis of human tumor sections from several organs showed a heterogeneus distribution in metastatic cases from colon and breast carcinoma. However, no staining was found in metastasis from melanom

Antígenos leucocitarios como genes candidatos para mejorar la respuesta inmune en cerdos

Leukocyte antigens (CD) have functions related to immune response and are of interest as classical candidate genes for health. Polymorphisms (e.g. SNPs) in these genes may be associated with variation in the immune response and consequently in disease response. This approach is being taken in search of susceptibility genes for swine disease. In addition, these genes may vary between populations, especially where specific adaptation to pathogens has occurred, and are of potential interest in characterising pig biodiversity.Los antígenos leucocitarios (CD) tienen funciones relacionadas con la respuesta inmune y son de interés con genes candidatos clásicos para la salud. Los Polimorfismos (ej. SNPs) en estos genes pueden estar asociados con variaciones en la respuesta inmune y consecuentemente con la respuesta a la enfermedad. Este ensayo se está desarrollando en la búsqueda de susceptibilidades genéticas a enfermedades porcinas. Adicionalmente, estos genes pueden variar entre poblaciones, especialmente en la que han ocurrido adaptaciones a patógenos, y suponen un interés potencial para la caracterización de la biodiversidad porcina

Descubriendo los ecosistemas estratégicos para el fortalecimiento de la gobernanza en el departamento de Santander (Santander Bio): documento de identificación de los servicios ecosistémicos de la naturaleza percibidos por las comunidades de los municipios del Carmen de Chucurí, Cimitarra y Santa Barbara

El proyecto de investigación “Descubriendo los ecosistemas estratégicos para el fortalecimiento de la gobernanza en el departamento de Santander” (Santander Bio), tuvo como principal objetivo generar conocimiento sobre la biodiversidad en ecosistemas estratégicos como un insumo para la gestión integral del territorio, los servicios ecosistémicos y la toma de decisiones en el departamento de Santander. Para ello se trabajó desde un enfoque de paisaje, bajo la mirada de la historia ambiental y recurriendo al método etnográfico a través del uso de encuestas, entrevistas, cartografía social, observación participante y recorridos guiados. Adicionalmente, se trianguló esta información primaria con fuentes secundarias y con estos insumos se estructuró este documento.BogotáCiencias sociales y saberes de la Biodiversida

Descubriendo los ecosistemas estratégicos para el fortalecimiento de la gobernanza en el departamento de Santander (Santander Bio): Documento de identificación de aspectos claves relacionados con los sistemas de gobernanza de los municipios del Carmen de Chucurí, Cimitarra y Santa Bárbara

El componente uno incluyó estudios biológicos y sociales. La investigación social se desarrolló desde una aproximación conceptual basada en el análisis de sistemas socioecológicos (SSE) y el marco conceptual de la Plataforma Intergubernamental Científiconormativa sobre Diversidad Biológica y Servicios de los Ecosistemas (Ipbes). Estas aproximaciones nos permiten entender el paisaje como un elemento configurado por la interacción de elementos sociales y naturales. Se analizaron dos ejes fundamentales: (1) la identificación de aspectos claves de la gobernanza local asociada a la biodiversidad y (2) la identificación de los servicios ecosistémicos percibidos por los pobladores locales. Este documento aborda el primer eje, es decir, las principales características de las instituciones, la gobernanza y otros impulsores indirectos de las veredas Islanda y La Belleza del municipio de El Carmen de Chucurí. De acuerdo con el marco conceptual, nos centramos en describir las relaciones entre los sistemas de gobernanza. la calidad de vida y los activos antropogénicos de los habitantes de estas veredas desde un enfoque multitemporal y multiescalar.BogotáCiencias sociales y saberes de la Biodiversida

