The Ursinus Weekly, December 14, 1953

MSGA-WSGA together, discuss U.C. honor system • Committee to pick Spring production • Senate hears complaints; Struth heads Booster Committee • MSGA warns men\u27s dorms • Audience stirred by Messiah, Thursday • Christmas Communion to be conducted by Chi Alpha • Morning watch services to be conducted this week by Y • Who\u27s who honors twelve in Ursinus class of 1954 • Debating Team opens season at tournament • Zimmerman, Price are lord, lady of senior ball • Alpha Psi Omega initiates new members, Kuebler, Allen • Editorials: Christmas spirit; Resolutions for a happy New Year • Letters to the editor • No Christ this Christmas? • Ursinus to participate in bridge tournament • Engagement announced • First Ursinus Christmas Fun in a magical snowfall • Awards available for graduate work • Mr. Dolman and Dr. Rice bring varied experience to new job • Paolone leads matmen; Expect excellent season • Phyl Stadler is hockey captain • Maliken, Aden are most valuable players: Football fullback, soccer halfback receive new honor • Belles begin practice; Friedlin leads cagers • Bears fall to Juniata; Wallop Pharmacy, 99-83 • Syvertsen captains mermaids; Excellent season expectedhttps://digitalcommons.ursinus.edu/weekly/1485/thumbnail.jp

The Ursinus Weekly, January 11, 1954

MSGA hears second case of cheating • Dr. James Martin is speaker at pre-med meeting • Dr. Garrett reads works of Proust • FTA hears talk by county school official • Alumni Office reports news of past graduates • Campus Chest reports total of $1,037.70 • F. W. Hankins is Bus. Ad. speaker • Baker, Miller debate on communist China in U.N. • Curtain Club schedules two one-act plays • French Club to discuss French art at next meeting • Greek columns • Editorials: Thanks, faculty • Recently announced engagements, pinnings • New Year\u27s congratulations • Examinations open for government positions • Practice teacher recalls woes, joys of high school life • Swami foresees U.C. fifty-four; Tells of strange revolutions • Matmen win thrilling Swarthmore opener: Dawkins, Paolone, Padula, Nunn pin; Briner decisions • Cubs remain undefeated in two league encounters • Cagers down Swarthmore; 77-67, on fast-breaking game • PMC and F&M defeat netmen • Knull illness hinders Bears • Philadelphia art museum exhibiting Van Gogh workshttps://digitalcommons.ursinus.edu/weekly/1486/thumbnail.jp

The Ursinus Weekly, November 16, 1953

Forum hears Norman Palmer talk on India • Honor system is MSGA topic at open discussion • U.C. group visits UN headquarters • Messiah features well-known soloists • Conditions in modern Austria revealed Monday by Thalburg • No easy answer seen by Chi Alpha Society • Faculty join students in show, Friday • Play polished by intense rehearsal • Music Club members attend harp concert • Dr. J. E. Wagner speaks, receives degree, Tuesday • High schools to tour campus • Doctors to appear at pre-med meeting • Dr. Yost presides at English lit reading • Pep talk on FTA affiliation given to campus members • Editorials: Education; Change in policy needed • Song and slogan spur Chest drive • Y sponsored work week commences November 30 • God and the atom to be coming attraction at vespers • Barbershop quartets present fine program • Beardwood Society plans field trip to exposition • Greek columns • Ursinus - F. & M. rivalry ends after fifty years • Variety of speakers highlight programs of past Founders Days • JVs lose second to strong Temple • Hockeyites down Temple in thrilling victory, 1-0 • Juniata defeats Bears for undefeated season • Cagemen initiate season tomorrow • Belles captain All-College teams • LaSalle defeats soccer team; Settles scores for Ursinus • Zartman, Settles, Dawkins score; Bakermen win, 6-2 • Writer satirizes sports jargonhttps://digitalcommons.ursinus.edu/weekly/1483/thumbnail.jp

The Ursinus Weekly, December 7, 1953

Prom to feature Johnny Austin, Sr. lord and lady • Wanamaker to give $1,000 scholarship • Sella resigns as senior prexy; Popowich unanimously chosen • Sixteenth Messiah performance to be held in Bomberger, Thursday • IRC to hear Chester Bowles at Bryn Mawr tonight • William S. Pettit named Dean of Ursinus College • MSGA hears student ideas at meeting • Raises revised by Stars and Players • Marge Merrifield wins hockey honor • Y plans party • Editorials: Honor at Ursinus; Maintenance mixup? • Cutting • Greek columns • Thespians present All my sons ; Reviewer notes fine performances • Pledge reveals fun and difficulties of informal Ursinus sorority initiation • Dorms eagerly anticipate vendors\u27 nightly visit • Hockey team ends season • JV Belles down Penn, W. Chester, Bryn Mawr • Soccermen lose to F&M; Season ends with party • Third team undefeated • Basketball season opens; Bears win, 84-66; 78-56 • Walker, Cox head 1954 football, soccer elevens • Dickinson downs Ursinus in football finale, 19-13 • Hockey-soccer game ends in 2-2 tie • Christmas vespers service to be held December 13 • Chemical society members visit chemical exposition • Truex speaks to pre-medders on opportunities in medicine • French Club holds program of vocal, piano music • Christmas dance plannedhttps://digitalcommons.ursinus.edu/weekly/1484/thumbnail.jp

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered.Multiple funders. See acknowledgments within article for details.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.semcancer.2015.09.00