269 research outputs found
A polĂtica de habitação rural e o desenvolvimento da agricultura familiar.
Este artigo analisa a contribuição do Programa Nacional de Habitação Rural (PNHR) para o desenvolvimento de territĂłrios predominantemente rurais. A partir do estudo de sua implementação na regiĂŁo Oeste Catarinense, ponder sobre os avanços e as restriçÔes desta polĂtica social. Para as anĂĄlises realizadas procedeu-se a uma revisĂŁo de literatura, Ă busca de documentação sobre a polĂtica e sua implementação na regiĂŁo estudada, bem como a entrevistas com lideranças e agricultores demandantes e beneficiados por uma casa nova ou reforma. Verificou-se que o PNHR cria uma oportunidade para as famĂlias rurais descapitalizadas construĂrem ou reformarem sua casa, apesar de ser ainda restrita a sua abrangĂȘncia para o conjunto dessas famĂlias. A reformulação do programa, reduzindo exigĂȘncias financeiras e para operação dos crĂ©ditos, pode oportunizar que maior nĂșmero de famĂlias dele se beneficie, com impacto social positivo no desenvolvimento regional
New human case reports of cutaneous leishmaniasis by Leishmania (Viannia) naiffi in the Amazon region, Brazil
SOIL COVER AND CHEMICAL AND PHYSICAL ATTRIBUTES IN OXISOL IN THE ATLANTIC FOREST BIOME
Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host. [Corrigendum]
published erratum2016 Apr 202016 01 21importedErratum for : Sequence-independent characterization of viruses based on the pattern of viral small RNAs produced by the host. [Nucleic Acids Res. 2015
Dyspeptic symptoms and delayed gastric emptying of solids in patients with inactive Crohnâs disease
Comparative study of the areas of osteochondral defects produced in the femoral condyles of rabbits treated with gel of sugarcane biopolymer
Antimalarial Activity and Mechanisms of Action of Two Novel 4-Aminoquinolines against Chloroquine-Resistant Parasites
Chloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index). However, CQ is no longer used alone to treat patients with Plasmodium falciparum due to the emergence and spread of CQ-resistant strains, also reported for P. vivax. Despite CQ resistance, novel drug candidates based on the structure of CQ continue to be considered, as in the present work. One CQ analog was synthesized as monoquinoline (MAQ) and compared with a previously synthesized bisquinoline (BAQ), both tested against P. falciparum in vitro and against P. berghei in mice, then evaluated in vitro for their cytotoxicity and ability to inhibit hemozoin formation. Their interactions with residues present in the NADH binding site of P falciparum lactate dehydrogenase were evaluated using docking analysis software. Both compounds were active in the nanomolar range evaluated through the HRPII and hypoxanthine tests. MAQ and BAQ derivatives were not toxic, and both compounds significantly inhibited hemozoin formation, in a dose-dependent manner. MAQ had a higher selectivity index than BAQ and both compounds were weak PfLDH inhibitors, a result previously reported also for CQ. Taken together, the two CQ analogues represent promising molecules which seem to act in a crucial point for the parasite, inhibiting hemozoin formation
Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences
The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & NemĂ©sio 2007; Donegan 2008, 2009; NemĂ©sio 2009aâb; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported
by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on
18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based
researchers who signed it in the short time span from 20 September to 6 October 2016
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