Wireless power transmission: R&D activities within Europe

Wireless power transmission (WPT) is an emerging technology that is gaining increased visibility in recent years. Efficient WPT circuits, systems and strategies can address a large group of applications spanning from batteryless systems, battery-free sensors, passive RF identification, near-field communications, and many others. WPT is a fundamental enabling technology of the Internet of Things concept, as well as machine-to-machine communications, since it minimizes the use of batteries and eliminates wired power connections. WPT technology brings together RF and dc circuit and system designers with different backgrounds on circuit design, novel materials and applications, and regulatory issues, forming a cross disciplinary team in order to achieve an efficient transmission of power over the air interface. This paper aims to present WPT technology in an integrated way, addressing state-of-the-art and challenges, and to discuss future R&D perspectives summarizing recent activities in Europe.The work of N. Borges Carvalho and A. J. S. Soares Boaventura was supported by the Portuguese Foundation for Science and Technology (FCT) under Project CREATION EXCL/EEI-TEL/0067/2012 and Doctoral Scholarship SFRH/BD/80615/2011. The work of H. Rogier was supported by BELSPO through the IAP Phase VII BESTCOM project and the Fund for Scientific Research-Flanders (FWO-V). The work of A. Georgiadis and A. Collado was supported by the European Union (EU) under Marie Curie FP7-PEOPLE-2009-IAPP 251557 and the Spanish Ministry of Economy and Competitiveness Project TEC 2012-39143. The work of J. A. García and M. N. Ruíz was supported by the Spanish Ministries MICINN and MINECO under FEDER co-funded Project TEC2011-29126-C03-01 and Project CSD2008-00068. The work of J. Kracek and M. Mazanek was supported in part by the Czech Ministry of Education Youth and Sports under Project OC09075–Novel Emerging Wireless Systems

Perceived feasibility of computer-generated auralization in concert halls

Over the years auralization has become a useful tool for simulating and evaluating the listening experience in virtual environments. Psychoacoustic phenomena, embodied by the human hearing system, highly determine the accuracy of sound-field recreation that is required for seemingly feasible auralization. In this scenario, the main aim of this study is to assess the suitability of computer-generated room impulse responses when used for auralizing spaces. To this purpose, simulated and experimentally measured binaural room impulse responses (BRIRs) have been convolved with iconic musical excerpts for various representative seats within a medium-sized concert hall. Listening tests have been thereby conducted and their results will be shown, analyzed and discussedEn estos últimos años, la auralización se ha convertido en una herramienta útil para la simulación y evaluación de la experiencia del oyente en entornos virtuales. En este ámbito, son de especial importancia los aspectos psicológicos y perceptivos, derivados del funcionamiento del sistema auditivo y del cerebro humanos, que determinan la precisión que se requiere para una recreación aparentemente creíble del campo sonoro. En este contexto, el principal objetivo de este estudio es evaluar la validez de respuestas al impulso de la sala generadas por ordenador para su utilización en la auralización de espacios. Con este propósito, para algunas localidades representativas de una sala de conciertos de tamaño medio, se han convolucionado varias respuestas al impulso binaurales (BRIRs), simuladas y medidas experimentalmente, con fragmentos musicales conocidos. Con los datos obtenidos, se han llevado a cabo pruebas de audición, cuyos resultados se presentan, analizan y discuten en esta comunicació

Estrategia marina demarcación marina levantino-balear parte IV. Descriptores del buen estado ambiental. Descriptor 1: biodiversidad evaluación inicial y buen estado ambiental

El descriptor 1 de la Ley 41/2010 de protección del medio marino, trasposición a la ley española de la Directiva Marco sobre la Estrategia Marina (DMEM: 2008/56/CE) dice textualmente "Se mantiene la biodiversidad. La calidad y la frecuencia de los hábitats y la distribución y abundancia de las especies están en consonancia con las condiciones fisiográficas, geográficas y climáticas". Según el Convenio sobre la Diversidad Biológica (UNCED, 1992), ésta se define como: "La variabilidad de organismos vivos de cualquier fuente, incluidos, entre otras cosas, los ecosistemas terrestres y marinos y otros ecosistemas acuáticos y los complejos ecológicos de los que forman parte; comprende la diversidad dentro de cada especie, entre especies y de los ecosistemas"

Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome

Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: -0.64 ml/min/1.73 m2; 95% CI: -1.21 to -0.08 and NEAP, β: -0.56 ml/min/1.73 m2; 95% CI: -1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07-1.54 and NEAP, OR: 1.24; 95% CI: 1.03-1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04-1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome. Keywords: albuminuria; chronic kidney disease (CKD); dietary acid load; glomerular filtration rate (GFR); kidney function; net endogenous acid production (NEAP); potential renal acid load (PRAL); renal nutrition

Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome

Background: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR). Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase. Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: –0.64 ml/min/1.73 m2; 95% CI: –1.21 to –0.08 and NEAP, β: –0.56 ml/min/1.73 m2; 95% CI: –1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07–1.54 and NEAP, OR: 1.24; 95% CI: 1.03–1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04–1.46) compared to individuals with lower dietary acid load. Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome