100 research outputs found

    ‘The Curse of the Caribbean’? Agency’s impact on the productivity of sugar estates on St. Vincent and the Grenadines, 1814-1829

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    This study estimates agency’s impact on sugar plantation productivity using a unique early 19th century panel data set from St. Vincent and the Grenadines. Results of fixed effects models, combined with a qualitative and quantitative analysis of potential endogeneity of the agency variable, provide no evidence that estates managed by agents were less productive than those managed by their owners. We discuss the results in the context of the historical and recent, revisionary, interpretations of agency and the emergence of managerial hierarchies in the Atlantic economy

    Chiral Symmetry Amplitudes in the S-Wave Isoscalar and Isovector Channels and the \sigma, f_0(980), a_0(980) Scalar Mesons

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    We use a nonperturbative approach which combines coupled channel Lippmann Schwinger equations with meson-meson potentials provided by the lowest order chiral Lagrangians. By means of one parameter, a cut off in the momentum of the loop integrals, which results of the order of 1 GeV, we obtain singularities in the S-wave amplitudes corresponding to the \sigma,f_0 and a_0 resonances. The \pi\pi-->\pi\pi, \pi\pi-->K\bar{K} phase shifts and inelasticities in the T=0 scalar channel are well reproduced as well as the \pi^-\eta and K^-K^0 mass distributions in the T=1 channel. Furthermore, the total and partial decay widths of the f_0 and a_0 resonances are properly reproduced including also the decay into the \gamma\gamma channel. The results seem to indicate that chiral symmetry constraints at low energy and unitarity in coupled channels is the basic information contained in the meson-meson interaction below \sqrt(s)=1.2 GeV.Comment: latex, 22 pages, 9 figure

    Cyclotron damping and Faraday rotation of gravitational waves

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    We study the propagation of gravitational waves in a collisionless plasma with an external magnetic field parallel to the direction of propagation. Due to resonant interaction with the plasma particles the gravitational wave experiences cyclotron damping or growth, the latter case being possible if the distribution function for any of the particle species deviates from thermodynamical equilibrium. Furthermore, we examine how the damping and dispersion depends on temperature and on the ratio between the cyclotron- and gravitational wave frequency. The presence of the magnetic field leads to different dispersion relations for different polarizations, which in turn imply Faraday rotation of gravitational waves.Comment: 15 pages, 3 figures. Accepted for publication in Phys. Rev.

    The Impact of Human Conflict on the Genetics of Mastomys natalensis and Lassa Virus in West Africa

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    Environmental changes have been shown to play an important role in the emergence of new human diseases of zoonotic origin. The contribution of social factors to their spread, especially conflicts followed by mass movement of populations, has not been extensively investigated. Here we reveal the effects of civil war on the phylogeography of a zoonotic emerging infectious disease by concomitantly studying the population structure, evolution and demography of Lassa virus and its natural reservoir, the rodent Mastomys natalensis, in Guinea, West Africa. Analysis of nucleoprotein gene sequences enabled us to reconstruct the evolutionary history of Lassa virus, which appeared 750 to 900 years ago in Nigeria and only recently spread across western Africa (170 years ago). Bayesian demographic inferences revealed that both the host and the virus populations have gone recently through severe genetic bottlenecks. The timing of these events matches civil war-related mass movements of refugees and accompanying environmental degradation. Forest and habitat destruction and human predation of the natural reservoir are likely explanations for the sharp decline observed in the rodent populations, the consequent virus population decline, and the coincident increased incidence of Lassa fever in these regions. Interestingly, we were also able to detect a similar pattern in Nigeria coinciding with the Biafra war. Our findings show that anthropogenic factors may profoundly impact the population genetics of a virus and its reservoir within the context of an emerging infectious disease

    Population, behavioural and environmental drivers of malaria prevalence in the Democratic Republic of Congo

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    <p>Abstract</p> <p>Background</p> <p>Malaria is highly endemic in the Democratic Republic of Congo (DRC), but the limits and intensity of transmission within the country are unknown. It is important to discern these patterns as well as the drivers which may underlie them in order for effective prevention measures to be carried out.</p> <p>Methods</p> <p>By applying high-throughput PCR analyses on leftover dried blood spots from the 2007 Demographic and Health Survey (DHS) for the DRC, prevalence estimates were generated and ecological drivers of malaria were explored using spatial statistical analyses and multilevel modelling.</p> <p>Results</p> <p>Of the 7,746 respondents, 2268 (29.3%) were parasitaemic; prevalence ranged from 0-82% within geographically-defined survey clusters. Regional variation in these rates was mapped using the inverse-distance weighting spatial interpolation technique. Males were more likely to be parasitaemic than older people or females (p < 0.0001), while wealthier people were at a lower risk (p < 0.001). Increased community use of bed nets (p = 0.001) and community wealth (p < 0.05) were protective against malaria at the community level but not at the individual level. Paradoxically, the number of battle events since 1994 surrounding one's community was negatively associated with malaria risk (p < 0.0001).</p> <p>Conclusions</p> <p>This research demonstrates the feasibility of using population-based behavioural and molecular surveillance in conjunction with DHS data and geographic methods to study endemic infectious diseases. This study provides the most accurate population-based estimates to date of where illness from malaria occurs in the DRC and what factors contribute to the estimated spatial patterns. This study suggests that spatial information and analyses can enable the DRC government to focus its control efforts against malaria.</p

    Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms

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    peer-reviewedIntestinal tissue, and specifically its mucosal layer, is a complex and gradient-rich environment. Gradients of soluble factor (BMP, Noggin, Notch, Hedgehog, and Wnt), insoluble extracellular matrix proteins (laminins, collagens, fibronectin, and their cognate receptors), stromal stiffness, oxygenation, and sheer stress induced by luminal fluid flow at the crypt-villus axis controls and supports healthy intestinal tissue homeostasis. However, due to current technological challenges, very few of these features have so far been included in in vitro intestinal tissue mimetic platforms. In this review, the tightly defined and dynamic microenvironment of the intestinal tissue is presented in detail. Additionally, the authors introduce the current state-of-the-art intestinal tissue mimetic platforms, as well as the design drawbacks and challenges they face while attempting to capture the complexity of the intestinal tissue’s physiology. Finally, the compositions of an “idealized” mimetic system is presented to guide future developmental efforts

    Detection chain and electronic readout of the QUBIC instrument

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    The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10⁻¹⁶ W/√Hz

    Detection chain and electronic readout of the QUBIC instrument

    Get PDF
    The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10⁻¹⁶ W/√Hz
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