31 research outputs found
Changes in BOLD variability are linked to the development of variable response inhibition: BOLD variability and variable response inhibition
Research on the development of response inhibition in humans has focused almost exclusively on average stopping performance. The development of intra-individual variability in stopping performance and its underlying
neural circuitry has remained largely unstudied, even though understanding variability is of core importance for
understanding development. In a total sample of 45 participants (19 children aged 10–12 years and 26 adults
aged 18–26 years) of either sex we aimed to identify age-related changes in intra-individual response inhibition
performance and its underlying brain signal variability. While there was no difference in average stopping performance between children and adults, stop signal latencies for the children were more variable. Further, brain
signal variability during successful stopping was significantly higher in adults compared to children, especially
in bilateral thalamus, but also across regions of the inhibition network. Finally, brain signal variability was significantly associated with stopping performance behavioral variability in adults. Together these results indicate
that variability in stopping performance decreases, whereas neural variability in the inhibition network increases,
from childhood to adulthood. Future work will need to assess whether developmental changes in neural variability drive those in behavioral variability. In sum, both, neural and behavioral variability indices might be a more
sensitive measure of developmental differences in response inhibition compared to the standard average-based
measurements
Molecular basis of structure and function of the microvillus membrane of intestinal epithelial cells
Correlation of molecular structure with biochemical functions of the plasma membrane of the microvilli of intestinal epithelial cells has been investigated by biochemical and electron microscopic procedures. Repeating
particles, measuring approximately 60 Åin diameter, were found on the surface of the microvilli membrane which had been isolated or purified from rabbit intestinal epithelial cells and negatively stained with phosphotungstic acid. These particles were proved to be inherent components of the microvillus membrane, attached to the outer surface of its trilaminar structure, and were designated as the elementary particles of the microvilli
of intestinal epithelial cells. Biochemical and electron microscopic identification of these elementary particles has been carried out by isolation of the elementary particles with papain from the isolated microvillus membrane, followed by purification of the particles by chromatographies on DEAE-cellulose and Sephadex columns. The partially purified particles containing invertase and leucine aminopeptidase are similar in size and structure to those of the elementary particles in the microvillus membrane. Evidence indicates that each of the elementary particles coincide with or include an enzyme molecule such as disaccharidase or peptidase, which carry out the terminal hydrolytic digestion of carbohydrates and proteins, respectively, on the surface of the microvillus membrane. Magnesium ionactivated adenosine triphosphatase and alkaline phosphatase cannot be solubilized with papain but remains in the smooth-surface membrane after
the elementary particles have been removed. Cytochemical electron microscopic observation revealed that the active site of magnesium ion-activated adenosine triphosphatase is localized predominantly in the inner surface of the trilaminar structure of the microvillus membrane.</p
The Prohibition of the Proposed Springer-Prosiebensat.1-Merger: How Much Economics in German Merger Control?
Sources of variation for indoor nitrogen dioxide in rural residences of Ethiopia
<p>Abstract</p> <p>Background</p> <p>Unprocessed biomass fuel is the primary source of indoor air pollution (IAP) in developing countries. The use of biomass fuel has been linked with acute respiratory infections. This study assesses sources of variations associated with the level of indoor nitrogen dioxide (NO<sub>2</sub>).</p> <p>Materials and methods</p> <p>This study examines household factors affecting the level of indoor pollution by measuring NO<sub>2</sub>. Repeated measurements of NO<sub>2 </sub>were made using a passive diffusive sampler. A <it>Saltzman </it>colorimetric method using a spectrometer calibrated at 540 nm was employed to analyze the mass of NO<sub>2 </sub>on the collection filter that was then subjected to a mass transfer equation to calculate the level of NO<sub>2 </sub>for the 24 hours of sampling duration. Structured questionnaire was used to collect data on fuel use characteristics. Data entry and cleaning was done in EPI INFO version 6.04, while data was analyzed using SPSS version 15.0. Analysis of variance, multiple linear regression and linear mixed model were used to isolate determining factors contributing to the variation of NO<sub>2 </sub>concentration.</p> <p>Results</p> <p>A total of 17,215 air samples were fully analyzed during the study period. Wood and crop were principal source of household energy. Biomass fuel characteristics were strongly related to indoor NO<sub>2 </sub>concentration in one-way analysis of variance. There was variation in repeated measurements of indoor NO<sub>2 </sub>over time. In a linear mixed model regression analysis, highland setting, wet season, cooking, use of fire events at least twice a day, frequency of cooked food items, and interaction between ecology and season were predictors of indoor NO<sub>2 </sub>concentration. The volume of the housing unit and the presence of kitchen showed little relevance in the level of NO<sub>2 </sub>concentration.</p> <p>Conclusion</p> <p>Agro-ecology, season, purpose of fire events, frequency of fire activities, frequency of cooking and physical conditions of housing are predictors of NO<sub>2 </sub>concentration. Improved kitchen conditions and ventilation are highly recommended.</p
