Effects of inertial overload resistance training on muscle function.

El entrenamiento de fuerza debe incluirse en todos los programas de ejercicio encaminados a mejorar la salud y la calidad de vida. Los programas de entrenamiento de fuerza han priorizado los regímenes de contracción concéntricos a los excéntricos, sin embargo, actualmente se está realizando un tipo de entrenamiento de fuerza basado en contracciones excéntricas mediante sobrecargas de tipo inercial. Por tanto, el objetivo del presente trabajo de revisión bibliográfica ha sido comprobar los efectos de este tipo de entrenamiento basado en contracciones excéntricas mediante sobrecargas de tipo inercial sobre la función muscular. Para ello se realizó una búsqueda bibliográfica en las bases de datos Web of Science, Pubmed, Medline, Dialnet y Scielo. Los resultados de nuestra revisión sugieren que este tipo de entrenamiento da lugar a una mayor actividad electromiográfica e hipertrofia muscular con respecto a programas de entrenamiento convencionales, al tiempo que podrían ser efectivos en la recuperación de lesiones músculo-tendinosasResistance training should be included in all exercise programmes which improve health and quality of live. These programmes have been focusing on both concentric-eccentric contractions, however, a new type of resistance training based on eccentric contractions provided by inertial overload is being carried out. Therefore, the aim of the present study is to prove the effects of this kind of training based on eccentric contractions by inertial overload. Databases utilized to carry out information research were Web of Science, Pubmed, Medline, Dialnet and Scielo. Results would suggest that inertial training based on inertial overload produces maximal EMG and an earlier muscular hypertrophy compared to conventional resistance training, besides the fact it could have successful on muscle-tendon injurie

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dependent aggravation of cholangiopathies

Development of a Tool to Measure the Clinical Response to Biologic Therapy in Uncontrolled Severe Asthma: The FEV1, Exacerbations, Oral Corticosteroids, Symptoms Score

Background: There is a lack of tools to quantify the response to monoclonal antibodies (mAbs) holistically in severe uncontrolled asthma patients. Objective: To develop a valid score to assist specialists in this clinical context. Methods: The score was developed in four subsequent phases: (1) elaboration of the theoretical model of the construct intended to be measured (response to mAbs); (2) definition and selection of items and measurement instruments by Delphi survey; (3) weight assignment of the selected items by multicriteria decision analysis using the Potentially All Pairwise RanKings of All Possible Alternatives methodology using the 1000minds software; and (4) face validity assessment of the obtained score. Results: Four core items, with different levels of response for each, were selected: severe exacerbations, oral corticosteroid use, symptoms (evaluated by Asthma Control Test), and bronchial obstruction (assessed by FEV1 percent predicted). Severe exacerbations and oral corticosteroid maintenance dose were weighted most heavily (38% each), followed by symptoms (13%) and FEV1 (11%). Higher scores in the weighted system indicate a better response and the range of responses runs from 0 (worsening) to 100 (best possible response). Face validity was high (intraclass correlation coefficient of 0.86). Conclusions: The FEV1, exacerbations, oral corticosteroids, symptoms score allows clinicians to quantify response in severe uncontrolled asthma patients who are being treated with mAbs

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Efectos del entrenamiento con sobrecargas inerciales sobre el rendimiento deportívo

SIN FINANCIACIÓNNo data (2015