Bringing Scholars to the Limelight: Publicizing an Institutional Repository amongst Faculty and Students

Touro Scholar, the institutional repository (IR) of the Touro College and University System (TCUS) and New York Medical College (NYMC), officially launched in April 2016, utilizing bepress’s Digital Commons repository platform.The IR is an online archive of scholarly output of an institution –in this case TCUS and NYMC. After assessing institutional knowledge of the scholarly benefits of depositing work in the repository, the libraries planned to create a concrete game plan to establish buy-in to Touro Scholar. Handouts, presentations, customized guides, liaison outreach, tutorials, and webinars were proposed methods of advertising the repository

Thriving in Student Affairs Professionals: An Exploration of Supporting Constructs

Student affairs professionals provide vital services to college students while also facing various challenges that impact their ability to thrive at work. This study examined overall thriving, its constructs and a set of predictors that impact thriving in student affairs professionals. Seligman’s (PERMA) theory of thriving provided the conceptual foundation for this study. Understanding the constructs that support thriving for student affairs professionals will help institutional leaders and professional organizations develop work environments and strategies that promote thriving. A global pandemic occurred during the time of this research, allowing exploration of how COVID-19 impacted thriving. This study also included variables of generation and functional areas to explore if there were variations of thriving. To test the research questions, an existing survey was modified for use in this study’s population. The original source of the survey was the Thriving Project at Azusa Pacific University under the leadership of Dr. Laurie Schreiner. The survey included questions related to PERMA (positive emotion, engagement, relationships, meaning and accomplishment) constructs, along with predictors of thriving (sense of community, spirituality, institutional integrity and commitment to staff welfare). The survey was administered to student affairs professionals at a mid-sized public university in the Midwest. The results supported the conclusion that student affairs professionals at this institution were experiencing a higher level of thriving. Pearson correlation revealed a positive relationship between all the PERMA constructs and overall thriving. A multiple regression revealed three of the four predictors contributed to overall thriving with commitment to staff welfare not having an impact. Results of two one-way ANOVAs revealed there was not a significant relationship of generation or functional area to overall thriving. However, the COVID-19 global pandemic was found to significantly impact thriving. Overall, the results of this study suggested that student affairs professionals at this public university were thriving and provided ways to further support thriving. This study included recommendations on ways this and other institutions could continue to bolster thriving among student affairs professionals

Prediction of phosphotyrosine signaling networks using a scoring matrix-assisted ligand identification approach

Systematic identification of binding partners for modular domains such as Src homology 2 (SH2) is important for understanding the biological function of the corresponding SH2 proteins. We have developed a worldwide web-accessible computer program dubbed SMALI for scoring matrix-assisted ligand identification for SH2 domains and other signaling modules. The current version of SMALI harbors 76 unique scoring matrices for SH2 domains derived from screening oriented peptide array libraries. These scoring matrices are used to search a protein database for short peptides preferred by an SH2 domain. An experimentally determined cut-off value is used to normalize an SMALI score, therefore allowing for direct comparison in peptide-binding potential for different SH2 domains. SMALI employs distinct scoring matrices from Scansite, a popular motif-scanning program. Moreover, SMALI contains built-in filters for phosphoproteins, Gene Ontology (GO) correlation and colocalization of subject and query proteins. Compared to Scansite, SMALI exhibited improved accuracy in identifying binding peptides for SH2 domains. Applying SMALI to a group of SH2 domains identified hundreds of interactions that overlap significantly with known networks mediated by the corresponding SH2 proteins, suggesting SMALI is a useful tool for facile identification of signaling networks mediated by modular domains that recognize short linear peptide motifs

The Equifinality of Archaeological Networks: an Agent-Based Exploratory Lab Approach

When we find an archaeological network, how can we explore the necessary versus contingent processes at play in the formation of that archaeological network? Given a set of circumstances or processes, what other possible network shapes could have emerged? This is the problem of equifinality, where many different means could potentially arrive at the same end result: the networks that we observe. This paper outlines how agent-based modelling can be used as a laboratory for exploring different processes of archaeological network formation. We begin by describing our best guess about how the (ancient) world worked, given our target materials (here, the networks of production and patronage surrounding the Roman brick industry in the hinterland of Rome). We then develop an agent-based model of the Roman extractive economy which generates different kinds of networks under various assumptions about how that economy works. The rules of the simulation are built upon the work of Bang (2006; 2008) who describes a model of the Roman economy which he calls the ‘imperial Bazaar’. The agents are allowed to interact, and the investigators compare the kinds of networks this description generates over an entire landscape of economic possibilities. By rigorously exploring this landscape, and comparing the resultant networks with those observed in the archaeological materials, the investigators will be able to employ the principle of equifinality to work out the representativeness of the archaeological network and thus the underlying processes

The effect of blue light exposure in an ocular melanoma animal model

<p>Abstract</p> <p>Background</p> <p>Uveal melanoma (UM) cell lines, when exposed to blue light in vitro, show a significant increase in proliferation. In order to determine if similar effects could be seen in vivo, we investigated the effect of blue light exposure in a xenograft animal model of UM.</p> <p>Methods</p> <p>Twenty New Zealand albino rabbits were injected with 1.0 × 10⁶human UM cells (92.1) in the suprachoroidal space of the right eye. Animals were equally divided into two groups; the experimental group was exposed to blue light, while the control group was protected from blue light exposure. The eyes were enucleated after sacrifice and the proliferation rates of the re-cultured tumor cells were assessed using a Sulforhodamine-B assay. Cells were re-cultured for 1 passage only in order to maintain any in vivo cellular changes. Furthermore, Proliferating Cell Nuclear Antigen (PCNA) protein expression was used to ascertain differences in cellular proliferation between both groups in formalin-fixed, paraffin-embedded eyes (FFPE).</p> <p>Results</p> <p>Blue light exposure led to a statistically significant increase in proliferation for cell lines derived from intraocular tumors (p < 0.01). PCNA expression was significantly higher in the FFPE blue light treated group when compared to controls (p = 0.0096).</p> <p>Conclusion</p> <p>There is an increasing amount of data suggesting that blue light exposure may influence the progression of UM. Our results support this notion and warrant further studies to evaluate the ability of blue light filtering lenses to slow disease progression in UM patients.</p

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Hargreaves, Andy, Lorna Earl, Shawn Moore, and Susan Manning, Learning to Change: Teaching Beyond Subjects and Standards. San Francisco: Jossey-Bass, 2000.

Reports a study of 29 teachers facing reforms in standards, assessment, and curriculum integration; gives their experiences and reactions to these changes in a broad context of research on the process of change in education