Sleepwalking into lock-in? Avoiding wrongs to future people in the governance of solar radiation management research

This paper argues for two ways in which we can avoid the reckless endangerment of future people in the governance of solar radiation management (SRM) research, which could happen through lock-in to SRM deployment from research. SRM research is at an early stage, one at which the mechanisms of lock-in could start to operate. However, lock-in fit to endanger future people could be slowed or stopped through targeted governance. This paper argues that governance of SRM research that does not include provisions to detect, slow, or stop lock-in fails the test of an intergenerationally adequate precautionary principle, and that research governed without these provisions cannot itself be justified as a precaution against the impacts of climate change

The Public Domain

Background/Aims: Growth Hormone (GH) dosage in childhood is adjusted for body size, but there is no consensus whether body weight (BW) or body surface area (BSA) should be used. We aimed at comparing the biological effect and cost-effectiveness of GH treatment dosed per m(2) BSA in comparison with dosing per kg BW in girls with Turner syndrome (TS). Methods: Serum IGF-I, GH dose, and adult height gain (AHG) from girls participating in two Dutch and five Swedish studies on the efficacy of GH were analyzed, and the cumulative GH dose and costs were calculated for both dose adjustment methods. Additional medication included estrogens (if no spontaneous puberty occurred) and oxandrolone in some studies. Results: At each GH dose, the serum IGF-I standard deviation score remained stable over time after an initial increase after the start of treatment. On a high dose (at 1 m(2) equivalent to 0.056-0.067 mg/kg/day), AHG was at least equal on GH dosed per m(2) BSA compared with dosing per kg BW. The cumulative dose and cost were significantly lower if the GH dose was adjusted for m(2) BSA. Conclusion: Dosing GH per m(2) BSA is at least as efficacious as dosing per kg BW, and is more cost-effective. (c) 2014 S. Karger AG, Basel

Hormone Therapy and the Risk of Breast Cancer in BRCA1 Mutation Carriers

Background: Hormone therapy (HT) is commonly given to women to alleviate the climacteric symptoms associated with menopause. There is concern that this treatment may increase the risk of breast cancer. The potential association of HT and breast cancer risk is of particular interest to women who carry a mutation in BRCA1 because they face a high lifetime risk of breast cancer and because many of these women take HT after undergoing prophylactic surgical oophorectomy at a young age. Methods: We conducted a matched case-control study of 472 postmenopausal women with a BRCA1 mutation to examine whether or not the use of HT is associated with subsequent risk of breast cancer. Breast cancer case patients and control subjects were matched with respect to age, age at menopause, and type of menopause (surgical or natural). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with conditional logistic regression. Statistical tests were two-sided. Results: In this group of BRCA1 mutation carriers, the adjusted OR for breast cancer associated with ever use of HT compared with never use was 0.58 (95% CI = 0.35 to 0.96; P =. 03). In analyses by type of HT, an inverse association with breast cancer risk was observed with use of estrogen only (OR = 0.51, 95% CI = 0.27 to 0.98; P =. 04); the association with use of estrogen plus progesterone was not statistically significant (OR = 0.66, 95% CI = 0.34 to 1.27; P =. 21). Conclusion: Among postmenopausal women with a BRCA1 mutation, HT use was not associated with increased risk of breast cancer; indeed, in this population, it was associated with a decreased risk

7th Drug hypersensitivity meeting: part two

No abstract availabl

Strangeness Suppression of q(q)over-bar Creation Observed in Exclusive Reactions

We measured the ratios of electroproduction cross-sections from a proton target for three exclusive meson-baryon final states: $\Lambda K^+$, $p\pi^0$, and $n\pi^+$, with the CLAS detector at Jefferson Lab. Using a simple model of quark hadronization we extract q-qbar creation probabilities for the first time in exclusive two-body production, in which only a single q-qbar pair is created. We observe a sizable suppression of strange quark-antiquark pairs compared to non-strange pairs, similar to that seen in high-energy production.Comment: 5pages, 2figure

First measurement of the helicity asymmetry E in eta photoproduction on the proton

Results are presented for the first measurement of the double-polarization helicity asymmetry E for the $\eta$ photoproduction reaction $\gamma p \rightarrow \eta p$. Data were obtained using the FROzen Spin Target (FROST) with the CLAS spectrometer in Hall B at Jefferson Lab, covering a range of center-of-mass energy W from threshold to 2.15 GeV and a large range in center-of-mass polar angle. As an initial application of these data, the results have been incorporated into the J\"ulich model to examine the case for the existence of a narrow $N^*$ resonance between 1.66 and 1.70 GeV. The addition of these data to the world database results in marked changes in the predictions for the E observable using that model. Further comparison with several theoretical approaches indicates these data will significantly enhance our understanding of nucleon resonances

Photon beam asymmetry Sigma for eta and eta ' photoproduction from the proton

Measurements of the linearly-polarized photon beam asymmetry $\Sigma$ for photoproduction from the proton of $\eta$ and $\eta^\prime$ mesons are reported. A linearly-polarized tagged photon beam produced by coherent bremsstrahlung was incident on a cryogenic hydrogen target within the CEBAF Large Acceptance Spectrometer. Results are presented for the $\gamma p \to \eta p$ reaction for incident photon energies from 1.070 to 1.876 GeV, and from 1.516 to 1.836 GeV for the $\gamma p \to \eta^\prime p$ reaction. For $\gamma p \to \eta p$, the data reported here considerably extend the range of measurements to higher energies, and are consistent with the few previously published measurements for this observable near threshold. For $\gamma p \to \eta^\prime p$, the results obtained are consistent with the few previously published measurements for this observable near threshold, but also greatly expand the incident photon energy coverage for that reaction. Initial analysis of the data reported here with the Bonn-Gatchina model strengthens the evidence for four nucleon resonances -- the $N(1895)1/2^-$, $N(1900)3/2^+$, $N(2100)1/2^+$ and $N(2120)3/2^-$ resonances -- which presently lack the "four-star" status in the current Particle Data Group compilation, providing examples of how these new measurements help refine models of the photoproduction process.Comment: 10 pages, 3 figure