Vocal Interactivity in-and-between Humans, Animals, and Robots
Almost all animals exploit vocal signals for a range of ecologically motivated purposes: detecting predators/prey and marking territory, expressing emotions, establishing social relations, and sharing information. Whether it is a bird raising an alarm, a whale calling to potential partners, a dog responding to human commands, a parent reading a story with a child, or a business-person accessing stock prices using Siri, vocalization provides a valuable communication channel through which behavior may be coordinated and controlled, and information may be distributed and acquired. Indeed, the ubiquity of vocal interaction has led to research across an extremely diverse array of fields, from assessing animal welfare, to understanding the precursors of human language, to developing voice-based human–machine interaction. Opportunities for cross-fertilization between these fields abound; for example, using artificial cognitive agents to investigate contemporary theories of language grounding, using machine learning to analyze different habitats or adding vocal expressivity to the next generation of language-enabled autonomous social agents. However, much of the research is conducted within well-defined disciplinary boundaries, and many fundamental issues remain. This paper attempts to redress the balance by presenting a comparative review of vocal interaction within-and-between humans, animals, and artificial agents (such as robots), and it identifies a rich set of open research questions that may benefit from an interdisciplinary analysis
A gestural repertoire of 1-2year old human children : in search of the ape gestures
This project was made possible with the generous financial help of the Baverstock Bequest to the Psychology and Neuroscience Department at the University of St Andrews.When we compare human gestures to those of other apes, it looks at first like there is nothing much to compare at all. In adult humans, gestures are thought to be a window into the thought processes accompanying language, and sign languages are equal to spoken language with all of its features. While some research firmly emphasises the difference between human gestures and those of other apes, the question about whether there are any commonalities has rarely been investigated, and is mostly confined to pointing gestures. The gestural repertoires of nonhuman ape species have been carefully studied and described with regard to their form and function – but similar approaches are much rarer in the study of human gestures. This paper applies the methodology commonly used in the study of nonhuman ape gestures to the gestural communication of human children in their second year of life. We recorded (n=13) children’s gestures in a natural setting with peers and caregivers in Germany and Uganda. Children employed 52 distinct gestures, 46 (89%) of which are present in the chimpanzee repertoire. Like chimpanzees, they used them both singly, and in sequences; and employed individual gestures flexibly towards different goals.Publisher PDFPeer reviewe
Where have all the (ape) gestures gone?
International audienceComparative analysis of the gestural communica- tion of our nearest animal relatives, the great apes, implies that humans should have the biological potential to produce and understand 60–70 gestures, by virtue of shared common de- scent. These gestures are used intentionally in apes to convey separate requests, rather than as referential items in syntacti- cally structured signals. At present, no such legacy of shared gesture has been described in humans. We suggest that the fate of Bape gestures^ in modern human communication is rele- vant to the debate regarding the evolution of language through a possible intermediate stage of gestural protolanguage
The impact of cognitive testing on the welfare of group housed primates
Providing cognitive challenges to zoo-housed animals may provide enriching effects and subsequently enhance their welfare. Primates may benefit most from such challenges as they often face complex problems in their natural environment and can be observed to seek problem solving opportunities in captivity. However, the extent to which welfare benefits can be achieved through programmes developed primarily for cognitive research is unknown. We tested the impact of voluntary participation cognitive testing on the welfare of a socially housed group of crested macaques (Macaca nigra) at the Macaque Study Centre (Marwell Zoo). First, we compared the rate of self-directed and social behaviours on testing and non-testing days, and between conditions within testing days. Minimal differences in behaviour were found when comparing testing and non-testing days, suggesting that there was no negative impact on welfare as a result of cognitive testing. Lipsmacking behaviours were found to increase and aggressive interaction was found to decrease in the group as a result of testing. Second, social network analysis was used to assess the effect of testing on associations and interactions between individuals. The social networks showed that testing subjects increased their association with others during testing days. One interpretation of this finding could be that providing socially housed primates with an opportunity for individuals to separate from the group for short periods could help mimic natural patterns of sub-group formation and reunion in captivity. The findings suggest, therefore, that the welfare of captive primates can be improved through the use of cognitive testing in zoo environments