Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype

Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the US and Canada might be disproportionately affected. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network

On the future of distributed modelling in hydrology.

The main impacts of riparian vegetation on hydrological processes are briefly reviewed in order to highlight needs and perspectives for research and management goals. This review is based upon three distinct influences of riparian vegetation on hydrological processes: (i) the control of runoff, i.e. the physical impact of living and dead plants on hydraulics, (ii) the impact of plant physiology on water uptake, storage and return to the atmosphere, and (iii) the impact of riparian vegetation functioning on water quality. Riparian vegetation influences runoff through complex hydraulic interactions during baseflows as well as overbank flows. The contribution of fine vegetational structures to landscape hydrological roughness needs to be considered in relation to the spatial complexity (patchiness, vertical stratification, rhizosphere) and temporal variability (phenology, succession) of plant communities. With the exception of some woody species, the uptake, storage and return of water to the atmosphere is poorly known for riparian communities, and therefore the assessment of the regional hydrological importance of the riparian corridor remains difficult to estimate. Although better understood than the above two influences of riparian vegetation on hydrological processes, there are still a number of unresolved issues concerning the role of riparian vegetation in controlling water quality. In particular, little is known about the coupling of microbial and vegetational functions in nutrient cycling and the dynamics of carbon release from coarse and fine plant debris. The influence of vegetation complexity and plant diversity on both qualitative and quantitative aspects of water cycling remains an important area for future research. Fundamental and management issues are identified in relation to the use of riparian vegetation as a model and as a tool

Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype

Background & aimsChronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network.MethodsThe HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America.ResultsHalf of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log10 IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range.ConclusionsThe HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America

Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype

Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the US and Canada might be disproportionately affected. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network